ライフサイエンスコーパス: histidine residue

1 rangement of three cysteine residues and one histidine residue.

2 A thioester bond near an invariant catalytic histidine residue.

3 ive-site serine and stable modification of a histidine residue.

4 ion, probably driven by protonation of a key histidine residue.

5 site cysteine of Grx3/4, glutathione, and a histidine residue.

6 he orientation of the GGQ domain without the histidine residue.

7 -dependent autophosphorylation reaction to a histidine residue.

8 site cysteine of Grx3/4, glutathione, and a histidine residue.

9 contain copper bound by two cysteines and a histidine residue.

10 n of HPr by the PTS enzyme EI at a conserved histidine residue.

11 ect almost entirely arises from a protonated histidine residue.

12 factor in the active site is replaced with a histidine residue.

13 ein family despite the lack of the signature histidine residue.

14 or but has the hydroxyl reactivity-conveying histidine residue.

15 le and protonation of the leaving group by a histidine residue.

16 lection via the dynamic flipping of a single histidine residue.

17 activated by a point mutation of a catalytic histidine residue.

18 to the pK(a) of the imidazole side chain of histidine residues.

19 the protonation/deprotonation of TIA-1 RRM3 histidine residues.

20 ta indicating important roles for lysine and histidine residues.

21 a series of peptides composed of lysine and histidine residues.

22 ed to the difference in the charged state of histidine residues.

23 eptide chain via proximal (CXXCH) and distal histidine residues.

24 tonable residues, including the cysteine and histidine residues.

25 ated by imidazole nitrogens of six conserved histidine residues.

26 rate release mechanism based on a cluster of histidine residues.

27 destabilization of one of two heme-ligating histidine residues.

28 highly mobile segment rich in methionine and histidine residues.

29 d a copper atom (Cu(B)) coordinated by three histidine residues.

30 dioxygenase (CDO), and is composed of three histidine residues.

31 by the native E7 histidine and two nonnative histidine residues.

32 osphorylation/dephosphorylation of conserved histidine residues.

33 nechocystis 6803, which binds zinc via three histidine residues.

34 s acetaldehyde adduct formation on lysine or histidine residues.

35 ch dominates in skin and cornea, incorporate histidine residues.

36 ous positively cooperative interactions with histidine residues.

37 [2Fe-2S] cluster via three cysteine and one histidine residues.

38 ss between one of the photoacids to proximal histidine residues.

39 ayload bound to the Fc region, presumably to histidine residues.

40 thyroid cells independently of extracellular histidine residues.

41 reveal the binding of two ruthenium atoms to histidine residues 146 and 242, which are both located w

42 Histidine residue 208 in BglG is essential for this phos

43 he alanine mutants, it was proposed that the histidine residues acted as acid-base catalysts, whereas

44 nvolves one of the two conserved active site histidine residues acting as a general base abstracting

45 g mechanism of catalysis and suggests that a histidine residue acts as the general acid.

46 ings indicate that mutations to the proximal histidine residues affect MtrA expression, leading to lo

47 r) composed of various numbers of lysine and histidine residues alone are not sufficient to mediate e

48 Multiple histidine residues along the rim of the VISTA extracellu

49 The tail histidine residues, along with two previously identified

50 Mutating this histidine residue also abolishes the ability of Cif to r

51 identified as the sole absolutely conserved histidine residue among family members.

52 ferential surface modification of lysine and histidine residues analyzed by mass spectrometry has bee

53 sphate molecule coordinated to the catalytic histidine residue and a second phosphate molecule in a p

54 l reactivity that is conveyed by a conserved histidine residue and allows conjugation to cell surface

55 center coordinated by a bidentate N-terminal histidine residue and another histidine ligand.

56 to demonstrate that both a C-terminal domain histidine residue and the 2-amino group of OG base are c

57 eing the formation of a C-C bond between the histidine residue and the 3-amino-3-carboxypropyl group

58 toNEET homodimer are each coordinated by one histidine residue and three cysteine residues.

59 s we mutated all extracellular glutamate and histidine residues and 4 of 11 aspartates.

60 The three tail histidine residues and His 63 in the recognition helix a

61 nd functional assays to show that pH-sensing histidine residues and K(+) ions mutually interact elect

62 h the catalytic zinc atom coordinated by two histidine residues and one aspartate residue approximate

63 sults also suggest tight binding between the histidine residues and the Cu(II) ion, which is likely t

64 aled several basic residues surrounding this histidine residue, and the mutation of these residues al

65 teine nucleophiles are often deprotonated by histidine residues, and histidine-235 was identified as

66 tion through protonation of CpxA periplasmic histidine residues, and upregulates the fabA and fabB ge

67 Thus, the C-terminal histidine residues are critical for the transition from

68 Four conserved histidine residues are demonstrated to be critical for e

69 The radical trapping properties of histidine residues are discussed.

70 Histidine residues are especially important for stabiliz

71 the conformational change are not known, but histidine residues are implicated because the pK(a) of h

72 In contrast, mutations to the distal histidine residues are less detrimental to protein expre

73 hyperstable variant of RAP-D3, in which four histidine residues are replaced with phenylalanine, has

74 Beta sheets containing histidine residues are used as a model system due to the

75 odel implicate displacements of the proximal histidine residue as the likely cause.

76 occurs around pH 6.5, we have looked toward histidine residues as a potential biophysical origin of

77 onophosphate end of the RNA is linked to the histidine residue at position 1,227 (H1227) of the L pro

78 I, binding to MCT1 and MCT4 is mediated by a histidine residue at position 64.

79 binding mechanism involves protonation of a histidine residue at the binding site.

80 ctivity, achieved by introducing a catalytic histidine residue at the terminus of a pH-responsive pep

81 eplicon engineered to have the tick-specific histidine residue at this position is replication defect

82 subjects, while the extents of conversion of histidine residues at alpha-His-20, alpha-His-50, and be

83 ly allowing VP5 to sense low pH via specific histidine residues at key positions.

84 nd steric repulsion builds up as the network histidine residues become protonated.

85 Depending on the position of the histidine residue, both enantiomers of the salsolidine p

86 ec residue farther away from the protonating histidine residue, but the lower pKa of Sec in compariso

87 ntiate side chain orientations in individual histidine residues, by correlating features in scanning

88 ntain a unique post-translationally modified histidine residue called diphthamide, which is the targe

89 and that the unique microstructure around a histidine residue can be identified by identifying the a

90 assignment of the p K a values to individual histidine residues can be achieved simultaneously based

91 t on their photodegradation kinetics and for histidine residues can explain most of the variation in

92 The high density of histidine residues combined with an abundance of basic r

93 is able to bind two b-type hemes through the histidine residues conserved between the MsrQ and NOX pr

94 In the M1 polymer, five histidine residues-contributed by three different monome

95 w that introduction of a suitably positioned histidine residue contributes to firmly anchor, via a da

96 enclose a large cavity where three conserved histidine residues coordinate a zinc ion.

97 ssess an active site of two highly conserved histidine residues coordinating a copper ion (the histid

98 ncentrations, the binding site consists of 4 histidine residues coordinating the copper through epsil

99 reacts with lysine, cysteine, tyrosine, and histidine residues, damaging critical immunogenic epitop

100 Ref, including several putative active site histidine residues, defines a new subclass of HNH-family

101 diphosphate (ADP)-ribosylation of a modified histidine residue, diphthamide, at His715, which blocks

102 Histidine residues direct oxidative coupling of boronic

103 ces, indicating that the paired cysteine and histidine residues do not function as a zinc finger DNA

104 m long fibrils with the hydrophobic edge and histidine residues extending in an ordered array as the

105 Mutation of the catalytic cysteine and histidine residues for either p29 or p48 was tolerated b

106 active site, the role of the two active site histidine residues for polarization of the substrate C h

107 indicate that the essential HBx cysteine and histidine residues form a zinc-binding motif that is req

108 Replacing the histidine residues forming the Zn(2+) binding site, His(

109 It is proposed that the histidine residue forms a hydrogen bond to a water/hydro

110 the protonable head group, and removing the histidine residue from the linker, both resulted in impr

111 conformational change removes one of the two histidine residues from the active site, likely triggeri

112 e consists of an Fe(II) ion ligated by three histidine residues from the protein, an interesting vari

113 ce of RIPK1 activation, suggesting that this histidine residue functions as a proton acceptor to modu

114 Murine HSP47 has 14 histidine residues grouped into three clusters, known as

115 Three histidine residues (H152, H155, and H156), located in fu

116 udies of mutant proteins, suggests that four histidine residues (H17 and H27 of S100A8; H91 and H95 o

117 Mutation of conserved histidine residues H200N, H293N, and H295N, expected to

118 Site-directed mutagenesis of a critical histidine residue (H233A) in the predicted active site o

119 In contrast, a cluster of three histidine residues (H245, H304, and H430) located near t

120 gests that it is a zinc metalloprotein, with histidine residues H32 and H82 required for NO. resistan

121 ort that replacement of the three C-terminal histidine residues, H322, H323, and H372, in triple-R or

122 ion for SFV zinc resistance identified a key histidine residue, H333 on E1 DIII, while other conserve

123 aracterized the role of two highly conserved histidine residues, H348 and H352, located in an externa

124 des an arginine replacement of the conserved histidine residue (H508R) located within the DEVH-contai

125 tive metal binding site with three conserved histidine residues (H73, H77 and H186).

126 ight into the role of the strictly conserved histidine residue, H79, in the reaction mechanism of the

127 Moreover, a single histidine residue, H906, was reported to be critical for

128 A novel steric gate histidine residue (H931 in Thermococcus sp. 9 degrees N

129 An invariant histidine residue has been proposed to function in the T

130 variant form of choline oxidase in which the histidine residue has been replaced with asparagine was

131 how that single substitution of only certain histidine residues has a lethal effect, indicating that

132 Specifically, protonation of histidine residues has been implicated in pH-dependent c

133 is unclear, and protonation of conserved E1 histidine residues has been proposed as a possible mecha

134 Histidine residues have been hypothesized to function as

135 Histidine residues have been suggested as triggers due t

136 and in contact with catalytically essential histidine residue (His(126)).

137 iated by the change in ionization state of a histidine residue (His(4)) that is not within the HA-bin

138 CN(-) and comparison of mutants identified a histidine residue (His-156) that coordinates the cobalt

139 ely eliminated by mutation of an active site histidine residue (His-287, murine ferrochelatase number

140 By site-directed mutagenesis we show that a histidine residue (His-347) downstream of S6 reduces inh

141 In Ngb, the imidazole of a histidine residue (His-64) in the distal position, above

142 the pH affinity curves indicate that another histidine residue, His(45), is largely responsible for t

143 The p K a values of three of four histidine residues (His12, -105, and -119) in RNase A we

144 taneously transfer a proton to a pore-lining histidine residue (His168).

145 nificantly reduced by the protonation of two histidine residues, His187 and His155.

146 tivity is enhanced by phosphorylation of the histidine residue (His232) located in its activation loo

147 ots were identified, which include conserved histidine residues His292 and His440 in the Fc region an

148 octahedral coordination for Fe(2+) with two histidine residues (His331 and His367), a bidentate carb

149 tion to calcium, phosphorylation of a single histidine residue (His358) in the cytoplasmic region, by

150 Four histidine residues (His37) in the center of the channel

151 Mutating any of the four conserved histidine residues (His51, 147, 210, or 354) in hSVCT1 t

152 olvent to the high flexibility of the distal histidine residue, His55, that provides a direct pathway

153 We demonstrate here that the distal pocket histidine residue (His64) of horse heart metMb(III) (i.e

154 structural features, including two prominent histidine residues, His685 and His686, which may be impo

155 Previous studies identified a histidine residue (His69) that functions as a pH sensor

156 The bound zinc ion is coordinated by three histidine residues (His78, His161 and His225) and one gl

157 ity in vitro and requires a highly conserved histidine residue identified in alpha/beta hydrolase fam

158 stamine chelation of copper(I) by a terminal histidine residue in copper hydroxylating enzymes activa

159 ed to investigate the function of the distal histidine residue in Cupriavidus metallidurans TDO (cmTD

160 lyzed oxidation of a specific, metal-binding histidine residue in domain 1 of the channel.

161 Our data indicate that mutation of one histidine residue in E1 is detrimental to the assembly o

162 c role was put forward for a fully conserved histidine residue in MraY (His-289 in BsMraY), which has

163 crepancy, we explored the role of the distal histidine residue in muting the reactivity of human neur

164 The Histidine residue in position 265 of the CdtB catalytic

165 ferent substrates with the conserved central histidine residue in protonated or neutral form.

166 that the catalytic proton transfer between a histidine residue in the active site and the 6-4PP, indu

167 riggers autophosphorylation of the catalytic histidine residue in the C-terminal domain to transmit t

168 A highly conserved histidine residue in the distal heme pocket has attracte

169 of this complex reveals that a non-conserved histidine residue in the ETS domain recognition helix he

170 entially autophosphorylate at each conserved histidine residue in the individual protomers, leading t

171 The pK(a) of the lone histidine residue in the peptide, which is likely respon

172 , Schuberth-Wagner et al. (2015) show that a histidine residue in the RNA binding pocket of RIG-I ste

173 acking interaction that positions a critical histidine residue in the substrate specificity loop of c

174 our work suggests a more general role of the histidine residue in the transport of copper by PIB-1-AT

175 This is the first report of a methylated histidine residue in yeast cells, and the first example

176 e aquaporin and M2 channels, the presence of histidine residues in a mostly hydrophobic channel has l

177 requires the presence of globally protected histidine residues in a protein's three-dimensional stru

178 tween pH 6.0 and 6.5 upon protonation of the histidine residues in acidic solutions.

179 We provide direct evidence that all three histidine residues in amyloid-beta 1-16 (Abeta 1-16) coo

180 rmational changes by precisely preorganizing histidine residues in buried hydrogen-bond networks.

181 In order to model the syn disposition of histidine residues in carboxylate-bridged non-heme diiro

182 Moreover, the introduction of histidine residues in cholesterol-peptide conjugates led

183 ing a Ctr1 mutant lacking only extracellular histidine residues in Ctr1-knockout mouse embryonic fibr

184 We identify five histidine residues in eEF2K that are crucial for the act

185 We found that five histidine residues in helices 5-8 of apoA-I are preferab

186 sphorylated serine, threonine, tyrosine, and histidine residues in phosphoproteins.

187 to determine the p K a values of individual histidine residues in proteins.

188 Although histidine residues in the absence of Zn(II) exhibit pNPA

189 on of 1.86 A established the presence of two histidine residues in the active site, which may partici

190 using phylogenetically conserved serine and histidine residues in the active site.

191 he hydrophobic tail, and (3) the presence of histidine residues in the amino acid linker for transfec

192 the role of conserved pairs of cysteine and histidine residues in the C-terminal region of L4-22K.

193 s studies showed that none of the lysines or histidine residues in the carboxyl-terminal protease dom

194 t in canine HSP47, where we have mutated all histidine residues in the collagen binding interface and

195 scopy establishes that Cu(2+) coordinates to histidine residues in the EcoRI endonuclease homodimer b

196 We investigated a requirement for histidine residues in the envelope (E) protein of West N

197 Thorough mutational analysis of conserved histidine residues in the envelope protein of tick-borne

198 een GAG anomeric position(s) and one or more histidine residues in the fibrils.

199 tivation causes oxidative damage to specific histidine residues in the key proteins in aldose reducta

200 he receptor-binding VP2 protein, and certain histidine residues in the membrane-penetrating VP5 prote

201 Two conserved histidine residues in the OSBP homology domain ORP4 are

202 ential for FrcB stability, as were conserved histidine residues in the protein that likely coordinate

203 drophilic angle of 140 degrees formed by the histidine residues in the Schiffer-Edmundson helical whe

204 Insertion of histidine residues in the sequence reduced kidney uptake

205 This property is likely caused by histidine residues in the vicinity of the mapped heparin

206 ted mZIP4 variants, we provide evidence that histidine residues in this motif coordinate a zinc ion i

207 all individual and selected clusters of GP64 histidine residues in triggering and mediating fusion by

208 amino acid substitutions for five conserved histidine residues in two PTS regulatory domains and an

209 nstrate that when arginine 132 is mutated to histidine, residues in the active site are shifted to pr

210 globin in both quail species contained eight histidine residues instead of the nine present in chicke

211 mophore that involves the incorporation of a histidine residue into the conjugated system.

212 de networks, the imidazole side chain of the histidine residue is deprotonated to afford Zn-imidazola

213 In both structures, a histidine residue is found at the normally hydrophobic p

214 1-16 analogues, in each of which a selected histidine residue is isotopically enriched with (15)N.

215 pH dependent (pK(a) approximately 7) when a histidine residue is located in the neighborhood of the

216 DAM active site with three zinc-coordinating histidine residues is introduced.

217 n of an alpha-helix stabilising sequence and histidine residues, lengthens the pharmacokinetic profil

218 line as a substrate and required a conserved histidine residue located in the FIC domain of the AnkX

219 BK channel requires an aspartic acid and two histidine residues located in the cytoplasmic RCK1 domai

220 tested; only mutations of three consecutive histidine residues, located in a single extracellular lo

221 ted CC' loop and a striking concentration of histidine residues, located in the complementarity-deter

222 microscopy, revealing that highly-conserved histidine residues near the C terminus of each microtubu

223 Finally, two histidine residues near the extracellular surface and th

224 Neither substitution of the phosphoaccepting histidine residue nor deletion of the entire catalytic A

225 ough a mechanism that involves a cytoplasmic histidine residue, not used by other TRPV1 agonists such

226 pecific post-translational modification of a histidine residue of eEF2, is involved in translocation.

227 up from S-adenosyl-l-methionine (SAM) to the histidine residue of EF2, forming a C-C bond.

228 EnUmt) by changing the codon for a catalytic histidine residue of EndoU to alanine (His226Ala).

229 itutions of either the conserved cysteine or histidine residue of SrtA known to be required for catal

230 e, mutation of the conserved phosphoacceptor histidine residue of the AHP, as well as disruption of m

231 A Src revealed the surprising finding that a histidine residue of the N-terminus of a symmetry-relate

232 monstrated that mutation of the two adjacent histidine residues of Abeta40 (H13,14G) resulted in a si

233 on via their interaction with the N-terminal histidine residues of amyloid-beta (Abeta).

234 in pKa values and tautomer distributions for histidine residues of an invisible on-pathway folding in

235 ents reveal that the six Mn(II)-coordinating histidine residues of Ca(II)- and Mn(II)-bound CP are sp

236 this study, we show the effects of mutating histidine residues of MtrA to arginine on protein expres

237 y structure of the APP CuBD, we examined the histidine residues of the copper binding site (His(147),

238 The pH dependency is due to the conserved histidine residues of the ENTH and ANTH domains, protona

239 Mutagenesis of the three ectodomain histidine residues of the HMPV F protein demonstrated th

240 pathogenicity and that a substitution of the histidine residues of the MHV-A59 ns2 His-x-Thr/Ser moti

241 ucidation of the myoglobin (Mb) structure, a histidine residue on the E helix (His-E7) has been propo

242 natures at pH <6.2 due to protonation of key histidine residues on helices 2 and 3.

243 king occurred across two identical conserved histidine residues on two separate heavy chains in the h

244 nonuclear copper center coordinated to three histidine residues, one of which is covalently cross-lin

245 es (AMPs) that contain a large proportion of histidine residues (pK(a) approximately 6) depends on th

246 do not strongly indicate that the conserved histidine residues play a role in the pH regulation of m

247 have investigated the protonation states of histidine residues (potential Bohr groups) in the deoxy

248 theoretical and experimental study of the 14 histidine residues present in canine HSP47, where we hav

249 We found that N(epsilon) of a histidine residue, presumably H75, carries most of the u

250 sequence, which replaces arginine 887 with a histidine residue (R887H), strongly inhibits PKCalpha-de

251 Mutation of the histidine residues resulted in a mutant with a similar p

252 Mutations to the distal histidine residues resulted in various degrees of ferrih

253 arily arises from salt bridges involving IgG histidine residues, resulting in moderate affinity at mi

254 ngated at pH 9.4, showing the involvement of histidine residue(s) in its folded-back structure.

255 ng from approximately 1 to 12%, and a single histidine residue separated the most and least reactive

256 ort here that the alkylation of an essential histidine residue showed no effect on the one-electron p

257 domains contribute equatorially coordinated histidine residue side-chains, resulting in a novel brid

258 e-rich (E/Q)XXXE plus PGXSRSXXT motifs and a histidine residue, specific to the bacterial UppP enzyme

259 -bound DrDXPS delineates how two active-site histidine residues stabilize the LThDP intermediate.

260 ia toxin, is a post-translationally modified histidine residue that is found in archaeal and eukaryot

261 in the positions of the proximal and distal histidine residues that appeared during DHP evolution.

262 T activity requires catalytic asparagine and histidine residues that are conserved in this family.

263 a putative catalytic triad consisting of two histidine residues that are hydrogen bonded to an ordere

264 We also identify key histidine residues that control this pH-dependent equili

265 This channel has four central histidine residues that form an acid-activated gate, bin

266 In addition to cysteine and histidine residues that form the catalytic site, 2 lysin

267 unique spacial arrangement of nine conserved histidine residues that implies a potentially novel mech

268 in pH have recently been shown to be the two histidine residues that ligate the [2Fe-2S] cluster.

269 It is characterized by two invariant histidine residues that play a critical role in catalyti

270 Many heme proteins have distal histidine residues that play important roles in determin

271 g by the side chains of an aspartate and two histidine residues; three water molecules complete octah

272 nitroazobenzene chromophore to tyrosine and histidine residues, thus endowing peptides with high pho

273 hypothesized that protonation of one or more histidine residues triggers this transition.

274 FdtA is characterized by a cluster of three histidine residues, two of which, His(49) and His(51), a

275 e, a plant homolog of KL, revealed that this histidine residue was at the base of the deep catalytic

276 ver, there are three deviant variants, whose histidine residue was found to be involved in site-speci

277 n which the electrostatic environment of the histidine residue was perturbed by altering charged and

278 Although a histidine residue was previously proposed to be the acti

279 tification, and site-directed mutagenesis of histidine residues, we demonstrated that MsrQ is able to

280 this disulfide bond with elimination of key histidine residues, we generated a stable RAP molecule t

281 analyses to assess the protonation state of histidine residues, we propose a new mechanistic scheme

282 s in which tryptophan 51 was replaced with a histidine residue were constructed.

283 These three histidine residues were important for efficient pore exp

284 e, H333 on E1 DIII, while other conserved E1 histidine residues were not involved.

285 (pKa = 7.7), suggesting the protonation of a histidine residue, which could hydrogen bond with the ca

286 A pair of histidine residues, which are conserved in coronavirus s

287 reates a single Mn(2+)-binding site from six histidine residues, which distinguishes CP from all othe

288 s for generation of peptide ions with unique histidine residues, which were overcome by employing ETD

289 lding were constructed by replacing interior histidine residues with phenylalanines.

290 iolases and replaced a pair of oxyanion-hole histidine residues with Tyr-246 and Tyr-344.

291 H229 residues, not the other methionine and histidine residues, with alanine convert UV-vis spectra

292 this subfamily were recently shown to use a histidine residue within a His-Asp dyad contained in a s

293 A histidine residue within NExo that is responsible for it

294 ion proceeds through a covalent guanylylated histidine residue within the histidine triad motif.

295 rk highlighted the importance of a conserved histidine residue within the propeptide of a widely stud

296 FFXRX6RX12PXD motif, two uniquely conserved histidine residues within a PXXYHXXHXP motif, and a uniq

297 of interest and inspired by nature's use of histidine residues within the active sites of various co

298 trate that the highly conserved cysteine and histidine residues within the C-X(8)-C-X(24-75)-H-X-G-G-

299 site-directed substitutions of cysteine with histidine residues within the PARP-1 zinc finger reveale

300 chment of an osmium bis-bipyrdine complex to histidine residues within the peptide.