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1 n each structure is roughly 18 basepairs per histone protein.
2 so increases acetylation of histones and non-histone proteins.
3 f acetyl groups from histones as well as non-histone proteins.
4 ally recognize methylated lysine residues on histone proteins.
5 versible epigenetic modifications of DNA and histone proteins.
6 ulated by chemical modifications of the core histone proteins.
7 binding partner of Bcl6 which ubiquitinates histone proteins.
8 n and increasingly through regulation of non-histone proteins.
9 ove active marks and add repressive marks to histone proteins.
10 of DNA wrapped around a symmetric octamer of histone proteins.
11 DNA into nucleosomes that contain a core of histone proteins.
12 cation that is found on both histone and non-histone proteins.
13 is wrapped around largely positively charged histone proteins.
14 nucleosomes, where the DNA is wrapped around histone proteins.
15 irect the post-translational modification of histone proteins.
16 ugh changes in the local environment and the histone proteins.
17 e future study of acetylated histone and non-histone proteins.
18 DNA is packaged into chromatin by canonical histone proteins.
19 at this Rtt106:HIR complex included Asf1 and histone proteins.
20 cription factors (NRF2, C/EBP, and E2F1) and histone proteins.
21 ssing, resulting in severe depletion of core histone proteins.
22 binding events and chemical modifications of histone proteins.
23 cently been found to also associate with non-histone proteins.
24 moval of post-translational modifications on histone proteins.
25 of acetyl groups from both histones and non-histone proteins.
26 zymes, and chromatin, the complex of DNA and histone proteins.
27 ylation of lysyl residues in histone and non-histone proteins.
28 ression by deacetylation of histones and non-histone proteins.
29 matin must be unwound and the DNA cleared of histone proteins.
30 ription, through methylating histone and non-histone proteins.
31 d intermediates that associate with cellular histone proteins.
32 verse tumour types and in crucial regions of histone proteins.
33 al macro domain that is not present in other histone proteins.
34 cell death acting through acetylation of non-histone proteins.
35 configuration imposed by the binding of the histone proteins.
36 s have been developed to purify and separate histone proteins.
37 ed in part by lysine methylation of the core histone proteins.
38 and post-translational modifications of the histone proteins.
39 s, such as posttranslational modification of histone proteins.
40 tone proteins and 5 mutations with increased histone proteins.
41 checkpoint and the resulting degradation of histone proteins.
42 ysine methylation events decorating the core histone proteins.
43 inked to epigenetic modifications on DNA and histone proteins.
44 , and/or post-translational modifications of histone proteins.
45 nslational modifications on core and variant histone proteins.
46 consists of DNA wound around a core of eight histone proteins.
47 cally by post-translational modifications of histone proteins.
48 me: 147bp of DNA wrapped about an octamer of histone proteins.
49 er lysine acylations in both histone and non-histone proteins.
50 s a dynamic PTM occurring on histone and non-histone proteins.
51 tion of the binding properties of individual histone proteins.
52 yl group from lysine residues of several non-histone proteins.
53 elements by supporting an adequate supply of histone proteins.
54 -aging proteome response by upregulating H2B histone proteins 1 week after 4-week intermittent fastin
55 ved in interactions between histones and non-histone proteins, 80-90% of residues in histones H3 and
56 nano-liquid chromatography (nanoLC) and, for histone proteins, a 2-d sample preparation that includes
57 model organism, we found that reducing yeast histone proteins accelerates chronological aging and inc
58 o known as TP53) was an early example of non-histone protein acetylation and its precise role remains
62 on, a process catalyzed by distinct types of histone/protein acetyltransferases (HATs) that regulate
64 ctivity is regulated post-translationally by histone/protein acetyltransferases and histone/protein d
65 table for the preparation of fully synthetic histone proteins, allowing for site-specific incorporati
66 Furthermore, an comparism of Khib sites in histone proteins among human, mouse and P. patens found
67 vered 15 substitution mutations with reduced histone proteins and 5 mutations with increased histone
68 The extensive interactions between the basic histone proteins and acidic DNA make the nucleosomal uni
70 tes the acetylation state of histone and non-histone proteins and could be a powerful regulator of th
72 , with differing preferences for the various histone proteins and for specific sites on individual hi
73 ty increased, including deacetylation of non-histone proteins and functional diversification in mamma
74 , such as post-translational modification of histone proteins and incorporation of histone variants,
75 s mRNA abnormalities through modification of histone proteins and may prove to be of therapeutic valu
76 one chaperone Rtt106 binds newly synthesized histone proteins and mediates their delivery into chroma
77 atens found conserved sites in the H3 and H4 histone proteins and novel sites in H1, H2A and H2B hist
78 stone deacetylases remove acetyl groups from histone proteins and play important roles in many genomi
79 al processes by acetylating histones and non-histone proteins and regulating chromatin and gene-speci
80 romatin, which consists of the histones, non-histone proteins and RNA molecules that package DNA.
81 ns decrease the attractive force between the histone proteins and the DNA but also stabilize H2A/H2B
82 tone gene transcription and depletion of the histone proteins, and (4) repression of E2F1-dependent g
83 ple peptides from various known prohormones, histone proteins, and DNA- and RNA-binding proteins as b
85 ts of purified NET components including DNA, histone proteins, and neutrophil enzymes on coagulation
86 romatin self-assembly, starting from DNA and histone proteins, and use these to understand the constr
87 of this, post-translational modifications of histone proteins are central to the regulation of chroma
88 to DNA replication, focusing on how parental histone proteins are chaperoned around the replication f
89 anslational modifications in histone and non-histone proteins are crucial to DNA replication, DNA rep
90 genomes, and which variant forms of the core histone proteins are deposited is incompletely understoo
92 INGS: Chemical modifications of DNA and core histone proteins are epigenetic marks that constitute th
99 Epigenetic modifications of both DNA and histone proteins are now emerging as fundamental mechani
106 intrinsically disordered terminal regions of histone proteins, are key modulators of the structure an
107 ails, which are the terminal segments of the histone proteins, are prominent IDPs that are implicated
108 that epigenetic methylation modification on histone protein arginine residues is a regulatory mechan
111 (immediate early, early, and late) bind with histone proteins at the start of viral gene expression.
112 methylarginine residues to citrulline, with histone proteins being among its best-described substrat
113 by posttranslational modifications (PTMs) of histone proteins bound to cccDNA through analysis of de
114 ow that LPS treatment reduces acetylation of histone proteins bound to the NAPE-PLD promoter, an effe
116 e reversible acetylation of histones and non-histone proteins by histone acetyltransferases and deace
120 Ubiquitin and ubiquitin-like (UBL) PTMs on histone proteins can function as signaling molecules by
122 ositions within nucleosomes reveals that the histone proteins catalyze strand scission and increase t
123 episomes and recruit the diatom centromeric histone protein CENH3, suggesting nonnative sequences ca
124 the elaborate combination of histone and non-histone protein complexes defines chromatin organization
126 ast promoters are predominantly bound by non-histone protein complexes, with little evidence for frag
127 abeled methyl groups in both DNA and the H2B histone protein component of the 200-kDa nucleosome core
128 ed by acetylation including histones and non-histone proteins component of transcription factors cont
129 ay of posttranslational modifications of the histone protein constituents of chromatin and regulatory
130 e covalent methylation of lysine residues on histone proteins constitutes a principal molecular mecha
134 me is typically centered around an octameric histone protein core: one central tetramer plus two sepa
136 rmacologic modulation of Treg function using histone/protein deacetylase inhibitors (HDACi) may allow
137 myces pombe (Sp) Hst4 is an NAD(+)-dependent histone/protein deacetylase involved in gene silencing a
138 duced by the Sir2-catalyzed NAD(+)-dependent histone/protein deacetylase reaction, regulates diverse
142 herefore, understanding the roles of various histone/protein deacetylases (HDAC) are key to promoting
143 experimental studies show that inhibition of histone/protein deacetylases (HDAC) can have important a
149 we discuss possible mechanisms whereby these histone/protein deacetylases facilitate the switch betwe
153 pression is mildly compromised, the maternal histone protein deposits are essential for proper early
156 phase of eukaryotic cells are unprotected by histone proteins during entire cell cycles and because t
158 to systematically dissect their roles on non-histone proteins, especially for their relationships wit
159 , 2 and 3 are members of the SMH (single Myb histone) protein family, which comprises double-stranded
163 ct "code," it is becoming clear that PTMs on histone proteins function in elaborate combinations to r
164 mmunoprecipitated proteins included cellular histone proteins H2A, H3, and H4; the intermediate filam
165 e, in vivo, we show that in murine cells the histone protein H2AX prevents nucleases other than Artem
167 eptide (MitoFlag) enables the trafficking of histone protein H2B, a nuclear protein, to the mitochond
168 differences in basal levels of trimethylated histone protein H3 at lysine 9 (H3K9me3) in hippocampus
169 ly conserved signature N-terminal peptide of histone protein H3 plays crucial roles in gene expressio
172 regulatory factors (CRF)] and genes encoding histone proteins harbor recurrent mutations in most huma
178 We conclude that unlike DNA or individual histone proteins, human intact NETs do not directly init
180 Finally, AspAlk was shown to modify the core histone proteins, implicating aspirin as a potential che
182 ms are the posttranslational modification of histone proteins in chromatin and the methylation of DNA
184 es encoding chromatin regulatory factors and histone proteins in human cancer, implicating them as ma
186 s have focused on the role of acetylation of histone proteins in modulating transcription, whereas de
187 ine residues in the N-terminal tails of core histone proteins in nucleosome is of fundamental importa
188 he DNA is often inaccessible, wrapped around histone proteins in nucleosomes forming the chromatin.
192 s accomplished by the wrapping of DNA around histone proteins in repeating units of nucleosomes to fo
193 Their ability to stabilize highly abundant histone proteins in the cellular environment prevents no
194 enrichment of permissive epigenetic marks on histone proteins in the hippocampus of male cocaine-sire
195 e of the highest binding affinities for core histone proteins in the mouse genome were not altered by
196 s post-translational modifications (PTMs) on histone proteins in the nucleosome and by nucleobase mod
198 Here we show that Acr forms adducts with histone proteins in vitro and in vivo and preferentially
199 tors, independently of FOXP3, as well as non-histone proteins, in addition to their effects on chroma
200 shown also to play a role in regulating non-histone proteins, including the tumor suppressor protein
201 n nucleosome core particles reveals that the histone proteins increase strand scission between 130- a
206 thylation of lysine residues on the tails of histone proteins is a major determinant of the transcrip
208 addition to DNA methylation, modification of histone proteins is also an important regulator of impri
215 mmetric dimethylarginine mark on histone/non-histone proteins, is reportedly overexpressed in various
216 may be regulating initiation by controlling histone protein levels and/or by affecting origin chroma
217 ucidated the posttranslational regulation of histone protein levels by the ubiquitin-proteasome pathw
220 Different mechanisms operate to regulate histone protein levels, and induction of human histone g
221 ative aging is accompanied by a reduction in histone protein levels, and this is a cause of aging in
223 form reversible DNA-protein conjugates with histone proteins, likely contributing to regulation of n
225 ated p300, which comprise the KAT3 family of histone/protein lysine acetyltransferases, interact with
226 s on how acetylation of both histone and non-histone proteins may drive cancer, and we will discuss t
227 ulatory roles of lysine methylation, the non-histone protein methylation may create binding sites for
229 in chromatin structure--hypersensitivity and histone protein modifications--between human embryonic s
231 are involved in binding epigenetic marks on histone proteins, more specifically acetylated lysine re
232 ion and association kinetics under different histone protein (NCP) and NaCl concentrations using sing
233 approximately 146 bp of DNA wrapped around a histone protein octamer that controls DNA accessibility
235 chemical modifications that are found on the histone proteins of eukaryotic cells form multiple compl
236 Post-translational modifications (PTMs) of histones, proteins onto which DNA is packaged, are invol
237 atin is a supramolecular assembly of DNA and histone proteins, organized into nucleosome repeat units
239 , however, as HATs and HDACs also target non-histone proteins particularly transcription factors to a
241 lational modifications of the DNA-associated histone proteins play fundamental roles in eukaryotic tr
243 ones, and that interaction between MeCP2 and histone proteins plays a key role in gene expression reg
245 e through post-translational modification of histone proteins, primarily histone H3 phosphorylation a
247 apply MAS NMR to directly probe the dynamic histone protein regions in (13)C,(15)N-enriched recombin
250 methyl groups to the amino terminal tails of histone proteins regulates cellular gene expression at v
252 encoded in covalent modifications of DNA and histone proteins regulates fundamental biological proces
254 tanding of the fundamental mechanisms of non-histone protein regulation through this dynamic and mult
258 ged molecules such as DNA, and any excess of histone proteins results in deleterious effects on genom
259 are responsible for binding the highly basic histone proteins, shielding them from non-specific inter
263 ucho interacts with histone deacetylases and histone proteins, suggesting that it may effect repressi
265 ociated with nucleosomes containing modified histone proteins that are generally found associated wit
266 ircular, gene dense, and organized either by histone proteins that are homologous to their eukaryotic
267 f select archaea have identified homologs of histone proteins that assemble into tetrameric nucleosom
269 important post-translational modification of histone proteins that defines epigenetic status and cont
270 Yeast Scm3 and human HJURP are conserved non-histone proteins that interact physically with the (CenH
273 Accelerated upregulation of genes encoding histone proteins that support DNA replication is the mos
274 otein modification for both histones and non-histone proteins, the mechanisms of acetylation-mediated
278 es negative feedback on the histone genes by histone proteins through the level of saturation of hist
279 lls, the genome is packaged and rolled up by histone proteins to create a series of DNA/histone core
284 echanism in which Rtt106 sensed the level of histone proteins to maintain the proper level of histone
285 icroviscosity in live cells experienced by a histone protein using the photoswitching kinetics of Dro
288 We determined that the levels of multiple histone proteins were markedly decreased in cohorts of i
289 hly flexible N- or C-terminal protrusions of histone proteins which facilitate the compaction of DNA
290 A and a variety of modified histones and non-histone proteins, which have an impact on cell different
291 n requires posttranslational modification of histone proteins, which, in concert with chromatin-remod
292 ctrophoresis; and immunoblotting of isolated histone proteins with modification-specific antibodies.
293 tant post-translational modifications on non-histone proteins, with emphasis on their roles in diseas
294 nts, the DNA unwinds asymmetrically from the histone proteins, with only one of its two ends preferen
295 llustrated through the chemical tailoring of histone proteins within a native chromatin setting.
298 st-translational modifications (PTMs) of the histone proteins within nucleosomes regulate these DNA p