ライフサイエンスコーパス: homopolymeric

1 s have shown that only NFL can assemble into homopolymeric 10-nm filaments.

2 nditions), T7 RNAP slips efficiently in both homopolymeric A and U tracts, and we have found that rep

3 AAA-lysines followed by ribosome sliding on homopolymeric A sequence.

4 The finding that ribosomes slide on homopolymeric A sequences explains bioinformatic analyse

5 ity assay (SPA) beads, and after addition of homopolymeric A template, NS5B enzyme, and radiolabeled

6 ucleotide steps as well as in varying length homopolymeric A(n).T(n) repeats (A(n)-tracts, where n =

7 ppage of elongating RNA polymerase (RNAP) on homopolymeric A/T tracts in DNA represents a special typ

8 on is due to loss or gain of a nucleotide in homopolymeric adenine or thymine tracts within flgR.

9 y of errors made during the transcription of homopolymeric adenine sequences, such that the A tract i

10 Dr fimbriae are homopolymeric adhesive organelles of uropathogenic Esche

11 The CAG repeats encode long glutamine homopolymeric amino acid chains in the amino-terminal do

12 es, including a bHLH domain, PAS domain, and homopolymeric amino acid stretches.

13 in protein-coding regions result in extended homopolymeric amino acid tracts, often polyglutamine or

14 ase in the Km for the dNTP substrate on both homopolymeric and heteropolymeric RNA and DNA templates.

15 (strain BK) has been investigated using both homopolymeric and heteropolymeric RNA templates.

16 Here we show that both homopolymeric and mixed-sequence 3'-NP-DNA templates can

17 nsion of the morpholino-terminated primer on homopolymeric and mixed-sequenced RNA templates.

18 , both parameterized on given error rates in homopolymeric and non-homopolymeric regions.

19 t three different subunit interfaces in this homopolymeric assembly.

20 ication of a specific and highly polymorphic homopolymeric C stretch (D310), located within the displ

21 five (42%) were deletions or insertions in a homopolymeric C-stretch between nucleotides 303-315 (D31

22 eoxy-D-manno-oct-2-ulopyranosonic acid (Kdo) homopolymeric capsular polysaccharide produced by strain

23 Bacillus anthracis elaborates a homopolymeric capsule composed of gamma-D-glutamic acid

24 es encoding the major sugar component of the homopolymeric capsule were up-expressed > 2.5-fold, but

25 secretion, and symbiotic function of the Kdo homopolymeric capsule.

26 mb20805 affect the polymerization of the Kdo homopolymeric capsule.

27 We further show that homopolymeric composition of the oligoA stretch is essen

28 hese cDNAs give rise to RNAs containing a 5'-homopolymeric cytidine (poly(C)) stretch.

29 re efficient in generating accurate edits in homopolymeric cytosine sites in cells or mouse embryos,

30 Altered specificity was observed when the homopolymeric dA.rU tract immediately 5' of the PPT was

31 udies have characterized the role of a 16 bp homopolymeric dA:dT DNA structural element in facilitati

32 ybrid formation: high transcription and long homopolymeric dA:dT tracts.

33 g experiments demonstrate that the MRE and a homopolymeric (dA x dT) element adjacent to the MRE are

34 d into a positioned nucleosome that exhibits homopolymeric (dA x dT)-dependent localized distortion.

35 f AMT1 autoactivation is greatly enhanced by homopolymeric (dA-dT) element (A16)-mediated nucleosomal

36 provide compelling evidence that nucleosomal homopolymeric (dA-dT) elements provide enhanced DNA acce

37 rs 2, 3, and 6 mediated association with the homopolymeric (dA.dT) COL1A1/MMP DNA consensus element.

38 ins known to bind within the minor groove of homopolymeric (dA.dT) DNA.

39 However, upon binding to the COL1A1/MMP homopolymeric (dA.dT) element, the native Nmp4 protein u

40 nduced upon zinc finger association with the homopolymeric (dA.dT) minor groove confer context-specif

41 rdings of DNA polymerase processing multiple homopolymeric DNA templates extended over 600 s and thro

42 on than for dCTP or dGTP into complementary, homopolymeric DNA templates.

43 leic acid (NA) duplexes, from B-like form of homopolymeric DNA, to mixed sequence DNA, to DNA:RNA hyb

44 u- and XLF-independent manner, but not other homopolymeric DNA.

45 Preannealed homopolymeric DNAs or RNAs are often used as templates a

46 teins, however, both in its binding to short homopolymeric dT(n) oligomers (as judged by polyacrylami

47 which crystal structures are available, the homopolymeric duplex sequences poly(dA) and poly(dG), an

48 actic Acid Bacteria (LAB) are well known for homopolymeric exopolysaccharide (EPS) production.

49 we demonstrate that four additional, novel, homopolymeric expansion proteins (polyAla, polySer, poly

50 trates are added iteratively, yielding short homopolymeric extensions whose lengths are controlled by

51 fected cells secrete overexpressed chains as homopolymeric ferritin into the media.

52 ffer in fibrils composed of single proteins (homopolymeric fibrils) from those generated by co-polyme

53 ible correlation between the ability to form homopolymeric filaments and the accelerated rate of hydr

54 At low ionic strength binding to the homopolymeric fluorescent RNA, poly(epsilonA), is electr

55 share a gene deletion and one-third exhibit homopolymeric frameshift mutations (HFMs).

56 nes from ACV-selected mutants identified two homopolymeric G-C nucleotide stretches as putative hot s

57 ivo analyses, we demonstrate that a variable homopolymeric G-repeat in the leader of the TlpB chemota

58 of the activation domain and insertion of a homopolymeric glutamine stretch was used to increase tra

59 Polysialic acid (PSA) is a homopolymeric glycan that plays crucial roles in the dev

60 uence of deafness/Crohn's disease-associated homopolymeric glycoproteins alpha-tectorin (TECTA) and g

61 A homopolymeric hexamer is optimal for producing mainly si

62 unction topics mainly related to the simpler homopolymeric IF networks composed of vimentin, and spec

63 biquitin-proteasome degradation pathway is a homopolymeric, K48-linked polyubiquitin chain: the chain

64 X-ray structures of homopolymeric L-ferritin obtained by freezing protein cr

65 accumulated in the cytosol as predominantly homopolymeric L-ferritin.

66 1115 coding homopolymeric loci with six or more nucleotides were ide

67 Conjugation of a homopolymeric multiubiquitin chain to a substrate lysine

68 rase RNA template domain may be analogous to homopolymeric mutational hot spots that lead to similar

69 ation to varying degrees included synthetic, homopolymeric nucleic acids such as poly(A) and poly(dT)

70 Homopolymeric nucleotide runs, also called mononucleotid

71 se a model in which DNA templates containing homopolymeric nucleotide runs, when bound to DinB, are i

72 the potential for creating -1 frameshifts in homopolymeric nucleotide runs.

73 function, as well as mutational hotspots at homopolymeric nucleotide stretches.

74 rotein is encoded by a gene that possesses a homopolymeric nucleotide tract containing eight adenine

75 The homopolymeric nucleotide tracts and dinucleotide repeats

76 regional preferences for env recombination, homopolymeric nucleotide tracts, i.e., sequences known t

77 gher than rates in the WT MA lines, although homopolymeric nucleotide-run (HP) loci composed of A:T b

78 ternating base sequence d(TG)n than with any homopolymeric oligodeoxyribonucleotide; thus, it shows a

79 The homopolymeric oligonucleotide dG/dC was modified while n

80 Using homopolymeric oligonucleotide-based substrates, we show

81 s are 1-2 bp in size and particularly affect homopolymeric or dinucleotide A or T stretch regions of

82 f individual AP sites in single molecules of homopolymeric or heteropolymeric DNA sequences.

83 ivity was detected for substrates with other homopolymeric or heteropolymeric sequences in the 5' ove

84 the La domain to discriminate 5'SL RNA from homopolymeric or purely helical hairpin RNAs with low-na

85 and between C.G and T.A base-pairs from the homopolymeric parts of the simulated sequence.

86 erase ribozyme (RPR) function, as do derived homopolymeric peptides comprising lysine or the non-prot

87 We examined the manner in which the homopolymeric poly(A) and poly(U) portions of poliovirus

88 The homopolymeric poly(A) and poly(U) portions of PV RNA pro

89 ardio- and aphthoviruses takes the form of a homopolymeric poly(C) tract.

90 nt aphthoviruses and cardioviruses have long homopolymeric poly(C) tracts in the 5' untranslated regi

91 nificant variability among genotypes, (ii) a homopolymeric poly(U) tract, (iii) a polypyrimidine stre

92 hier poly(U/UC) sequences, and possibly pure homopolymeric poly(U) tracts, were associated with more

93 or T nucleotides and occur preferentially in homopolymeric (poly A or poly T) genomic stretches.

94 r of guanine (G) residues contained within a homopolymeric [poly(G)]tract located upstream of the usp

95 eat in the Huntingtin (HTT) gene, encoding a homopolymeric polyglutamine (polyQ) tract.

96 Homopolymeric polyglutamine forms a mixture of amorphous

97 s and increases the driving force, vis-a-vis homopolymeric polyglutamine, for forming insoluble aggre

98 overed that CAG expansion constructs express homopolymeric polyglutamine, polyalanine, and polyserine

99 We show that most short homopolymeric polyleucine transmembrane proteins contain

100 eduction of interchain entanglements through homopolymeric polyQ and barriers to intermolecular assoc

101 ents a number of unique challenges: the long homopolymeric polyQ tract contains nearly identical resi

102 on of enzyme when radioactive nucleotide and homopolymeric primer/template substrates are employed.

103 Homopolymeric primer/templates of defined length were us

104 Moreover, these toxic, unexpected, homopolymeric proteins now should be considered in patho

105 These results indicated that the homopolymeric Psa fimbriae are multimeric adhesins.

106 ed proteins that assemble predominantly into homopolymeric (rather than heteropolymeric) fibrils, whi

107 were successfully demonstrated to sequence a homopolymeric region of a DNA template, facilitating the

108 ty resided in the core aspartate hexapeptide homopolymeric region, and MBC50 values of aspartate dipe

109 To sequence DNA, templates containing homopolymeric regions are immobilized on Sepharose beads

110 Disordered homopolymeric regions of single-stranded RNA, such as U

111 ent difficulty in accurately deciphering the homopolymeric regions of the DNA templates.

112 A polymerase I, Sequenase could read through homopolymeric regions with more than five T bases.

113 n given error rates in homopolymeric and non-homopolymeric regions.

114 rporated into the growing DNA strand even in homopolymeric regions.

115 nt derivatives, for +1 and -1 base errors in homopolymeric repeat sequences of three to eight base pa

116 ersible gain and loss of single bases within homopolymeric repeats as short as 6 bases, (ii) deletion

117 tern of transcription, and the presence of G homopolymeric repeats of variable lengths upstream of th

118 -I binding, which was primarily dependent on homopolymeric ribonucleotide composition, linear structu

119 r extension; these products are subjected to homopolymeric ribonucleotide tailing at the 3' termini w

120 efficient copying of all four nucleobases on homopolymeric RNA and DNA templates.

121 rmed by intrinsically disordered proteins or homopolymeric RNA molecules.

122 de a conceptual advance by defining specific homopolymeric RNA motifs within the genome of HCV and ot

123 ve in an in vitro RNA polymerase assay using homopolymeric RNA or BVDV minigenomic RNA templates.

124 nts in which capsid proteins assemble around homopolymeric RNA or synthetic polyelectrolytes.

125 he N protein forms spherical assemblies with homopolymeric RNA substrates that do not form base pairi

126 The RdRp used some homopolymeric RNA templates only in the presence of a pr

127 inds to multiple reporter mRNAs and all four homopolymeric RNAs.

128 data indicate that rootlets are composed of homopolymeric rootletin protofilaments bundled into vari

129 erein the rate of single-base deletions in a homopolymeric run in the LYS2 gene is 10 000-fold higher

130 decreases substantially as the length of the homopolymeric run increases.

131 s (G8 and G9) or one base deletion (G6) in a homopolymeric run of seven guanines (G string) in the ge

132 o single insertion frameshift mutations in a homopolymeric run, and a base substitution.

133 Pol adds single nucleotides to homopolymeric runs at particularly high rates, exceeding

134 These data suggest that homopolymeric runs in mitochondrial DNA may be particula

135 iptional slippage, is particularly likely on homopolymeric runs in the template.

136 , the sequence contains motifs consisting of homopolymeric runs of amino acids found in several other

137 These short homopolymeric runs of nucleotides were commonly found in

138 e error rate for one-nucleotide deletions in homopolymeric runs was similar for the polymerase with o

139 Changes within homopolymeric runs within lgtA, lgtC, and lgtD affect th

140 known DNA templates, the ability to quantify homopolymeric runs, and a short sequencing example of se

141 fluorescein labels, which impedes readout of homopolymeric runs, is avoided by diluting the labeled d

142 ads single nucleotide deletion mismatches in homopolymeric runs, such that the error rate is 30 singl

143 one for single nucleotide addition errors in homopolymeric runs.

144 pairs, the last occurring most frequently in homopolymeric runs.

145 le in suppressing base substitutions in N(3) homopolymeric runs.

146 mechanism to create single base deletions on homopolymeric runs.

147 e model for investigating whether functional homopolymeric septin filaments also exist.

148 in many Gram-negative organisms that possess homopolymeric sequence repeats or motifs for site-specif

149 patients contain insertions or deletions in homopolymeric sequences in the thymidine kinase (TK) gen

150 However, when copying homopolymeric sequences longer than four nucleotides, po

151 and frequently longer than the corresponding homopolymeric sequences of the respective viral RNA temp

152 DinB2 induces frameshift mutations in homopolymeric sequences, both in vitro and in vivo.

153 t lack TK activity due to mutations on other homopolymeric sequences, reactivation can occur via reve

154 had neither the pentanucleotide sequence nor homopolymeric sequences, yet replacement of the S-segmen

155 ce of several structural features, including homopolymeric serine and threonine residues, a putative

156 Within the variety of homopolymeric single- and double-stranded deoxy- and rib

157 halted complexes that can readily carry out homopolymeric slippage synthesis, this study reveals tha

158 tructure that promotes -1 frameshifting on a homopolymeric slippery sequence.

159 , (GCG)(6) encodes the first 6 alanines in a homopolymeric stretch of 10 alanines.

160 The CREB-binding protein (CBP), containing a homopolymeric stretch of 19 glutamines, was likewise fou

161 on was an insertion of an A:T base pair in a homopolymeric stretch of eight A:T base pairs, and readi

162 (GCG)6 codes for the first six alanines in a homopolymeric stretch of ten alanines.

163 trahigh localized mutation rates in specific homopolymeric stretch regions.

164 at the likelihood of occurrence of indels in homopolymeric stretches is strongly related to stretch l

165 adenylation sites due to internal priming in homopolymeric stretches of adenines.

166 e higher rates were strongly associated with homopolymeric stretches on the 454 platform.

167 ion was also observed for regions containing homopolymeric stretches.

168 challenging the view of filaments as simple homopolymeric structures that work as freely whirling wh

169 eltaC RT) retains DNA polymerase activity on homopolymeric substrates and partial RNase H activity, r

170 Using homopolymeric substrates, the minimal DNA length for act

171 H]poly(rA).poly(dT) or [3H]poly(rG).poly(dC) homopolymeric substrates.

172 ndependent transcription when transcribing a homopolymeric template such as poly(dC).

173 ication wherein reiterative transcription of homopolymeric templates ensures the synthesis of long 3'

174 Experiments with different homopolymeric templates indicate that initial deoxyribon

175 he length of one of these microsatellites, a homopolymeric thymidine [poly(T)] repeat, is measured in

176 In this study, we investigated the role of a homopolymeric thymine [poly(T)] tract -50 to -33 relativ

177 potentially non-ATG-mediated translation of homopolymeric toxic proteins.

178 aused by transient frameshift mutations in a homopolymeric tract (HT) of 7 cytosines (7C) in the glpK

179 bstitution at the TA step or in the adjacent homopolymeric tract dramatically affected affinity and p

180 Analysis of the distribution of homopolymeric tract lengths indicates that this species

181 ubject to localized hypermutation in a short homopolymeric tract of adenine residues located in the N

182 This gene contains a homopolymeric tract of cytidine [poly(C)] and we demonst

183 tG phase variation mediated by slippage of a homopolymeric tract of cytidines.

184 C. jejuni 81-176 revealed the presence of a homopolymeric tract of G residues within a gene encoding

185 ns dca is prematurely terminated following a homopolymeric tract of G's, the length of which differs

186 A homopolymeric tract of Gs (poly-G) is present in the pgt

187 d to contain an N-terminal signal peptide, a homopolymeric tract of serine residues, 36 sites of O-li

188 and deletion frameshift mutations in a short homopolymeric tract of thymine residues located in the N

189 also show that the presence of an intragenic homopolymeric tract renders the expression of a function

190 An exhaustive search for homopolymeric tracts (HPTs) identified a total of 54 var

191 insertions and deletions (INDELs) in genomic homopolymeric tracts (HT) can silence and regulate genes

192 outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding

193 bacter pylori through their association with homopolymeric tracts and dinucleotide repeats.

194 aled variation in the sequence and length of homopolymeric tracts found within these genes, providing

195 e apparently high rate of variation of these homopolymeric tracts may be important in the survival st

196 Homopolymeric tracts of C sequences, which were located

197 Likewise, the homopolymeric tracts of G sequences that are found upstr

198 aluation of the length variation of multiple homopolymeric tracts within ITS1-5.8S-ITS2.

199 The genes encoding each protein contain homopolymeric tracts, suggestive of phase variation medi

200 retation of the length variation in multiple homopolymeric tracts.