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1                    Opiate use was determined historically.
2                                              Historically, 4-4.7 years per decade showed either NPP s
3                                 Silicosis is historically a disease of miners; however, failure to re
4 er tract connecting to this region, has been historically a target for the surgical treatment of intr
5                                              Historically, a primary focus in this context has been t
6  depending on whether invasive predators are historically absent, present, or eradicated?
7                                              Historically accessed through two-electron, anionic chem
8                                              Historically, acute appendicitis was treated with emerge
9 raordinary opportunity to investigate issues historically addressed by the arts, humanities, and soci
10               Consensus recommendations have historically advised thyroidectomy for definitive diagno
11 malian brain, while systems neuroscience has historically analyzed the encoding properties of cortica
12 iteria for paediatric high-grade glioma vary historically and across different cooperative groups.
13             Antimalarial drug resistance has historically arisen through convergent de novo mutations
14  across treatment cohorts, pathologists have historically assigned a semi-quantitative histopathology
15 ents, our results show that fish communities historically associated with coral reefs will not re-est
16 tically distinct serotypes, each of which is historically assumed to be antigenically uniform.
17                                              Historically, asymptomatic hyperuricaemia was considered
18                 This feedback cycle operated historically at within-reef scales; however, our results
19                                              Historically, attempts to understand the factors that pr
20                                              Historically, autoimmune and inflammatory diseases have
21                                              Historically, bacterial and archaeal genomes were recons
22 al niches and spatial distribution have been historically based on simple metrics such as low-resolut
23 ce to plant habitats which have been present historically (based on the relatedness between native an
24  (MGIA) to discriminate vaccine responses in historically BCG-vaccinated human volunteers and to asse
25                  Drosophila melanogaster has historically been a workhorse model organism for studyin
26 ty spectrometry (IMS)-based instruments have historically been accurate to, at best, +/-2% of the red
27 ery common manifestation of cancer that have historically been approached as a single disease entity
28 (T-ALL) is an aggressive malignancy that has historically been associated with a very poor prognosis.
29     Fast ventricular tachycardias (VTs) have historically been attributed to shorter path lengths wit
30 t-translational modifications (PTMs), it has historically been biased towards just a few.
31                Improving traits in wheat has historically been challenging due to its large and polyp
32      Neonatal CD4(+) and CD8(+) T cells have historically been characterized as immature or defective
33                   Somatosensory neurons have historically been classified by a variety of approaches,
34                              The disease has historically been defined by evidence of distinctive his
35                                     ISOW has historically been depicted as flowing counter-clockwise
36 er interactions responsible for the OSE have historically been described by a two-level dressed-atom
37                                 Squalene has historically been harvested from shark liver oil, which
38 to updating beliefs with new information has historically been interpreted as reflecting bias or moti
39 te vaccine in the poor communities that have historically been left behind.
40 ife mortality due to endemic infections have historically been limited by an inability to directly ob
41 poietic stem cell transplantation (HSCT) has historically been limited by infrequent marrow biopsies,
42 sing HIV incidence among Black MSM, who have historically been more likely to acquire HIV due to stru
43                         Rare cells that have historically been obscured by bulk measurement technique
44 rained saturated hydrocarbon system that has historically been of interest in theoretical organic che
45 ies below ground, while little attention has historically been paid to the above ground portions of p
46 iscovered Kihnu native sheep in Estonia have historically been part of the first migratory episode an
47  in a large randomized superiority trial has historically been predominant in oncology.
48                    Microfluidic devices have historically been prepared using fabrication techniques
49 und ubiquitously in the environment that has historically been regarded as nonpathogenic.
50                             Malnutrition has historically been researched and addressed within two di
51 ay explain why rodent islet architecture has historically been seen as having a core-mantle arrangeme
52 ancer in men from sexual minority groups has historically been sparse, peer-reviewed research in this
53          Although the bacterial ribosome has historically been the most well exploited RNA target, ad
54 mmalian sleep expression and regulation have historically been thought to reflect the activity of neu
55 homa that, like other Hodgkin lymphomas, has historically been treated aggressively.
56 ural and functional complexity, glycans have historically been underexplored compared with other area
57 reach to institutions and students that have historically been underrepresented at SER; we hope this
58 schools and residencies, Black/AA women have historically been underrepresented in academic surgery.
59 emal and nontreponemal serologic testing has historically been used for the diagnosis of syphilis.
60 ed to the full gamut of approaches that have historically been used to link brain to behavior, from p
61               The central nervous system has historically been viewed as an immune-privileged site, b
62  surface waters in southwestern regions have historically been well within the settlement thermal env
63                                              Historically, brain death legislation was adopted in Asi
64 been resilient to stand-replacing fires that historically burned at 100- to 300-year intervals.
65  antibodies (DSA), including those that were historically C1q+ binding.
66                                              Historically, California has been a world leader in the
67 elt where Neisseria meningitidis serogroup A historically caused large-scale epidemics.
68 lt, where Neisseria meningitidis serogroup A historically caused large-scale epidemics.
69 teria interacting with their environment has historically centered on strategies for obtaining nutrie
70 icting outcomes in elderly patients has been historically challenging and POTTER has not yet been tes
71 hesis of collections of macrocycles has been historically challenging due to difficulties in the form
72             O-Glycoprotein analysis has been historically challenging due, in part, to a dearth of av
73 ino acid counterparts in peptides has been a historically challenging prospect due to the diminished
74 lecule antagonists of interleukins have been historically challenging to generate.
75                          Inbred animals were historically chosen for genome analysis to circumvent as
76                                              Historically, clinical trials have aimed to reduce place
77                       Daphnia pulicaria that historically coexisted with fish reached greater biomass
78 as warming advances polewards/mountainwards, historically cold-climates shrink, leading viviparous sp
79 e complexity of biogeochemical processes and historically compartmentalized disciplines, ecosystem-sp
80 e of the intellectual battle between the two historically competing wing origin hypotheses.
81                                              Historically, computations of the inbreeding coefficient
82 ity hotspots, and that tetrapod sampling has historically concentrated in only a few areas.
83 and also are found in river basins that were historically connected.
84 FDs, especially invasive mold diseases, were historically considered a contraindication for HSCT.
85 aring single-cusped teeth can be recognized, historically considered as juveniles and adults of the s
86                                     AFFF has historically contained high levels of long-chain per- an
87                             AFFF formulation historically contains per- and polyfluoroalkyl substance
88 oxy-PCBs, in soil samples coming from a site historically contaminated by the industrial production o
89 y, Sweden, where the drinking water has been historically contaminated with perfluorobutanesulfonate
90 lvability depended upon prior mutations in a historically contingent fashion.
91 d tallgrass prairies, thereby supporting the historically contingent model of community assembly in a
92                       APOBEC3 mutations also historically contribute to the evolution of HPV16 lineag
93 uctural inequities and health care gaps have historically contributed to and continue to compound dis
94                                              Historically, conventional treatments for sarcomatoid RC
95 n landscapes where much of the land had been historically converted from grassland to crop.
96 nd psychophysical color recognition has been historically debated.
97    The "cavitary" form of retinoblastoma has historically demonstrated minimal treatment response wit
98 pathogenic allo- and autoantibodies and have historically demonstrated resistance to therapeutic targ
99                                  Glucagon is historically described as the counterregulatory hormone
100 ntial for genome interpretation but has been historically difficult due to limitations inherent to av
101 rally, spatially, and taxonomically has been historically difficult to analyze at a genome-wide scale
102                                    Among 195 historically difficult-to-diagnose tumours in the archiv
103 r include, support, and elevate members from historically disadvantaged groups.
104 , healthy lives of Black Americans and other historically disenfranchised groups.
105 grative approach, leveraging techniques from historically distinct disciplines-developmental anatomy
106  are becoming more commonplace in areas that historically do not regularly experience fire, causing a
107             However, empirical evidence from historically documented colonisations suggest that, in m
108                 The oldest event from a less historically documented event occurred in 1537.
109          Even though Native Californians are historically documented to have used Datura to enter tra
110                             In conflict with historically dominant models of time perception, recent
111 eavily fished, causing a decline among their historically dominant small pelagic fish stocks, or have
112                                              Historically, ductal carcinoma in situ (DCIS) of the bre
113                                              Historically, DVGs were studied for their ability to int
114                                              Historically, EBV genes that contribute to virus replica
115 ofiles between alligators originating from a historically EDC-contaminated site, Lake Apopka, and a r
116 nthesis followed by derivative synthesis has historically enabled a deeper understanding of structure
117  concept of "therapeutic hierarchy" has been historically endorsed by the Asia-Pacific treatment algo
118 t people with severe mental illness have not historically engaged with smoking cessation services.
119                                              Historically, ePADs have relied almost exclusively on si
120                                              Historically, epidermal-innervating sensory neurons were
121 cs, and medicine, the underrepresentation of historically excluded groups continues due to persisting
122             We estimate that, if operated as historically, existing infrastructure will cumulatively
123 rog" effect: The declining noteworthiness of historically extreme temperatures is not accompanied by
124 creting cells following beta-cell failure, a historically fatal condition now sustainable only by adm
125                                              Historically, fetal circadian rhythms have been consider
126 als (RCTs) evaluating clinical outcomes, but historically, few clinical guideline recommendations hav
127                                              Historically, FM was almost exclusively diagnosed at aut
128         While the field of islet biology has historically focused its attention on understanding beta
129   Studies on macrophage gene expression have historically focused on events leading to RNA polymerase
130 al immune responses at mucosal surfaces have historically focused on IgA.
131 empts to develop MET-targeted therapies have historically focused on MET-expressing cancers, with lim
132                    Renal trauma research has historically focused on parenchymal injuries and the ris
133  the mechanisms underlying DCM formation has historically focused on phytoplankton physiology (e.g.,
134             Surveillance within the belt has historically focused on the clinical syndrome of meningi
135       Although studies of drug activity have historically focused on the primary drug-target interact
136 ch into malaria biology and pathogenesis has historically focused on two model systems, in vitro cult
137 ers from extreme climate events and is known historically for cyclic flooding events and, within the
138  these exceptional heatwaves, hotter than in historically forced coupled climate model simulations, w
139                                              Historically, [Formula: see text]-based SETs exhibit tim
140                                              Historically, fruit and vegetable availability has consi
141                                              Historically, graduate school training has focused on pr
142  the rate of extracellular NE clearance that historically has been believed to occur solely through s
143 r example, increased tissue stiffness, which historically has been used to detect cancer by palpation
144 cules are produced in biological systems and historically have been considered causal mediators of da
145 zophrenia, but the outcomes of most patients historically have been suboptimal.
146 erculosis have limited treatment options and historically have had poor outcomes.
147 August 2011 to May 2016 in Tororo, Uganda, a historically high malaria transmission setting.
148                The United States experienced historically high numbers of measles cases in 2019, desp
149  large size of the ASFV genome (~180 kb) has historically hindered efforts to rapidly obtain a full-g
150 k of resolution of species relationships has historically hindered their investigation, particularly
151   Giant pandas (Ailuropoda melanoleuca) were historically hunted using dogs and are currently threate
152 e with changes in Arctic sea ice dynamics as historically ice-covered areas become increasingly ice-f
153                                              Historically, impacts of novel parasites have been asses
154 ing Mycobacterium leprae in axenic media has historically impaired assessments of M. leprae resistanc
155 s of this classical arsonium-ylide that have historically impeded its wider study.
156 ough such models can correctly identify some historically important documents, they tend to overpredi
157    Glycoside hydrolase family 74 (GH74) is a historically important family of endo-beta-glucanases.
158             Since wild nonhuman primates are historically important sources or reservoirs of human pa
159 e 'estrus-mediated variability hypothesis'); historically in biomedical research, females have been e
160                                              Historically, in vitro assessments focused on a few biol
161             The same pattern was observed in historically inbred lines, indicating a high frequency o
162 ation, devaluation, rejection, and exclusion historically increased risk for physical injury and infe
163  maritimus) subpopulations, where bears have historically inhabited a mix of thick multiyear and annu
164                       Here, we reveal that a historically innocuous grazer-the marsh crab Sesarma ret
165  lateral sclerosis (ALS) today face the same historically intransigent problem that has existed since
166                                              Historically, intravenous acetylcysteine has been delive
167                       Genomics analysis of a historically intriguing and predicted emergent human ade
168 ve to the western United States (US) and was historically introduced to several locations in the sout
169                                              Historically it has been challenging to identify inhibit
170 blem in deep artificial neural networks, but historically it has been viewed as biologically problema
171                                              Historically, it has been difficult to biochemically cha
172                                              Historically, it was thought that case-control studies r
173                                              Historically, Jiangxi province has had the largest HFRS
174 s size and type of swine, counties in states historically known for breeding and feeding operations a
175 ssay combined with the ability to automate a historically labor-intensive assay is an appealing attri
176 59; p = 0.29) among historically smaller and historically larger clinics, respectively.
177 of rheumatology in the past several decades, historically led by publicly funded academic innovators
178  undermining species boundaries or expanding historically limited introgression.
179 pically associated with limbic input but was historically linked to high-level motor control.
180                            Although they are historically linked, no direct comparison has been perfo
181                     It was hypothesized that historically logged areas would be recovering biomass wh
182                                We found that historically logged forests were recovering biomass near
183 rade serous ovarian carcinomas (LGSOCs) have historically low chemotherapy responses.
184 areas have reduced the occurrence of gHAT to historically low levels.
185                                              Historically, many biologists assumed that evolution and
186                                              Historically, many transition metals have been employed,
187 commitment to transforming the conditions of historically marginalized communities, improving the qua
188  that centers the voices and perspectives of historically marginalized populations in epidemiologic w
189 park, with clinic discounts offsetting costs historically met through illegal logging.
190                                              Historically, micro-computed tomography (muCT) has been
191                                              Historically, microbiologists have mostly relied on cult
192 on." Tropical forests, which have adapted to historically moist conditions, are less resilient and ea
193 ganization (OPO) pairs between which kidneys historically most likely traveled by direct flight (High
194                                              Historically, most chambers have operated in batch mode.
195                                              Historically, most research on understanding space radia
196                                              Historically, most studies of terrorism focused on its s
197                                              Historically, much research in this field has focused on
198                                              Historically, murine models of inflammation in biomedica
199 seases represent a vastly underestimated and historically neglected public health problem, disproport
200                                              Historically neurodegenerative diseases, Alzheimer's dis
201                                              Historically, non-surgical treatment was the preferred s
202 f resistance on genomic backgrounds that are historically nonagricultural.
203  sites, creating novel assemblages that have historically not interacted.
204   Potential reinterpretations of a series of historically notable observations in carbocation reactio
205                                              Historically, NPP in extreme surplus and deficit years b
206 ality during isolation for many networks has historically obscured otherwise effective polymerization
207 nst illness from A(H1N1)pdm09 was lower than historically observed effectiveness of 40-60%, due to la
208 sing frequencies of temperatures that exceed historically observed tolerances help explain widespread
209 s and precipitation begin to exceed species' historically observed tolerances.
210                                              Historically, older people who inject drugs (PWID) have
211 iology, studies of metazoan development have historically opened new fields of study and consistently
212 is a 4 decade long debate on this topic that historically originates from the observation of a multil
213 ecular biodiversity monitoring that has been historically out of reach for many researchers in habita
214 ion models suggest that all populations were historically panmictic, with little unidirectional migra
215                                              Historically, patients have been risk stratified on the
216 ntial to overcome these limitations but have historically performed poorly as vaccine antigens, becau
217     However, E protein subunit vaccines have historically performed poorly, in part because the antig
218             Although these formulations have historically played an important role, they can be limit
219 ients with most responsible prescribers that historically prescribed higher daily doses of opioids (>
220                                   ME/CFS has historically presented in outbreaks, often has a flu-lik
221                     These findings challenge historically proposed relationships between LD and AL an
222 ural crops even in fertile regions that have historically received ample precipitation.
223                                   The EC has historically received attention for being the primary me
224  biology in tissues and cell types that have historically received little attention in the field.
225                               While surgeons historically recommended colon resection for uncomplicat
226 that are more geographically proximate, more historically related and/or spoken by more-similar cultu
227 unction analyses of the mammalian brain have historically relied on anatomically-based approaches.
228                      The latter approach has historically relied on in vivo mouse xenografts and in v
229 o wave-making resistance phenomena have been historically reported.
230  to gain and loss of cis-regulatory features historically required complex workflows, preventing wide
231 f trace element hyperaccumulator plants have historically required time-consuming destructive chemica
232                                              Historically, researchers have put considerable effort i
233               H. influenzae type b (Hib) was historically responsible for the majority of invasive H.
234                                              Historically, RNA editing has attracted major research e
235                                              Historically, ryanodine receptors (RyRs) have presented
236                                              Historically, saline (0.9% sodium chloride) has been the
237                                              Historically, sea ice loss in the Arctic Ocean has promo
238                                              Historically, senescence has been described as a negativ
239  2012 and 2013, including those from several historically severe smog events.
240                                              Historically, sleep problems have been viewed as symptom
241  and 1.23 (95% CI 0.87-1.59; p = 0.29) among historically smaller and historically larger clinics, re
242                                              Historically, SSCs have been defined as bone marrow-deri
243 ation with a negative CDC crossmatch against historically strong, C1q binding antibodies.
244 n which model-based planning approaches have historically struggled(4)-the MuZero algorithm achieved
245                                              Historically, studies of the adipose secretome have pred
246                                              Historically, successful eradication has often relied on
247                                              Historically, such cell types were broadly defined by th
248                                              Historically, surgeons have not played a role in the tre
249 in reproductive boundaries that separate two historically sympatric fish species (Gila cypha and G. r
250                                              Historically, the ancestry of modern Ugandans was best r
251 he first intracellular structures visualized historically, the biophysical rules governing its assemb
252                                              Historically, the classification of EEG as showing norma
253                                              Historically, the development model for the Amazon has f
254                                              Historically, the diagnostic process was slow and patien
255                                              Historically, the evolution of bats has been analyzed us
256                                              Historically, the giant panda was widely distributed fro
257                                              Historically, the gold standard for treating acute uncom
258                                              Historically, the intracellular membranes used for parti
259                                              Historically, the majority of statistical association me
260                                              Historically, the membrane attack complex, composed of c
261                                              Historically, the number of cyclopentyl and cyclohexyl r
262                                              Historically, the onset of fuel-cladding chemical intera
263                                              Historically, the PPR has been a highly productive area
264                                              Historically, the primary source of clinically used anti
265                                              Historically, the region has remained on the periphery o
266 lagged behind that of the left ventricle and historically, the RV has even been referred to as a 'pas
267                                              Historically, the screening deck was an assembly of all
268                                              Historically, the structural disease model proposed mech
269                                              Historically, the thalamus has been viewed as little mor
270                                              Historically, their therapeutic benefit is due to ADC ta
271                                              Historically, there have been very few selective modulat
272 by PCR is highly sensitive and specific, but historically these assays have been performed in central
273                                              Historically, these 'nacreous walls' have been considere
274                                              Historically, these behaviors have been the focus of stu
275                                              Historically, these DAMPs have been shown to be pro-infl
276                                              Historically, this term was used to describe a severe ca
277                                              Historically, tissue sectioning, confocal microscopy, an
278 ial and near-ground insectivores than it did historically, today's fragments and second growth are mo
279                                              Historically, tuberculosis in children has been thought
280                                              Historically, two contrasting hypotheses have been sugge
281                                              Historically, two distinct scenarios have been proposed
282                                              Historically, type I glial-like TBCs have been thought t
283       NIH trials were more likely to support historically underfunded subspecialties, whereas Industr
284 ptor-positive (HR(+)) breast cancer has been historically underlooked.
285 n, we were concerned that many students from historically underrepresented (HU) groups may be unable
286 stdoctoral fellows) in academic science from historically underrepresented groups has steadily increa
287  participants are from groups that have been historically underrepresented in biomedical research.
288 t some impacts were descriptively larger for historically underserved minority students and boys.
289                              We identified a historically unprecedented period of heightened storm ac
290 urvival and motor functions were better than historically untreated patients.
291                                              Historically, urology has pioneered new surgical techniq
292                   Although microbiology labs historically use manual processes, the advent of total l
293   The river continuum concept (RCC) has been historically used as a model to predict the fate and qua
294 e toxic mercury salts and pungent thiophenol historically used in methods aimed at preparing DNG olig
295 sustainable alternative to more commonly and historically used precious metals.
296      Here, we describe how genomics has been historically used to investigate Ebola virus disease out
297 k absorption-based linear dichroism has been historically used to investigate molecular orientations
298                                              Historically, venous thromboembolism has received the gr
299                                              Historically viewed as a simple sensorimotor controller
300  social and health disparities among several historically vulnerable populations, with stark differen

 
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