ライフサイエンスコーパス: homology domain

1 a antigen (MAGE) proteins all contain a MAGE homology domain.

2 the N-terminal beta-N-acetylglucosaminidase homology domain.

3 t of the CCM3 focal adhesion targeting (FAT) homology domain.

4 tein that contains a Cyclin A (CycA)-binding homology domain.

5 obular domain that has been termed the ICP27 homology domain.

6 th the DH domain but not with the pleckstrin homology domain.

7 a Dbl homology (DH) domain and a pleckstrin homology domain.

8 from its neighboring diffuse B-cell lymphoma homology domain.

9 AP is actively targeted in rods by its SNARE homology domain.

10 PR binding to the cytosolic C-terminal NudT9-homology domain.

11 ough a domain located within its myosin-tail homology domain.

12 e site for binding to BubR1's conserved Mad3 homology domain.

13 lysine endopeptidase activity via a NlpC/P60 homology domain.

14 and the regulator of the G protein signaling homology domain.

15 adixin-moesin (FERM) domain and a pleckstrin homology domain.

16 al myristolyation and the co-factor C (TBCC) homology domain.

17 have increased DNA binding through the runt homology domain.

18 usion regulator, Fus2p, which contains a Dbl-homology domain.

19 nd encode for proteins sharing a common MAGE homology domain.

20 (TPR) region capped by a cryptic pleckstrin homology domain.

21 e assembly of proteins containing prohibitin homology domains.

22 amin-2 at its GTPase, middle, and pleckstrin homology domains.

23 with p115 RhoGEF involving their pleckstrin homology domains.

24 in, which binds a site in the SNX5/SNX6 phox homology domains.

25 m2, which associate with the PM via plextrin homology domains.

26 igomerize through self-interacting T1 and H1 homology domains.

27 ger domain and a pair of BAH (bromo adjacent homology) domains.

28 Here, we show that the calponin homology domain 1 (CH1), within the filamin A (FLNa) act

29 We found that Eps15-homology domain 1 (EHD1), a protein that associates with

30 is a multidomain protein containing a Munc13 homology domain 1 (MHD1).

31 le alpha/Armadillo/Toll-Interleukin receptor homology domain 1 protein (SARM1) in Wallerian-like dege

32 al structure of human PECAM-1 immunoglobulin homology domain 1 reveals that a glycan emanating from t

33 VASP [vasodilator-stimulated phosphoprotein] homology domain 1) binding domains of Lpd and the host V

34 s, mediated by amino-terminal immunoglobulin homology domain 1, contribute to maintenance of the vasc

35 s fiber-associated protein, LIM and calponin-homology domains 1 (LIMCH1), which regulates NM-II activ

36 is composed of amino-terminal immunoglobulin homology domains 1 and 2 (IgD1 and IgD2).

37 with the C-terminal extension of the formin homology domain 2 (FH2) domain of Fmn2, called FSI.

38 differential binding partners of the formin-homology domain 2 (FH2) of mDia1, mDia2, and mDia3, whic

39 Small Src homology domain 2 (SH2) and 3 (SH3) adapter proteins reg

40 y identified class of actin nucleators, WASp homology domain 2 (WH2) nucleators, use tandem repeats o

41 n cooperates with profilin and Spire, a WASP homology domain 2 (WH2) repeat protein, to stimulate ass

42 protein kinase A (PKA) pathway activates Src homology domain 2 containing protein tyrosine phosphatas

43 noglobulin-like loop epidermal growth factor homology domain 2, vascular endothelial growth factor, s

44 noglobulin-like loop epidermal growth factor homology domain 2, vascular endothelial growth factor, v

45 protein tyrosine phosphatase (SHP) 2 and Src homology domain 2-containing inositol phosphatase 1 (SHI

46 SIRP-alpha and downstream activation of Src homology domain 2-containing phosphatase-1.

47 We observed that ICAM-1 interacts with Src homology domain 2-containing phosphatase-2 (SHP-2), and

48 nding to DCIR induced phosphorylation of Src homology domain 2-containing protein tyrosine phosphatas

49 equence of FGFRL1 consists of a putative Src homology domain-2 (SH2)-binding motif adjacent to a hist

50 ing both heme oxygenase-1 (HO-1) and the Src homology domain-2 containing tyrosine phosphatase-1 micr

51 kinase with Ig and endothelial growth factor homology domains-2 (TIE2) receptor, protein kinase B, an

52 Binding of the Borg homology domain 3 (BD3) domain of Borg3 results in disti

53 Select BCL-2 homology domain 3 (BH3) helices activate BAX directly by

54 poptosis (PUMA), a B-cell lymphoma-2 (Bcl-2) homology domain 3 (BH3)-only Bcl-2 family member, was ma

55 e role of the proapoptotic B-cell lymphoma 2 homology domain 3 (BH3)-only protein BH3 interacting-dom

56 ecently identified that in response to Bcl-2 homology domain 3 (BH3)-only proteins and mitochondrial

57 We identify the endosome-based Eps15 homology domain 3 (EHD3) pathway as essential for cardia

58 ine rich, the hypothesis that it targets Src homology domain 3 (SH3) domains was tested, but mutation

59 tic agents, such as fludarabine and the BCL2 homology domain 3 mimetic ABT-737.

60 studied the therapeutic potential of a BCL-2 homology domain 3 mimetic inhibitor, ABT-737.

61 bition of Bcl-xL by the small molecule Bcl-2 homology domain 3 mimetic, A-1331852, or Bcl-xL-specific

62 We used bcl-2 homology domain-3 (BH3) profiling to test the mitochondr

63 that adaptor protein containing a pleckstrin-homology domain, a phosphotyrosine-binding domain, and a

64 h the N-terminal actin depolymerizing factor homology domain (ADFH) domain of mAbp1.

65 rom that of other CDPKs; it has a pleckstrin homology domain adjacent to the kinase domain and two ca

66 inositide recognition through its pleckstrin homology domain all result in failure to build the later

67 Although the PX (phox homology) domain alone binds PI3P, we theorized that the

68 Gef3p contains a putative DH homology domain and a BAR/IMD-like domain.

69 a long isoform of VAB-3, comprising a Paired homology domain and a homeodomain, represses expression

70 t both a conserved surface on the pleckstrin homology domain and an intact TPR region are required fo

71 hanistically, AMOTL2 binds to AKT pleckstrin homology domain and interrupts AKT's membrane localizati

72 Pleckstrin homology domain and leucine rich repeat protein phosphat

73 In this study, we identified pleckstrin homology domain and leucine-rich repeat protein phosphat

74 of ANTI-SILENCING 1 (ASI1), a bromo-adjacent homology domain and RNA recognition motif-containing pro

75 d in and adjacent to both the N-terminal Rel homology domain and the C-terminal transactivation domai

76 ractions between the diffuse B-cell lymphoma homology domain and the pleckstrin homology domain of Cb

77 of amisyn in exocytosis: Both the pleckstrin homology domain and the SNARE motif are needed for its i

78 y, epsin binds Dvl2 via its epsin N-terminal homology domain and ubiquitin-interacting motifs and pro

79 e RNA binding protein owing to two central K-homology domains and a C-terminal arginine-glycine-glyci

80 ear motifs through its MATH (meprin and TRAF homology) domain and forms higher-order oligomers throug

81 cue, we demonstrate that both the GEF (CDC25 homology domain) and RA2 domains of PLC are required for

82 domains, a GTPase-like domain, a pleckstrin homology domain, and an ArfGAP domain, and exists as a c

83 similar to PLCdelta1, it lacks a pleckstrin homology domain, and it remains unclear how PLCzeta targ

84 mbrane topology of their conserved reticulon homology domain, and scaffolding, arising from the abili

85 ding to basic residues in the Akt pleckstrin homology domain, aPKCs lack this domain.

86 ntified two regions on its double-pleckstrin homology domain architecture that mediated histone bindi

87 the membrane-bound O-acyltransferase (MBOAT) homology domain are segregated on opposite sides of the

88 iated by its 2 amino-terminal immunoglobulin homology domains, are essential for concentrating PECAM-

89 ne kinase family with immunoglobulin and EGF homology domains, are receptor tyrosine kinases found pr

90 pulldown analyses identified Akt1 pleckstrin homology domain as the interactive domain.

91 for its GEF activity, whereas the pleckstrin homology domain assists in the PX-mediated activity.

92 calization of mTORC2 via the Sin1 pleckstrin homology domain at the plasma membrane is PI3K and growt

93 cochleas in mice lacking the critical Bcl-2 homology domain (BH-3) inducers of p53- and p63-mediated

94 Noxa is a Bcl-2-homology domain (BH3)-only protein reported to be a proa

95 ports that Pob3 and Rtt106 double pleckstrin homology domains bind histones H3-H4, we also find that

96 on promotes ASK1 activity via its pleckstrin homology domain but also facilitates ASK1 autoinhibition

97 ngement is not the F-BAR domain or the micro-homology domain, but rather is an uncharacterized 90 ami

98 fied two cysteine residues in the pleckstrin homology domain (C60 and C77) to be reversibly oxidized.

99 cent region of the cyclic nucleotide-binding homology domain, can fully account for the differential

100 e C-terminal region of p130Cas or Cas family homology domain (CCHD) has been reported to adopt a stru

101 g measurements, we show that tandem calponin homology domains (CH1-CH2) can be mutated to preferentia

102 The C-terminal homology domain (CHD) of Af4 was sufficient to confer th

103 ter anaphase and is mediated by the calponin homology domain (CHD) of Iqg1, but the regulatory mechan

104 elongation complex subunits and a C-terminal homology domain (CHD) that is conserved among AF4/FMR2 f

105 region contains a cyclic nucleotide-binding homology domain (CNBHD), which is connected to the pore

106 The structure of an Eps15/RFcho1 mu-homology domain complex reveals a spacing-dependent DPF

107 We identified PRDI-BF1 and RIZ homology domain containing 8 (PRDM8) as a highly conserv

108 PLEKHA7 (pleckstrin homology domain containing family A member 7) has been f

109 The Src homology domain containing phosphatase 2 (SHP2) and the

110 Eps15-homology domain containing protein 2 (EHD2) is a dynamin

111 Herein, we show that Pleckstrin homology domain containing protein family member 1 (PLEK

112 een we identified the fly homologue of Eps15 homology domain containing protein-binding protein 1 (dE

113 growth factor receptor pathway substrate 15)-homology domain containing proteins (EHDs) comprise a fa

114 PRDM (PRDI-BF1 and RIZ homology domain containing) family members are sequence-

115 The Eps15-homology domain-containing (EHD) protein family comprise

116 Members of the four-member C-terminal EPS15-Homology Domain-containing (EHD) protein family play cru

117 others, which function together with EPS-15 homology domain-containing (EHD) proteins in non-T cell

118 Eps15 homology domain-containing 2 (EHD2) belongs to the EHD-c

119 inhibit Rac1 and activate a RhoA-ROCK-Formin homology domain-containing 3 (FHOD3) pathway and generat

120 Pleckstrin homology domain-containing A7 (PLEKHA7) is a cytoplasmic

121 this study, we provide evidence that the Src-homology domain-containing adaptor Nck1 negatively regul

122 - and kinesin-interacting protein/pleckstrin homology domain-containing family M member 2 (SKIP/PLEKH

123 s (LNPs) encapsulating osteogenic pleckstrin homology domain-containing family O member 1 (Plekho1) s

124 Among them, the formin homology domain-containing protein (FHOD) family of form

125 Here, we identify a pleckstrin homology domain-containing protein (PHLDB3)-encoding gen

126 idermal growth factor receptor substrate 15] homology domain-containing protein 1) as a novel interac

127 tations in PRDM12 (encoding PRDI-BF1 and RIZ homology domain-containing protein 12) in subjects with

128 We previously linked the C-terminal Eps15 homology domain-containing protein 3 (EHD3) with endosom

129 with coiled-coil, Ank repeat, and pleckstrin homology domain-containing protein ACAP2 as an Rab35 eff

130 We show that Pleckstrin homology domain-containing protein family member 1 (PLEK

131 ol of PI-4P specifically recruits pleckstrin homology domain-containing proteins involved in lipid tr

132 PIP3 recruits pleckstrin homology domain-containing proteins to the membrane to a

133 Biology, Lu et al. (2015) identify two Eps15-homology-domain-containing proteins as critical effector

134 ntain a C-terminal cyclic nucleotide-binding homology domain coupled to the pore of the channel by a

135 three-nucleotide microexon in the pleckstrin homology domain, display differential affinity for PI(4,

136 etween their N-terminal Src homology and Bcr homology domains disrupts homodimer formation and impact

137 llular domain of VEGFRs consists of seven Ig homology domains; domains 1-3 (D1-3) are responsible for

138 lular receptor domain (ECD) consists of 7 Ig-homology domains; domains 2 and 3 (D23) represent the li

139 ia alpha/Armadillo/Toll-interleukin receptor homology domain (dSarm)/Axundead signaling, and independ

140 to the hypothesis that the C-terminal Eps15 homology domain (EHD) ATPase proteins are involved in th

141 nserved membrane-remodeling C-terminal Eps15 Homology Domain (EHD) protein Past1 is required for the

142 cell lines to investigate the role of Eps15 Homology Domain (EHD) proteins at the neck of caveolae.

143 The C-terminal Eps15 homology domain (EHD)-containing proteins have been impl

144 The epsin N-terminal homology domain (ENTH) is a major player in clathrin-med

145 involved in membrane bending, the N-terminal homology domain (ENTH) of Epsin1.

146 sing the endocytic protein epsin1 N-terminal homology domain (ENTH), previously thought to drive fiss

147 the basic helix-loop-helix PAS (Per-Arnt-Sim homology domain) family known to mediate the toxic and c

148 rough a C-terminal KASH (Klarsicht/Anc1/Syne homology) domain (Figure 1A) [1-4].

149 ion on four serine acceptor sites in the Rel homology domain for the expression of an array of NF-kap

150 lsolin in the linker region between gelsolin homology domains G3 and G4, which, in the absence of cal

151 uct containing the juxta-membrane and kinase homology domain harbored an exclusive binding site for G

152 ependent Rac exchanger 1 (P-Rex1) pleckstrin homology domain has effects consistent with P-Rex1 inhib

153 ver direct interaction between CCM2 harmonin homology domain (HHD) and the N terminus of MEKK3, and d

154 h phospholipid binding in related pleckstrin homology domains, however, suggests that ISPs do not ret

155 ique role of the C-terminal citrate synthase homology domain in ACLY function and catalysis, adding t

156 In place of the pleckstrin homology domain in dynamin, however, Drp1 contains an un

157 he Polalpha-recruitment and putative primase homology domain in Mcm10/Cdc23 abrogate the ribonucleoti

158 absence of a recognized G protein signaling homology domain in Rgnef, no proximal linkage to G prote

159 merization domains, but also included a phox-homology domain in the converter region.

160 gin-Cullin E3 ligase complex via a ubiquitin-homology domain in the Ela1 protein.

161 aracterized ACLY C-terminal citrate synthase homology domain in the mechanism of acetyl-CoA formation

162 of yeast Sac1, containing the conserved Sac1 homology domain, in complex with Vps74, a phosphatidylin

163 Upon disruption of the myosin-tail homology domain, inner segment plasma membrane proteins,

164 ith an N-terminal F0 domain and a pleckstrin homology domain inserted in the F2 domain.

165 Here, we show that pleckstrin homology domain interacting protein (PHIP), acting throu

166 dynamics simulations of the epsin N-terminal homology domain interacting with a lipid bilayer and dem

167 assessed the prognostic impact of pleckstrin homology domain-interacting protein (PHIP) copy number a

168 e, we show that the activation of Pleckstrin homology domain-interacting protein (PHIP), promotes mel

169 -associated regulator of G-protein signaling homology domain-interacting protein), a component of the

170 vesicular Rab proteins via an N-terminal Slp homology domain, interacts with plasma membrane SNARE co

171 al interactions that tether the two calponin homology domains into a closed ABD conformation.

172 mitochondria, and the C-terminal pleckstrin homology domain is associated with the plasma membrane.

173 We show that the mu-homology domain is dispensable for COPI function in the

174 demonstrate that the Arg C-terminal calponin homology domain is necessary and sufficient to increase

175 P1 constructs demonstrated that the calponin homology domain is required for IQGAP1 localization to e

176 The SUN (Sad1-UNC-84 homology) domain is conserved in a number of nuclear env

177 -binding protein containing a bromo-adjacent homology domain, is required to process functional trans

178 KinG is a calponin homology domain kinesin that directly interacts with the

179 Here we show that the pleckstrin homology domain leucine-rich repeat protein phosphatase

180 regulatory factor 1 (NHERF1) and pleckstrin-homology domain leucine-rich repeat protein phosphatases

181 dephosphorylation of Akt through pleckstrin homology domain leucine-rich repeats protein phosphatase

182 e phospholipid binding profile of pleckstrin homology domain localizing mutations.

183 9 including the mannose 6-phosphate receptor homology domain mediates the association with Hrd3 in vi

184 These behaviors require a pleckstrin homology-domain membrane tether and a WD40 clustering do

185 interesting challenge given that their motor homology domain (MHD) cannot bind ATP.

186 st the core and N terminus of the Vik1 motor homology domain (MHD).

187 PARP13 features a divergent PARP homology domain missing a PARP consensus sequence motif;

188 ibit actin binding by latching both calponin homology domains more tightly.

189 The mu-homology domain (muHD) of FCHO2 binds directly to DPF se

190 hese adaptors bind cargo via a C-terminal mu-homology domain (muHD); however, few cargoes exhibiting

191 ns increased kinase activity, and pleckstrin homology domain mutants exhibited enhanced phospholipid

192 Numerous proteins possess Nudix homology domains (NHDs) that have no known function.

193 hat contained a deletion of all of the Bcl-2 homology domains, none of which impacted anti-CIS capabi

194 re of the C-linker/cyclic nucleotide-binding homology domain of a mosquito ERG channel at 2.5-A resol

195 interacted specifically with the pleckstrin homology domain of BchC1.

196 In vitro, the pleckstrin homology domain of Cb binds phosphoinositides, specifica

197 ense mutation in the diffuse B-cell lymphoma homology domain of Cb, which carries the guanine nucleot

198 lymphoma homology domain and the pleckstrin homology domain of Cb.

199 ts active, GTP-bound state to the pleckstrin homology domain of Cb.

200 nt mice, in which the C-terminal myosin-tail homology domain of CEP290 is disrupted after the connect

201 In silico analysis predicted the calponin-homology domain of CLAMP to contain conserved amino acid

202 are comparable with those of the pleckstrin homology domain of cytohesin-3 (general receptor for pho

203 -binding and curvature-generating pleckstrin homology domain of Dyn1 plays an important role in stabi

204 Hook proteins, which resembles the calponin-homology domain of end-binding (EB) proteins but cannot

205 d that the Tudor domain of Esa1 and the EPcA homology domain of Epl1 play critical roles in Piccolo N

206 ion to kinetochores depended on the calponin homology domain of HEC1 but not on Aurora B-dependent ph

207 gene consists of the Tec homology-pleckstrin homology domain of ITK and the kinase domain of SYK, and

208 Moreover, deletion of the pleckstrin homology domain of kindlin-1 also failed to rescue elect

209 This interaction involves the pleckstrin homology domain of kindlin-3 and blades 5-7 of RACK1.

210 s with multiple CESA proteins through the mu-homology domain of mu2, which is involved in specific in

211 In contrast, mutations in the calponin homology domain of Ndc80 abrogated kinetochore function

212 tivation of the mannose 6-phosphate receptor homology domain of OS9 had no effect on its action on NK

213 tional analysis revealed that the pleckstrin homology domain of P-Rex1 is required.

214 d the effects of K-to-Q mutations in the REL homology domain of p65 on the response to IL-1beta in 29

215 The crystal structure of the PARP homology domain of PARP13 shows obstruction of the canon

216 5 interacts specifically with the pleckstrin homology domain of PDK1 and impairs formation of a PDK1/

217 s, such as the PI(4,5)P2-specific pleckstrin homology domain of phospholipase Cdelta1 (PHPLCdelta1),

218 oop motif located on the surface of the RecA homology domain of RAD51.

219 ppaB through direct interaction with the Rel homology domain of RelA.

220 previous report, the actin-binding calponin homology domain of Rng2p is not required for viability,

221 p and the nucleosome binding, Bromo-Adjacent-Homology domain of Sir3p.

222 Slm1, can be bypassed by fusing the plextrin homology domain of Slm1 alone onto Ypk1, demonstrating t

223 ransforming point mutation in the pleckstrin homology domain of the Akt1 oncoprotein.

224 Walker A motif, KNRXG motif and Lon protease homology domain of the Escherichia coli RadA protein are

225 substitution R145C within the conserved TNF-homology domain of the full-length protein.

226 f instances the mannose 6-phosphate receptor homology domain of the gamma subunit is required for opt

227 is approximately 75 nm outside the calponin homology domain of the Ndc80 complex.

228 l ensemble of the fully disordered verprolin homology domain of the neural Aldrich syndrome protein i

229 cs, actin binding by the N-terminal calponin homology domain of the scaffold is shown to help the sca

230 The prohibitin homology domain of the slit diaphragm protein podocin co

231 e present the structure of the C-terminal mu-homology domain of the yeast delta-COP subunit in comple

232 YOD1 binds to the C-terminal TRAF homology domain of TRAF6 that also serves as the interac

233 rin by interacting directly with the Epsin15 homology domains of Eps15 and intersectin-1.

234 Three-dimensional alignment of the PARP homology domains of PARP13, PARP12, and PARP15 illustrat

235 uster in the second coiled-coil and calponin homology domains of SPECC1L and severely affect the abil

236 ding to the KASH (Klarsicht, ANC-1, and Syne homology) domain of nesprin 2, and the regions involved

237 ted X protein, BAX) cooperate with the BCL-2 homology domain only (BH3-only) subclass (e.g. BCL-2 int

238 patches when it was attached to a pleckstrin homology domain or a CAAX motif.

239 ire Net1A catalytic activity, its pleckstrin homology domain, or its regulatory C terminus.

240 Two conserved histidine residues in the OSBP homology domain ORP4 are essential for binding phosphati

241 mong the Akt isoforms in both the pleckstrin homology domain (P domain) and regulatory domain (R doma

242 a protein from the src homology and collagen homology domain (p66Shc) and reduced the expression of s

243 ositol-4,5-bisphosphate using the pleckstrin-homology domain (PHD) and engage in rapid membrane fissi

244 y direct interactions between its pleckstrin homology domain (PHD) and phosphatidylinositol 3,4,5-tri

245 y direct interactions between its pleckstrin homology domain (PHD) and phosphatidylinositol 3,4,5-tri

246 ses detect large movements of the pleckstrin homology domain (PHD) from a 'closed' conformation docke

247 sing the N-terminal to C-terminal pleckstrin homology domains (PHn-PHc), are auto-inhibited.

248 APPL1 (adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leuc

249 d sensor, phospholipase C delta 1 pleckstrin homology domain (PLC delta1-PH), is completely inhibited

250 gi PI-4P that was detected with a pleckstrin homology domain probe.

251 High expression of the formin homology domain protein 1 outlines the LC population.

252 lts indicate human LCs (SIRPalpha(+), formin homology domain protein 1(+), CD8alpha/alpha(+), CD34(-)

253 tudies suggest that a dynamin-homolog, Eps15 homology domain protein 1, catalyzes fission and release

254 te meiotic spindle assembly are the calponin homology domain protein encoded by aspm-1, the katanin f

255 le alpha/Armadillo/Toll-Interleukin receptor homology domain protein) cell-autonomously suppresses Wa

256 le alpha/Armadillo/Toll-Interleukin receptor homology domain protein) gene, a key mediator of Walleri

257 d vesicular membranes decorated by the Eps15 homology domain protein, EHD1, is responsible for recept

258 he lipid-binding specificity of a pleckstrin homology domain protein.

259 proteins is mediated by a characteristic PUM homology domain (PUM-HD).

260 , which lie between the motor and pleckstrin homology domains, reduced the instantaneous velocity of

261 boring the human HIP1 ANTH (AP180 N-terminal homology) domain rescued Orsay infection in C. elegans,

262 med "regulated endocrine-specific protein 18 homology domain" (RESP18HD), which encompasses residues

263 Tuberin contains a RapGAP homology domain responsible for inactivation of Rheb, bu

264 impaired inhibition by the TGEF2 pleckstrin-homology domain, resulting in dramatically increased TGE

265 GEF (Sec7) and membrane-binding (pleckstrin homology) domains, revealing that it has a constitutivel

266 Both MsRel2A and MsRel2B contain only a Rel homology domain (RHD) and lack the ankyrin-repeat inhibi

267 sexta Fkh (MsFkh) interacted with Relish-Rel-homology domain (RHD) but not with Dorsal-RHD.

268 ain and the regulator of G protein signaling homology domain (RHD) is highly correlated with establis

269 LRR domain of LRRC25 interacted with the Rel Homology domain (RHD) of p65/RelA and promotes the degra

270 nforeseen structural similarity with the Rel homology domain (RHD) of the mammalian transcription fac

271 wn activity of RUNX1 required an intact runt homology domain (RHD), a domain where most leukemia-asso

272 Reticulon/DP1 proteins contain reticulon homology domains (RHDs) that have unusually long hydroph

273 romote ER tubulation through their reticulon homology domains (RHDs).

274 ent the first crystal structure of the ICP27 homology domain, solved to 1.9 A resolution.

275 and -16 contain an additional C-terminal H2 homology domain that is not sequence-related to the H1 d

276 re, amisyn contains an N-terminal pleckstrin homology domain that mediates its transient association

277 Vik1 contains a motor homology domain that retains microtubule binding propert

278 FolVam7 contains SNARE and PX (Phox homology) domains that are indispensable for normal loca

279 These propeptides flank the central VEGF homology domain, that contains the binding sites for VEG

280 Although the TNF homology domain (THD) of human (h)4-1BBL forms non-coval

281 n TNF ligands (scTNF) comprised of three TNF homology domain (THD) protomers that mimic tmTNF.

282 Along with an N-terminal pleckstrin homology domain, the central domain affects neurite outg

283 -783 in the beta1 tail, and that the Arg Src homology domain then engages this phosphorylated region

284 ly "opens" CB2SH3+ and allows the pleckstrin homology domain to properly bind lipids depending on the

285 nstead requires a neighboring PH (Pleckstrin Homology) domain to achieve these functions.

286 n neurons, which initiate expression of Runt homology domain transcription factor RUNX1 and the nerve

287 of neural Aldrich syndrome protein verprolin homology domain, two generated with the program flexible

288 In contrast, substitutions in the kinase homology domain, W708R and I734T, linked to Leber congen

289 that the RNA-binding protein PumHD (Pumilio homology domain), which has been widely used in native a

290 Fragments of CynA lacking the pleckstrin homology domain, which are normally found in the cytosol

291 its FERM (band 4.1, ezrin, radixin, moesin) homology domain, which exposes a region important for FA

292 ffects a highly conserved residue in the DBL homology domain, which is required for the interaction a

293 av activity through stabilization of the Dbl homology domain, which is responsible for exchange activ

294 ue to a lack of the lipid-binding pleckstrin homology domain, which is used for lipid-mediated regula

295 interacts with PI(4,5)P2 via its pleckstrin homology domain, which may guide its subcellular localiz

296 We find that a part of the Bem1 Phox homology domain, which overlaps with a region interactin

297 c motor domain and a Vik1/Cik1 partner motor homology domain whose interactions with microtubules are

298 interaction of the adhesion of a pleckstrin homology domain with phosphatidylinositol 4,5-bisphospha

299 (PM) via the interaction of their pleckstrin homology domains with phosphatidylinositol 4-phosphate (

300 nvolves the N-terminal subdomain of the Sac1 homology domain, within which mutations in the related S