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1  All copies are therefore near-identical, or homoplasmic.
2 ion that plant mitochondrial populations are homoplasmic.
3  conventional wisdom--these mutations can be homoplasmic.
4 conventional wisdom - these mutations can be homoplasmic.
5 e mutation has subsequently been shown to be homoplasmic.
6  a Brazilian pedigree with LHON carrying the homoplasmic 11778/ND4 mitochondrial DNA mutation.
7 in steady-state mt-tRNA(Val) observed in the homoplasmic 1624C>T-cell lines is caused by a rapid degr
8 NT) enabled replacement of mutant mtDNA from homoplasmic 8993T>G fibroblasts to generate corrected Le
9                       Of other variants, the homoplasmic A15951G mutation is of special interest as i
10 patial differentiation will be identical for homoplasmic and heteroplasmic conditions.
11 rmal tissues, cancer cells harboured further homoplasmic and heteroplasmic mutations that could also
12 ation of the method using samples with known homoplasmic and heteroplasmic mutations, as well as CEPH
13 as effective in reducing the transmission of homoplasmic and heteroplasmic pathogenic mtDNA variants.
14  occurs in multiple copies resulting in both homoplasmic and heteroplasmic pathogenic mtDNA variants.
15 es three technical challenges: (1) detecting homoplasmic and heteroplasmic variants, present, respect
16                             We identified 12 homoplasmic and one heteroplasmic variant (m.3243A>G) wi
17 acid (tRNA)(Ile) gene, which was shown to be homoplasmic by polymerase chain reaction/restriction fra
18 ochondrial DNA in this pedigree identified a homoplasmic C-to-T transition at position 1494 (C1494T)
19 y, of the individuals involved exhibited the homoplasmic C150T mutation.
20 subjects of an Italian population revealed a homoplasmic C150T transition near an origin of heavy mtD
21                        Among several billion homoplasmic cells tested, we were unable to detect any s
22 dicts the considerable observed frequency of homoplasmic cells.
23  the NZB-129 heteroplasmic mice, but neither homoplasmic counterpart, had reduced activity, food inta
24 eteroplasmic mice and their NZB or 129 mtDNA homoplasmic counterparts.
25 r findings may explain the high frequency of homoplasmic D310 somatic mutations in many tumor types.
26 nd that the mtDNA population shifted towards homoplasmic dimers, suggesting that there may be circums
27                            All subjects were homoplasmic except the two 3,460 carriers, who showed 80
28  be heteroplasmic for one of the markers and homoplasmic fathers showed that once heteroplasmy enters
29 y inherited by the males resulting in mostly homoplasmic females and heteroplasmic males.
30               Consistently, the viability of homoplasmic flies at 29 degrees C was fully restored by
31                            ND6-P25L mice are homoplasmic for a disease-causing mtDNA point mutation e
32 plified and cloned from a synaptosome cybrid homoplasmic for a mtDNA with nine Cs.
33 ls directly, two cell lines were fused, each homoplasmic for a partially deleted mtDNA in which the d
34 d from crosses between individuals that were homoplasmic for different mtDNA marker genotypes showed
35 ly homoplasmic for wild-type mtDNA or nearly homoplasmic for mutant mtDNA.
36 in clinical presentation between individuals homoplasmic for the 1624C>T mutation.
37 ed from the fusion of enucleated fibroblasts homoplasmic for the A3460G mutation with 206 (osteosarco
38 rm strain, chpIR (M, CB4856>N2), was bred as homoplasmic for the CB4856 mtDNA genome in the N2 nuclea
39  one of which (clone CA17.1) was essentially homoplasmic for the duplication.
40                                  Females are homoplasmic for the F mitotype which is inherited matern
41 DNA, and so with both procedures mouse cells homoplasmic for the mouse mtDNA in the injected mitochon
42                            Cell lines nearly homoplasmic for the mutation exhibited a strong (70-75%)
43                                        Cells homoplasmic for the mutation had no detectable COX activ
44  subunits in a multisubunit complex in cells homoplasmic for the mutation, thus indicating that there
45 function in a human lymphoblastoid cell-line homoplasmic for the np 7445, deafness-associated mitocho
46                       Regenerated plants are homoplasmic for the spectinomycin resistance and the Pst
47  remained constant in four clones apparently homoplasmic for wild-type mtDNA or nearly homoplasmic fo
48 ved from an asymptomatic individual were all homoplasmic for wild-type mtDNA.
49  Zealand pedigree exhibiting the mutation in homoplasmic form and from control individuals.
50  of a large family carrying this mutation in homoplasmic form and from control individuals.
51 ty of cultured human cell lines (carrying in homoplasmic form either the mitochondrial tRNA(Lys) A834
52 ntly enhanced tumor growth, while cells with homoplasmic form of the same mutation inhibited tumor fo
53 ab-Israeli family, carrying this mutation in homoplasmic form, exhibited significant decreases compar
54                This cell line carries a near-homoplasmic frameshift mutation in the mtDNA gene for th
55 -) cell line derivative C4T, which carries a homoplasmic frameshift mutation in the ND4 gene.
56                           Variants were near homoplasmic in affected individuals.
57 The majority of these somatic mutations were homoplasmic in nature, indicating that the mutant mtDNA
58 s can "take over the system" and even become homoplasmic, in a manner similar to what has been shown
59                   Most of the mutations were homoplasmic, indicating that the mutant genome was domin
60  intron; however, only the P4 mutants became homoplasmic, indicating that the other mutations were le
61       Fewer repeats among heteroplasmic than homoplasmic individuals in a species with up to nine rep
62 ts and more repeats among heteroplasmic than homoplasmic individuals in two species with few repeats
63 rary, which we named MitoKO, to produce near-homoplasmic knockout cells in vitro and to generate a mo
64                  Unlike the available set of homoplasmic knockout mutants in 25 plastid genes, the rb
65                                 Cybrids with homoplasmic levels of pathogenic mtDNA reliably establis
66     The revertant lines contained apparently homoplasmic levels of the mutation and no other detectab
67 lthough transmitochondrial cybrids harboring homoplasmic levels of the mutation do not survive in gal
68                 RIRCD is associated with the homoplasmic m.14674T>C mitochondrial DNA mutation; howev
69 order by identifying a maternally inherited, homoplasmic m.14674T>C mt-tRNA(Glu) mutation in 17 patie
70 on, giving rise to heteroplasmic females and homoplasmic males.
71 boratories have reported a high frequency of homoplasmic mitochondrial DNA (mtDNA) mutations in human
72 that contains nDNA from one mouse strain and homoplasmic mitochondrial haplotypes from different mous
73 report documents, for the first time, that a homoplasmic mitochondrial tRNA mutation may cause matern
74 highlights the significant contribution that homoplasmic mitochondrial tRNA substitutions may play in
75 eir human counterparts, cybrids carrying the homoplasmic mouse LHON mutation demonstrated reduced res
76           This family highlights the role of homoplasmic mt-tRNA mutations in genetic disease.
77 spiratory chain deficiency (RIRCD), due to a homoplasmic mt-tRNA(Glu) mutation, and reversible infant
78 C4936T (p.T156I) in ND2 of complex I and the homoplasmic mtDNA mutation A9181G (p.S219G) in ATPase 6
79                         Furthermore, several homoplasmic mtDNA mutations affecting subunits of NADH d
80 s are sufficient to explain the incidence of homoplasmic mtDNA mutations in human tumors.
81 mised fertility, but escaper progeny carried homoplasmic mtDNA mutations lacking the cleavage site.
82 he tissue specificity of disorders caused by homoplasmic mtDNA mutations.
83                                              Homoplasmic mtDNA somatic mutations and novel variants w
84 alling analysis against showed that 99.5% of homoplasmic mtDNA variants can be reliably identified pr
85 ines or mitochondrial replacement by SCNT in homoplasmic mtDNA-based disease.
86 y acid metabolism pathways that lack in near homoplasmic mutant cells compared to wild type cells.
87  complex IV, COX I, and the other a distinct homoplasmic mutation in a subunit of complex III, cytoch
88 s by fusing two cell lines, one containing a homoplasmic mutation in a subunit of respiratory chain c
89 CCs) display two exceptional genotypes: near-homoplasmic mutation of mitochondrial DNA (mtDNA) and ge
90  genome of the maternal lineage identified a homoplasmic mutation substituting cytidine for uridine i
91         We describe a family with an unusual homoplasmic mutation that resulted in six neonatal death
92 ry complex I) subunit 5 gene (ND5); the same homoplasmic mutation was also identified in a human colo
93                      4AR still contained the homoplasmic mutation, and apparently there was no ND6 pr
94 5% confidence interval = .05 to .31) but not homoplasmic mutations (B = -.008, 95% confidence interva
95 5% confidence interval = .05 to .31) but not homoplasmic mutations (beta = -.008, 95% confidence inte
96                                              Homoplasmic mutations (present in every copy of the geno
97 These findings provide the first examples of homoplasmic mutations in the mtDNA of tumour cells and h
98 tion is similar to the reported frequency of homoplasmic mutations in tumors.
99 carried an elevated load of heteroplasmic or homoplasmic mutations, suggesting that somatic mutations
100 r(UCN)) T7511C mutation, in conjunction with homoplasmic ND1 T3308C and tRNA(Ala) T5655C mutations us
101 ations in the D310 region were predominantly homoplasmic only 7 days after exposure to damage.
102 art of a two-step selection system to obtain homoplasmic plant lines.
103                                              Homoplasmic plastid transformants are readily obtained i
104 nd for characterizing the steps that lead to homoplasmic plastid transformation.
105              We have previously associated a homoplasmic point mutation (1624C>T) in MTTV with a prof
106 or-infiltrating lymphocytes, promoting their homoplasmic replacement and undermining cancer immunity.
107 ttleneck), to the partitioning of mtDNA into homoplasmic segregating units, or to the selection of a
108 ne to CDDP is associated with the hetero- to homoplasmic shift of a nonsynonymous mutation in MT-ND2,
109                       Segregation toward the homoplasmic state can occur within a single generation i
110 o its uniparental inheritance and subsequent homoplasmic state, which excludes the biological need fo
111 n affected matrilineal relative carrying the homoplasmic T7511C mutation, exhibited approximately 75%
112                                              Homoplasmic transgenic plants exhibiting high levels of
113 NA-delivery and efficiently regenerated into homoplasmic transplastomic lines.
114                     RNA-gel blot analysis of homoplasmic transplastomic plants identified gfp transcr
115 cL and accD genes in tobacco plastid DNA and homoplasmic transplastomic plants were crossed with tran
116 le blood samples carried a similar number of homoplasmic variants (p = 0.45) per sample while the LCL
117                                              Homoplasmic variants account for most variant calls (98%
118  diabetes, deafness and heart failure and 12 homoplasmic variants increased aspartate aminotransferas
119 tified might represent a random evolution of homoplasmic variants, rather than necessarily being a pr
120 rial genetics and can be inaccurate even for homoplasmic variants.
121  constructs in cytoplasmic hybrids (cybrids) homoplasmic with respect to the 8993T-->G mutation showe
122 o hearing impairment in humans are generally homoplasmic, yet some individuals with these mutations h

 
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