ライフサイエンスコーパス: histone methyltransferase

1 n) and enhancer of zeste homolog 2 (EZH2) (a histone methyltransferase).

2 ities are determined by PRDM9, a DNA-binding histone methyltransferase.

3 thus potentially connecting PRC2 to another histone methyltransferase.

4 U(Z)12 assembly with E(Z) and stimulation of histone methyltransferase.

5 thermophila, we identified TXR1, encoding a histone methyltransferase.

6 = 6 nM) with broad selectivity against other histone methyltransferases.

7 st a universal regulation mechanism for most histone methyltransferases.

8 TOR pathway effectors, SWI/SNF subunits, and histone methyltransferases.

9 interacts with and activates all MLL family histone methyltransferases.

10 teracts with a complex containing repressive histone methyltransferases.

11 ghting regulatory specificity for MLL family histone methyltransferases.

12 aining family, calcium channel subunits, and histone methyltransferases.

13 n, and these effects are distinct from other histone methyltransferases.

14 ations or deletions of the human Euchromatin Histone Methyltransferase 1 (EHMT1) gene are the main ca

15 NRF1) regulates transcription of euchromatic histone methyltransferase 1 (EHMT1) to ensure normal pat

16 caused by haploinsufficiency of euchromatic histone methyltransferase-1 (EHMT1).

17 The euchromatin histone methyltransferase 2 (also known as G9a) methylat

18 the SETD1A gene, which encodes a subunit of histone methyltransferase, a finding unlikely to have oc

19 Although SUVH2 and SUVH9 resemble histone methyltransferases, a crystal structure reveals

20 hylated EZH2/PRC2 exhibits a higher level of histone methyltransferase activity and is required for a

21 function to EZH2 that is independent of its histone methyltransferase activity and reconcile how EZH

22 Using a photo-cross-linking MS strategy and histone methyltransferase activity assays on PRC2 mutant

23 SETD5 lacks histone methyltransferase activity but scaffolds a co-re

24 automethylation allows PRC2 to modulate its histone methyltransferase activity by sensing histone H3

25 Silencing EZH2 or inhibiting its histone methyltransferase activity conferred increased a

26 presence of a PRDI-BF1-RIZ1 (PR) domain with histone methyltransferase activity in the ME isoform.

27 riguingly, ectopic EZH2 mutant deficient for histone methyltransferase activity is also able to confe

28 Importantly, catalytic inactivation of the histone methyltransferase activity of MLL3 also severely

29 Recent studies suggest that the histone methyltransferase activity of MMSET plays an imp

30 The histone methyltransferase activity of PRC2 is central to

31 d (btd) locus in an active state through the histone methyltransferase activity of the SET1/MLL compl

32 f polycomb repressive complexes 2, possesses histone methyltransferase activity that catalyzes the tr

33 at exhibited Ras-mediated dependence on PRC2 histone methyltransferase activity, a finding that is si

34 In vitro, both noncoding RNAs inhibit PRC2 histone methyltransferase activity, but, in vivo, only t

35 Methylation of these lysines increases PRC2 histone methyltransferase activity, whereas their mutati

36 t CCAT1 is likely a direct target of ASH1L's histone methyltransferase activity.

37 mediated gene repression, which requires its histone methyltransferase activity.

38 at they are only partially dependent on EZH2 histone methyltransferase activity.

39 nd H3K36 methylation by interfering with the histone methyltransferase activity.

40 d plays an important role in CSR through its histone methyltransferase activity.

41 st the PARylation significantly reduces NSD2 histone methyltransferase activity.

42 ting DSB formation depends on PRDM9-mediated histone methyltransferase activity.

43 e capability of clemastine in elevating H3K9 histone methyltransferases activity in cultured primary

44 ow cells regulate the opposing activities of histone methyltransferase and demethylase enzymes to set

45 ve interaction of the tail peptides with G9a histone methyltransferase and histone deacetylase 1 (HDA

46 abolism can alter the expression of specific histone methyltransferases and acetyltransferases confer

47 unction mutations to inhibit a wide range of histone methyltransferases and are thought to promote tu

48 binding protein 2, histone deacetylases, and histone methyltransferases and demethylase in the fronta

49 therefore screened gene expression of known histone methyltransferases and demethylases in three NSC

50 Dysregulated expression of histone methyltransferases and demethylases is an emergi

51 lymerase chain reaction array, we found that histone methyltransferases and demethylases that regulat

52 ebellum; no changes in histone deacetylases, histone methyltransferases and demethylases, or methyl C

53 regulation that is dynamically modulated by histone methyltransferases and demethylases.

54 It interacts with histone methyltransferases and facilitates their recruit

55 le, we will review the emerging functions of histone methyltransferases and histone demethylases in A

56 In summary, uniquely and as opposed to other histone methyltransferases and histone marks, maternal D

57 g noncoding RNAs (lncRNAs) are regulators of histone methyltransferases and other chromatin-modifying

58 otential mechanism of action of our dual G9a histone-methyltransferase and DNA-methyltransferase 1 (D

59 is mediated by the counteracting activity of histone-methyltransferases and histone-demethylases, is,

60 Growing evidence suggests that histone methyltransferases are associated with the devel

61 Mixed lineage leukemia (MLL) family histone methyltransferases are enzymes that deposit hist

62 ease the catalytic activity of EZH2 and NSD2 histone methyltransferases are found in distinct subsets

63 Although histone methyltransferases are key epigenetic regulators

64 ing epigenetic landscapes in organisms where histone methyltransferases are uncharacterized.

65 its coactivator, the mixed-lineage leukemia histone methyltransferase, are recruited to the BRCA1, R

66 In vitro studies identified SET1/MLL histone methyltransferases as redox sensitive units of t

67 (SET domain, bifurcated 1), an H3K9-specific histone methyltransferase, as the most significantly up-

68 cilitates the binding of the trithorax group histone methyltransferases ASH1 and TRX to active genes,

69 mice carrying a hypomorphic mutation of the histone methyltransferase Ash1l [(absent, small, or home

70 Here, we took advantage of an in vitro histone methyltransferase assay employing a reconstitute

71 , including HP1, the NuRD complex, H2A.Z and histone methyltransferases at the DSB.

72 eins, including histone deacetylases (HDAC), histone methyltransferases, bromodomain-containing prote

73 tro indicating that PRDM9 is a highly active histone methyltransferase catalyzing mono-, di-, and tri

74 The histone methyltransferase complex PRC2 controls key step

75 SUMO ligase Su(var)2-10, which recruits the histone methyltransferase complex SetDB1/Wde.

76 nd nascent RNAs in the nucleus and recruit a histone methyltransferase complex that catalyzes chromat

77 d activates the Slc14a2 gene by recruiting a histone methyltransferase complex to the promoter.

78 promoter by CFP1, a component of the COMPASS histone methyltransferase complex, and promoter-specific

79 omponent of the mixed-lineage leukemia (MLL) histone methyltransferase complex, and transcription fac

80 ses in Ash2l mRNA, encoding a component of a histone methyltransferase complex.

81 P complex that regulate the function of this histone methyltransferase complex.

82 WDR5 proteins are conserved components of histone methyltransferase complexes normally associated

83 s affect alternative exon usage by targeting histone methyltransferase complexes to form localized fa

84 ate independently of its established role in histone methyltransferase complexes.

85 nction from histone-methyltransferase to non-histone methyltransferase, consequently methylating the

86 nic and chromatin-related proteins including histone methyltransferases, correlated with their phenot

87 atalyzed, respectively, by a conserved SUV39 histone methyltransferase, DIM-5, and a DNMT1-like cytos

88 ated and decelerated epigenetic aging in two histone methyltransferase disorders: NSD1 Sotos syndrome

89 target genes in part via recruitment of the histone methyltransferase DOT1L (disruptor of telomeric

90 Histone methyltransferase Dot1L is a coactivator for thy

91 inhibitor studies have demonstrated that the histone methyltransferase DOT1L is required for the deve

92 The histone methyltransferase DOT1L methylates lysine 79 (K7

93 Here we show that the histone methyltransferase DOT1L, which marks the nucleos

94 transcription levels and is catalyzed by the histone methyltransferase DOT1L.

95 t MLL-AF6 requires continued activity of the histone-methyltransferase DOT1L to maintain expression o

96 Histone methyltransferase, DOT1L, is also up-regulated b

97 indings strongly support the contention that histone methyltransferase, DOT1L-associated epigenetic c

98 SUMO-dependent recruitment of the SetDB1/Wde histone methyltransferase effector.

99 lation at lysine 9 (H3K9me2) and euchromatic histone methyltransferases EHMT1 and EHMT2 were signific

100 We found that histone methyltransferases EHMT1 and EHMT2, as well as h

101 638 to inhibit the catalytic activity of the histone methyltransferases EHMT1 and EHMT2.

102 imals, the HDAC2-dependent downregulation of histone methyltransferase Ehmt2 (G9a) led to the loss of

103 with RA and coactivator Rere/Atrophin2 and a histone methyltransferase Ehmt2 to regulate embryonic sy

104 We also identify the Rere-binding histone methyltransferase Ehmt2/G9a, as a RA coactivator

105 EDAL binds to the conserved histone methyltransferase enhancer of zest homolog 2 (EZ

106 is epigenetically controlled by the polycomb histone methyltransferase enhancer of zeste homolog 2 (E

107 Inactivating mutations in histone methyltransferase enhancer of zeste homolog 2 (E

108 The histone methyltransferase Enhancer of Zeste Homolog 2 (E

109 product H3K27me3, a process catalyzed by the histone methyltransferase enhancer of zeste homolog 2 (E

110 The histone methyltransferase enhancer of zeste homolog 2 (E

111 The histone methyltransferase enhancer of zeste homolog 2 (E

112 ls and activity of the epigenetic repressor, histone methyltransferase enhancer of zeste homolog 2 (E

113 one mark H3K27me3 (mediated via the polycomb histone methyltransferase, enhancer of zeste homologue 2

114 Here, we investigated the function of the histone methyltransferase enzyme enhancer of zeste homol

115 zyme are similar to previously characterized histone methyltransferase enzymes from other organisms,

116 Histone methyltransferases EZH1 and EZH2 catalyse the tr

117 e roles of the Polycomb repressive complex 2 histone methyltransferases EZH1 and EZH2.

118 vely regulated by miR-101 expression include histone methyltransferase EZH2 (enhancer of zeste homolo

119 which was associated with recruitment of the histone methyltransferase Ezh2 and downregulation of the

120 inding of histone H1, thereby recruiting the histone methyltransferase EZH2 and elevating H3K27me3 le

121 Here, we identified loss of the histone methyltransferase EZH2 and subsequent reduction

122 , FoxP3 was inactive when complexed with the histone methyltransferase EZH2 and transcription factors

123 ivated STAT3 and increased expression of the histone methyltransferase EZH2 are independently associa

124 (RIP-seq), we identified the Polycomb-group histone methyltransferase EZH2 as a p53 mRNA-binding pro

125 SAFB1 formed a complex with the histone methyltransferase EZH2 at AR-interacting chromat

126 Herein, we show that the histone methyltransferase Ezh2 controls CD8(+) T memory

127 A cytosolic role for the histone methyltransferase Ezh2 in regulating lymphocyte

128 The histone methyltransferase EZH2 is frequently mutated in

129 Our data show that the histone methyltransferase EZH2 is overexpressed in ACC i

130 The histone methyltransferase EZH2 is required for B and T c

131 urther reveal a novel mechanism that reduced histone methyltransferase EZH2 leads to a lower trimethy

132 Here, we show that the histone methyltransferase Ezh2 maintains integrity of th

133 ate the epigenetic modifications mediated by histone methyltransferase EZH2 or miR-150 and thus calib

134 me3 histone mark and binding of the Polycomb histone methyltransferase Ezh2 persisted at differentiat

135 hosphorylation of Rb and release of E2F1.The histone methyltransferase EZH2 silences genes by generat

136 epressive YAP-TEAD4 complexes containing the histone methyltransferase EZH2 were detected in the geno

137 Breast cancers frequently overexpress the histone methyltransferase EZH2, the catalytic subunit of

138 between allogeneic T-cell responses and the histone methyltransferase Ezh2, which catalyzes histone

139 ID), is caused by pathogenic variants in the histone methyltransferase EZH2, which encodes a core com

140 alterations in DNA methylation at potential histone methyltransferase EZH2-binding sites.

141 mouse subventricular zone (SVZ) express the histone methyltransferase EZH2.

142 events within TIL resulting from loss of the histone methyltransferase EZH2.

143 rent mutations in the gene encoding the EZH2 histone methyltransferase (EZH2), but the carcinogenic r

144 hough an established RNA-binding protein and histone methyltransferase, EZH2 is not known to be a nuc

145 key epigenetic regulators, whether and how a histone methyltransferase forms a network with miRNAs an

146 Here we present evidence that histone methyltransferase G9a mediates E4BP4-dependent r

147 The results indicated that histone methyltransferase G9a, but not GLP, was involved

148 ly, dyclonine also inhibited the activity of histone methyltransferase G9a, known to methylate histon

149 tment of DNA methyltransferase (DNMT) 3a and histone methyltransferase G9a.

150 at UNC0638, a highly potent inhibitor of the histone methyltransferases G9a and GLP, was a weak inhib

151 B family member RelB, and RelB recruited the histone methyltransferases G9a and SETDB1 to the Il17 lo

152 d with high expression of the E2F target and histone methyltransferase gene EZH2.

153 was abolished in cells upon depletion of the histone methyltransferase gene SET-domain containing 2 (

154 The MLL1 histone methyltransferase gene undergoes many distinct c

155 The E(z) histone methyltransferase heterozygous mutation in Droso

156 ng evidence has implicated a small number of histone methyltransferase (HMT) and histone demethylase

157 ment of the DNA methyltransferase DNMT3B and histone methyltransferase (HMT) complex components (G9A,

158 ntaining protein 5 (WDR5), a core subunit of histone methyltransferase (HMT) complexes.

159 We found that embryonic deletion of the histone methyltransferase (HMT) Ezh2 from all retinal pr

160 Cocaine-mediated repression of the histone methyltransferase (HMT) G9a has recently been im

161 gene loci encoding adipogenesis regulators, histone methyltransferase (HMT) G9a-mediated repressive

162 Here, we used gene targeted inactivation of histone methyltransferase (HMT) multiple myeloma SET dom

163 MMSET/WHSC1 is a histone methyltransferase (HMT) overexpressed in t(4;14)

164 s a member of the trithorax (TrxG) family of histone methyltransferases (HMT) that methylate H3K4 at

165 Histone methyltransferases (HMTases), as chromatin modif

166 histone H4, which facilitates recruitment of histone methyltransferases (HMTases), SET8 and SUV4-20H,

167 nosyl homocysteine (SAH) detection assay for histone methyltransferases (HMTs) and its applications i

168 Defects in histone methyltransferases (HMTs) are major contributing

169 ct other mixed-lineage leukemia (MLL) family histone methyltransferases (HMTs), revealing a unique re

170 e defined a role for activated STAT3 and G9a histone methyltransferase in epigenetic silencing of miR

171 Setd8 is the sole histone methyltransferase in mammals capable of monometh

172 We identified EZH2, a histone methyltransferase in the Polycomb repressive com

173 Although the role of some histone methyltransferases in establishing the transcrip

174 dependent kinase [CDK] inhibitor), and Set8 (histone methyltransferase) in S phase.

175 the mixed lineage leukaemia (MLL) family of histone methyltransferases including MLL1, MLL2, MLL3, M

176 2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a, and Pr-

177 To identify essential histone methyltransferase-independent functions of Trr,

178 38, a selective inhibitor of EHMT1 and EHMT2 histone methyltransferases, induces gamma-globin express

179 Histone deacetylase or histone methyltransferase inhibition also increases Mpl-

180 Demethylation of H3K27 mediated by the histone methyltransferase inhibitor GSK343 in primary re

181 eatment of cultured pancreatic islets with a histone methyltransferase inhibitor leads to colocalizat

182 In contrast, a histone methyltransferase inhibitor selectively promotes

183 d histone deacetylase inhibitor), UNC0646 (a histone methyltransferase inhibitor), and vitamin C (a T

184 e 1 IFN-stimulated genes and inhibition with histone methyltransferase inhibitor.

185 Histone methyltransferase inhibitors (HMTis) and histone

186 creening and in vivo characterization of new histone methyltransferase inhibitors and accelerate the

187 ng histone methylation status in response to histone methyltransferase inhibitors in living animals.

188 In contrast, certain histone methyltransferase inhibitors stimulate metastati

189 tylase inhibitors to increase euchromatin or histone methyltransferase inhibitors to decrease heteroc

190 ncy in different regions, including Smyd3, a histone methyltransferase involved in gene transcription

191 The yeast Set2 histone methyltransferase is a critical enzyme that play

192 The EZH2 histone methyltransferase is a member of the polycomb re

193 otein with a SET domain, also called SETDB1) histone methyltransferase is expressed in articular cart

194 The EZH2 histone methyltransferase is required for B cells to for

195 of proteins associated with Set1) family of histone methyltransferases is known to activate transcri

196 Mutation in MLL2, encoding a histone methyltransferase, is a driver in numerous diffe

197 Histone methyltransferase KMT2D (a COMPASS-like enzyme,

198 The gene encoding the lysine-specific histone methyltransferase KMT2D has emerged as one of th

199 transferase CHROMOMETHYLASE3 (CMT3) and H3K9 histone methyltransferase KRYPTONITE/SUVH4 (KYP).

200 tored by mutations in the genes encoding the histone methyltransferase KYP and DNA methyltransferase

201 The EZH2 histone methyltransferase mediates the humoral immune re

202 A third interactor, the histone methyltransferase MES-4, is also enriched in het

203 of histone H3K9 through the activity of the histone methyltransferase met-2 and the nuclear co-facto

204 1, LIN-13, LIN-61, LET-418/Mi-2, and H3K9me2 histone methyltransferase MET-2/SETDB1 also show functio

205 The histone methyltransferase Mixed Lineage Leukemia (MLL) i

206 The histone methyltransferase mixed-lineage leukemia-4 (MLL4

207 correlated with increased expression of the histone methyltransferase, mixed-lineage leukemia 1 (MLL

208 ive H3K9me2 marks, but also helps to recruit histone methyltransferase MLL1 to promote H3K4 methylati

209 to be due to a lack of interaction with the histone methyltransferase, MLL1, resulting in decreased

210 shown that this program is controlled by two histone methyltransferases, MLL1 and DOT1L, as deletion

211 tin remodelling genes, ARID1A and ARID1B, in histone methyltransferase MLL3, in histone deacetylase m

212 g et al. describe an unexpected role for the histone methyltransferases MLL3 and MLL4 in the repressi

213 We previously showed that histone methyltransferases MLL3/MLL4 and associated PTIP

214 Histone methyltransferase MLL4 is centrally involved in

215 ding more than twofold overexpression of the histone methyltransferase MLL5 and LINE-1 elements trans

216 The histone methyltransferase MMSET/WHSC1 (Multiple Myeloma

217 Here we show that mice lacking the histone-methyltransferase myeloid/lymphoid or mixed-line

218 iochemical purification identifies the H3K36 histone methyltransferase NSD/dMes-4 as a novel IBP cofa

219 indicate that inactivating mutations in the histone methyltransferase NSD1 define an intrinsic subty

220 that loss-of-function mutations in the H3K36 histone methyltransferase NSD1, which cause Sotos syndro

221 disability syndrome caused by mutations in a histone methyltransferase, NSD1.

222 The histone methyltransferase NSD2/WHSC1/MMSET is overexpres

223 translocation induces overexpression of the histone methyltransferase, NSD2, resulting in expansion

224 Histone methyltransferases of the nuclear receptor-bindi

225 In-frame fusion transcripts involving histone methyltransferase or histone demethylase genes w

226 mb group protein Ezh2 is a histone H3 Lys-27 histone methyltransferase orchestrating an extensive epi

227 me1) is mediated by the cell cycle-regulated histone methyltransferase PR-Set7.

228 The histone methyltransferase PRC2 plays a central role in g

229 oncohistone" mutation acts by inhibiting the histone methyltransferase PRC2, the details of this prop

230 of chromatin context on the activity of the histone methyltransferase PRC2.

231 Here, we reveal that BCL11A interacts with histone methyltransferase (PRC2) and histone deacetylase

232 ationships between SPO11, chromatin, and the histone methyltransferase PRDM9.

233 Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from

234 Polycomb repressive complex-2 (PRC2) is a histone methyltransferase required for epigenetic silenc

235 However, the counteracting histone methyltransferase required for the active chroma

236 SETDB1, a histone methyltransferase responsible for methylation of

237 ectly with Suv39h1, Suv39h2, and SETDB1, the histone methyltransferases responsible for H3K9 trimethy

238 Moreover, depletion of SETDB1, a histone methyltransferase, resulted in a loss of transcr

239 arked mRNAs, including those coding for SETD histone methyltransferases, ribosomal components, and po

240 The histone methyltransferase SDG8 functions to regulate the

241 ere, we report a deletion of the Arabidopsis histone methyltransferase SDG8 in this mutant (renamed s

242 that the Arabidopsis (Arabidopsis thaliana) histone methyltransferase SET DOMAIN GROUP8 (SDG8) media

243 We demonstrate that the histone methyltransferase SET-32, methylates H3K23 in vi

244 s a PTM of dynamic microtubules and that the histone methyltransferase SET-domain-containing 2 (SETD2

245 Importantly, we identify the histone methyltransferase Set1 as a GSC-specific self-re

246 down of either SAM synthetase (Sam-S) or the histone methyltransferase Set1 is restored to near norma

247 anges in the number of binding sites for the histone methyltransferase Set2, thereby influencing both

248 f the central players in this pathway is the histone methyltransferase Set2.

249 Cellular studies showed that histone methyltransferase Set7 mediates high glucose-ind

250 Ott1, which associates with Hdac3 and the histone methyltransferase, Setd1b, binds to both c-Mpl R

251 to these stage-specific effects, loss of the histone methyltransferase Setd2 had robust tumor-promoti

252 lation-responsive genes directly engages the histone methyltransferase SETD2, a component of the acti

253 oic acids 1-5 are in vitro inhibitors of the histone methyltransferase SETD8, and nahuoic acid A (1)

254 In this issue, Cuellar et al. find that the histone methyltransferase SETDB1 enables acute myeloid l

255 tinct from that in murine EC cell lines: the histone methyltransferase SETDB1 is required, but the wi

256 y essential genes in ES cells, including the histone methyltransferase Setdb1.

257 NSD2, a histone methyltransferase specific for methylation of hi

258 Here, we identify that SUV4-20 histone methyltransferases, specifically SUV4-20 H1, pla

259 then recruits heterochromatin protein 1a and histone methyltransferase Su(Var)3-9 to the sites.

260 e deacetylases (HDACs) and a lysine-specific histone methyltransferase, SU(VAR)3-9, play a significan

261 ORC1 binds to RB, the histone methyltransferase SUV39H1 and to its repressive

262 around the role of the major heterochromatic histone methyltransferase Suv39h1 in the aging process.

263 Here we find that the histone methyltransferase SUV39H2 methylates histone H2A

264 didate epigenetic factors and identified the histone methyltransferase SUV420H2 (KMT5C) as favoring t

265 ressive histone modification H4K20me3 or the histone methyltransferase SUV420H2 regulates embryonic s

266 h is caused by haploinsufficiency of NSD1, a histone methyltransferase that catalyses the dimethylati

267 onal activation, and DOT1L is the only known histone methyltransferase that catalyzes H3K79 methylati

268 We demonstrated that SetD8, a histone methyltransferase that catalyzes monomethylation

269 nd siRNA knockdown studies show that EZH2, a histone methyltransferase that catalyzes trimethylation

270 dy, we investigated the role of G9a/Ehmt2, a histone methyltransferase that defines a repressive epig

271 Polycomb-repressive complex 2 (PRC2) is a histone methyltransferase that is critical for regulatin

272 Polycomb repressive complex 2 (PRC2) is a histone methyltransferase that is localized to thousands

273 Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that is overexpressed by pancr

274 ning protein 7 (PRDM7) is a primate-specific histone methyltransferase that is the result of a recent

275 Polycomb repressive complex 2 (PRC2) is a histone methyltransferase that maintains cell identity d

276 Polycomb repressive complex 2 (PRC2) is a histone methyltransferase that methylates histone H3 at

277 ll molecule inhibitor of the DOT1L enzyme, a histone methyltransferase that methylates lysine 79 of h

278 The polycomb group protein Ezh2 is a histone methyltransferase that modifies chromatin struct

279 stently decreased the expression of Prdm2, a histone methyltransferase that monomethylates histone 3

280 e recently demonstrated that WRAD is a novel histone methyltransferase that preferentially catalyzes

281 NSD2 is a histone methyltransferase that specifically dimethylates

282 Polycomb repressive complex 2 (PRC2) is a histone methyltransferase that trimethylates H3K27, a ma

283 SETD1A is a member of trithorax-related histone methyltransferases that methylate lysine 4 at hi

284 M) is the methyl-donor substrate for DNA and histone methyltransferases that regulate epigenetic stat

285 DD4L and recruit enhancer of zeste homolog 2 histone methyltransferase to repress NEDD4L transcriptio

286 1 also interferes with binding of the SET7/9 histone methyltransferase to the imprinting control regi

287 omatin remodelers, histone deacetylases, and histone methyltransferases to repress transcription.

288 Previous studies have linked histone methyltransferases to the differentiation of mam

289 lements, which switch the EZH2 function from histone-methyltransferase to non-histone methyltransfera

290 gramming to direct CREB or G9a (a repressive histone methyltransferase) to the Zfp189 promoter in pre

291 quire the interaction of NKX3.1 with the G9a histone methyltransferase via the homeodomain and are me

292 otic discs 1 (ASH1), and Compass member SET1 histone methyltransferases were O-GlcNAc-modified in oga

293 A number of histone methyltransferases were then tested on these nuc

294 YND domain containing protein 3 (SMYD3) is a histone methyltransferase, which has been implicated in

295 subunits and the transcription-coupled Set2 histone methyltransferase, which is involved in suppress

296 show that TERRA associates with SUV39H1 H3K9 histone methyltransferase, which promotes accumulation o

297 -repressor, together with HP1 and the SETDB1 histone methyltransferase, which results in transcriptio

298 ssembly in fission yeast depends on the Clr4 histone methyltransferase, which targets H3K9.

299 y to study the global function of a specific histone methyltransferase within a multicellular organis

300 We investigated the role of the histone methyltransferase Wolf-Hirschhorn syndrome candi