ライフサイエンスコーパス: histone demethylase

1 pid degradation via Jumonji-D3 (JMJD3/KDM6B) histone demethylase.

2 t Fbxl10 is rather a H3K4me3 than a H3K36me2 histone demethylase.

3 to be a potent inhibitor of a host cellular histone demethylase.

4 catalytic activity of JmjC-domain containing histone demethylases.

5 rogenase (ALDH) activity and upregulation of histone demethylases.

6 n and chromatin remodeling at CpG islands by histone demethylases.

7 histone demethylation by the JMJD2 family of histone demethylases.

8 Ni-induced inhibition of the JMJD2 family of histone demethylases.

9 4 by means of histone methyl transferases or histone demethylases.

10 ule inhibitor of Jumonji C domain-containing histone demethylases.

11 n-containing proteins are generally known as histone demethylases.

12 e dioxygenases, including the jumonji-domain histone demethylases.

13 netic landscape by reducing VitC for DNA and histone demethylases.

14 ydroxyglutarate caused inhibition of several histone demethylases.

15 transcription factor (REST)-lysine-specific histone demethylase 1 (LSD1) co-repressor complex associ

16 urthermore, we find that the lysine-specific histone demethylase 1 (LSD1), the protein arginine N-met

17 e, histone deacetylases, and lysine-specific histone demethylase 1) are additionally involved as a co

18 Lysine-specific histone demethylase 1A (LSD1 also known as KDM1A) inhibi

19 of the epigenetic regulator lysine-specific histone demethylase 1A (LSD1) induces a rapid expansion

20 an Arabidopsis JHDM2 (JmjC domain-containing histone demethylase 2) family protein, which modulates d

21 iral gene expression that was independent of histone demethylase activity and linked to histone phosp

22 This targeted processing triggers localized histone demethylase activity and results in reduced FLC

23 s et al. reveal key roles for transient LSD1 histone demethylase activity in activation of a single o

24 of aberrant development can be initiated by histone demethylase activity in developing sperm, withou

25 These studies link RBP2 histone demethylase activity to tumorigenesis and nomina

26 JMJD1A (wild type or mutant lacking histone demethylase activity) bound to HUWE1, attenuated

27 trimethylated peptides and determination of histone demethylase activity.

28 ring conserved domains critical for putative histone demethylase activity.

29 umonji C domain, but is devoid of detectable histone demethylase activity.

30 The Jumonji C (JmjC)-domain-containing histone demethylases also require ascorbate as a cofacto

31 ha; however, they are dependent on the KDM4A histone demethylase and are blocked by inhibition of KDM

32 th Jumonji C domain-containing (JMJD) 1 A, a histone demethylase and epigenetic regulator involved in

33 2 protein so that the proper balance between histone demethylase and histone methyltransferase activi

34 rmline variants in JMJD1C, which codes for a histone demethylase and is a coactivator of the androgen

35 KDM3B encodes for a histone demethylase and is involved in H3K9 demethylatio

36 ggesting an inverse correlation between NO66 histone demethylase and the activity of IGF1R/Akt signal

37 2, including IBM1 encoding an essential H3K9 histone demethylase and the disease resistance gene RECO

38 However, the roles of histone demethylases and activating histone modification

39 ly of DNA demethylases and Jumonji family of histone demethylases and cause epigenetic changes that l

40 nhibit alpha-KG-dependent enzymes, including histone demethylases and DNA hydroxylases, potentially l

41 The mRNA of several histone demethylases and methyltransferases was also dif

42 veral chromatin-modifying enzymes, including histone demethylases and the Tet family of enzymes that

43 ng hypoxia inducible factor hydroxylases and histone demethylases, and K(D) values were determined fo

44 In addition to HIFs, multiple histone demethylases are altered in their expression and

45 The KDM4 histone demethylases are conserved epigenetic regulators

46 We demonstrate that these histone demethylases are direct HIF targets, and their u

47 -specific demethylase 4 (KDM4) A-D family of histone demethylases are dysregulated in several types o

48 The jumonji (JMJ) family of histone demethylases are Fe2+- and alpha-ketoglutarate-d

49 known about how the catalytic activities of histone demethylases are regulated.

50 During developmental transitions, histone demethylases are required to dramatically alter

51 Histone demethylases are the most recent family of histo

52 n and serotonin signalling, identifying this histone demethylase as a potential target for the treatm

53 uggest a novel pharmacologic basis to target histone demethylases as an indirect MYC-targeting approa

54 ancer Cell, Mohammad et al. describe LSD1, a histone demethylase, as a therapeutic target in SCLC wit

55 rated in Saccharomyces cerevisiae, which has histone demethylases but not DNA methylases or demethyla

56 Flavin-dependent histone demethylases catalyze the posttranslational oxid

57 scription factor corepressor 1 (LSD1/CoREST) histone demethylase complex interacts with BCL11A and is

58 The LSD1-CoREST histone demethylase complex is required to repress neuro

59 The LSD1 (also known as KDM1A) histone demethylase complex modifies chromatin and repre

60 Here, we show that TAL1 is associated with histone demethylase complexes containing lysine-specific

61 Rph1 is a histone demethylase containing a Jumonji C (JmjC) domain

62 The 2-OGDD histone demethylases control histone methylation.

63 y effects of Jmjd3 are produced through both histone demethylase-dependent and -independent pathways.

64 Enzymes termed histone demethylases directly remove the methyl marks fr

65 demethylase; also known as KDM1A), the first histone demethylase discovered, regulates cell-fate dete

66 Here, we examine these and related facets of histone demethylases discovered to date, focusing on the

67 Temporally, AA-dependent histone demethylase effects are important early, whereas

68 L) effector repeat domains fused to the LSD1 histone demethylase efficiently remove enhancer-associat

69 Drosophila testis niche an H3K27me3-specific histone demethylase encoded by Ubiquitously transcribed

70 leads to the activation of alphaKG-dependent histone demethylases, enhancing chromatin accessibility

71 We show that the histone demethylase enzyme Kdm5b (Jarid1b) negatively re

72 by regulating the phosphorylation status of histone demethylase enzymes in response to SAM levels.

73 Mutations in genes encoding histone demethylase enzymes were identified as cofactors

74 A subclass of molecular dioxygenases is the histone demethylase enzymes, which are characterized by

75 However, inactivation of the putative histone demethylase Epe1 allows H3K9 methylation and sil

76 inversion of this paradigm where a putative histone demethylase Epe1 in fission yeast, has a non-enz

77 w-cycling cells with high Notch activity and histone demethylase expression are present in primary gl

78 tion of emerging targeted inhibitors of this histone demethylase family in cancer therapy.

79 d member of the JHDM (JmjC domain-containing histone demethylase) family.

80 d knockdown of the jumonji domain-containing histone demethylase fbxl10/kdm2bb, a repressor of riboso

81 Here, we show that JMJD1C is a specific histone demethylase for lipogenic gene transcription in

82 n 66 (NO66), the Jumonji C-domain-containing histone demethylase for methylated histone H3K4 and H3K3

83 re, we use a nuclease-deficient Cas9 (dCas9)-histone demethylase fusion to functionally characterize

84 uthors examined the contribution of Kdm6a, a histone demethylase gene known to escape X inactivation.

85 ruitment of OCT4 to the promoter of Kdm2b, a histone demethylase gene that promotes reprogramming by

86 Recent studies have shown that the histone demethylase genes JMJD1A, JMJD2B, and JARID1B ar

87 ripts involving histone methyltransferase or histone demethylase genes were detected in 111 samples (

88 Histone demethylases have been shown to play a key role

89 is conserved among a family of proteins with histone demethylase (HDM) activity.

90 umber of histone methyltransferase (HMT) and histone demethylase (HDM) enzymes as regulators of ER si

91 was recently identified as the major H3K4me3 histone demethylase (HDM) in Saccharomyces cerevisiae.

92 rs, including chromatin-associated proteins, histone demethylases (HDMs) and methyltransferases.

93 The JumonjiC (JmjC)-containing histone demethylases (HDMs) catalyze the demethylation o

94 The roles of histone demethylases (HDMs) in these programs are incomp

95 The histone demethylase IBM1 suppresses DNA methylation and

96 known as Ndy1, FBXL10, and JHDM1B), an H3K36 histone demethylase implicated in bypass of cellular sen

97 shed light on the biological functions of a histone demethylase in vivo.

98 functions of histone methyltransferases and histone demethylases in AML, especially MLL-rearranged l

99 nale to support the therapeutic targeting of histone demethylases in breast cancer patients.

100 he evidence strongly supports a key role for histone demethylases in eukaryotic transcription and oth

101 ver a conserved role for the JMJD2 family of histone demethylases in promoting replication within sil

102 s unique among the Jumonji domain-containing histone demethylases in that there is an atypical insert

103 estion of the conservation of this family of histone demethylases in the oyster.

104 hibits the activity of the Jumonji family of histone demethylases in vitro, in cancer cells, and in t

105 e complexity of functional interplay between histone demethylases in vivo, providing insights into th

106 cer of zeste 2 and mixed lineage leukemia 2, histone demethylases including ubiquitously transcribed

107 Ciclopirox targeted several histone demethylases, including KDM4B implicated in MYC

108 e expression of RBP2 and other JARID1 family histone demethylases, including PLU-1, SMCX, and LSD1, v

109 activating H3K4 methylation is catalyzed by histone demethylases, including the Jumonji C (JmjC) KDM

110 The Jmj family was identified as histone demethylases, indicating epigenetic regulation b

111 now demonstrate that the overexpression of a histone demethylase induces transient copy gain of speci

112 Here we show that multiple histone demethylases influence the viability and poor pr

113 cultured preadipocytes, the levels of KDM5C histone demethylase influenced chromatin accessibility (

114 oxygen sensing by chromatin occurs via JmjC-histone demethylase inhibition.

115 Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the t

116 We further demonstrated that a pan jumonji histone demethylase inhibitor, JIB-04, inhibits MINA53-m

117 Hence, histone demethylase inhibitor-based therapy may represen

118 e antifungal agent ciclopirox as a novel pan-histone demethylase inhibitor.

119 Conversely, treatment with histone demethylase inhibitors increases heterochromatin

120 his screen, we identified several known JmjC histone demethylase inhibitors, including 2,4-pyridinedi

121 GASC1 is a histone demethylase involved in the deregulation of hist

122 gulation of p21(WAF-1), suggesting that this histone demethylase is involved in the priming of the p2

123 t the Drosophila melanogaster KDM4A (dKDM4A) histone demethylase is required for heterochromatic DSB

124 The KDM4/JMJD2 family of histone demethylases is amplified in human cancers.

125 iple that pharmacological inhibition of KDM5 histone-demethylases is a new strategy for the personali

126 demethylase 1 (LSD1; also known as KDM1A), a histone demethylase, is essential to this process.

127 JMJD3, a histone demethylase, is simultaneously recruited to thes

128 1, a member of the Jarid1 family of putative histone demethylases, is required for chromosome stabili

129 g activity of histone-methyltransferases and histone-demethylases, is, however, not well understood.

130 d transcriptional complex also recruited the histone demethylase JARID1B and histone deacetylase HDAC

131 Controlled by the histone demethylase JARID1B, MANTIS was downregulated in

132 y exon-array analysis after knockdown of the histone demethylase JARID1B.

133 For example, the histone demethylase JARID1C is frequently inactivated in

134 ne methytransferases (Dot1 and Set1) and one histone demethylase (Jhd2) to the dynamics of silencing.

135 ed two kinases of RNAP II (Bur1 and Ctk1), a histone demethylase (Jhd2), and a mutated form of a nucl

136 H3K4 mono- and trimethylation) and two yeast histone demethylases, Jhd2 and Rph1, which were previous

137 ive inhibitor of jumonji C domain-containing histone demethylases (JHDMs).

138 ongs to the JmjC domain-containing family of histone demethylases (JHDMs).

139 Here, we document that a histone demethylase, JMJ17, belonging to the KDM5/JARID1

140 ition, we show that PBAF cooperates with the histone demethylase, JMJC-1/NO66, to promote expression

141 Using histone demethylase JMJD1A and DNA repair enzyme ABH2 as

142 The messenger RNA that encodes the histone demethylase JMJD1A is a direct target of miR-627

143 The histone demethylase JMJD1A, which controls gene expressi

144 complex consisting of LANA and the H3K9me1/2 histone demethylase JMJD1A/KDM3A.

145 Here we demonstrate that the histone demethylase JMJD1C functions as a coactivator fo

146 urthermore, we reveal an adaptor function of histone demethylase JMJD2A, which is important for recog

147 ion of Lgr4 down-regulated the expression of histone demethylases Jmjd2a and Fbxl10 through cAMP-CREB

148 recruitment of histone methylase (COMPASS)-, histone demethylase (Jmjd2a/Jmjd3)-, and SWI/SNF-contain

149 tment of the transcription factor RelA and a histone demethylase, JMJD2A.

150 We show that the histone demethylase JMJD2B is induced by EndMT-promoting

151 Here, we show the histone demethylase JMJD2B is regulated by both ERalpha

152 and function is critically controlled by the histone demethylase JMJD2B, which is induced by EndMT-pr

153 t systems for the double Tudor domain of the histone demethylase JMJD2C.

154 tivator activating signal cointegrator-2 and histone demethylase JMJD2d participated in this CAR-depe

155 ved deubiqutination and stabilization of the histone demethylase Jmjd2d.

156 the ES cell factor Tbx3 associates with the histone demethylase Jmjd3 at the enhancer element of the

157 The present report documents that the histone demethylase JMJD3 is an activating transcription

158 ration alone transiently increased the H3K27 histone demethylase Jmjd3, persistently increased bone m

159 The JmjC domain-containing H3K4 histone demethylase jumonji AT-rich interactive domain 1

160 We report that the histone demethylase jumonji domain containing protein 2C

161 Here, we investigated the influence of the histone demethylase Jumonji/ARID1 B (JARID1B) on miR reg

162 microarray experiments, we have identified a histone demethylase, jumonji domain containing 5 (JMJD5)

163 The histone demethylase, JumonjiD2A (JmjD2A/KDM4A), is expre

164 several histone methyltransferases (KMT) and histone demethylases (KDM) that mediate histone methylat

165 PELP1 interactions with histone demethylase KDM1 play a critical role in its onc

166 of NOTCH ICD, RBPJ recruits L3MBTL3 and the histone demethylase KDM1A (also known as LSD1) to the en

167 H3K4me2 at each promoter via recruitment of histone demethylase KDM1A.

168 s effect is mediated by interaction with the histone demethylase KDM1A/LSD1.

169 ferases (DAC), histone deacetylases (Depsi), histone demethylases (KDM1A inhibitor S2101), and histon

170 We previously demonstrated that the histone demethylase KDM2A is specifically recruited to C

171 Here, we identified histone demethylase KDM2B as a critical regulator of def

172 contains the BCL6 co-repressor BCOR and the histone demethylase KDM2B.

173 Sustained expression of the histone demethylase, KDM2B (Ndy1/FBXL10/JHDM1B), bypasse

174 K1 interacts with the estrogen receptor (ER)/histone demethylase KDM3A (JHDM2a) complex, which modifi

175 Our studies further identify the H3K9me1/2 histone demethylase KDM3A (JMJD1A/JHDM2A) as a new miR-2

176 Together, our studies identify the histone demethylase KDM3A as a new, miR-regulated, tumor

177 onal pathway in Ewing Sarcoma, involving the histone demethylase KDM3A, previously identified by our

178 hich is in part through association with the histone demethylase KDM3A.

179 In conditions where the histone demethylase KDM4A is depleted or inactive, H3K9m

180 Up-regulation of the histone demethylase KDM4A promotes transient site-specif

181 to their promoter regions and recruiting the histone demethylase Kdm4a to remove repressive histone m

182 Here we report that histone demethylase KDM4A/JMJD2A, which is involved in t

183 We report that histone demethylase KDM4B is dynamically expressed durin

184 e have determined that the hypoxia-inducible histone demethylase KDM4B is expressed in approximately

185 This effect appeared to be mediated by the histone demethylase KDM4C (Figure 4D).

186 n natural variation in the gene encoding the histone demethylase, KDM4C, which promotes transcription

187 entiation in part through its binding to the histone demethylase KDM5A (also known as RBP2 or JARID1A

188 Previously, we identified the histone demethylase KDM5A (lysine [K]-specific demethyla

189 In this issue, Gong et al. identify the histone demethylase KDM5A as a critical editor of the ce

190 s study, we report the identification of the histone demethylase KDM5A as a key regulator of the brom

191 Histone demethylase KDM5A removes methyl marks from lysi

192 studies showed that AW112010 interacted with histone demethylase KDM5A, which led to decreased H3K4 m

193 reduced expression of CDK inhibitors and the histone demethylase KDM5A.

194 unction, cobound by the MYC oncogene and the histone demethylase KDM5A.

195 Loss-of-function mutations in the histone demethylases KDM5A, KDM5B, or KDM5C are found in

196 PARylation, inhibition, and exclusion of the histone demethylase KDM5B; and (2) promoting the exclusi

197 A locus, DINO expression is regulated by the histone demethylase KDM6A.

198 at interacts with histone chaperone SPT6 and histone demethylase KDM6A.

199 We found that the H3K27 histone demethylase KDM6A/UTX, but not its paralog KDM6B

200 r GSCs upregulate, and are dependent on, the histone demethylases KDM6A/B.

201 cterized by activation of p65 and requires a histone demethylase KDM6B.

202 The JmjC histone demethylases (KDMs) are linked to tumour cell pr

203 this study, in silico analyses of the lysine histone demethylases (KDMs) involved in diverse biologic

204 nes by protein methyltransferases (PMTs) and histone demethylases (KDMs) play an important role in th

205 the KMT2D histone methylase (KS1) or the UTX histone demethylase (KS2).

206 hematopoietic cells, inhibition of TET2 and histone demethylases leads to epigenetic alterations and

207 ghts a finely tuned mechanism for regulating histone demethylase levels and emphasizes the need to ti

208 ditionally identified factors, including the histone demethylase little imaginal discs and histone-in

209 s further OR activation by down-regulating a histone demethylase Lsd1 (also known as Aof2 or Kdm1a),

210 In vivo, histone demethylase LSD1 (KDM1; BCH110) is a component o

211 1 physically interacts with and recruits the histone demethylase LSD1 (KDM1A) to epithelial gene prom

212 ys that read out enzymatic inhibition of the histone demethylase LSD1 (lysine-specific demethylase 1)

213 be functions of epigenetic enzymes including histone demethylase LSD1 and histone acetyltransferase T

214 ere, we identify the transient expression of histone demethylase LSD1 and the OR-dependent expression

215 cells, Esrrb interacts in TS cells with the histone demethylase Lsd1 and with the RNA Polymerase II-

216 e signalling environment and activity of the histone demethylase LSD1 during differentiation of hESC-

217 epression of hepatic autophagy by recruiting histone demethylase LSD1 in response to a late fed-state

218 Previously, our laboratory implicated the histone demethylase LSD1 in tau-induced neurodegeneratio

219 The histone demethylase LSD1 is an epigenetic modifier that

220 Thus, our data revealed that histone demethylase LSD1 may negatively regulate SALL4-m

221 1 or MLL1 histone methyltransferases and the histone demethylase LSD1 to promote the installation of

222 t SUMO-1, and CoREST1 bridges binding of the histone demethylase LSD1 to SUMO-2.

223 at it promotes lipogenesis by recruiting the histone demethylase Lsd1 to the fatty acid synthase gene

224 kage of the TGFbeta pathway or inhibition of histone demethylase LSD1 with small molecule inhibitors

225 The histone demethylase LSD1, a component of the CoREST (cor

226 ith the histone deacetylases HDAC1/2 and the histone demethylase LSD1, enzymes that also participate

227 ich forms a complex with the lysine-specific histone demethylase LSD1.

228 modification produced by the lysine-specific histone demethylase LSD1.

229 entiated cells, here we inducibly delete the histone demethylase LSD1/KDM1A in adult mice.

230 We report a role for the histone demethylase LSD1/KDM1A in the DNA damage respons

231 In this issue, Katz et al. show that the histone demethylase Lsd1/Spr-5 may participate in this r

232 cetylases (HDAC8, Sir2Tm, and SIRT1) and the histone demethylase, LSD1.

233 Histone demethylase LSDl (KDMlA) belongs to the flavin a

234 Here we show that the histone demethylase lysine-specific demethylase 1 (LSD1;

235 We explored whether the conserved histone demethylase, lysine-specific demethylase 1 (LSD1

236 tone 3 lysine 4 (H3K4) methyltransferase and histone demethylase maintain a dynamic and homeostatic s

237 strate that epigenetic regulators, including histone demethylases, may control the cell-to-cell varia

238 R/Cas9 sgRNA screens, we identified that the histone demethylase, MINA53, is potentially a novel HIV-

239 We further show that in UTX H3K27 histone demethylase mutant embryos, these genes are even

240 ly recently, with the discovery of the first histone demethylase nearly five years ago.

241 Here, we explored the role of histone demethylase NO66 in the pathogenesis of PCa and

242 here elevated PRL-3 protein increases JMJD2C histone demethylase occupancy on Leo1 promoter, thereby

243 2E3 loss promotes the recruitment of LSD1, a histone demethylase of histone 3 lysine 4 di-methylation

244 the top sexually dimorphic gene was Kdm6a, a histone demethylase on the X chromosome.

245 but whether this is a direct effect on JmjC-histone demethylases or due to other mechanisms is unkno

246 but whether this reflects direct effects on histone demethylases or indirect effects caused by the h

247 an affect gene expression through inhibiting histone demethylases, orthologous mutations to those kno

248 prolyl hydroxylases, JmjC domain-containing histone demethylases (part of the JMJD family) and the t

249 cruitment of the Jumonji C domain-containing histone demethylase PHF2 for epigenetic activation of th

250 gers epigenetic reprogramming of TICs by the histone demethylase PHF2, which promotes their different

251 ieved by NF-kappaB-dependent delivery of the histone demethylase PHF2.

252 We identified the histone demethylase PHF8 as a coactivator that is specif

253 The histone demethylase PHF8 has been implicated in multiple

254 Histone demethylase PHF8 is upregulated and plays oncoge

255 specific interaction between TopBP1 and the histone demethylase PHF8.

256 Here we report that the KDM3 family of histone demethylases plays an important role in tumorige

257 ifferent environmental cues, suggesting that histone demethylase protein levels must be tightly regul

258 Rph1 is a histone demethylase protein, but it regulates autophagy

259 an altered chromatin state that requires the histone demethylase RBP2/KDM5A/Jarid1A.

260 demonstrated that inhibitors of H3K9me2/me3 histone demethylases reduce the ability of HSV-1 to reac

261 he first demonstration that a Jumonji-domain histone demethylase regulates cellular processes require

262 ne (K)-specific demethylase (LSD1) family of histone demethylases regulates chromatin structure and t

263 that LSD1 (lysine-specific demethylase 1), a histone demethylase, regulates brown adipocyte metabolis

264 The KDM5 family of histone demethylases removes the H3K4 tri-methylation (H

265 ly oogenesis, through depletion of the dKDM5 histone demethylase, results in the temporal deregulatio

266 The family of KDM4A-D histone demethylases selectively demethylates H3K9 and H

267 a unique role for the Caenorhabditis elegans histone demethylase SPR-5 in meiotic DNA double-strand b

268 Gene expression levels of various histone demethylases, such as the JARID1 family, show di

269 KDM5C encodes a histone demethylase, suggesting that alterations in chro

270 ny enzymes, including JmjC domain-containing histone demethylases, TET 5-methylcytosine hydroxylases,

271 , these antibiotics inhibited jumonji domain histone demethylases, TET DNA demethylases, and collagen

272 KDM6B (also known as JMJD3) is a histone demethylase that might activate gene expression

273 LSD1 is a flavin-dependent histone demethylase that oxidatively removes methyl grou

274 LSD1 (KDM1A) is a histone demethylase that plays both oncogenic and tumor

275 he function of LSD1 in AD and FTD."LSD1 is a histone demethylase that plays many roles during develop

276 noblastoma binding protein RBP2 (KDM5A) is a histone demethylase that promotes gastric cancer cell gr

277 that VRS3 encodes a putative Jumonji C-type histone demethylase that regulates expression of other V

278 Jarid1b/KDM5b is a histone demethylase that regulates self-renewal and diff

279 However, the histone demethylase that specifically controls histone m

280 on chromosome X (UTX, encoded by KDM6A) is a histone demethylase that targets di- and tri-methylated

281 KDM4A is a histone demethylase that targets tri- and dimethylation

282 JARID1 proteins are histone demethylases that both regulate normal cell fate

283 viral gene induction occurs independently of histone demethylases that remove repressive lysine modif

284 JMJD2s are a family of histone demethylases that remove tri-methyl groups from

285 r results indicate that JMJ27 functions as a histone demethylase to modulate both physiological (defe

286 y alpha-KG-dependent dioxygenases, including histone demethylases, to cause broad histone hypermethyl

287 Our results demonstrate a new function of a histone demethylase under dehydration stress in plants.

288 Histone demethylase upregulation has been observed in hu

289 Here, we focus on loss of the histone demethylase UTX (also known as KDM6A) and activa

290 The X chromosome-encoded histone demethylase UTX (also known as KDM6A) mediates r

291 Here we found that the H3K27me3 histone demethylase UTX was an essential cell-intrinsic

292 complex 2 (PRC2), and identify the conserved histone demethylase UTX-1 as a crucial GLP-1/Notch targe

293 GSK-J4, a specific inhibitor of the H3K27me3 histone demethylases UTX and JMJD3, inhibits HSV-1 react

294 gested that the recently discovered class of histone demethylases (UTX and JMJD3) that specifically t

295 main containing 1A (JMJD1A), which encodes a histone demethylase, was found to be a target of miR-627

296 Recently, histone demethylases were found to play important roles

297 se enzymes, KDM6B formally known as JMJD3, a histone demethylase, which removes the trimethyl mark fr

298 s examples, we show that the JMJD2 family of histone demethylases, which are products of putative onc

299 Jumonji (Jmj) proteins are histone demethylases, which control the identity of stem

300 PHF8 is a histone demethylase with specificity for repressive modi