ライフサイエンスコーパス: homology

1 ould increase the likelihood of encountering homology.

2 etectable by search algorithms used to infer homology.

3 icted beta-barrel fold, and cross-phylogroup homology.

4 ery limited, despite high levels of sequence homology.

5 gth and with up to 80 base pair terminal non-homology.

6 X-Y pair, with NLGN4Y sharing ~97% sequence homology.

7 ret hydrolase and has close protein sequence homology.

8 is enticing, but challenging given the close homology.

9 generally correlated with allergen sequence homology.

10 t were explained by analysis of primer/probe homology.

11 ncreas developmental biology may have useful homologies.

12 ad actin monomers onto their flexible Formin Homology 1 (FH1) domains.

13 en bind polyproline tracts located in formin homology 1 (FH1) domains.

14 The Src homology 2 (SH2) domain has a highly conserved architect

15 rt linear peptides, such as those of the Src homology 2 (SH2) domain with phosphotyrosine-containing

16 Kinetics of binding were assessed in Src homology 2 domain (SH2) or phosphotyrosine-binding (PTB)

17 Activation of the Src homology 2 domain-containing collagen-related (Shc) prot

18 Src homology 2 domain-containing phosphatase (SHP2) is a pho

19 Src homology 2 domain-containing phosphatase 2 (SHP2) is an

20 Src Homology 2-containing Inositol Phosphatase-1 (SHIP-1) is

21 SF1 protein expression and show that the Src-homology 3 (SH3) domain of ABL2 directly interacts with

22 ce (PRS) in CD3e that binds to the first Src homology 3 (SH3) domain of Nck (Nck-SH3.1).

23 of cellular proteins and also binds the Src homology 3 (SH3) domain-containing proteins CD2AP and SH

24 cs for the binding of a fluorine-labeled Src homology 3 (SH3) protein domain to four proline-rich pep

25 ule, denoted PSG, which consists of PDZ, Src homology 3 (SH3), and guanylate kinase-like domains.

26 C-terminal polyproline sequence with the Src homology 3 domain of SNX9.

27 ubiquitin-association domain, a central Src homology 3 domain, and a C-terminal histidine phosphatas

28 The disruption of the noncanonical Src homology 3 recognition motif by P366L reduces syndapin I

29 keletogenic competence, and that this serial homology accounts for their parallel anatomical organiza

30 ifficult to achieve due to the high sequence homology across the class I PI3K isoforms.

31 The low sequence homology among unrelated kinases with bulky DFG-1 residu

32 cular representation derived from persistent homology, an applied branch of mathematics.

33 ion of firefly luciferase, and (iv) sequence homology analysis indicated that ICP22 contains an N-ter

34 d 'Ribosolve' pipeline detects and falsifies homologies and conformational rearrangements in 11 previ

35 llenges, compensatory mutagenesis, cross-RNA homologies and internal controls demonstrate that Riboso

36 ork focused on gene expression has suggested homologies and potential evolutionary relationships betw

37 ine-rich region between their N-terminal Src homology and Bcr homology domains disrupts homodimer for

38 How synaptic filaments form, search for homology and catalyse strand exchange is poorly understo

39 Here we show that, despite sequence homology and coexpression from the same operon, both pro

40 a curated data set that accounts for protein homology and is balanced with direct and reverse mutatio

41 BEAST2 package for simultaneous inference of homology and phylogeny, and find strong evidence for the

42 ein complex composed of Klarsicht/ANC-1/SYNE homology and Sad1/UNC-84 (SUN) proteins, in the NE of li

43 , which can stem from erroneous inference of homology and saturation of substitutions, are thought to

44 to form synaptic filaments, which search for homology and then catalyse the exchange of the complemen

45 ocal sequence similarity and overall protein homology and thus don't mirror the complex multidomain a

46 erase read-throughs, mis-mapping due to gene homology, and fusions occurring in healthy normal tissue

47 S-CoV and MERS-CoV FPs share a high sequence homology, and here, we investigated whether Ca(2+) is re

48 nstruction, which combines the advantages of homology- and rearrangements-based methods.

49 for cleavage of the target locus, and short homology arms for directed integration via homologous re

50 ence which enables in vivo liberation of the homology arms.

51 g two loxP sites in cis and 900-700 bp 5'/3' homology arms.

52 anked by four flexible acetyl-CoA synthetase homology (ASH) domains; CoA is bound at the CSH-ASH inte

53 y by Polmu, facilitated by single-nucleotide homology at the break site, wherein both ends of the dis

54 These serovars share a high degree of homology at the genome and the proteome level.

55 The inability to detect homology at the sequence level arises from the sampling

56 We report that a conserved bromo-adjacent homology (BAH) module of BAHCC1 (BAHCC1(BAH)) 'recognize

57 ergent and difficult-to-identify genes using homology-based methods.

58 ing synthetic peptides, and mapped them on a homology-based model of the tertiary structure of Asp t

59 nnotations and protein 3D structures through homology-based search.

60 -Hotpep, CUPP and eCAMI) perform better than homology-based tools and deep-learning tools in enzyme E

61 sed Acr and Aca datasets); (iii) it combines homology-based, GBA-based, and self-targeting approaches

62 Despite the sequence homology between acid-sensing ion channels (ASICs) and e

63 ize, low natural abundance and high sequence homology between family members they are challenging to

64 ignment and homology modeling showed distant homology between GP38 and the ectodomain of Gn (a struct

65 age, and a requirement for long stretches of homology between gRNA and DNA target.

66 Amino acid homology between HCMVpp65(422-439) and TAF9(134-144) (TA

67 ing given the high level of polymorphism and homology between HLA genes.

68 Genomic sequencing identified >99.5% homology between SEOV sequences in this outbreak, and th

69 We further show that homology between Ssym and widely used training sets like

70 Patients with higher T cell repertoire homology between the tumor and uninvolved tumor-adjacent

71 occur across vertebrate groups, clouding the homology between their developmental programs.

72 y1 mutant identified a novel F-BAR (Fes/CIP4 homology-Bin-Amphiphysin-Rvs protein)-containing RhoGAP,

73 rotein of unknown function with low sequence homology but high structural homology to both yeast Get2

74 ort sequence, low concentration and sequence homology challenge routine techniques.

75 formational biosensors representing all four homology clusters of FZDs, we discover yet unappreciated

76 vealed a new TGF-beta-dependent role for Src homology/collagen adaptor protein (SHCA) in the initiati

77 a homotetramer with a rigid citrate synthase homology (CSH) module, flanked by four flexible acetyl-C

78 by showing that they suppress the pathway of homology-dependent repair (HDR)(5,6) and confer an exqui

79 ks (DSB) is performed by two major pathways, homology-dependent repair and classical nonhomologous en

80 MMEJ has similarities to homology-dependent repair, in that repair is initiated w

81 of EXO1 diverts repair away from error-free homology-dependent repair.

82 which is RNA mediated and triggered through homology-dependent RNA degradation mechanisms, has been

83 y recognition datasets and 10 protein remote homology detection datasets.

84 c genes call for special explanations beyond homology detection failure, highlighting them as interes

85 that domains C-terminal to its catalytic Dbl homology (DH) domain confer autoinhibition.

86 , causing them to expose their catalytic Dbl-homology (DH)/pleckstrin-homology (PH) regions, which tr

87 in gene disruption or gene modification via homology directed repair (HDR) from donor DNA.

88 (CRISPR)-CRISPR associated protein 9 (Cas9) homology directed repair (HDR) to create isogenic lines

89 of specific alleles using DNA templates and homology directed repair (HDR).

90 (HR) donor template into embryos to trigger homology directed repair (HDR).

91 nthetic gRNAs and dsDNA templates to perform homology directed repair and genome editing in vivo.

92 To improve Cas9's homology directed repair capacity, here we report the de

93 motes localization of DNA damage factors and homology directed repair of dysfunctional telomeres lack

94 rror-prone non-homologous end joining or the homology directed repair pathways.

95 of CRISPR/Cas9 with repair template-mediated homology directed repair to introduce the LRRK2 G2019S m

96 PRMT5 results in RPA depletion and impaired homology-directed DNA repair (HDR) activity.

97 Here we describe a homology-directed insertion method to knockout genes in

98 To explore this issue, we analyzed homology-directed mutations in the C-terminal, DNA-wrapp

99 mination of EXO5 in a PCa cell line impaired homology-directed recombination repair (HDR) and caused

100 e IOPD model generated utilizing CRISPR-Cas9 homology-directed recombination to harbor the orthologou

101 Vargula luciferases to simultaneously detect homology-directed repair (HDR) and non-homologous end jo

102 ngs at both ends increased the efficiency of homology-directed repair (HDR) in embryonic stem cells.

103 However, the limited efficiency of homology-directed repair (HDR) in HSCs and the unknown i

104 ver, we also find that RNF8 is important for homology-directed repair (HDR) independently of KU, whic

105 re, we show that inhibition of PARG disrupts homology-directed repair (HDR) mechanisms that underpin

106 le-strand breaks (DSBs) are repaired through homology-directed repair (HDR) or non-homologous end joi

107 on of exogenous DNA or gene knock-in via the homology-directed repair (HDR) pathway has seldom been a

108 t sequences (tCTSs) added at the ends of the homology-directed repair (HDR) template interact with Ca

109 patient using CRISPR/Cas9 genome editing and homology-directed repair (HDR), resulting in replacement

110 ysical search for an ectopic template during homology-directed repair (HDR), we tested the effects of

111 cise genome editing is the low efficiency of homology-directed repair (HDR).

112 damage and replicative stress that activate homology-directed repair (HDR).

113 hich causes substantial indel formation) and homology-directed repair (which typically leads to low e

114 is finding suggests that the balance between homology-directed repair and nonhomologous end joining i

115 ontaining an additional introgression of the homology-directed repair donor plasmid along with the P(

116 Meiotic crossovers result from homology-directed repair of DNA double-strand breaks (DS

117 ogen-induced double strand breaks repair via homology-directed repair pathway and prostate tumorigene

118 catalyzed addition of telomeric repeats with homology-directed repair serving as a back-up mechanism.

119 n boundaries were efficiently specified by a homology-directed repair template during editing with Ca

120 In contrast to traditional CRISPR-Cas9 homology-directed repair, base editing can correct point

121 a method for gene replacement that relies on homology-directed repair, chemically modified donor DNA

122 into naive CD8(+) T cells using CRISPR-based homology-directed repair.

123 ters the balance between indel formation and homology-directed repair.

124 ia alpha/Armadillo/Toll-interleukin receptor homology domain (dSarm)/Axundead signaling, and independ

125 involved in membrane bending, the N-terminal homology domain (ENTH) of Epsin1.

126 noglobulin-like loop epidermal growth factor homology domain 2, vascular endothelial growth factor, s

127 noglobulin-like loop epidermal growth factor homology domain 2, vascular endothelial growth factor, v

128 Binding of the Borg homology domain 3 (BD3) domain of Borg3 results in disti

129 of amisyn in exocytosis: Both the pleckstrin homology domain and the SNARE motif are needed for its i

130 Eps15-homology domain containing protein 2 (EHD2) is a dynamin

131 PRDM (PRDI-BF1 and RIZ homology domain containing) family members are sequence-

132 ependent Rac exchanger 1 (P-Rex1) pleckstrin homology domain has effects consistent with P-Rex1 inhib

133 Here, we show that pleckstrin homology domain interacting protein (PHIP), acting throu

134 cs, actin binding by the N-terminal calponin homology domain of the scaffold is shown to help the sca

135 tudies suggest that a dynamin-homolog, Eps15 homology domain protein 1, catalyzes fission and release

136 re, amisyn contains an N-terminal pleckstrin homology domain that mediates its transient association

137 vesicular Rab proteins via an N-terminal Slp homology domain, interacts with plasma membrane SNARE co

138 We used bcl-2 homology domain-3 (BH3) profiling to test the mitochondr

139 Pleckstrin homology domain-containing A7 (PLEKHA7) is a cytoplasmic

140 idermal growth factor receptor substrate 15] homology domain-containing protein 1) as a novel interac

141 a antigen (MAGE) proteins all contain a MAGE homology domain.

142 boring the human HIP1 ANTH (AP180 N-terminal homology) domain rescued Orsay infection in C. elegans,

143 g measurements, we show that tandem calponin homology domains (CH1-CH2) can be mutated to preferentia

144 etween their N-terminal Src homology and Bcr homology domains disrupts homodimer formation and impact

145 uster in the second coiled-coil and calponin homology domains of SPECC1L and severely affect the abil

146 rated to describe the alignment of a dynamic homology for [Formula: see text].

147 rk quantification method based on persistent homology for identifying APOE epsilon4-related network d

148 d by the DOCK GEF, DOCK2, but not by the Dbl homology GEF, TIAM1, both of which activate the parent p

149 Alignments' (TOGA) software with de novo and homology gene predictions as well as short- and long-rea

150 erons and polarity) and eukaryotic molecular homology (general transcription apparatus) that is obser

151 agweed species can be considered an allergen homology group with Amb a as the representative species

152 We defined 156 homology groups (H-groups), which were further clustered

153 ich were further clustered into 123 possible homology groups (X-groups).

154 Intrafamily homology has impeded correlation of expression of indivi

155 NLR expression and high intrafamily sequence homology hinder their accurate annotation.

156 We next exploited the differences and homologies in the peptide binding pockets of these four

157 dish neuroanatomist Bertil Hanstrom to claim homology in insects and crustaceans.

158 We observed approximately 91% homology in the expressed genes between the 2 sites.

159 istinct clusters, which had >=95% nucleotide homology in the VP1 coding region.

160 tion and functional evidence supporting such homology in true crabs (Brachyura) has recently been sho

161 and, forming either a new heteroduplex or-if homology is limited-a D-loop(1,2).

162 s the length of ssDNA sampled for pairing if homology is not encountered, and could allow for the for

163 The K-homology (KH) domain is a nucleic acid-binding domain pr

164 ed positive charges and a central pleckstrin homology-like domain are important for plasma membrane b

165 Despite their homology, LRMP and IRAG have distinct effects on HCN4.

166 ence strain and target strains to generate a homology matrix; (iii) generate draft strain-specific mo

167 nerate draft strain-specific models from the homology matrix; and (iv) manually curate draft models.

168 The homology-mediated end joining (HMEJ) approach has been s

169 ted integration of DNA reporter cassettes by homology-mediated end joining (HMEJ) at high frequency a

170 ulations with an alpha7 extracellular domain homology model and two acetylcholine-binding protein hom

171 ular dynamics (MD) simulations with a UGT2B7 homology model can be used to identify critical binding

172 n its nucleotide-free state and a derivative homology model containing 61 amino acid substitutions un

173 A homology model of GPR84 was generated to perform docking

174 Homology modeling also showed that among some, but not a

175 Results from homology modeling analyses suggest that the unusual stru

176 Our study used homology modeling and a coarse-grained model to generate

177 Using homology modeling and binding and contractility assays w

178 s, we developed a new approach that combined homology modeling and molecular dynamics simulations to

179 -carbonic and gamma-carbonic anhydrases, and homology modeling and molecular dynamics simulations wer

180 Homology modeling and normal mode analysis demonstrated

181 s for the differences based on a full-length homology modeling approach.

182 orresponding P2Y(14)R region is predicted by homology modeling as a deep, sterically limited hydropho

183 with the receptor based on a conformational homology modeling associated with docking simulations.

184 class for pharmaceutical therapies in which homology modeling could fill the knowledge gap for struc

185 of improved threading algorithms for remote homology modeling is a critical step forward in template

186 Homology modeling is used to bridge this gap but relies

187 Homology modeling of the modifying enzyme DpdA provides

188 Homology modeling predicts that contact between the enve

189 Sequence alignment and homology modeling showed distant homology between GP38 a

190 Homology modeling suggested that the primary V3 loop bnA

191 Homology modeling suggests that the Ebola virus polymera

192 ike agonist (E2) of the TSHR, and structural homology modeling to unravel the functional and structur

193 isms underlying nAChR lipid sensing, we used homology modeling, coevolutionary analyses, site-directe

194 Homology modeling, combined with a recently reported cry

195 Homology modeling, molecular dynamics simulations, and l

196 erent and complementary techniques including homology modeling, network theory, and machine learning.

197 9% among 31 HoTP structures obtained through homology modeling, while ZDOCK alone returns 14 and 3%,

198 yo-EM), cross-linking mass spectrometry, and homology modeling.

199 e shifts for the RRM2,3 isolated domains and homology modeling.

200 Sequence analysis and homology modelling indicate that Rv2509 belongs to the s

201 tures and slightly fewer of those mapping to homology models being within 30 angstrom.

202 of LBDs from nonplant species and generated homology models for other GLR isoforms.

203 Receptor usage information and homology models may be useful for predicting V3 loop bnA

204 Knowledge of receptor usage and homology models may be useful in developing future algor

205 by using an in silico approach, we built 3D homology models of human DNAJA1 and mutp53(R175H) protei

206 The server also allows users to upload homology models of microbial proteins.

207 sing compatibility of candidate molecules to homology models of sugar-binding site.

208 molecular modeling suite, we generated three homology models of the alpha (2) beta (3) gamma (2) rece

209 n with newly constructed mA(3)AR and hA(3)AR homology models.

210 Lastly, we identified short-sequence homologies of surface-exposed residues within the human

211 Our approach uses short homology of 24-48 bp to drive targeted integration of DN

212 ould help to refine the establishment of the homology of DA nuclei between vertebrate species.

213 These results demonstrate the homology of this EEG signature between humans and macaqu

214 Comparison of the structure and sequence homology of TYK2 between human and preclinical species w

215 pecies, neuroscience relies on cross-species homologies, particularly in terms of brain areas.

216 e also showed that the PLCepsilon pleckstrin homology (PH) domain and first two EF hands (EF1/2) are

217 nteraction between its N-terminal pleckstrin homology (PH) domain and kinase domain, which is relieve

218 own that binding of PIP(3) to the pleckstrin homology (PH) domain of P-Rex1 is required for its activ

219 o the plasma membrane through its pleckstrin homology (PH) domain that recognizes phosphatidylinosito

220 n, we found that ArfGAP with dual pleckstrin homology (PH) domains 2 (ADAP2), gamma-interferon-induci

221 -terminal region comprising three pleckstrin homology (PH) domains interacts with the N-terminal regi

222 e, we demonstrate that binding of pleckstrin homology (PH) domains to phosphatidylinositol 4-phosphat

223 their catalytic Dbl-homology (DH)/pleckstrin-homology (PH) regions, which triggers downstream signals

224 vating protein [ArfGAP] with dual pleckstrin homology [PH] domains 1) has been suggested to control d

225 The Src homology phosphatase 2 (SHP2) is a cytoplasmic enzyme th

226 Mechanistically, this response involves src-homology phosphatase activation leading to Akt-mediated

227 Using a combination of homology protein modeling, ligand docking, site-directed

228 UN protein SUN2 and the Klarsicht/ANC-1/SYNE homology protein nesprin-2 to form a heterocomplex in vi

229 and CI-MPR or IGF1R is mediated by the phox-homology (PX) domain of SNX5 or SNX6 and a bipartite mot

230 nteraction is dependent on the C-terminal EB homology region of EB1 and partially dependent on an SxL

231 We previously showed how the PHR (photolyase homology region) domain of CRY1 interacts with distinct

232 For example, Galpha(13) binding to the RGS-homology (RH) domains of several RH-RhoGEFs allosterical

233 Ras homology (Rho) GTPases regulate cell polarity and signal

234 The Homology Score is an exceptional feature that captures t

235 Most methods for biological sequence homology search and alignment work with primary sequence

236 test an HPM implementation on RNA structure homology search benchmarks, where we can compare directl

237 ructure prediction to sequence alignment and homology search by developing what we call a hidden Pott

238 emplate through a process referred to as the homology search.

239 Surprisingly, sequence and structural homology searches reveal no other cell-surface or secret

240 iles, collected from structural and sequence homology searches, with a physics-based energy function

241 egy that has difficulty handling repeats and homology sequences.

242 al data proceeds from a fixed set of primary homology statements, the character-by-taxon matrix.

243 Homology suppresses this process, through the cooperatio

244 tivity between components with no structural homology tended to co-occur among participants with seve

245 Despite sharing structural homology, they have functionally diverged to suit their

246 face charge complementarity, as suggested by homology three-dimensional modeling.

247 tional feature that captures the genome-wide homology through single-base-offset tiling windows of 10

248 It has structural homology to a cytoskeleton-interacting protein and accum

249 This cluster also shows strong homology to a putative ET cluster in human temporal cort

250 38, which revealed a novel fold with distant homology to another CCHFV glycoprotein that is suggestiv

251 the receptor-binding domain 1 lacks sequence homology to any other known toxin, and the receptor-bind

252 th low sequence homology but high structural homology to both yeast Get2 and mammalian CAML.

253 irculation, role in ceramide metabolism, and homology to C1q suggest an overlooked role as a lipid-bi

254 ith a high degree of sequence and structural homology to Dengue virus (DENV), the role of immunologic

255 e two additional loci encoding proteins with homology to enzymes involved in polysaccharide synthesis

256 Using persistent homology to extract topological features from the fused

257 -annotated mouse classification shows strong homology to extratelencephalic (ET) excitatory neurons t

258 tructures of insect poxins reveal unexpected homology to flavivirus proteases and enable identificati

259 The WLS membrane domain has close structural homology to G protein-coupled receptors (GPCRs).

260 The LCAT-PLAs were shown to exhibit homology to LCAT and mammalian lysosomal PLA(2) , and to

261 base target site duplication and do not have homology to other characterized TEs.

262 codes a transcriptional co-regulator without homology to other proteins, previously implicated in acu

263 ), whose predicted gene products show little homology to proteins with known functions.

264 We found PNNs in brain regions with putative homology to regions in mammals with known PNN function,

265 es in the spike protein, which show a higher homology to spike glycoproteins of human endemic coronav

266 The filament protein lacks detectable homology to structurally or functionally characterized p

267 (-)}, a NBS-LRR resistance protein (R) with homology to the Arabidopsis thaliana PM resistance prote

268 rst-time, interactions between proteins with homology to the conserved T4SS outer membrane core prote

269 GDAP1 contains primary sequence homology to the GST superfamily; however, the question o

270 pecific regions in SARS-CoV-2 that have high homology to the SARS-CoV virus.

271 SHR4z has significant homology to the short leucine-rich repeat (LRR) domain o

272 The IMAC bears remarkable homology to the Usher complex, whose disruption results

273 variant is genetically closest, with 98.73% homology, to the Ebola virus Mayinga variant isolated fr

274 Despite having no sequence homology, TPSs and IDSs share a conserved "alpha terpeno

275 Extensive structural homology was found across the range of eukaryotic RNA po

276 dissect the activation mechanism, structural homology was used to identify an unstructured loop of ap

277 striking degree of structural and functional homology, whereby CTIP2 or SATB2 of either species is su

278 We do this by means of persistent homology, which allows us to simultaneously select appro

279 and two homodimers) have obvious structural homology while sequence similarity can be nonexistent.

280 significant nucleic acids and their sequence homology with abundant wild-type nucleic acids.

281 and 19 Dpp sequences that shared very little homology with any other sequence suggesting an expansive

282 Fission yeast Mso1 shares homology with budding yeast Mso1 and human Mint1, protei

283 CRISPR-Cas12c/d proteins share limited homology with Cas12a and Cas9 bacterial CRISPR RNA (crRN

284 Structural homology with genome maintenance proteins identifies con

285 1.1 is a prokaryotic Kir channel that shares homology with human Kir channels.

286 omocytomas and paragangliomas because of its homology with MIBG and the general advantages of PET ima

287 metalloprotein sharing structural/functional homology with NifDK, is a major challenge in the heterol

288 d on computational predictions and relies on homology with other coronaviruses.

289 STING shares no structural homology with other known signalling proteins(6-9), whic

290 V-derived, CD8(+) T cell epitopes that share homology with other poxviruses.

291 Even though it shares low sequence homology with the cannabinoid receptors CB(1)R and CB(2)

292 evious sequence analysis has revealed strong homology with the mammalian pituitary adenylate cyclase-

293 dRp), whereas the dsRNA2 ORF sequence showed homology with the putative capsid proteins (CPs) of myco

294 It shares sequence homology with three enzymes (STEAP2-STEAP4) that catalyz

295 Orc6 in metazoans carries a structural homology with transcription factor TFIIB and can bind DN

296 Human SETD3 shares a high structural homology with two known protein lysine methyltransferase

297 n-binding protein, advillin which shares 75% homology with villin, has a tuft cell restricted express

298 Structural homology with YidC and the ER membrane protein complex (

299 via RNA-binding proteins that use a YT521-B homology (YTH) domain for specific m(6)A recognition.

300 reveal that TgDelta185 consists of a YT521-B homology (YTH) domain, which is commonly found in eukary