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1 slational modifications of cccDNA-associated histones.
2 H3K9 tri/di-methylation (H3K9me3/2)-modified histones.
3 , we show that glucose starvation suppresses histone 2A K119 monoubiquitination (H2Aub), a histone mo
4 DM4B results in aberrant hypermethylation of histone 3 lysine 9 (H3K9) at loci surrounding DNA breaks
6 sion, miRNA expression, DNA methylation, and histone acetylation from ASD and control brains to ident
7 e a hierarchical view about the functions of histone acetylation in auxin signaling and root morphoge
9 ent studies have elucidated the functions of histone acetylation in the modulation of auxin signaling
12 ne methylations occur first in prometaphase, histone acetylation, and CTCF in anaphase/telophase, tra
13 alyzed by Bicoid and Zelda, possibly through histone acetylation, and found that this model can predi
14 ed the method to an AD dataset consisting of histone acetylation, DNA methylation, and RNA transcript
15 min A/C binding was accompanied by increased histone acetylation, increased c-Jun binding, and upregu
17 igenetic regulator with intrinsic kinase and histone acetyltransferase (HAT) activities that activate
20 on at sites of injury, paralleling increased histone acetyltransferase general transcription factor I
21 CT 116 cells lacking p300 suggested that the histone acetyltransferase is a negative regulator of Hip
24 acute degradation system, we found that the histone acetyltransferases P300 and CBP maintained H3K27
27 CoREST makes critical contacts with both histone and DNA components of the nucleosome, explaining
28 suggest that it may unfold the Cse4(CENP-A) histone and hand it over to Scm3(HJURP) for subsequent d
29 dock to DNA or post-translationally modified histones and a caspase activation and recruitment domain
30 criptional activation, only demethylation of histones and cytosine-phosphate-guanines (CpGs) in gene
31 fence which includes a process of release of histones and DNA as neutrophil extracellular traps (NETs
34 tein PARP1 and its paralogue PARP2 to modify histones and other substrates through the addition of mo
35 traps (NETs) composed of DNA complexed with histones and toxic antimicrobial proteins that ensnare p
36 how that megakaryocytes contain extranuclear histones and transfer histones to their platelet progeny
37 are associated with increased acetylation of histones and with increased phosphorylation of H2AX and
40 tween the cellular signaling network and the histone-based gene regulatory system and propose an inte
41 To investigate the functional relevance of histone-binding activity of Pygo2 in malignant progressi
42 c target in metastatic breast cancer, as its histone-binding capability promotes beta-catenin-mediate
45 Engineering of the essential CENTROMERIC HISTONE (CENH3) gene induces paternal HI in Arabidopsis(
46 ve-cell imaging to reveal a key role for the histone chaperone complex FACT (SPT16 and SSRP1) in gove
47 icative stress caused by defects in the ATRX-histone chaperone complex, and that induced by MYCN-medi
48 us laevis egg extract identified the dimeric histone chaperone facilitates chromatin transcription (F
50 s of machine learning, CEFCIG reveals unique histone codes for transcriptional regulation of reported
51 end is flexible and partly detached from the histone core, suggesting sequence-dependent dynamics of
52 mework for understanding mechanisms of trans-histone cross-talk and the dynamic role of H2B ubiquitin
53 ing (1) auxin/indole-3-acetic acid (AUX/IAA)-histone deacetylase (HDA) and (2) auxin response factor
54 stat, vorinostat) and selective (romidepsin) histone deacetylase (HDAC) inhibitors elicited metabolic
55 ular interest, pharmacological inhibition of histone deacetylase 11 (HDAC11) and suppressor of varieg
56 e reporter assay developed, we find that the histone deacetylase 3 (HDAC3)-selective inhibitor, RGFP9
59 cluding DNA methyltransferase inhibitors and histone deacetylase 6 inhibitors (DNMTis and HDAC6is) in
61 onsistent with the known control of the Set3 histone deacetylase complex (HDAC) by H3K4 di-methylatio
63 stone Deacetylase1 (RPD3/HDA1) type class II histone deacetylase HDA15 in Arabidopsis (Arabidopsis th
64 factor MutSbeta (Msh2-Msh3 complex) and the histone deacetylase HDAC3 function in the same pathway t
67 n line with this finding, treatment with the histone deacetylase inhibitor givinostat caused a signif
70 conducted to investigate the effects of the histone deacetylase inhibitor valproate and all-trans re
71 efforts has been on a class of drugs called histone deacetylase inhibitors (HDACi), which have the p
74 disrupt heterochromatin by outcompeting the histone deacetylase, Clr3 from sites of heterochromatin
75 ugs for three distinct epi-drugs that target histone deacetylase, DNA methylation and bromodomain pro
77 ructure of the Reduced Potassium Dependency3/Histone Deacetylase1 (RPD3/HDA1) type class II histone d
79 ANG II enhanced the activities of Class I histone deacetylases (HDACs 1/2), thereby decreased hist
85 multi-protein complexes that recruit class I histone deacetylases to the genome to regulate gene expr
86 y-as well as with nucleosome remodellers and histone deacetylases-at active enhancers and promoters.
89 demethylase; also known as KDM1A), the first histone demethylase discovered, regulates cell-fate dete
91 and function is critically controlled by the histone demethylase JMJD2B, which is induced by EndMT-pr
92 Previously, our laboratory implicated the histone demethylase LSD1 in tau-induced neurodegeneratio
93 at it promotes lipogenesis by recruiting the histone demethylase Lsd1 to the fatty acid synthase gene
95 this study, in silico analyses of the lysine histone demethylases (KDMs) involved in diverse biologic
96 es showed no pixel-by-pixel correlation with histone density, although slower diffusion was observed
97 with wild-type kinetics, arguing that global histone depletion rather than DSB movement is rate limit
99 al modeling indicate that because unmodified histones dilute H3K27me3 by 50% each time DNA replicates
100 and platelets may be a source of circulating histones during sepsis and should be further explored.
105 , and that the large number of endogenous RD histone gene copies sequester available factor(s) from a
106 of p53, increases markedly the expression of histone genes and results in reversible upregulation of
110 s the DNA damage response (DDR) by modifying histone H2A at Lys15 (H2AK15ub) and triggering downstrea
111 e also observed partial ordering of the core histone H2A C-terminal and H3 N-terminal tails in the ch
114 on toward nucleosomes with the non-canonical histone H2A.Z, thereby focusing the pathway on select si
115 hydrocarbon receptor, and phosphorylation of histone H2AX, a known marker of double-strand DNA breaks
117 We used fluorescence anisotropy imaging of histone H2B-EGFP to interrogate global chromatin compact
119 ion and metastasis through trimethylation of histone H3 at lysine 27 (H3K27me3) at their promoters.
123 ssa type A ependymomas contain the recurrent histone H3 lysine 27 (H3 K27M) mutation and express the
125 key enzymatic protein complex that catalyzes histone H3 lysine 27 (H3K27) methylation to mediate epig
126 nces transcription through trimethylation of histone H3 lysine 27 (H3K27me3) and has emerged as an im
127 pression during cell-fate change(5), whereas histone H3 lysine 4 (H3K4) trimethylation marks active g
128 families of the TrxG - the COMPASS family of histone H3 lysine 4 methyltransferases and the SWI/SNF f
130 ine 310 and associated increases in H3K9me2 (histone H3 lysine 9 dimethylation) in the dorsal hippoca
132 he effect of the methyltransferase SETD1B on histone H3 lysine K4 (H3K4) histone trimethylation on in
136 posttranscriptional modifications (marks) to histone H3 lysines (H3K4me3, H3K4me1, H3K27ac, H3K27me3,
137 he detection of protein kinases, telomerase, histone H3 methyltransferase SET7/9, and polypeptide N-a
139 ncer Research, Liao and colleagues show that histone H3 trimethylation on lysine 27, induced by polyc
140 centromere DNA through transcription-coupled histone H3 turnover, driving the replacement of resident
143 ) is a deposition factor for the centromeric histone H3 variant Cse4(CENP-A) at the centromere in yea
145 (LSD1) targets cellular proteins, including histone H3, p53, E2F, and Dnmt1, and is involved in the
146 n resulted in a widespread redistribution of histone H3, with increased accumulation around transcrip
148 on in the yeast Saccharomyces cerevisiae The histone H3-H4 tetramer, therefore, has a role other than
151 ere, we report that maternal contribution of histone H3.3 assembly complexes can prevent the expressi
152 eres during the G2 phase and is required for histone H3.3 deposition and telomere DNA synthesis.
155 etric di-methylation of arginine residues in histones H3 and H4, marks that are generally associated
158 7, Atgl, and Fgf21, through demethylation of histone H3K27-me3, resulting in autophagy-mediated lipid
159 Gene expression changes, redistribution of histone H3K27me3 profiles and global DNA hypomethylation
162 tin accessibility and significant changes in histone H3K9me3 over many sites, including genes that ar
163 we have quantified an endogenous peptide of histone H4 by matrix-assisted laser desorption/ionizatio
166 responsible for the interaction of CENH3 and histone H4, which indicates that CENH3 maintains deposit
167 enzyme A-dependent carbon metabolism through histone hyper-acetylation, and Sirtuin-mediated silencin
168 that rather than simply unfolding chromatin, histone hyperacetylation results in interactions between
170 e demonstrate an integral role for H1 linker histones in silencing repetitive elements in mouse embry
171 ed chromatin-binding proteins, the H1 linker histone influences a myriad of chromatin characteristics
173 lysis of topological properties of the human histone interactome reveals its scale free behavior and
176 teins results in hypermethylation of DNA and histones, leading to blocked haemopoietic differentiatio
179 on of methyl groups by multiple complexes of histone lysine methyltransferase 2 (KMT2) family protein
180 ase (HAT) p300 and its paralog CBP acetylate histone lysine side chains and play critical roles in re
182 rbor a high density of the enhancer-specific histone mark H3K4me1 and carry sequences that match enha
183 le showed increased levels of the repressive histone mark H3K9me3 in mdx mice compared to wild-type m
184 s mutually exclusive with another repressive histone mark, H3K9me2, that mainly silences transposons
187 romatin profiles particularly for methylated histone marks but is not optimized for H3K27ac profiling
188 s, including repressive H3K9me3 and H3K27me3 histone marks on extracellular matrix gene promoters and
190 in the forest, cotranscriptionally acquired histone methylation acts as a memory of prior transcript
191 -induced post-translational modifications in histone methylation and acetylation associated with epit
192 ur SLC43A2 correlated negatively with T cell histone methylation and functional gene signatures.
193 1 is essential for promoting PRDM9-dependent histone methylation and normal meiotic progress, possibl
194 uss the consequences of failure to reprogram histone methylation during three crucial epigenetic repr
195 expression, but the functions of repressive histone methylation dynamics during inflammatory respons
196 While most kinases upstream of the yeast histone methylation enzymes remain unknown, we model the
197 lex 2 (PRC2) installs and spreads repressive histone methylation marks on eukaryotic chromosomes.
198 ndings suggest that HSI2- and HSL1-dependent histone methylation plays critical roles in regulation o
199 during periodontal disease result in unique histone methylation signatures in affected cell populati
201 reorganized in a sequential order, in which histone methylations occur first in prometaphase, histon
206 ectly with Suv39h1, Suv39h2, and SETDB1, the histone methyltransferases responsible for H3K9 trimethy
208 pport the importance of physical coupling of histone modification activities to promote epigenetic sw
210 dent dioxygenases that remove the repressive histone modification H3K27me3 and activate differentiati
211 DNA methylation, chromatin accessibility and histone modification level, that can be partially recapi
213 istone 2A K119 monoubiquitination (H2Aub), a histone modification that correlates with gene repressio
215 e regulatory processes including genome-wide histone modification, transcriptional regulation, and RN
216 Using genome-wide profiling of the H3K27ac histone modification, we identify neuron-subtype-specifi
217 ts into the nucleosome-based recognition and histone-modification mechanisms of NSD2 and NSD3, which
218 ns (TADs) demonstrate similar expression and histone-modification profiles, and boundaries separating
219 unique and shared epigenetic alterations in histone modifications and potential regulators for BCCs
220 al epigenetic regulators of DNA methylation, histone modifications and RNA methylation in adult F1 ma
223 ription (H3K9(ac) or H3K27(ac)), but not the histone modifications marking constitutive (H3K9(me3)) o
224 ots are decorated by a unique combination of histone modifications not found at other regulatory elem
225 ated with the reduction of cccDNA-associated histone modifications specifying active transcription (H
226 level as well as prominent associations with histone modifications that typify active genes and enhan
227 tion embryos, including atypical patterns of histone modifications(2-4) and differences in chromosome
228 measured the cellular levels of 6 classes of histone modifications, and 1 histone variant in 11 major
229 otation of the genome by chromatin proteins, histone modifications, and differential compaction is la
230 acteristics include coactivator recruitment, histone modifications, and noncoding RNA transcription.
233 t have examined epigenetic mechanisms (e.g., histone modifications, chromatin remodeler-associated mo
238 In summary, we show that cross talk between histone modifiers regulates miR156 and alters hormonal r
239 ng the RNA-dependent ATPase UAP56/DDX39B and histone modifiers such as the SIN3 deacetylase in humans
240 actors, nucleosome remodeling complexes, and histone modifiers to engage chromatin, thereby initiatin
242 genes is poorly understood, and whether its histone-modifying activities are required for transcript
244 of variegation 3-9 homolog 2 (SUV39H2), key histone-modifying enzymes involved in promoting reduced
245 w heterozygous loss-of-function mutations in histone-modifying enzymes may cause severe neurodevelopm
246 decay (NMD) component, Upf1, which promotes histone mRNA uridylation and degradation in response to
249 e modulated by accessory subunits, oncogenic histone mutations, and the methylation state of chromati
252 in domain to interact with H2A/H2B and H3/H4 histone oligomers, individually, as well as simultaneous
254 ave increased amounts of platelet-associated histones (PAHs), which appear to be correlated with the
257 ons that regulate epigenetic inheritance via histone post-translational modifications and DNA methyla
258 netic mechanisms, including DNA methylation, histone post-translational modifications, and chromatin
259 y electron microscopy and ability to support histone pre-mRNA processing in the presence of polyadeny
263 omparatively less is known about the role of histone PTMs in the cellular adaptive response to stress
267 oncept, we characterized the function of the histone residues H4-S47 and H4-T30 in response to osmoti
269 ylase complex (HDAC) by H3K4 di-methylation, histone sumoylation directly recruits the Set3 complex t
270 ary of nucleosomes that disrupts all exposed histone surfaces to comprehensively assess how proteins
271 actor), which involves reading of acetylated histone tails by the bromodomain-containing proteins SMA
273 nd to specific acetylated lysine residues on histone tails where they facilitate the assembly of tran
276 severe glucose dependence, caused by excess histones through two separable mechanisms: dampening of
278 ging has a significant but limited effect on histone transcript regulation, consistent with multiple
279 f EWSR1 causes meiotic arrest with decreased histone trimethylation at meiotic hotspots, impaired DNA
280 ferase SETD1B on histone H3 lysine K4 (H3K4) histone trimethylation on inflammatory gene promoters.
281 or Swi6 association with FACT that precludes histone turnover to promote gene silencing and preserve
285 n-associated protein 6 (DAXX) to deposit the histone variant H3.3 into specific genomic regions.
286 hat enable rapid transcription involving the histone variant H3.3, its phosphorylation, and both the
287 of 6 classes of histone modifications, and 1 histone variant in 11 major cell subsets (i.e., B, CD3 +
288 the local chromatin environment both through histone variant sequence-specific effects and through th
289 rry a mutation in H3F3A, leading to a mutant histone variant, H3.3-G34W, as a sole recurrent genetic
290 ultiple chromatin marks, including the H2A.Z histone variant, H3K4me3 modification, and nucleosome po
291 escence microscopy, using phosphorylation of histone-variant H2AX (gamma-H2AX) to mark radiation-indu
296 ha- and STS-induced acetylation of H3 and H4 histones was attenuated by the LrS, as was the productio
297 D1) to function on a nucleosome and not just histones, we have determined the crystal structure of th
298 ernal genome undergoes a massive exchange of histone with protamine for compaction into sperm during
300 Padi2 is required for the citrullination of histones within a group of cells in the notochord bead a