ライフサイエンスコーパス: homeobox

1 he 180-base pair DNA fragment comprising the homeobox.

2 m includes the activation of aristaless-like homeobox 1 (alx1), a conserved transcriptional regulator

3 ed by engrailed 1 (En1) and developing brain homeobox 1 (Dbx1).

4 n of the transcription factor genomic screen homeobox 1 (gsx1) produced profound defects in PPI in ze

5 sis-associated genes, we identified Iroquois homeobox 1 (IRX1).

6 P1; from mesoderm to cardiac mesoderm), meis homeobox 1 (MEIS1) and GATA-binding protein 4 (GATA4) (p

7 ear receptor 2f2 (Nr2f2) in addition to Meis homeobox 1 (Meis1) and Meis homeobox 2 (Meis2) gene fami

8 1), paired box 3 (Pax3), Paraxis, mesenchyme homeobox 1 (Meox1), sine oculis-related homeobox 1 (Six1

9 ssion of the transcription factor mesenchyme homeobox 1 (MEOX1).

10 is inhibited by the transcription factor NK2 homeobox 1 (NKX2-1).

11 tor 4 alpha (Hnf4a), which competed with NK2 homeobox 1 (Nkx2.1) for binding to forkhead box A2 (Foxa

12 NK3 homeobox 1 (Nkx3.1), a transcription factor expressed in

13 ncreatic and duodenal homeobox 1 (PDX1), NK6 homeobox 1 (NKX6.1), forkhead box A2 (FOXA2), and NK2 ho

14 Pre-B cell leukemia homeobox 1 (Pbx1)-d is a dominant-negative splice isofor

15 he beta cell markers pancreatic and duodenal homeobox 1 (Pdx1) and paired box 4 (Pax4).

16 iverse functions for pancreatic and duodenal homeobox 1 (PDX1), a transcription factor indispensable

17 in sites occupied by pancreatic and duodenal homeobox 1 (PDX1), NK6 homeobox 1 (NKX6.1), forkhead box

18 Pituitary homeobox 1 (PITX1) functions as a tumor suppressor in he

19 t the expression pattern of prospero-related homeobox 1 (PROX1) in the developing chick colon.

20 ression of the transcription factor prospero homeobox 1 (PROX1) was reduced in desmoplastic APC-mutan

21 em through the transcription factor prospero homeobox 1 (PROX1).

22 nchymal lineage as defined by Paired related homeobox 1 (Prx).

23 hyme homeobox 1 (Meox1), sine oculis-related homeobox 1 (Six1), and myogenic factor 5 (Myf5)-in parax

24 nduced by the EMT, zinc finger E-box binding homeobox 1 (ZEB1) binds and silences IRF1.

25 Zinc finger E-box binding homeobox 1 (Zeb1) has been demonstrated to participate i

26 d depletion of the zinc finger E-box binding homeobox 1 (ZEB1) in claudin-low tumor cells or forced e

27 related to the mesoderm stage; E-box-binding homeobox 1 (ZEB1) in the module correlated with postcard

28 ased expression of zinc finger E-box binding homeobox 1 (ZEB1) is associated with tumor grade and met

29 c anhydrase IX and zinc finger E-box binding homeobox 1 (Zeb1) protein levels increased in 1% oxygen.

30 ough activation of zinc finger E-box binding homeobox 1 (ZEB1) sensitized tumor cells to the antiprol

31 n (EMT) regulator, Zinc finger E-box binding homeobox 1 (ZEB1), or overexpression of the ZEB1-repress

32 Zinc finger E-box binding homeobox 1 (ZEB1), primarily studied in the context of t

33 panel (homeobox A1 [HOXA1], empty spiracles homeobox 1 [EMX1], AK055957, endothelin-converting enzym

34 s of function mutations/deletions in the PBX homeobox 1 gene (PBX1), a gene known to have a crucial r

35 oR-HDAC3 complex as well as Prospero-related homeobox 1 protein (PROX1).

36 sess the effect of zinc finger E box-binding homeobox 1 transcription factor (ZEB1), siRNA-mediated k

37 transgene driven by the Prx1 (paired related homeobox 1) promoter.

38 ind that the ZEB1 (zinc finger E-box binding homeobox 1) transcription factor activity in highly mese

39 T-box transcription factor 3), ISL1 (ISL LIM homeobox 1), and SHOX2 (short stature homeobox 2).

40 box O1 (FOXO1), Paired box 6, SRY box 9, NK6 Homeobox 1, NK6 Homeobox 2] and cell stress markers (DNA

41 eceptor nuclear translocator and sine oculis homeobox 1-and found that their distributions were simil

42 treatment and in fibrotic lungs of prospero homeobox 1-enhanced green fluorescent protein (Prox1-EGF

43 elium derive from embryonic, endodermal, NK2 homeobox 1-expressing (NKX2-1+) precursor cells.

44 ription regulator, zinc finger E-box binding homeobox 1.

45 ve tumor suppressor roles in T-cell leukemia homeobox 1/3-transformed human T-ALL cell lines and NOTC

46 The Zinc-finger E-box-binding Homeobox-1 (ZEB1) is a transcription factor that promote

47 transcriptional activity, including cut-like homeobox 2 (a protein coded by CUX2), Glu504Lys of aceta

48 array screening reveals that caudal-related homeobox 2 (Cdx2) and Rbl2/p130 are remarkably suppresse

49 Distal-less homeobox 2 (Dlx2) acted downstream of Ascl1 in promoting

50 e transcriptional determinants, including GS Homeobox 2 (Gsx2) and Early B-cell factor 1 (Ebf1).

51 n mice to investigate the role of the TF LIM homeobox 2 (Lhx2) in this process and report that in con

52 generated iPS cell lines overexpressing LIM homeobox 2 (LHX2), which suppresses myofibroblastic chan

53 addition to Meis homeobox 1 (Meis1) and Meis homeobox 2 (Meis2) gene family members were identified b

54 1 (NKX6.1), forkhead box A2 (FOXA2), and NK2 homeobox 2 (NKX2.2) - factors that co-occupy active enha

55 ectives on how the transcription factors NK2 homeobox 2 (NKX2.2), paired box 6 (PAX6), and LIM domain

56 lopmental transcription factor orthodenticle homeobox 2 (Otx2) as an upstream mediator of these endur

57 many of these genes, including orthodenticle homeobox 2 (OTX2), can present with a broad range of cli

58 expression of the homeobox TF, orthodenticle homeobox 2 (Otx2), is regulated in a cell type- and stag

59 ed with a similar reduction in orthodenticle homeobox 2 (Otx2), which is restricted to VTA neurons at

60 xogenous (eGFP) or endogenous [orthodenticle homeobox 2 (Otx2)] genes can be efficiently targeted to

61 as upregulated, one of which was POU class 3 homeobox 2 (Pou3f2).

62 wo novel candidate driver genes, POU class 4 homeobox 2 (POU4F2) (mutated in 9 [8.9%] samples) and ZK

63 ional null mutation (R200Q) in visual system homeobox 2 (VSX2), a transcription factor involved in ea

64 we identify the TF zinc finger E box-binding homeobox 2 (Zeb2) to play a crucial role in regulating D

65 box 10 (SOX10) and zinc finger E-box binding homeobox 2 (ZEB2).

66 e demonstrate that zinc-finger E-box-binding homeobox 2 (Zeb2, also called Sip1) transcription factor

67 uction of transcription factor orthodenticle homeobox 2 expression.

68 SIX2 (SIX homeobox 2)-positive nephron progenitor cells (NPCs) giv

69 SL LIM homeobox 1), and SHOX2 (short stature homeobox 2).

70 ne morphogenic protein 2, and muscle segment homeobox 2, the production of osteocalcin, and the forma

71 Paired box 6, SRY box 9, NK6 Homeobox 1, NK6 Homeobox 2] and cell stress markers (DNA damage inducibl

72 previously identified Zhx2 (zinc fingers and homeoboxes 2) as a regulator of numerous liver-enriched

73 d to the current hypothesis that Caudal-type homeobox-2 (Cdx2) cells in placenta may represent a nove

74 PA-induced dyskinetic movements in pituitary homeobox 3 (Pitx3)-deficient mice that lack of ALDH1A1-e

75 -associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3).

76 homeodomain transcription factor distal-less homeobox 3 gene (DLX3) is required for hair, tooth and s

77 ound that tfap2a acts downstream of Iroquois homeobox 3b (irx3b), a distal lineage transcription fact

78 zed by the aberrant expression of the Double homeobox 4 (DUX4) transcription factor leading to altere

79 pancy and transcriptional activity of double homeobox 4 (DUX4), a protein whose aberrant expression h

80 xpression of the transcription factor Double Homeobox 4 (DUX4).

81 ts from expression of the full-length double homeobox 4 (DUX4-FL) retrogene in skeletal muscle.

82 ity and cooperation with sine oculis-related homeobox 4 (Six4) and TEA domain family member 2 (Tead2)

83 ein, which fuses Capicua (CIC) to the double homeobox 4 gene, DUX4.

84 pecific transcription factor DUX4-fl (double homeobox 4, full-length isoform) linked to the chromosom

85 ciated with higher expression of distal-less homeobox 5 (DLX5) ([Formula: see text]), and lower expre

86 ermore, the homeodomain proteins distal-less homeobox 5 (DLX5) and DLX6 reciprocally inhibit BMP/H2-m

87 ed CHD by repressing Isl1 and activating NK2 homeobox 5 (Nkx2.5), resulting in decreased cell prolife

88 WUSCHEL-RELATED HOMEOBOX 5 (WOX5) is ectopically expressed in vascular c

89 WUSCHEL-RELATED HOMEOBOX 5 (WOX5), which is specifically expressed in th

90 eam SHR regulators SEUSS and WUSCHEL-RELATED HOMEOBOX 5 and to experimentally validate their roles in

91 and atrial conduction, including Nkx2-5 (NK2 homeobox 5), Tbx3, and Tbx5 are dysregulated.

92 (PV)-expressing GPe neurons over that of Lim homeobox 6 (Lhx6)-expressing GPe neurons, restores movem

93 associated with hepatocyte nuclear factor 1 homeobox A (Hnf1a) and hepatocyte nuclear factor 4A (Hnf

94 We focused on the Iroquois Homeobox A (IRXA) gene cluster, where hypomethylation in

95 also report that EtOH-mediated increases in homeobox A1 (Hoxa1) and cytochrome P450 family 26 subfam

96 Homeobox a1 (Hoxa1) is one of the most rapidly induced g

97 In phase II, a six-marker MDM panel (homeobox A1 [HOXA1], empty spiracles homeobox 1 [EMX1],

98 nonhematopoietic BMDCs to pregnancy, we used Homeobox a11 (Hoxa11)-deficient mice, having endometrial

99 t 6, ecotropic viral integration site 1, and homeobox A11.

100 entified both common gene targets, including homeobox A5 (HOXA5), which could account for some of the

101 homeodomain transcription factors, including homeobox A9 (HOXA9) and HOXA10.

102 y and caused differentiation of MLL-AF9- and homeobox A9-driven (HOXA9-driven) leukemias.

103 Hepatocyte nuclear factor 1 homeobox alpha (HNF1alpha) is a transcription factor inv

104 ther through the expression of KNOTTED1-LIKE HOMEOBOX and other indeterminacy genes, altering known d

105 is significant co-occupancy of Nanog (Nanog homeobox) and Hoxa1 on many common target sites, and the

106 Interestingly, aristaless-related homeobox (ARX), a homeobox-containing transcription fact

107 Previously we showed that aristaless-related homeobox (ARX), a paired-like transcription factor, regu

108 n polycystic kidney disease 1 (PKD1) or HNF1 homeobox B (HNF1B), inherited from the unaffected parent

109 sin A and HNF1B (hepatocyte nuclear factor 1 homeobox B), markers of clear-cell adenocarcinoma.

110 screening, identification of a single gene, homeobox B5 (Hoxb5, also known as Hox-2.1), with express

111 ZEB1 and ZEB2 are zinc-finger E homeobox-binding transcription factors best known for th

112 Here, we show that the mouse Caudal-related homeobox (Cdx) proteins (mCdx1, mCdx2, and mCdx4) are al

113 t Hox and the first loose ecdysozoan ParaHox homeobox clusters are identified, and a myriapod-specifi

114 In mammals, there are three Dlx homeobox clusters with closely located gene pairs (Dlx1/

115 The homeobox coding DNA may therefore have a secondary funct

116 The most notable examples of homeobox containing genes are the Hox genes, arranged on

117 GhTCP4 interacts with a homeobox-containing factor, GhHOX3, and repressing its t

118 tingly, aristaless-related homeobox (ARX), a homeobox-containing transcription factor critical for th

119 VAX1 encodes a homeobox-containing transcription factor identified as a

120 t of the 39 mammalian Hox genes and in other homeobox-containing transcription factors.

121 The use of cone-rod homeobox (CRX) transcription factor messenger RNA for MD

122 ding retinoic acid receptor alpha (RARA) and homeobox D (HOXD).

123 The transcription factor homeobox D3 (Hoxd3) is known to regulate an invasive end

124 We demonstrate that the homeobox DNA has a characteristic 3-base-pair periodicit

125 analysis also revealed roles for zinc-finger homeobox domain and SOX2-interacting genes in OFC etiolo

126 caused impaired structural stability of the homeobox domain and weaker interaction with DNA accordin

127 ed this phenotype to deleterious nonsense or homeobox domain missense mutations in NKX6-2.

128 PROX1 is a homeobox domain transcription factor that plays a role i

129 t affected a highly conserved residue of the homeobox domain, was consistently predicted as pathogeni

130 inactivating mutations affecting the NKX6-2 homeobox domain.

131 The homeobox encodes a DNA-binding domain found in transcrip

132 (RXR), jun proto-oncogene (JUN), sine oculis homeobox factor (SIX), and other factors.

133 During EGA, homeobox factor binding becomes more prevalent and requi

134 s glucocorticoid receptor and brain-specific homeobox factor.

135 d, we have established a library of relevant homeobox family inhibitors and developed a high-throughp

136 gene, encoding for the teashirt zinc-finger homeobox family member 3 (TSHZ3) transcription factor th

137 e WUS-box, which is conserved in WUS-related HOMEOBOX family members, and the ethylene-responsive ele

138 ver 15 000 LA-specific enhancers, defined by homeobox family motifs, and annotated several cardiovasc

139 NKX2 homeobox family proteins have a role in cancer developme

140 Transcription factors in the TALE-class homeobox family, GSM1 and GSP1, predominantly control ge

141 transcription factors, such as newborn ovary homeobox gene (NOBOX), are candidate genes for primary o

142 divergence created the growth-repressing RCO homeobox gene and facilitated evolution of dissected cru

143 Here, we identified the conserved NK-2 homeobox gene ceh-24 to be crucially required for flippi

144 The homeobox gene clusters are characterised by interdigitat

145 are undifferentiated and aberrantly express homeobox gene clusters.

146 f polycomb repression such as the Hox and NK homeobox gene clusters.

147 The homeobox gene Emx1 is expressed in three guanylate cycla

148 lication, including upregulation of proximal homeobox gene expression and silencing of distal-associa

149 encephalon, members of the distal-less (Dlx) homeobox gene family are expressed in, and regulate the

150 lustered HOX genes, the role of nonclustered homeobox gene family members in hematopoiesis and leukem

151 Meis1, which belongs to TALE-type class of homeobox gene family, appeared as one of the key regulat

152 e found that the hematopoietically expressed homeobox gene Hhex is overexpressed in acute myeloid leu

153 We report that the Otx2 homeobox gene is essential for the proper development of

154 The NKX3.1 homeobox gene plays essential roles in prostate differen

155 m under the control of the pancreas duodenal homeobox gene promoter.

156 mesters to determine methylation patterns of homeobox gene promoters across gestation.

157 that evolution of an enhancer element in the homeobox gene REDUCED COMPLEXITY (RCO) altered leaf shap

158 ed the lineage of selected Emx2+ [vertebrate homeobox gene related to Drosophila empty spiracles (ems

159 ibuted greatly to the expansion of the grape homeobox gene superfamily.

160 The homeobox gene Tshz1 is expressed in a unique patchy patt

161 The Dlx5 homeobox gene was first implicated as an oncogene in a T

162 nvestigated the role of the homeodomain-only homeobox gene, HOPX, in the pathogenesis of HNSCC.

163 of DLX4, a transcription factor encoded by a homeobox gene, is associated with reduced survival of ov

164 t SHOOT MERISTEMLESS, a class I KNOTTED-LIKE HOMEOBOX gene, is likely to play a role in PLB regenerat

165 re, we report the identification of a poplar homeobox gene, PuHox52, which was induced rapidly (withi

166 into Hoxa9 impaired leukemogenicity of this homeobox gene.

167 6 (KNAT6) together with ARABIDOPSIS THALIANA HOMEOBOX GENE1 (ATH1).

168 buting to activation of ARABIDOPSIS THALIANA HOMEOBOX GENE1, which is needed for boundary establishme

169 d transcription factors, including dozens of homeobox genes and other genes implicated in cancer.

170 nvolved in intestinal development, including homeobox genes and targets of the Polycomb repressive co

171 TMERISTEMLESS (STM) and BREVIPEDICELLUS (BP) homeobox genes and their ability to modify leaf form.

172 architecture and phylogenetic analyses grape homeobox genes can be classified into eleven subfamilies

173 Homeobox genes constitute a large family of genes widely

174 Analyses of homeobox genes during development show that some of thes

175 found that conditional knockout of the mouse homeobox genes En1 and En2 in the excitatory cerebellar

176 We hypothesized that Dlx1, Dlx2 and Brn3b homeobox genes function in parallel intrinsic pathways t

177 am in the cell of origin, which includes the homeobox genes Hoxa9 and Meis1 as key components.

178 We speculate that the pervasive use of homeobox genes in defining unique neuronal identities re

179 erize the expression patterns of a set of 49 homeobox genes in the MOE with in situ hybridization.

180 Genome clustering of homeobox genes is often thought to reflect arrangements

181 ity results from the distinct effects of two homeobox genes on these growth modes: SHOOTMERISTEMLESS

182 aneously with GATA4 (GATA-binding protein 4) homeobox genes PBX1 (pre-B-cell leukemia transcription f

183 Homeobox genes regulate embryonic and placental developm

184 We show that Dlx1/Dlx2 homeobox genes regulate GABA synthesis during forebrain

185 ontrast, expression of TCP, TPR and KNOTTED1 homeobox genes showed a sustained down-regulation.

186 The tissue-specific expression patterns of homeobox genes suggested roles in both vegetative and re

187 attenuate the potential of stem cell active homeobox genes to acquire oncogenic properties.

188 Most homeobox genes were hypo-methylated throughout gestation

189 ificant changes in the expression of several homeobox genes, as well as other transcription factors,

190 alyse the chromosomal organization of the NK homeobox genes, presumed to be part of a single cluster

191 and sequence analyses of their Hox and other homeobox genes, which encode crucial transcription facto

192 ified processes, including transcription and homeobox genes.

193 The Sine oculis homeobox homolog 1 (SIX1)/eyes absent (EYA) transcriptio

194 e we uncover unique RNA regulons embedded in homeobox (Hox) 5' untranslated regions (UTRs) that confe

195 ome binding to a regulatory element within a Homeobox (Hox) 5' UTR, we identify a modular stem-loop w

196 activation of most developmentally critical homeobox (Hox) a-d genes.

197 but also relate it to genomic imprinting and homeobox (Hox) gene cluster repression.

198 etermination of defined roles for endogenous homeobox (Hox) genes in adult hematopoietic stem and pro

199 tosis of AML cells through inhibition of the homeobox (HOX)A9 oncogene expression, reducing the trans

200 biquitylation of H2A and thereby derepresses homeobox HOXC5 and HOXC13 gene expression.

201 hich ectopic expression of the KNOTTED1-like Homeobox (KNOX) gene, BKn3, causes inverted polarity of

202 phology of RNAi lines resemble KNOTTED1-LIKE HOMEOBOX (KNOX) mutants, consistent with a mechanistic c

203 Class I KNOTTED-LIKE HOMEOBOX (KNOX) proteins regulate development of the mul

204 s of transcription factors: ERF/AP2 class I, homeobox-leucine zipper and R2R3 MYB.

205 kpoint (MEC)-3 (LIM)-homeobox subfamily, LIM homeobox (Lhx)6 and -8 are remarkably conserved and invo

206 It consists of two MT-A70 proteins and two homeobox-like DNA-binding proteins and specifically meth

207 e present study, we identified a total of 73 homeobox-like genes in the grapevine genome and analyzed

208 by leveraging methylated CpG sites in a LIM homeobox member gene (LHX9), which may have a role in th

209 We report that mohawk homeobox (Mkx), a tendon-specific transcription factor,

210 Cone-rod homeobox mRNA was expressed in all tumors (relative expr

211 the dorsal patterning factor, Muscle segment homeobox (Msh; ortholog of MSX1/2/3) binds directly to t

212 Uterine inactivation of muscle segment homeobox (Msx) genes alters epithelial cell junction pro

213 xpression of regenerative genes, such as Msh homeobox (Msx) genes, are absent in this animal group.

214 of the embryonic transcription factor Nanog homeobox (NANOG) restored COL3 expression by restoring t

215 Pre-B-cell leukemia homeobox (PBX) and myeloid ecotropic viral integration s

216 Pre-B-cell leukemia homeobox (PBX) transcription factors are known to regula

217 ability to initiate Pancreatic and duodenal homeobox (Pdx1) expression for the first time.

218 these cellular factors, including POU class homeobox (POU) proteins, have known Notch or herpesvirus

219 related orphan receptor beta, brain-specific homeobox/POU domain protein 3b, Ets variant gene 1, subs

220 eodomain protein/hematopoietically expressed homeobox (PRH/HHEX) transcription factor forms a positiv

221 ked by the activity-dependent neuroprotector homeobox Protein (ADNP) and located near cell-cycle gene

222 ral retina leucine zipper (NRL) and cone-rod homeobox protein (CRX), two rod-specific differentiation

223 or and human diabetes gene pancreas/duodenum homeobox protein 1 (Pdx1) regulates beta-cell survival a

224 levels of the transcription factor prospero homeobox protein 1 (PROX1), which relieved repression of

225 type, expressing lymphatic markers (prospero homeobox protein 1 and vascular endothelial growth facto

226 reciprocal downregulation of paired related homeobox protein 1.

227 r 3 (VEGFR-3) but not of LYVE-1 and prospero homeobox protein 1.

228 onan receptor 1]: p < 0.05; PROX-1 [prospero homeobox protein 1]: p < 0.001) compared with control su

229 cription factor 3), and Shox2 (short-stature homeobox protein 2), have been identified, the cis-regul

230 r observed that MSEW increased orthodenticle homeobox protein 2, a transcription factor promoting PNN

231 n-positive interneurons, PNNs, orthodenticle homeobox protein 2, and MSEW-induced anxiety and hyperac

232 cine zipper protein (HD-ZIP)-encoding genes: HOMEOBOX PROTEIN 21 (HB21), HOMEOBOX PROTEIN 40 (HB40),

233 xpression of the transcription factor double homeobox protein 4 (DUX4) can lead to a number of diseas

234 -encoding genes: HOMEOBOX PROTEIN 21 (HB21), HOMEOBOX PROTEIN 40 (HB40), and HOMEOBOX PROTEIN 53 (HB5

235 N 21 (HB21), HOMEOBOX PROTEIN 40 (HB40), and HOMEOBOX PROTEIN 53 (HB53).

236 cgn), specificity protein 8 (SP8) and/or LIM homeobox protein 7 (Lhx7) separates striatal CR+ interne

237 Our previous study of LPS predicted homeobox protein A5 (HOXA5) as a target of miR-26a-2, an

238 Mutations in the cone-rod-homeobox protein CRX are typically associated with domin

239 e identified the hematopoietically expressed homeobox protein Hhex as a transcription factor regulati

240 up-regulated Ape1 via a transcription factor homeobox protein Hox-A5-dependent mechanism.

241 In breast cancer, high levels of homeobox protein Hox-B13 (HOXB13) have been associated w

242 of KRAS-mutant NSCLCs aberrantly express the homeobox protein HOXC10, largely due to unappreciated de

243 dings suggest that these variants affect the homeobox protein IRX3.

244 We report here that the intestine-specific homeobox protein ISX is critical to control the metaboli

245 Here we show that homeobox protein Mohawk (Mkx) is a key transcription fac

246 rentiation from a primitive and pluripotent (homeobox protein Nanog+/ sex-determining region Y-box 9+

247 ough RNA seq and qPCR analysis we identified homeobox protein, Barx1, as a marker for DPSCs.

248 tative NKE elements, possible targets of NK2 homeobox proteins like the essential islet transcription

249 Further, residual homeobox pseudogenes are observed in the three lineages.

250 The X-linked reproductive homeobox (RHOX) gene cluster encodes transcription facto

251 Here we show that the sine oculis homeobox (SIX) homologue family transcription factors SI

252 teins are encoded by the sine oculis-related homeobox Six1-Six6 genes in vertebrates.

253 sl)-1/mitosis entry checkpoint (MEC)-3 (LIM)-homeobox subfamily, LIM homeobox (Lhx)6 and -8 are remar

254 ures are the first example of human MADS-box/homeobox ternary complex structures involved in cardioge

255 We found that the homeobox TF Lmx1a can activate the Cux2 enhancer in vitr

256 We analyzed how the expression of the homeobox TF, orthodenticle homeobox 2 (Otx2), is regulat

257 creatic transcription factor 1a (Ptf1a), the homeobox TF-Lbx1 and the Lim-homeodomain (Lim-HD), and T

258 ally activate CCAAT displacement protein/cut homeobox transcription factor (CUX1).

259 Mutations in the LIM homeobox transcription factor 1-beta (LMX1B) are a cause

260 activation and/or maintenance of LMX1A (LIM homeobox transcription factor 1alpha) and PITX3 (paired-

261 profiling, we identify the Engrailed-1 (EN1) homeobox transcription factor as a key BRD4-S coregulato

262 The caudal-related homeobox transcription factor CDX2 is expressed in leuke

263 The WUSCHEL-related homeobox transcription factor DWT1 is a key regulator of

264 Here we show that deregulation of the homeobox transcription factor gene DUX4 and the ETS tran

265 d signals, directly activates the LIM domain homeobox transcription factor Lhx1 in the visceral endod

266 Hcrt neurons in vivo, we identified the LIM homeobox transcription factor Lhx9 as necessary and suff

267 ncer, resulting in altered expression of the homeobox transcription factor PDX1 and its target genes

268 n chromosome 4q25, close to the gene for the homeobox transcription factor PITX2.

269 The homeobox transcription factor PROX1 is necessary for the

270 This includes Meis1, a TALE class homeobox transcription factor required for B-cell develo

271 licated in senescence, we identified DLX2, a homeobox transcription factor that has been shown to be

272 Lhx1 encodes a LIM homeobox transcription factor that is expressed in the p

273 DUX4 is a double homeobox transcription factor that is normally expressed

274 The Pitx2 gene encodes a homeobox transcription factor that is required for mamma

275 PAX7 is a paired-homeobox transcription factor that specifies the myogeni

276 an specifically synergize with the oncogenic homeobox transcription factor TLX3 to cause lymphoid neo

277 mportantly, we identify Lhx2 (encoding a LIM/homeobox transcription factor) as a direct NF-kappaB tar

278 We report that zinc finger and homeobox transcription factor-1 (Zeb1), a master regulat

279 expression of the Zinc finger E-box binding homeobox transcription factor-2 (ZEB2) is correlated wit

280 ownstream of the Colias homolog of BarH-1, a homeobox transcription factor.

281 HD-ZIP I subfamily of homeobox transcription factors (TFs) are involved in abi

282 of spontaneous resistance, we identify bHLH/homeobox transcription factors and cell-cycle regulators

283 The 40-CpG melanoma classifier included homeobox transcription factors and genes with roles in s

284 Genes encoding homeobox transcription factors are mis-expressed in the

285 polycomb target genes at low levels and that homeobox transcription factors are upregulated when this

286 Short homeobox transcription factors distinguish neuronal popu

287 The role of Homeobox transcription factors during fin and limb devel

288 ansformation by regulating the expression of homeobox transcription factors in mice.

289 opment in grape revealed that genes encoding homeobox transcription factors were differentially regul

290 In Hand2-overexpressing mutants, non-Hox homeobox transcription factors were dysregulated.

291 We have identified two planarian homeobox transcription factors, Smed-nkx2.1 and Smed-arx

292 al and abaxial domains and maintained by WOX homeobox transcription factors, whereas other marginal e

293 in the GSX2 gene, a member of the family of homeobox transcription factors, which are key regulators

294 tate and expression of lineage-specific bHLH/homeobox transcription factors.

295 Epidermal-specific deletion of the homeobox transcription regulator DLX3 disrupts keratinoc

296 how that SIX1, a member of the SIX family of homeobox transcriptional factors, is a novel repressor o

297 a identified ectopic increased expression of homeobox-type transcription factors (Hoxa5, Hoxa4, Hoxb5

298 t that WOX7, a member of the WUSCHEL related homeobox (WOX) family transcription factors, inhibits la

299 ample of this is seen in the WUSCHEL-RELATED HOMEOBOX (WOX) gene family, named after the Arabidopsis

300 The WUSCHEL-RELATED HOMEOBOX (WOX) genes WOX1 and PRS are expressed in the l