ライフサイエンスコーパス: holding potential

1 ize and intruder pressure (relative resource-holding potential).

2 ceived chances of winning contests (resource holding potential).

3 g skeletal and cardiac RyRs recorded at 0 mV holding potential.

4 ubconductance at a positive but not negative holding potential.

5 slow kinetics that were not affected by the holding potential.

6 by 20 to 30% in the presence of Iso at each holding potential.

7 ffeine-induced release did not depend on the holding potential.

8 hasic with time constants that depend on the holding potential.

9 1 s voltage steps of +60 to +90 mV from the holding potential.

10 egative potentials and was very sensitive to holding potential.

11 ChR than for alpha4beta4-nAChR at a positive holding potential.

12 threshold, and was relatively insensitive to holding potential.

13 This effect was independent of membrane holding potential.

14 n characteristics brought about by shifts in holding potential.

15 rease in channel availability at depolarized holding potentials.

16 duce a response with outward currents at all holding potentials.

17 effect of Waglerin-1 was greater at negative holding potentials.

18 spikes when depolarized from hyperpolarized holding potentials.

19 channel activities at positive and negative holding potentials.

20 e tonic block in IZs than NZs at depolarized holding potentials.

21 IZ channels at depolarized (> or = -100-mV) holding potentials.

22 he fast component decreased with depolarized holding potentials.

23 has the opposite direction at physiological holding potentials.

24 tive firing (< or = 1 spike/stimulus) at all holding potentials.

25 Channel activity remained low at positive holding potentials.

26 ng open time constants were seen at negative holding potentials.

27 picosiemens (pS) in the +/- 100 mV range of holding potentials.

28 This block was evident only at positive holding potentials.

29 entials and increased activities at positive holding potentials.

30 plain why I(KNa) can be evoked from negative holding potentials.

31 dulation of the open probability at negative holding potentials.

32 uncharged molecules at negative and positive holding potentials.

33 of current flow was reversed by changing the holding potentials.

34 itions to 29% at either positive or negative holding potentials.

35 modulated by small changes in difference of holding potentials.

36 ased taurine-induced inward currents at both holding potentials.

37 transport across cell membranes at positive holding potential, (3) alters the pH inside liposomes ex

38 elicited an inward current (9.7 +/- 0.9 pA; holding potential, -40 to -55 mV; n = 25 neurons) that r

39 1/2 values for activation from -70 or -90 mV holding potentials (-44 mV vs. -24 mV; p<0.01).

40 ed to 184 % of baseline) in voltage-clamped (holding potential = -60 mV) preBotC inspiratory neurons

41 pendent inward currents in all cells tested (holding potential, -62 mV), with EC50 values of 437, 15

42 alternated our mapping protocol between two holding potentials (-70 and +40 mV) allowing us to detec

43 rd current activated between -50 and -40 mV (holding potential, -80 mV) and was maximal near -10 mV.

44 Whole-cell Na+ currents (holding potential, -80 mV; test potential, -30 mV) in ra

45 The effects of BDM were compared at two holding potentials, -80 and -30 mV, using the halpha1C-D

46 s of whether the imposed transition from the holding potential (-90 mV) to the test potential took pl

47 ed hamster SCN neurons from a hyperpolarized holding potential activated both I(A) and I(DR).

48 the currents obtained from more depolarized holding potentials activating more slowly and deviating

49 Metaflumizone perfusion at a hyperpolarized holding potential also shifted the conductance-voltage c

50 rd current that was sensitive to the initial holding potential and had properties similar to the A-ty

51 activated by small depolarizations above the holding potential and reversed near 0 mV.

52 The peak current was dependent on the holding potential and showed little rectification; howev

53 of AA by the negative electric field at the holding potential and the irreversible redox reaction.

54 Length reduction at the holding potential and voltage shifts of the motile activ

55 a decrease in channel activities at negative holding potentials and increased activities at positive

56 fast-mode gating was favored by depolarized holding potentials and rapid depolarizations.

57 in cardiac RyR at negative but not positive holding potentials and several subconductances in skelet

58 ow-mode gating was favored by hyperpolarized holding potentials and slow depolarizing rates, whereas

59 [Ca2+] was similar at negative and positive holding potentials and was not influenced by high cytoso

60 ms with similar affinity and a dependence on holding potential, and drug off-rate was slowed at depol

61 turn in better condition, with high resource holding potential, and outcompete residents to retain th

62 efradil was increased at less hyperpolarized holding potentials, and the apparent affinity was correl

63 l of -0.6 V, multiple scan rates, and a 3 ms holding potential at a positive, oxidizing potential of

64 and required hyperpolarization and prolonged holding potentials at -130 mV.

65 ere reduced compared with controls, even for holding potentials at which all NaV1.4 are fully recover

66 + and exhibited steady-state inactivation at holding potentials below -60 mV.

67 Currents recorded at 40 mV from holding potentials between -60 and -120 mV showed an unu

68 dione-sensitive glutamate EPSCs, recorded at holding potentials between -80 and -90 mV, was reversibl

69 der which small changes in the difference of holding potentials between cells forming heterotypic jun

70 sible to MTSET in choline buffer at negative holding potentials, but there was no effect of voltage i

71 mewhat surprisingly, we find that effects of holding potential can be relatively modest when presynap

72 that depolarizing changes in the presynaptic holding potential can increase the rate at which facilit

73 At resting or holding potentials close to threshold either single or b

74 ed at progressively more depolarized preopen holding potentials, cross-linking of F57Bpa with KCNQ1 w

75 2b), or beta(3a) produced currents that were holding potential dependent.

76 ssessment of the adipose tissue composition, holding potential diagnostic significance for metabolic

77 us, the present study measures the effect of holding potential, duration, and intensity on the light-

78 Defined holding potentials eliminated differences in flecainide'

79 eurons, when depolarized from hyperpolarized holding potentials, exhibited a high-frequency burst of

80 he degree of EPSC inhibition by the prepulse holding potential followed the current-voltage relations

81 -ferromagnetic transition can be gate tuned, holding potential for applications in magnetic storage a

82 TP53 mutational information more actionable, holding potential for better precision-based medicine.

83 demonstrated, with the use of -100 mV as the holding potential for fully reprimed channels and -65 mV

84 thographically defined on planar substrates, holding potential for high-volume manufacturing.

85 nnectedness of these two neonatal disorders, holding potential for the discovery of novel targets to

86 bilities for the field of neural interfaces, holding potential for various applications, including as

87 In both cases shifts in holding potential from -90 to -50 mV produced a partial

88 ion of an outwardly rectifying K+ current at holding potentials from -50 to +50 mV.

89 ane potential in cells clamped at a range of holding potentials from -90 to -45 mV.

90 20 and +40 mV prepulse states with long-term holding potentials (> 2 min) at -80 mV was 14.67 +/- 0.9

91 In contrast, the holding potential had little effect on mEPSC kinetics.

92 ous research in this area is that effects of holding potential have been studied in relative isolatio

93 Under patch clamping, at holding potential (HP) = -120 mV, the peak I(Na) was sim

94 Changes in holding potential (HP) markedly altered the severity of

95 elective cation channel, ICa elicited from a holding potential (HP) of -100 mV showed significant pot

96 , at various subthreshold and near-threshold holding potentials in the presence of synaptic blockers.

97 olarizing current pulses from hyperpolarized holding potentials in whole-cell recordings in vitro.

98 n of bovine alpha(1B) with beta(2a) produced holding potential-independent calcium currents that clos

99 lamp studies, carried out at the appropriate holding potential, indicate that NBQX enhances glutamate

100 Furthermore, at a holding potential intermediate for the reversal potentia

101 ent synapses: they do not respond unless the holding potential is moved from -70 mV to +40 mV.

102 Using steady holding potentials, lacosamide block was very weak at -1

103 gs suggest that the presentation of resource holding potential may be larger than the actual storage

104 In voltage clamp mode at a holding potential near resting potential, there were sma

105 This current peaked at holding potentials near -25 mV and was blocked by the NM

106 inward current (6-68 pA) in most neurons at holding potentials near rest.

107 inward and outward currents in SON cells at holding potentials near resting membrane potential follo

108 At holding potentials negative to -50 mV, 5-HT increased st

109 ed a region of negative slope conductance at holding potentials negative to around -70 mV.

110 At a holding potential of +40 mV, spermine at the intracellul

111 ccording to the polarity of the current at a holding potential of +40 to +60 mV (with Ringer's in the

112 The rate of desensitization was faster at a holding potential of +50 mV than at -70 mV.

113 From a holding potential of -100 mV, step depolarizations elici

114 e amplitude and current density of I(h) at a holding potential of -130 mV was significantly larger in

115 , but these differences were diminished at a holding potential of -150 mV, suggesting that the differ

116 was a large reduction of IPSC amplitude at a holding potential of -20 mV in neurons from bilaterally

117 HVA current was inactivated completely at a holding potential of -35 mV and fully deinactivated at a

118 more depolarized potentials from a prolonged holding potential of -40 mV and was sensitive to all thr

119 The predominant K+ current evoked from a holding potential of -40 mV was slowly activating, long-

120 evoked by depolarizing voltage steps from a holding potential of -40 mV were recorded using the whol

121 From a holding potential of -40 mV, depolarizing voltage steps

122 nsensitive outward current was evoked from a holding potential of -40 mV.

123 y 300-ms depolarizing pulses to 0 mV, from a holding potential of -50 mV at 0.5 Hz.

124 kaloid (-)-indolactam (20-100 microM) from a holding potential of -50 mV elicited an inward current,

125 s (e.g. -34.0+/-1.5 to -38.4+/-1.7 mV from a holding potential of -50 mV in phasic PGN, P<0.005).

126 slowed by hyperpolarization to -90 mV from a holding potential of -50 mV, consistent with a 1 Ca2+ :

127 ited by hyperpolarizing voltage steps from a holding potential of -50 mV.

128 ses, activated a "noisy" inward current at a holding potential of -50 mV.

129 It occurred at a constant holding potential of -60 mV and was not inhibited by the

130 At a constant holding potential of -60 mV ET-1 induced a transient fol

131 K(ATP) currents were measured at a holding potential of -60 mV in high K(+) external soluti

132 d external solutions, voltage steps from the holding potential of -60 mV to levels positive to +20 mV

133 logical temperature of 35 degrees C and at a holding potential of -60 mV we recorded three kineticall

134 Sodium currents elicited from a holding potential of -60 mV were blocked with an IC(50)

135 This current was reduced at a holding potential of -60 mV, activated on depolarization

136 At a holding potential of -60 mV, in NaCl external saline and

137 At a holding potential of -60 mV, rapid application of extrac

138 vated an inward current in DRG neurones at a holding potential of -60 mV.

139 ntial of -35 mV and fully deinactivated at a holding potential of -65 mV (V50, -52.26 mV +/- 0.27; n

140 LVA current was inactivated completely at a holding potential of -65 mV and deinactivated fully at a

141 little or no current in 0.3 microM TTX at a holding potential of -67 mV.

142 trazepam (1 microM) slowed deactivation at a holding potential of -70 mV but not at +50 mV.

143 Depolarization to 0 mV from a holding potential of -70 mV increased [Ca2+]i.

144 y of INa from inactivation was slower from a holding potential of -70 mV than from -90 mV; isoflurane

145 In the whole-cell recording configuration (holding potential of -70 mV) while buffering internal ca

146 In the whole-cell recording configuration (holding potential of -70 mV) while buffering internal ca

147 At a holding potential of -70 mV, a maximally effective conce

148 At a holding potential of -70 mV, application of capsaicin (0

149 At a holding potential of -70 mV, quisqualate (2 microM) indu

150 At a holding potential of -70 mV, the Kapp for mibefradil inh

151 ith a range in hundreds of milliseconds at a holding potential of -70 mV.

152 s (sIPSCs) were seen as inward currents at a holding potential of -70 mV.

153 S in turn 4 to 40 nS in turn 2 measured at a holding potential of -70 mV.

154 at both chemicals reduced cell length at the holding potential of -75 mV and induced positive shifts

155 At a holding potential of -75 mV, spontaneous sparks were inf

156 Stepping back to the holding potential of -80 mV evoked large inward tail cur

157 smooth muscle cells by depolarization from a holding potential of -80 mV using the whole-cell patch-c

158 ep depolarizations positive to -50 mV from a holding potential of -80 mV were decreased by up to 70%

159 At a holding potential of -80 mV, 10(-5)M ACh decreased L-typ

160 At a holding potential of -80 mV, the Ca2+ current (ICa) reac

161 between -42 and +49 mV (44% at 0 mV) from a holding potential of -80 mV.

162 nditions, the mean NP(o) value was 1.06 at a holding potential of -80 mV.

163 s with 2 ms long test depolarizations from a holding potential of -89 mV.

164 +) currents in vitro with IC(50) values at a holding potential of -90 mV ranging from 2.8 to 40 micro

165 Using a holding potential of -90 mV, the following IC(50) values

166 oked along with the sustained current from a holding potential of -90 mV.

167 a sixfold acceleration of recovery rate at a holding potential of -90 mV.

168 tial induction (by 15-16 mV) assessed from a holding potential of -90 mV.

169 ntial of -65 mV and deinactivated fully at a holding potential of -95 mV (mean, V50 = -82.40 mV +/- 0

170 For a prepulse to -150 mV, from a holding potential of 0 mV, V(pkcm) shifted 6.4 mV, and w

171 evoked Ca2+-activated potassium current at a holding potential of 0 mV.

172 e was 20 pA in both NRT and relay cells at a holding potential of 0 mV.

173 n is modified by subthreshold changes in the holding potential of the presynaptic neuron.

174 The inhibitory effect of 5-HT was evident at holding potentials of +60 and -60 mV; with the calcium c

175 ll conductances were 18 microM and 960 nM at holding potentials of -120 mV and -50 mV, respectively.

176 With holding potentials of -120 to -150 mV, which completely

177 At holding potentials of -70 or -90 mV, isoflurane inhibite

178 membrane conductance or holding current (at holding potentials of -80 to -90 mV), suggesting that th

179 l by small changes in the difference between holding potentials of the coupled cells.

180 monstrate that small differences in resting (holding) potentials of communicating cells can fully blo

181 We also explored the effects of varying the holding potential on current threshold, and the effect o

182 described as a graded potentiating effect of holding potential on spike-mediated synaptic transmissio

183 earch suggests a novel view of the effect of holding potential on synaptic transmission.

184 investigated the influence of transmembrane holding potential on the kinetics of interaction of a ca

185 rder to investigate the effects of different holding potentials on the rate of development and amplit

186 At holding potentials positive to approximately -50 mV, a s

187 Voltage steps from the holding potential preceding the measurement of capacitan

188 Firstly, negative holding potentials reduced inward currents (i.e. at nega

189 Ca2+ concentrations or positive postsynaptic holding potentials reduced paired-pulse depression of NM

190 More positive holding potentials replicated the increased effectivenes

191 efly depolarizing from a relatively negative holding potential resulted in a low-affinity inhibition

192 tatory and inhibitory inputs using different holding potentials revealed that inhibition could be evo

193 Recordings under different holding potentials revealed that the enhanced response w

194 ng their own and their competitors' resource holding potential (RHP) in escalation decisions.

195 are considered to have the highest resource holding potential (RHP) in MMA.

196 assesses its own fighting ability (Resource Holding Potential, RHP) and compares it to that of its o

197 Channel amplitudes at different holding potentials showed that single-channel conductanc

198 At hyperpolarized holding potentials, small numbers of unitary currents (a

199 40 to 70 ms in atrial myocytes (depending on holding potential) so this current could be responsible

200 FSCV parameters (holding potential, switching potential, and scan rate) w

201 e, current passed linearly over the range of holding potentials tested.

202 sinusoidal voltage signals was a function of holding potential, tether diameter, and tether length.

203 ted an inward whole-cell current at negative holding potentials that was inwardly rectifying and show

204 At -100 mV holding potential, the reduction in LA affinity was maxi

205 At -80 mV holding potentials, the current was also suppressed by a

206 similar current amplitudes across a range of holding potentials; the T721A channel is not functional.

207 Current amplitude increased on changing the holding potential to -107 mV.

208 cal characteristics to use negative membrane holding potentials to mimic the resting potential of neu

209 ng depolarizations and that require negative holding potentials to remove inactivation, many chromaff

210 0 mV, with flickering increasing at negative holding potentials to the point where single-channel cur

211 CA), untagged NBCe1-A, and protocols keeping holding potential (V(h) ) far from NBCe1-A's reversal po

212 )) in 51 of 58 voltage clamped DRG neurones (holding potential (V(h)) = -80 mV) that were in contact

213 At a holding potential (V(H)) of -30 mV, the enzyme decreased

214 Voltage ramps (-110 to -30 mV) from a holding potential (V(h)) of -60 mV in the absence and pr

215 f INa from inactivation was dependent on the holding potential (VH) in both cell types but was signif

216 At a pHo of 7.0 and a holding potential (Vh) of -50 mV, the charge movements w

217 potentiated the peak amplitude of Icat at a holding potential (Vh) of -50 mV.

218 ge ramps required much smaller currents at a holding potential (Vh) of -60 mV than at -80 mV and were

219 Changing the membrane holding potential (Vh) to +40 mV for brief period before

220 (0.5 microM) was significantly less when the holding potential (Vh) was +40 mV rather than -60 mV.

221 This relationship was obtained when holding potential (Vh) was either -40 or -70 mV; however

222 are held at more physiological, in vivo-like holding potentials (Vh = -60 mV) that facilitate multive

223 current, activated by hyperpolarizing steps (holding potential, Vh = -40 mV), with a reversal potenti

224 ular Ca(2+) concentration was 0.5 mm and the holding potential was -80 mV.

225 s exhibited virtually no inactivation as the holding potential was altered whereas others exhibited s

226 ICa,L at -40 mV inactivated when the holding potential was decreased (VL = -57.8 +/- 0.49 mV)

227 itude of inward current was decreased as the holding potential was depolarized.

228 nt potentiation (above 38%) at more positive holding potentials was precisely equal to a K(+)-depende

229 At more positive holding potentials, which produced steady-state inactiva

230 ) displayed inward rectification at positive holding potentials, which were not altered by lowering b

231 onship between LTS amplitude and the initial holding potential without affecting the maximum LTS ampl