ライフサイエンスコーパス: histamine receptor

1 but contrast with findings regarding the H2 histamine receptor.

2 identified and cloned a novel high-affinity histamine receptor.

3 that the AXOR35 receptor was a high-affinity histamine receptor.

4 , respective antagonists to lobster GABA and histamine receptors.

5 or Gs vs. Gi coupling differences among the histamine receptors.

6 argeted pharmacology, and shRNA knockdown of histamine receptors.

7 f histamine are inhibitory and exerted at H3 histamine receptors.

8 ude proteinase-activated receptor (PAR) 1 or histamine receptors.

9 ally mediated by histamine via H(2) and H(4) histamine receptors.

10 ic preoptic neurons by activating H3 subtype histamine receptors.

11 rate via activation of H(1) and H(2) subtype histamine receptors.

12 ounds that modulate the function of specific histamine receptors.

13 Histamine receptor 1 (HR1) antagonists, B-adrenergic ago

14 Histamine receptor 1 (HR1) antagonists, beta-adrenergic

15 In animal models, histamine receptor 1 (HRH1) agonists and histamine recep

16 ed responsiveness to histamine-primarily via histamine receptor 1 (Hrh1)-and an augmented relaxation

17 (EAE), mediated by T helper 1 (Th1) T cells, histamine receptor 1 and 2 (H1R and H2R) are present on

18 ndothelial cells via a pathway that involved histamine receptor 1 and phospholipase C beta signaling.

19 The perfusion of a histamine receptor 1 antagonist into the BF decreased bo

20 cell degranulation, but not by azelastine, a histamine receptor 1 antagonist, or by ketanserin, a ser

21 ed by platelet-activating factor receptor or histamine receptor 1 blockade.

22 ells, IgE-mediated mast cell activation, and histamine receptor 1 or 2 blockade on oral tolerance dev

23 Pretreatment with histamine receptor-1 antagonist, azelastine prevented th

24 Histamine receptor 2 (H(2)R)-deficient mice, histamine r

25 proinflammatory responses via activation of histamine receptor 2 (H2 R).

26 In histamine receptor 2 (H2R)-deficient mice, administratio

27 ing stress ulcer prophylaxis was $6,707 with histamine receptor-2 antagonist and $7,802 with proton p

28 Histamine receptor-2 antagonist or proton pump inhibitor

29 Histamine receptor-2 antagonist therapy appears to reduc

30 The probabilities that histamine receptor-2 antagonist was less costly and prov

31 r, resulting in a cost saving of $1,095 with histamine receptor-2 antagonist.

32 an absolute survival benefit of 0.006% with histamine receptor-2 antagonist.

33 infection showed a cost saving of $908 with histamine receptor-2 antagonists, but the survival benef

34 nd were not using a proton-pump inhibitor or histamine-receptor-2 (H2) blocker.

35 ls, histamine receptor 1 (HRH1) agonists and histamine receptor 3 (HRH3) antagonists decrease food in

36 gonists targeting different GPCRs, including histamine receptors, 5-HT (serotonin) receptors, muscari

37 We conclude that H1 histamine receptors activate ICat through coupling to Gi

38 on was also observed in the presence of H(2) histamine receptor activation and cholera toxin treatmen

39 ation of the Ca(2+) current mediated by H(2) histamine receptor activation.

40 tially dependent on nitric oxide (NO) and H1 histamine receptor activation.

41 es mediated by beta-adrenergic, but not H(2) histamine, receptor activation suggests that the inhibit

42 mouse models and the development of multiple histamine receptor agonists and antagonists have helped

43 ns in the presence and absence of histamine, histamine receptor agonists and antagonists.

44 Herein, we profiled the pharmacology of histamine receptor agonists at the two most abundant hH3

45 s, including endogenous M3 muscarinic and H1 histamine receptor and expressed cysteinyl leukotriene t

46 he first ultrastructural localization of any histamine receptor and the first direct evidence that HR

47 ts, suggesting the presence of an ionotropic histamine receptor and the possible nonspecificity of cu

48 Crosstalk between histamine receptors and other membrane or nuclear recept

49 study was to determine the role of H1 and H2 histamine receptors and to examine a potential interacti

50 hput screening of compounds against multiple histamine receptors and, thus, facilitates drug discover

51 (2) decreases CNS serotonin (via inhibitory histamine receptors), and (3) prevents a selective serot

52 Histamine receptor 2 (H(2)R)-deficient mice, histamine receptors, and their signaling pathways were i

53 Consistently, the histamine receptor antagonist chlorpheniramine potently

54 The H1 histamine receptor antagonist chlorpheniramine, but not

55 Improgan, an analog of the histamine receptor antagonist cimetidine, produces highl

56 Meclizine is an H1 histamine receptor antagonist known to have neuroprotect

57 idine (100 microg; 5 microl; i.c.v.), the H2 histamine receptor antagonist with imidazoline receptor

58 c.v. preadministration of cimetidine, the H2-histamine receptor antagonist, failed to antagonize the

59 receptor (mGluR) agonist, LY379268 or the H1 histamine receptor antagonist, meclizine decreases cispl

60 Group II mGluR agonist, LY379268, and the H1 histamine receptor antagonist, meclizine.

61 st cell stabilizer, doxantrazole, and the H1 histamine receptor antagonist, pyrilamine.

62 ii) Simultaneous administration of H1 and H2 histamine receptor antagonists (pyrilamine and famotidin

63 nhibitory effect on PyrNs was not blocked by histamine receptor antagonists but was blocked by GABA(A

64 arnosine was found to be neuroprotective but histamine receptor antagonists had no effect on the exte

65 ve been prescribed proton pump inhibitors or histamine receptor antagonists prior to endoscopy.

66 H1 and H2 histamine receptor antagonists, although developed many

67 Seven of nine trials of histamine-receptor antagonists showed a treatment-relate

68 anti-histaminergic effects, we show that H1 histamine receptors are not responsible for this effect

69 measure the affinity of compounds binding to histamine receptors are still routinely analyzed using a

70 ated, cannabinoid, opioid, cytokine, and new histamine receptors) are discussed.

71 The HDC/histamine/histamine receptor axis, ductular reaction, and biliary

72 e those for the analogous residues in the H1 histamine receptor but contrast with findings regarding

73 gonist cimetidine that does not act on known histamine receptors, but induces highly effective analge

74 mepyramine, a specific antagonist of the H1 histamine receptor, causes a delay in the birth of subse

75 ding histamine and leukotrienes that bind to histamine receptors causing vasodilation and extravasati

76 low during whole body heating contains an H1 histamine receptor component but do not support an H2 hi

77 receptor component but do not support an H2 histamine receptor component.

78 The emergence of histamine receptor-deficient mouse models and the develo

79 at GRK2 is the principal kinase mediating H1 histamine receptor desensitization in HEK293 cells and s

80 Blockade of histamine receptors does not prevent NGF-induced hyperal

81 , little is known about its role or specific histamine receptors during the host response to bacteria

82 ch physically interacts with macrophages via histamine receptors, exhibits substantially diminished b

83 n is further established postsynaptically by histamine-receptor-expressing unicolumnar retinotopic ne

84 These effects are influenced by host histamine receptor expression and the expression of hist

85 n of histamine degrading enzymes and reduced histamine receptor expression.

86 ntagonists specific for other members of the histamine receptor family had no effect in this assay fo

87 n exceptional selectivity profile within the histamine receptor family.

88 fusion demonstrates expression of functional histamine receptors from the first postnatal week onward

89 n the third intracellular loop of the murine histamine receptor H(1) (H(1)R) are candidates for Bphs,

90 Finally, treatment with histamine receptor H(1) antagonist pyrilamine blocked th

91 This aberrant pain signalling resulted from histamine receptor H(1)-mediated sensitization of viscer

92 otein-coupled receptors: H1, H2, H3, and H4 (histamine receptors; H(1-4)R).

93 Histamine receptor H1 (H1R) is a susceptibility gene in

94 We uncovered that histamine and histamine receptor H1 (HRH1) are frequently increased in

95 rome (IBS) and evaluated if an antagonist of histamine receptor H1 (HRH1) could reduce symptoms of pa

96 stress by antagonizing their common target, histamine receptor H1 (HRH1).

97 selected NE genes (adrenomedullin 2 [ADM2], histamine receptor H1 [HRH1], neuron-specific enolase [N

98 The histamine receptor H1 antagonist diphenhydramine, the an

99 lated molecules including MrgprA3, MrgprC11, histamine receptor H1, IL-31 receptor, 5-hydroxytryptami

100 h selectivity against other sites, including histamine receptors H1, H2, and H4.

101 We demonstrate that iDCs express two active histamine receptors, H1 and H2.

102 The H1 histamine receptor (H1HR) is a member of the G protein-c

103 A clone containing the H1 histamine receptor (H1HR)-encoding gene was isolated fro

104 The histamine receptor H1R agonist, 2-pyridylethylamine, sup

105 ve study of the cross-talk between H1 and H2 histamine receptors (H1R and H2R) in U937 cells and Chin

106 d liver spheroids, we identify nizatidine, a histamine receptor H2 (HRH2) blocker, for treatment of a

107 ectively activates the proinflammatory human histamine receptor H4 (HRH4).

108 The most recently discovered histamine receptor (H4) has emerged as a promising drug

109 Thus, histamine receptors have been actively pursued as therap

110 ion and activity of the four currently known histamine receptors; however, the relative protective or

111 Histidine decarboxylase (HDC) and histamine receptor (HR) expression were detected by qPCR

112 release of histamine, which acts on various histamine receptors (HR) 1-4, expressed by immune cells.

113 orld monkey retinas, we have been localizing histamine receptors (HR) and studying the effects of his

114 ets of these retinopetal axons, we localized histamine receptors (HR) in monkey and rat retinas by li

115 The presence and relative expression of histamine receptors HR1-4 and TLRs were determined as we

116 In prior work, type 3 histamine receptors (HR3) have been localized to the tip

117 t cells, and it exerts its functions through histamine receptors (HRs).

118 e describe here the protein expression of H4 histamine receptor in cells of the innate immune system,

119 2 (GRK2) regulates endogenously expressed H1 histamine receptor in human embryonic kidney 293 cells.

120 e glutamatergic marker Vglut2 and for the H1 histamine receptor in neurons excited by histamine.

121 Existing data on the expression of H(4) histamine receptor in the CNS are conflicting and inconc

122 ron microscopy (cryo-EM) structures of the 4 histamine receptors in complex with four different G pro

123 amine a potential interaction between NO and histamine receptors in cutaneous active vasodilatation.

124 rther substantiated by the identification of histamine receptors in human sebaceous glands.

125 ichment of nine Mrgpr family members and two histamine receptors in MrgprA3(+) neurons, suggesting th

126 R shows transcripts for H(1), H(2), and H(3) histamine receptors in striatum from the first postnatal

127 Here, we sought to define the necessity for histamine receptors in the pathology of anaphylaxis usin

128 this study, we investigated the role of the histamine receptors, in particular that of the histamine

129 Their ability to outcompete histamine receptors indicates that they suppress inflamm

130 the hypothesis that NFAT participates in H1 histamine receptor-induced interleukin-8 gene expression

131 lated by LTD4 yet had almost no effect on H1 histamine receptor internalization or signaling.

132 e research and the important applications of histamine receptor ligands, assays to measure the affini

133 The differences in histamine receptor localization may reflect the differen

134 DBu treatment produced similar effects on H2 histamine receptor-mediated ICa,L responses.

135 rmeability, gene and protein expression, and histamine receptor-mediated signaling.

136 Signaling through histamine receptors on dendritic cells (DCs) may be invo

137 In conclusion, our data show the presence of histamine receptors on sebocytes, demonstrate how an ant

138 , histamine (an agonist of the Gq-coupled H1 histamine receptor) or isoproterenol (an agonist of the

139 tanding of the different aspects involved in histamine receptor pharmacology, which in turn will cont

140 In the future, particular histamine receptors, protease pathway molecules, and van

141 Likewise, biased signaling at histamine receptors seems to be a pharmacological featur

142 ed AXOR35, is most closely related to the H3 histamine receptor, sharing 37% protein sequence identit

143 patitis patients had increased HDC/histamine/histamine receptor signaling.

144 plasma histamine in Alt+PNE sensitized pups, histamine receptor stimulation of endothelial PKCalpha s

145 ese data demonstrate that GPCR105 is a novel histamine receptor structurally and pharmacologically re

146 Activation of each histamine receptor subtype (H(1)-H(4)) increased [Ca(2+)

147 ogical role suggest that GPCR105 is a fourth histamine receptor subtype (H(4)) and may be a therapeut

148 e neurone and involve activation of the same histamine receptor subtype, the histamine H1 receptor.

149 effect that was mimicked by either H1 or H3 histamine receptor subtype-specific agonists.

150 The four histamine receptor subtypes (H1R, H2R, H3R, and H4R) res

151 er than 1000-fold selectivity over the other histamine receptor subtypes and favorable pharmacokineti

152 s secretion, and that activation of all four histamine receptor subtypes can increase [Ca(2+)](i).

153 ntrast to: 1) analyze the specificity of the histamine receptor subtypes for different heterotrimeric

154 hion similar to that predicted for the other histamine receptor subtypes, there are also important di

155 algorithms showed enrichment of genes within histamine receptor (subtypes 1 and 2) signaling pathways

156 dentified ort as a candidate gene encoding a histamine receptor subunit on L1/L2.

157 ition of glutamate, GABA, acetylcholine, and histamine receptors, suggesting cell-autonomous mechanis

158 There are currently four histamine receptors that have been cloned, all of which

159 the pharmacology and molecular mechanisms of histamine receptors that should be contemplated for opti

160 coupling of cardiac beta1-adrenergic and H2 histamine receptors to Gi/o mediated inhibitory response

161 sponses, including prostaglandin D synthase, histamine receptor type 1 (H1R), platelet activating fac

162 eprivation, and this effect was abolished by histamine receptor type I antagonist.

163 The mRNA expression of the histamine receptors was measured by real-time PCR.

164 he striatum also expresses a high density of histamine receptors, we hypothesized that released hista

165 recognition and G protein coupling of all 4 histamine receptors, which may facilitate the rational d

166 identification and localization of this new histamine receptor will expand our understanding of the

167 al effects of histamine are mediated by four histamine receptors with distinct functions and distribu