ライフサイエンスコーパス: homing receptor

1 ablished that HCELL serves as a 'bone marrow homing receptor'.

2 4)beta(7) (alpha(4)beta(7)), the gut mucosal homing receptor.

3 thymus that drives expression of a cutaneous homing receptor.

4 alphaalpha cells and their expression of gut-homing receptors.

5 te-associated Ag while the majority lack gut-homing receptors.

6 promote gut-tropism and instead induced skin-homing receptors.

7 eta(7), alpha(4)beta(1), and alpha(e)beta(7) homing receptors.

8 esting CD8+ lymphocytes signaled through the homing receptors.

9 int-specific Ags or because of expression of homing receptors.

10 ion of homing receptors from lymphoid to gut homing receptors.

11 th expression of activation markers and skin homing receptors.

12 secreting cells (ASCs), and analysis of ASC homing receptors.

13 erging perspectives of the biology of these 'homing receptors.'

14 27%), low T-TIL numbers, and absence of CD44 homing receptor (92% versus 14%).

15 of inflammatory signals and tissue-selective homing receptors acquired by T cells during activation a

16 itated by the expression of a unique set of "homing" receptors acquired by memory T cells.

17 a failure of CD8 T cells to increase tissue homing receptors after allo-stimulation, together with a

18 ential and high expression of the intestinal homing receptor alpha(4)beta(7) integrin.

19 r, CCR9, was coexpressed with the intestinal homing receptor alpha(4)beta(7) on IgA(+) plasmablasts.

20 taneous lymphocyte Ag (CLA), but not the gut-homing receptor alpha(4)beta(7).

21 cervical tissue T cells express the mucosal homing receptor, alpha(4)beta(7) surface integrin.

22 The intestinal homing receptor, alpha(4)beta(7), helps target lymphocyt

23 gainst mucosal challenge, express the mucosa-homing receptor alpha4beta7 and traffic to the intestina

24 study we examined the regulation of the gut homing receptor alpha4beta7 integrin by manipulating at

25 These findings show that the mucosal homing receptor alpha4beta7 is utilized by a subset of C

26 ut it did decrease the expression of the gut-homing receptor alpha4beta7 on plasmacytoid dendritic ce

27 The homing receptor alpha4beta7 was expressed more frequentl

28 Cells expressing the mucosal homing receptor alpha4beta7 were dramatically decreased

29 lycoproteins have been shown to bind the gut-homing receptor alpha4beta7, and it has been suggested t

30 in each animal also expressed the intestinal homing receptor alpha4beta7.

31 ory phenotype cells that display the mucosal homing receptor alpha4beta7.

32 matory sites and decreased expression of the homing receptor alpha4beta7.

33 contrast, 1,25(OH)(2)D(3) suppressed the gut-homing receptors alpha4beta7 and CCR9.

34 BW preterm neonates, their expression of the homing receptors alpha4beta7, CCR4, and CCR9 was altered

35 evaluated the role of the mucosa-associated homing receptor, alpha4beta7, in trafficking to the geni

36 -MoPn expressed higher levels of the mucosal homing receptor, alpha4beta7.

37 phenotype B cells expressing the intestinal homing receptor, alpha4beta7.

38 Blockade of other homing receptors also prevents tolerization.

39 tor and regulatory T cells with skin- or gut-homing receptors also remained proportionally high over

40 The expression of the lymphocyte homing receptor and activation marker L-selectin is diff

41 In this study, we examined lymphocyte homing receptor and vascular addressin expression in a c

42 y in part reflect differential expression of homing receptors and chemokine receptors.

43 cells from patients with SSc expressed skin-homing receptors and induced a profibrotic phenotype in

44 We show that human ILC2s express skin homing receptors and infiltrate the skin after allergen

45 to the expression of transcription factors, homing receptors and inflammatory cytokines.

46 ndida infection, CD3(+) cells expressing the homing receptors and integrins alpha(4)beta(7), alpha(M2

47 The cross-talk among the homing receptors and integrins opens a new 'avenue' to l

48 ing microenvironmental differences in immune homing receptors and ligands that affect immune cell rec

49 g from the lung expressed low levels of both homing receptors and likely utilize molecules other than

50 cells alter their expression of homeostatic homing receptors and subsequently undergo apoptosis due

51 Expression of gut-homing receptors and the occurrence of cTRMs in gastroin

52 gs inhibit T(conv) cell expression of tissue-homing receptors and their production of proinflammatory

53 g to alter the expression levels of multiple homing receptors and transcription factors with known fu

54 I Rag1(-/-) mice were induced to express gut-homing receptors and transferred to C57BL/6J mice; level

55 nfiltrating cytotoxic T cells (T-TILs), CD44 homing receptor, and p53 and Bcl-2 oncogenic proteins.

56 viral entry receptors, pro-survival factors, homing receptors, and activation markers, and to play a

57 ase in Th2 CD4+ T cells expressing cutaneous homing receptors, and elevated serum levels of IgE.

58 rue circulating Treg express functional skin-homing receptors, and human Treg may regulate local immu

59 ion and expression of transcription factors, homing receptors, and signaling molecules appear to play

60 a regulation of homeostatic and inflammatory homing receptors, and that in its absence KLF2-deficient

61 h nodes owing to increased expression of gut-homing receptors, and that their expansion is regulated

62 xpressed the IL-15 receptor beta chain, skin-homing receptors, and thymic exiting receptors.

63 Although several homing receptors are known to be differentially expresse

64 Recent findings suggest that homing receptors are not merely molecular brakes.

65 Although gastrointestinal-homing receptors are required for lymphocyte migration t

66 ocked in wild-type mice, indicating that gut-homing receptors are required for oral tolerization.

67 While chemokine- and other homing-receptors are important for T cell migration, it

68 Recent reports that some lymphocyte homing-receptors are shared by the liver and gut provide

69 ing receptors along with the lymphoid tissue homing receptors at reduced frequencies.

70 ment into inflamed skin is dependent on skin-homing receptor binding to endothelial (E)- and platelet

71 se findings suggest expression of lymphocyte homing receptors by B cells and vascular addressins by m

72 at infiltrate the skin express a unique skin-homing receptor called cutaneous lymphocyte-associated a

73 imarily through short-distance interactions, homing receptors can identify colocalizing cells that se

74 tively analyzed the expression patterns of 9 homing receptors (CCR/CXCR) in naive and memory CD4+ and

75 ubset of RORgammat(+) ILC2s express the skin-homing receptor CCR10, and the frequencies of IL-17-prod

76 e; (ii) significant upregulation of the skin-homing receptor CCR4 in peanut-reactive CD4(+) T and Th2

77 Skin homing receptors CCR4 and CCR10 in contrast were transcr

78 sed the chemokine receptor CCR6 and the skin-homing receptors CCR4 and CCR10.

79 sL/IL-22-secreting clones expressed the skin-homing receptors CCR4, CCR10, and CLA and migrated in re

80 sa but expressing the central nervous system-homing receptor CCR6.

81 p66Shc also controls the expression of the homing receptor CCR7, which opposes S1P1 by promoting ly

82 jority lack the expression of the lymph node homing receptor CCR7.

83 normal increase in the surface levels of the homing receptors CCR7 and CXCR4 concomitant with low S1P

84 ry few of these cells expressed the lymphoid-homing receptors CCR7 or CXCR5.

85 t varied in expression of CD7; CD10; and the homing receptors CCR7, CCR9, and ITGB7.

86 issue had significantly higher expression of homing receptors CCR7, S1PR1, and SELL compared to non-b

87 R5) with a concurrent increase in lymph node homing receptors (CCR7, CD11c) on the membrane of DCs.

88 g dendritic cells, with RA up-regulating gut-homing receptor CCR9 expression by ILC3s.

89 Furthermore, the small intestinal homing receptor CCR9 is preferentially expressed on gamm

90 counterparts, promoted expression of the gut-homing receptor CCR9 on T cells.

91 Expression of the gut homing receptor CCR9 on T-effector memory cells 30 days

92 inal homing receptor, CD103, and the mucosal homing receptor CCR9.

93 lls, which further induced expression of gut-homing receptors CCR9 and alpha4beta7 on Bcl11b-deficien

94 afficking of CD4+ T cells expressing the gut-homing receptors CCR9 and integrin alpha4beta7 and found

95 naive HIV+ patients, and upregulated the gut-homing receptor CD103 compared with uninfected controls.

96 milk CD8(+) T cells expressed the intestinal homing receptor, CD103, and the mucosal homing receptor

97 mory phenotype, re-expressing the lymph node homing receptor CD62L and homeostatic cytokine receptors

98 n more pronounced shedding of the lymphocyte homing receptor CD62L and in increased programmed cell d

99 ed high expression of Foxp3, Bcl-2, lymphoid homing receptor CD62L, and chemokine receptor CCR7, pred

100 een, AA4(+) CD23(+) BM B cells expressed the homing receptor CD62L, were dependent on the antiapoptot

101 The key lymph node-homing receptors CD62L (L-selectin) and CCR7 were highly

102 1 activity led to enhanced expression of the homing receptors CD62L and CCR7.

103 bsets that differ in their expression of the homing receptors CD62L and CD11a.

104 ult of abnormal expression of the lymph node homing receptor (CD62L) on the mu MT CD4+ T cells.

105 P3(+) T cells mainly express lymphoid tissue homing receptors (CD62L, CCR7, and CXCR4), while CD45RO(

106 we show that secondary signaling through the homing receptors (CD62L, CD44, CD11a) of abortively infe

107 , CD69 and IL-2R; down-regulate the lymphoid homing receptor, CD62L; proliferate spontaneously in vit

108 peptide antigens reinforce expression of two homing receptors (CD69 and CD103) which help recently ac

109 eceptor chain, beta7, but not the peripheral homing receptor chain beta1 (CD29), was detected on GT C

110 Furthermore, the mucosal homing receptor chain, beta7, but not the peripheral hom

111 We also observed up-regulation of homing receptors containing LFA-1 (CD11a) and alpha4 (CD

112 CD4 and CD8 T cells that coexpress the skin-homing receptor cutaneous lymphocyte Ag (CLA), but not t

113 , these lymphocytes did not express the skin-homing receptor cutaneous lymphocyte antigen, were pheno

114 o depend on expression of the skin-selective homing receptor cutaneous lymphocyte-associated Ag (CLA)

115 ouse model of OS abundantly express the skin homing receptors cutaneous lymphocyte associated antigen

116 homing capacity via upregulation of the skin homing receptor, cutaneous lymphocyte-associated antigen

117 cells that express the vascular endothelium-homing receptor CX3CR1 (fractalkine receptor) are enrich

118 cells also express the vascular endothelium-homing receptor CX3CR1 and migrate toward CX3CL1-express

119 significantly higher expression of the brain homing receptors CX3CR1 and CXCR3 in comparison to their

120 Expression of the mucosal homing receptor CXCR3 in peripheral CD19(+) CD20(+) CD38

121 n selectively up-regulated expression of the homing receptor CXCR4 in EPCs.

122 e of conditional deletion of the bone marrow homing receptor CXCR4 on antiviral T cell responses.

123 ceptors, but showed low expression of the BM homing receptor CXCR4.

124 b treatment reduced the expression of tissue homing receptors CXCR4 in ILC2, and GPR183 in ILC2, Th2,

125 27(-) T cells highly express the B cell zone homing receptor CXCR5 with concomitant loss of CCR7.

126 iquely defined by expression of the follicle-homing receptor CXCR5, the guidance receptor promoting t

127 icient T cells had reduced expression of gut homing receptors, diminished production of inflammatory

128 d alters the expression levels of several of homing receptors during infection.

129 ells from TSLPR(-/-) mice expressed the skin homing receptor E-selectin ligand normally, and homed to

130 ming effector T cells in LNs to express skin-homing receptors, eliciting skin lesions upon food aller

131 Peripheral tissue homing receptors enable T cells to access inflamed nonly

132 ls, exclusively expressing alpha 4 beta 7 as homing receptors, enters the lymph nodes.

133 y reduces T-competent progenitors and thymus-homing receptor expression among bone marrow hematopoiet

134 Skin-homing receptor expression and IL-13 production by CD8+

135 We examined the homing receptor expression and tissue distribution of T

136 LC2, Th2, and Tc2 cells, with reduced tissue homing receptor expression but increased type 2 cytokine

137 ets of memory T cells defined by patterns of homing receptor expression display differential homing t

138 e first to follow changes in tissue-specific homing receptor expression during Ag-specific B cell dev

139 Homing receptor expression in MALT lymphoma B cells was

140 Homing receptor expression on CD8 T cells activated in v

141 Homing receptor expression on lymphocytes strongly corre

142 fects on CD8 responses include modulation of homing receptor expression or induction of antigen-speci

143 nd acquired immunity to promote a pattern of homing receptor expression that is physiologically appro

144 ble on how this function is coregulated with homing receptor expression.

145 hemokine receptor CCR7 is a well-established homing receptor for dendritic cells and T cells.

146 Our findings thus describe a T cell-homing receptor for LILP and indicate that GPR15 plays a

147 We first demonstrated that the primary homing receptor for linTT1, p32 (or gC1qR), is expressed

148 lymphoid tissues, defining CD22 as a lectin-homing receptor for mucosal HEVs.

149 MAdCAM-1 binds the lymphocyte homing receptor for Peyer's patches, the integrin alpha

150 human and mouse lymphocytes that express the homing receptor for Peyer's patches, the integrin alpha

151 infection-induced plasmablasts lack the CLA homing receptor for skin, consistent with mechanisms of

152 eptor and was also recently found as a novel homing receptor for T-cells implicated in colitis.

153 or C-C motif chemokine receptor 9, specific homing receptors for colon or small intestine, respectiv

154 Bonzo+ T cells lack L-selectin and/or CCR7, homing receptors for lymphoid tissues.

155 sis, ILCP in PB of mouse and human expressed homing receptors for secondary lymphoid organs, mainly C

156 expression of specific chemoattractants and homing receptors for T-cell recruitment and retention, i

157 st undergo a "switch" in their expression of homing receptors from lymphoid to gut homing receptors.

158 unexpected role for lectin CD22 as a B-cell homing receptor GALT, and identification of the orphan G

159 ssion of pro-survival, pro-proliferative and homing receptor genes in the mesenchymal stem cells, sug

160 he transcription level of the colonic T cell homing receptor, GPR15, hence affecting the number of co

161 Expression of distinct homing receptors guides adaptive immune cells to antigen

162 espectively) expressed alpha4 beta7, the gut homing receptor (HR), whereas L-selectin, the peripheral

163 In contrast, ILC2 acquire gut homing receptors in a largely RA-independent manner duri

164 is known about the expression of intestinal homing receptors in human T lymphocytes.

165 ablasts, yet no data have thus far described homing receptors in pneumonia.

166 localization of lymphocytes to the gut (gut-homing receptors) in induction of OT, we studied CCR9(-/

167 testinal DC, but PLN-DC did not suppress gut-homing receptors induced by intestinal DC.

168 of effector immune responses is mediated by homing receptors induced upon activation in secondary ly

169 SI homing receptor induction was impaired during T cell pri

170 The lymphocyte homing receptor integrin alpha(4)beta(7) is unusual for

171 reover, UF reduced the expression of the gut homing receptor integrin beta7 on blood T cells from IBD

172 Furthermore, expression of the mucosal homing receptor integrin beta7 was increased on mucosal,

173 lular bacteria and expressing the intestinal homing receptor integrin beta7.

174 s and its counterreceptor, the Peyer's patch homing receptor, integrin alpha 4 beta 7 on circulating

175 This change in homing receptors is required for long-term population an

176 L-selectin, the lymph node homing receptor, is central to the control of lymphocyte

177 tional analyses revealed that the lymphocyte homing receptor L-selectin (CD62L) is the key factor con

178 st only with up-regulation of the peripheral homing receptor L-selectin during the latest stages of t

179 The homing receptor L-selectin mediates adhesion to the lumi

180 SCs to downregulate expression of the T-cell homing receptor L-selectin.

181 The homing receptors L-selectin and alpha4beta7 integrin fac

182 tified as the lymph node-specific lymphocyte homing receptor, L-selectin has also been suggested to p

183 effect was due to CD43 interference with the homing receptor, L-selectin, and was most pronounced in

184 The peripheral lymph node homing receptor, L-selectin, was expressed at higher lev

185 with the Mel-14 mAb to CD62L, the lymph node homing receptor, limits trafficking of naive T cells int

186 na propria is mediated by lymphocyte surface homing receptors, mainly the alpha4beta7-integrin.

187 beta7 binding activity, suggesting that this homing receptor may play a limited role in direct HIV-1

188 ue' to lymphocyte migration, suggesting that homing receptors may be sufficient alone, in some cases,

189 Therapies designed to block gut-homing receptors might, under some conditions, interfere

190 adhesion molecule-1 (MAdCAM-1), the primary homing receptor of gut-mucosa for lymphocytes, was stron

191 expression of the L-selectin lymph node (LN) homing receptor on naive T and B cells.

192 T cell-independent expression of IgA and gut-homing receptors on B cells.

193 Ralpha is required for the expression of gut-homing receptors on CD8(+) T cells and survival of CD8(+

194 lecule 1 (MAdCAM-1), which correspond to the homing receptors on GT CD4 cells.

195 The expression of homing receptors on intrahepatic lymphocytes is associat

196 Identification of lymphocyte-homing receptors on L-Sel(-/-) and L-Sel(+/+) CONALT lym

197 nt up-regulation of alpha4beta7 and CCR9 gut-homing receptors on local IgA-expressing B cells.

198 lved in homing to lymph nodes are L-selectin homing receptors on lymphocytes and the peripheral lymph

199 siologically to induce the expression of gut-homing receptors on lymphocytes.

200 in the expression of CCR9 and CD103 mucosal homing receptors on peripheral blood gammadelta T cells

201 acid synthesis, which in turn imprinted gut-homing receptors on responding T cells.

202 mmune response can be evaluated by exploring homing receptors on such plasmablasts, yet no data have

203 cytokines, inhibiting the expression of gut-homing receptors on T and B cells.

204 characterizing the expression of a panel of homing receptors on Tc1 and Tc2 cells, we found that ver

205 differed among pairs of these extralymphoid homing receptors on the intrahepatic T cells.

206 oantigen exposure provoked expression of gut homing receptors on their surface.

207 were essential to maintain this typical TFH homing receptor pattern.

208 dary lymphoid organs (SLOs) imprint distinct homing receptor phenotypes on evolving alloreactive effe

209 For each subject within the homing receptor-positive compartment, the CD8 cytotoxic

210 The homing receptor profile in patients with pneumonia was u

211 These observations indicate that reversal of homing receptor profile in the gastric tumor by antigen

212 onal diversity, functional properties, and a homing receptor profile similar to untransduced peripher

213 Based on homing receptor profile, CLA+ Treg should enter normal s

214 Similar homing receptor profiles were induced in the same sites

215 from peripheral lymph nodes (PLN-DC) induce homing receptors promoting CD8 T cell accumulation in in

216 cursors also led to upregulation of the skin-homing receptor, providing an explanation for how thymic

217 Here, engineered expression of the CCR9 homing receptor redirected CD8 T cells to the small inte

218 th AD, peT(H)2 cells expressed gut- and skin-homing receptors, respectively.

219 gulation of a number of memory/effector type homing receptors, resulting in generation of heterogeneo

220 s (e.g., Notch1), and expression of distinct homing receptors separately contribute to confirmation o

221 riving the expression of intestinal-specific homing receptors, such as alpha4beta7 and CCR9, upon T a

222 Although skin B cells express typical skin-homing receptors, such as E-selectin ligand and alpha-4

223 is that FoxP3(+) T cells undergo the second homing receptor switch at a highly accelerated rate comp

224 ILC3, but not ILC2, undergo the RA-dependent homing receptor switch in gut-associated lymphoid tissue

225 lymphocyte-associated antigen (CLA), a skin-homing receptor, than do circulating HSV-specific CD8 T

226 L-selectin is a homing receptor that mediates the selective attachment o

227 These data implicate CD103 as a homing receptor that targets graft-infiltrating CD8+ CTL

228 tory T cells is their high expression of gut-homing receptors that are important for migration to the

229 +) T cells to express adhesion molecules and homing receptors that facilitate their migration to site

230 The acquisition of homing receptors that redirect lymphocyte trafficking to

231 K cell lineage via regulation of a subset of homing receptors that respond to homeostatic ligands whi

232 quires the expression of two tissue-specific homing receptors, the integrin alpha4beta7 and the CCL25

233 of Ag encounter determines the expression of homing receptors, the present study is the first to prov

234 es the function of the L-selectin lymphocyte homing receptor through an interleukin-6 (IL-6)-dependen

235 T cells expressing CD62L and CCR7 lymph node homing receptors vigorously expanded in mesenteric lymph