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1 lation, provide the basis of a "chromatin or histone code".
2 dues communicate information via a specific 'histone code'.
3 leosome particles, blurring readouts of the 'histone code'.
4 iously reported H4K20me1-H3K9me1 trans-tail 'histone code'.
5 ntenance of the H4K20me1-H3K9me1 trans-tail 'histone code'.
6 ndicate that unmodified H3K4 is part of the 'histone code'.
7 within a protein complex to read a specific histone code.
8 n of histone marks known collectively as the histone code.
9 pression may be further regulated beyond the histone code.
10 ls and thereby facilitate the reading of the histone code.
11 code' that underlies the instructions of the histone code.
12 ssibility of a complex DNA damage responsive histone code.
13 stone modifications that may contribute to a histone code.
14 his modification is a part of the DNA-repair histone code.
15 chromatin-associated factors in reading the histone code.
16 g chromatin modifications that establish the histone code.
17 ptional elongation and in the development of histone code.
18 tin remodeling complex can read a DNA repair histone code.
19 at the domain is involved in deciphering the histone code.
20 ecificity generate further complexity of the histone code.
21 and provides a further understanding of the histone code.
22 th epigenetic "writers" and "erasers" of the histone code.
23 ions of conserved readers and writers of the histone code.
24 ors of gene transcription and readers of the histone code.
25 switch mark recognition by "readers" of the histone code.
26 n histones and can be considered part of the histone code.
27 modifications (erasers), and readers of the histone code.
28 anslational modification 'codes' such as the histone code.
29 ng on chromatin substrates and 'setting' the histone code.
30 ranscriptional outcome is referred to as the histone code.
31 ethyltransferase to establish the trans-tail histone code.
32 ression, which broadens our understanding of histone code.
33 tic examination of proteins that interpret a histone code.
34 e Set2, thereby influencing both the CTD and histone codes.
35 ty and the integrity of both the tubulin and histone codes.
36 V) is accompanied by specific alterations of histone codes.
37 ntially, elucidate the role of combinatorial histone codes.
38 provide evidence for a potential apoptotic "histone code."
39 cinal residues as part of the syntax of the 'histone code.'
40 valent modifications as a new chapter in the histone code' ([2], see, e.g., Figure 3), and Jennifer C
42 epigenetic characteristics, particularly the histone code, along the length of the hepatic IGF-1 gene
43 de." PTMs of histones comprise an analogous "histone code," although the "readers, writers, and erase
44 veals a new kinase involved in composing the histone code and adds haspin to the select group of kina
46 e a powerful approach for elucidation of the histone code and identification of histone post-translat
47 DP) is an ideal approach for deciphering the histone code and it routinely employs reversed-phase liq
49 complex plays critical roles in altering the histone code and repressing transcription of a broad ran
50 study characterizes a regulatory mark in the histone code and reveals a role for H3P16oh in regulatin
51 arget promoters, where it likely impacts the histone code and/or methylates other chromatin-associate
52 odifications that constitute the DNA damage "histone code" and suggest a model for the underlying chr
53 that Brd4 specifically recognizes acetylated histone codes, and this recognition is passed onto the c
55 ications, which collectively constitute the 'histone code', are capable of affecting chromatin struct
56 presence or absence of multiple HMs, or the histone codes, are believed to coregulate important biol
58 ggest that the nature of the heterochromatin histone code associated with X inactivation may be more
59 riments provide an in-depth analysis of the "histone code" associated with chromatin replication and
60 ion, maintain key repressive elements of the histone code at a hypermethylated gene promoter in cance
62 IV-1) latency is controlled by a restrictive histone code at, or DNA methylation of, the integrated v
65 er, changes in DNA methylation can reset the histone code by impacting multiple H3 modifications.
67 als for transcriptional regulation, specific histone "codes" can coordinate and target multiple activ
68 etween aberrant DNA hypermethylation and key histone code components at a hypermethylated, silenced t
69 ith open chromatin and have a characteristic histone code comprised of significantly high levels of h
70 f reader domains necessitates we refine the 'histone code' concept and interrogate it at the nucleoso
72 duce a distinct bi-modular 'syllable' in the histone 'code' conveying different meaning on specific g
73 rate under the assumption that a restrictive histone code could govern latent infection and that eith
75 cleotide sequence and epigenetically by the "histone code," DNA methylation, and higher-order packagi
77 Our findings have direct bearing on how the histone code drives changes in DNA methylation and highl
80 ght fit within the framework of a so-called 'histone code', emphasizing the physiological relevance o
81 equential histone modifications establish a "histone code" essential for the epigenetic inheritance o
82 mpacts transcription and interfaces with the histone code, far less is known about how it regulates g
83 cipitation assays were used to establish the histone code for pIII and determine the differences betw
84 finding implies a further complexity to the histone code for regulation of chromatin structure and s
85 by an unknown enzyme provide a combinatorial histone code for the recruitment of CMT3 to silent loci.
86 s of machine learning, CEFCIG reveals unique histone codes for transcriptional regulation of reported
88 rylation of serine are important PTMs in the histone code found to modulate chromatin packing, which
89 he first genome-wide characterization of the histone code from a stramenopile and a marine phytoplank
90 hese findings unveiled a nutrient-instructed histone code governing CD8(+) T cell differentiation, wi
93 The regulation of gene expression via the histone code has, for the most part, revealed that histo
95 as novel reagents for the evaluation of the histone code hypothesis and analysis of epigenetic signa
96 tone H2A phosphorylation with respect to the histone code hypothesis and found that it is required fo
97 hese results provide further support for the histone code hypothesis and raise specific concerns with
103 outcomes, as postulated in the influential "Histone code hypothesis", introduced by Allis and collea
105 a review that provides a current view of the histone code hypothesis, the lessons we have learned ove
115 e findings provide critical support for the "histone code" hypothesis, demonstrating that multivalent
119 between modifications has strengthened the 'histone code' hypothesis, in which histone modifications
123 least in part on an HMT-dependent inhibitory histone code, imposes a requirement for specific histone
124 he SMRT HID participates in interpreting the histone code in a feed-forward mechanism that promotes a
125 E-MS/MS as a useful tool for deciphering the histone code in a proteoform-specific manner and on a gl
129 eats and that CENP-C and DNMT3B regulate the histone code in these regions, including marks character
131 lts suggest a specialized adaptation of the "histone code" in which distinct histone tail-protein int
135 hat patterns of epigenetic modifiers and the histone code influence the propensity of a gene to becom
136 pattern of histone modifications, called the histone code, influences transitions between chromatin s
138 ed for epigenetic reading and writing of the histone code involved in hormone-stimulated gene program
139 asting gene activities and may be part of a 'histone code' involved in establishing and maintaining f
141 ly, these findings define a novel trans-tail histone code involving monomethylated H4 Lys-20 and H3 L
142 We previously discovered a novel trans-tail histone code involving monomethylated histone H4 lysine
143 tin-associated protein-1 (HP1) recognizes a 'histone code' involving methylated Lys9 (methyl-K9) in h
144 ers suggests that the recognition of H3K4me3 histone code is a general feature of the ING/YNG protein
145 tions of nitrate depletion and show that the histone code is dynamic and targets specific sets of gen
148 ur studies provide an in vivo example that a histone code is not read independently but is recognized
151 impacts the ET-specific reprogramming of the histone code landscape, chromatin remodelling and the ac
152 hanges in chromatin accessibility and in the histone code, leading to gene transcriptional changes.
153 chromatin modifications, suggesting that the histone code may be a prequel to the splicing code.
154 response, altering chromatin by modifying a histone-code mediator protein, HP1, but not the code its
155 tion that departs from the long-predominant "histone code" metaphor, emphasizing complex-disrupting i
156 methyl-lysine recognition motif involved in histone code modification and epigenetic regulation of g
157 ude that epigenetic mechanisms consisting of histone code modifications repress skeletal muscle glut4
159 le DNA methylation levels did not affect the histone code of the LHR gene promoter, demethylation of
161 the posttranslational modification-mediated "histone code" of mH2A, a variant generally associated wi
162 ne modification enzymes may re-establish the histone code on newly assembled unmethylated histones an
163 constitute an "actin code," similar to the "histone code" or "tubulin code," controlling functional
164 dies to investigate aberrant methylation and histone code patterns, the two major epigenetic markers.
167 , it is unclear how L3MBTL1, a methyl-lysine histone code reader, recognizes equally well both mono-
169 by generating or blocking docking sites for histone code readers or by altering the higher order chr
170 he CPC combines phase separation, kinase and histone code-reading activities to enable the formation
171 onstrated that in addition to its kinase and histone code-reading activities, the CPC also can underg
172 the molecular mechanism of the methyl-Lys 27 histone code recognition, we have determined a 1.4-A-res
177 methylation of FLC chromatin is part of the histone code that is required for mitotic stability of t
178 r interaction with unliganded TR generates a histone code that serves to stabilize their own recruitm
179 and other modifications on histones comprise histone codes that govern transcriptional regulatory pro
180 dent methylation of histones is part of the "histone code" that can profoundly influence gene express
181 se KDM5A as a critical editor of the cells' "histone code" that is required to recruit DNA repair com
182 f chromatin has been proposed to generate a 'histone code' that epigenetically regulates gene express
183 ct sequentially or in combination to form a 'histone code' that is, read by other proteins to bring a
184 etic memory of winter is thus mediated by a 'histone code' that specifies a silent chromatin state co
185 posed that these modifications constitute a 'histone code' that specifies epigenetic information for
186 their function as epigenetic readers of the histone code, the BET family of bromodomain-containing p
189 to the pattern of histone modifications, the histone code, this complex pattern of chaperone PTMs is
190 n via a point-by-point interpretation of the histone code through the ordered recruitment of bromodom
191 k an inhibitory methylation component of the histone code to a broadly used strategy that circumvents
194 ts and directly extend the principles of the histone code to the regulation of nonhistone proteins.
195 mportance of using the functional readout of histone codes to define the roles of specific pathways.
196 l appearance of the Xi, a range of different histone code types were detected at different sites alon
201 enetic regulation and is a component of the "histone code," which engenders histones with gene regula