ライフサイエンスコーパス: homoserine lactone

1 ble levels of 3-oxo-C6-HL (N-3-oxohexanoyl-l-homoserine lactone).

2 to its cognate substrate 3-oxo-C10 AHL (Acyl-Homoserine Lactone).

3 of TraR and its signal N-(3-oxo-octanoyl)-L-homoserine lactone.

4 ative transfer in response to exogenous acyl-homoserine lactone.

5 e (3-oxo-C12-HSL), and N-(3-oxotetradecanoyl)homoserine lactone.

6 -L-homoserine lactone and N-3-oxo-hexanoyl-L-homoserine lactone.

7 thentic N-butyrylvinylglycine to N-butyryl-L-homoserine lactone.

8 is composed of RhlR and the signal N-butyryl homoserine lactone.

9 low, even in the presence of added butanoyl-homoserine lactone.

10 rreversibly bound two molecules of 3-oxo-C12-homoserine lactone.

11 ation was suppressed by 200 microM 3-oxo-C12 homoserine lactone.

12 N-octanoyl-homoserine lactone and N-decanoyl-homoserine lactone.

13 te autoinducer ligand and not by N-butyryl-L-homoserine lactone.

14 esponse to its quormone, N-(3-oxooctanoyl)-L-homoserine lactone.

15 s a more potent activator of LasR than other homoserine lactones.

16 irects the enzyme toward production of 3-oxo-homoserine lactones.

17 ncreases the potency of 3OC(12)HSL and other homoserine lactones.

18 llei strain GB8 that was unable to make acyl-homoserine lactones.

19 AiiA, a lactonase enzyme that degrades acyl-homoserine lactones.

20 dodecanoyl) homoserine lactone and N-butyryl homoserine lactone].

21 bel-free, realtime detection of N-hexanoyl-L-homoserine lactone (199 Da), a gram-negative bacterial i

22 sely related molecule paraquat) and the acyl-homoserine lactone 3-OC12-HSL significantly increased th

23 rast to its parent molecule 3-oxo-dodecanoyl homoserine lactone (3-oxo-C(12)-HSL), neither activation

24 dem mass spectrometry identified 3-oxo-C(14)-homoserine lactone (3-oxo-C(14)-HSL), C(16)-HSL, 3-oxo-C

25 ave determined that the AHL, 3-oxododecanoyl homoserine lactone (3-oxo-C12-(L)-HSL) can down-regulate

26 ially detectable QSSM, N-(3-oxododecanoyl)-L-homoserine lactone (3-oxo-C12-HSL) and 2-heptyl-3-hydrox

27 anoyl)homoserine lactone, N-(3-oxododecanoyl)homoserine lactone (3-oxo-C12-HSL), and N-(3-oxotetradec

28 of evidence establish that N-3-oxohexanoyl-L-homoserine lactone (3-oxo-C6-HL), the major AHL analog p

29 nI directs the synthesis of N-3-(oxohexanoyl)homoserine lactone (3-oxo-C6-HSL) and N-hexanoylhomoseri

30 to the agonistic analog N-(3-oxo-hexanoyl)-L-homoserine lactone (3-oxo-C6-HSL) exhibited similar indu

31 ne lactone (C6-HSL) and N-(3-oxo-hexanoyl)-l-homoserine lactone (3-oxo-C6-HSL) in Y. enterocolitica a

32 n was dependent on LuxR and 3-oxo-hexanoyl-l-homoserine lactone (3-oxo-C6-HSL).

33 serine lactone quormone N-(3-oxo-octanoyl)-L-homoserine lactone (3-oxo-C8-HSL).

34 serine lactone (acyl-HSL) N-3-oxo-octanoyl-L-homoserine lactone (3-oxo-C8-HSL).

35 k we report that the AHL N-(3-oxododecanoyl) homoserine lactone (3O-C(12)-HSL) from P. aeruginosa ind

36 patients and secretes N-(3-oxo-dodecanoyl)-S-homoserine lactone (3O-C12) to regulate bacterial gene e

37 ine lactones, such as N-(3-oxo-dodecanoyl)-l-homoserine lactone (3O-C12-HSL), that promote biofilm fo

38 onas aeruginosa utilizes the 3-oxododecanoyl homoserine lactone (3OC(12)-HSL) autoinducer as a signal

39 The cognate autoinducer, 3OC(12) homoserine lactone (3OC(12)HSL), is a more potent activa

40 catalyses the synthesis of N-3-oxododecanoyl homoserine lactone (3OC12) and LasR is a transcription f

41 s aeruginosa produces N-(3-oxo-dodecanoyl)-L-homoserine lactone (3OC12), a crucial signaling molecule

42 rum-sensing molecules, N-(3-oxododecanoyl)-l-homoserine lactone (3OC12-HSL) and N-butanoyl-l-homoseri

43 N-(3-oxododecanoyl)-L-homoserine lactone (3OC12-HSL) is a key component of P.

44 The signaling molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) is thought to play a cent

45 t triggers the cascade is N-3-oxo-dodecanoyl homoserine lactone (3OC12-HSL), which interacts with two

46 ctone (3OHC12-HSL) and N-(3-oxododecanoyl)-l-homoserine lactone (3OC12-HSL).

47 heri quorum-sensing signal N-3-oxohexanoyl-l-homoserine lactone (3OC6-HSL) activates expression of th

48 its quorum-sensing signal, N-(3-oxohexanoyl) homoserine lactone (3OC6-HSL), LuxR binds to lux box DNA

49 inding the signaling molecule 3-oxo-hexanoyl-homoserine lactone (3OC6HSL), an acyl-HSL with a carbony

50 ing its cognate quorum signal, 3-oxohexanoyl-homoserine lactone (3OC6HSL).

51 the autoinducer N-((R)-3-hydroxybutanoyl)-L-homoserine lactone (3OH-C4 HSL) via the two-component re

52 differentially to N-(3-hydroxydodecanoyl)-l-homoserine lactone (3OHC12-HSL) and N-(3-oxododecanoyl)-

53 rough these studies, we found that 3-oxo-C12 homoserine lactone, a cell-cell signalling molecule prod

54 protein, catalyzes synthesis of the acylated homoserine lactone (acyl-HSL) N-3-oxo-octanoyl-L-homoser

55 element and increased production of the acyl-homoserine lactone (acyl-HSL) quormone.

56 nistic pathogen Pseudomonas aeruginosa, acyl-homoserine lactone (acyl-HSL) quorum sensing (QS) regula

57 Acyl-homoserine lactone (acyl-HSL) quorum sensing is common t

58 Many Proteobacteria use N-acyl-homoserine lactone (acyl-HSL) quorum sensing to control

59 Acyl-homoserine lactone (acyl-HSL) quorum-sensing signaling i

60 rine bacterium Vibrio fischeri uses two acyl-homoserine lactone (acyl-HSL) quorum-sensing systems.

61 Burkholderia mallei has two acyl-homoserine lactone (acyl-HSL) signal generator-receptor

62 Acyl-homoserine lactone (acyl-HSL) signaling is thought to me

63 a are capable of quorum sensing using N-acyl-homoserine lactone (acyl-HSL) signaling molecules that a

64 monas aeruginosa possesses two complete acyl-homoserine lactone (acyl-HSL) signaling systems.

65 pathogen Pseudomonas aeruginosa has two acyl-homoserine lactone (acyl-HSL) signalling systems, LasR-I

66 respond to the LasI- and RhlI-generated acyl-homoserine lactone (acyl-HSL) signals 3OC12-HSL and C4-H

67 sensing systems that produce and detect acyl-homoserine lactone (acyl-HSL) signals.

68 BtaI2 is an acyl-homoserine lactone (acyl-HSL) synthase that produces two

69 Many bacteria use acyl-homoserine lactone (acyl-HSL) synthases to generate fatt

70 Bacterial quorum sensing using acyl-homoserine lactones (acyl-HSLs) as cell-density dependen

71 s in quorum-sensing systems that employ acyl-homoserine lactones (acyl-HSLs) as signal molecules.

72 antibiotics, as well as a suite of six acyl-homoserine lactones (acyl-HSLs) that includes four 3-hyd

73 (QS) as the common signaling molecule N-acyl-homoserine lactone (AHL) at concentrations 100-fold lowe

74 Gram-negative bacteria use acyl-homoserine lactone (AHL) autoinducers, which are detecte

75 example of membrane-bound receptors for acyl-homoserine lactone (AHL) autoinducers.

76 In Erwinia carotovora subspecies, N-acyl homoserine lactone (AHL) controls the expression of vari

77 oxo-dodecanoyl-L-homoserine lactone, an acyl-homoserine lactone (AHL) intercellular signaling molecul

78 N-acyl homoserine lactone (AHL) is required by Erwinia carotovo

79 N-Acyl-l-homoserine lactone (AHL) mediated quorum-sensing regulat

80 Acyl-homoserine lactone (AHL) quorum sensing controls gene ex

81 interactions with their plant hosts via acyl-homoserine lactone (AHL) quorum sensing, pectin metaboli

82 vosphingobium genus that produces the N-acyl-homoserine lactone (AHL) quorum-sensing (QS) signals.

83 N-acyl-homoserine lactone (AHL) quorum-sensing molecules produc

84 QS) system, which is mediated by an N-acyl L-homoserine lactone (AHL) signal (C(8)-AHL) and its cogna

85 ation based on chemical gradients of an acyl-homoserine lactone (AHL) signal that is synthesized by '

86 Although each system generates an acyl-homoserine lactone (AHL) signal, the protein sequences o

87 on in the presence of their cognate acylated homoserine lactone (AHL) signal.

88 g affinity is modulated by diffusible N-acyl homoserine lactone (AHL) signalling molecules.

89 olves at least half a dozen different N-acyl homoserine lactone (AHL) signals and perhaps an equal nu

90 strain M2 was found to produce distinct acyl-homoserine lactone (AHL) signals based on the use of an

91 of lasRI/rhlRI or the production of N-acyl-L-homoserine lactone (AHL) signals.

92 we report the crystal structure of the acyl-homoserine lactone (AHL) synthase LasI that produces 3-o

93 R-type proteins, LasR and RhlR, and two acyl homoserine lactone (AHL) synthases, LasI and RhlI.

94 -sensing signaling molecules of the N-acyl-l-homoserine lactone (AHL) type but they can detect AHLs p

95 sender cells synthesize an inducer, an acyl-homoserine lactone (AHL), which freely diffuses to spati

96 fects of non-thermal plasma exposure on acyl homoserine lactone (AHL)-dependent quorum sensing (QS).

97 a LuxR homologue that is inactivated by acyl-homoserine lactone (AHL).

98 nities, the exchange of signals such as acyl-homoserine lactones (AHL) enables communication within a

99 pe enzymes catalyze the biosynthesis of acyl-homoserine lactones (AHL) signals using S-adenosyl-l-met

100 biological and chemical properties with acyl-homoserine lactones (AHL), suggesting some AHLs might ac

101 ynthesis and perception of diffusible N-acyl-homoserine lactones (AHL).

102 bacteria produce a specific set of N-acyl-L-homoserine-lactone (AHL) signaling molecules for the pur

103 ter bond of the homoserine lactone of N-acyl homoserine lactone (AHLs).

104 LuxR-type transcription factors detect acyl homoserine lactones (AHLs) and are typically used by bac

105 Acyl homoserine lactones (AHLs) are a major class of quorum s

106 tive of bacterial quorum sensing, where acyl homoserine lactones (AHLs) are both produced and sensed

107 quorum sensing in bacteria that use N-acyl-l-homoserine lactones (AHLs) as intercellular signaling mo

108 in natural biofilm communities using N-acyl homoserine lactones (AHLs) as one type of signaling mole

109 Quorum sensing (QS) using N-acyl homoserine lactones (AHLs) as signal molecules is a comm

110 mber of Gram-negative bacteria employ N-acyl homoserine lactones (AHLs) as signaling molecules in quo

111 ignal exchange, such as the exchange of acyl-homoserine lactones (AHLs) by Gram-negative bacteria.

112 sensing systems are those that use acylated homoserine lactones (AHLs) for communication.

113 Enzymes able to degrade or modify acyl-homoserine lactones (AHLs) have drawn considerable inter

114 ent manner by auto-inducers, like the N-acyl homoserine lactones (AHLs) in numerous Gram-negative bac

115 We reported that SdiA senses acyl homoserine lactones (AHLs) in the bovine rumen to activa

116 Profiles of N-acyl-homoserine lactones (AHLs) isolated from the wild type a

117 phiphilic inducer molecules such as N-acyl-L-homoserine lactones (AHLs) or isopropyl-beta-D-thio-gala

118 uxR homolog, SdiA, which can detect the acyl-homoserine lactones (AHLs) produced by other bacteria an

119 C harbors SdiA, a regulator that senses acyl-homoserine lactones (AHLs) produced by other bacteria.

120 reviously demonstrated that EHEC senses acyl-homoserine lactones (AHLs) produced by the microbiota in

121 cteria produce and utilize diffusible N-acyl-homoserine lactones (AHLs) to regulate the expression of

122 Enzymes capable of hydrolyzing N-acyl- l-homoserine lactones (AHLs) used in some bacterial quorum

123 oserine, homoserine lactone and certain acyl homoserine lactones (AHLs) were found to substitute for

124 Here, we propose a mechanism for how N-acyl-homoserine lactones (AHLs), a group of QS molecules, inf

125 ensing-associated signaling molecules N-acyl homoserine lactones (AHLs), such as butanoyl and hexanoy

126 cell-cell communication via exchange of acyl homoserine lactones (AHLs).

127 lular signal molecules, such as the N-acyl-l-homoserine lactones (AHLs).

128 onella is a LuxR homolog that detects N-acyl homoserine lactones (AHLs).

129 actor(s) that is not lipopolysaccharide, C12 homoserine lactone, alginate, CIF, or exotoxin A, S, T,

130 ned biochar sorption of N-3-oxo-dodecanoyl-L-homoserine lactone, an acyl-homoserine lactone (AHL) int

131 sformation into procyclic forms, homoserine, homoserine lactone and certain acyl homoserine lactones

132 with a 12-carbon chain length, e.g. C12-acyl homoserine lactone and dodecanol also affected C. albica

133 t PAO-MW1 alongside plasma treated N-butyryl-homoserine lactone and n-(3-oxo-dodecanoyl)-homoserine l

134 the predominant AHLs were N-3-oxooctanoyl-L-homoserine lactone and N-3-oxo-hexanoyl-L-homoserine lac

135 exogenous autoinducers [N-(3-oxododecanoyl) homoserine lactone and N-butyryl homoserine lactone].

136 . aeruginosa autoinducers, N-3-oxododecanoyl-homoserine lactone and N-butyryl-homoserine lactone, can

137 produces the signaling molecules N-octanoyl-homoserine lactone and N-decanoyl-homoserine lactone.

138 cited against a lactam mimetic of the N-acyl homoserine lactone and represents the only reported mono

139 em is RhlI and RhlR, which generate butanoyl-homoserine lactone and respond to butanoyl-homoserine la

140 t is measured for hydrolysis of N-hexanoyl-l-homoserine lactone and the corresponding thiolactone by

141 ed library of synthetic, non-native N-acyl l-homoserine lactones and identified compounds that can dr

142 focused collections of non-native N-acylated homoserine lactones and the systematic evaluation of the

143 ased production of the QS molecule 3-O-C(12)-homoserine lactone, and QS-regulated virulence factors p

144 odecanoyl)-L-homoserine lactone, N-butyryl-L-homoserine lactone, and the Pseudomonas quinolone signal

145 xy-4(1H)-quinolone and N-(3-oxododecanoyl)-l-homoserine lactone, and the redox mediator pyocyanin bin

146 its cell-to-cell signal, N-(3-oxododecanoyl) homoserine lactone, and the rhl system is composed of Rh

147 ds, including expensive N-alkyl amino acids, homoserine lactones, and Agl lactams, and to achieve the

148 ch as diffusible signal factors (DSFs), acyl-homoserine lactones, and autoinducer-2 systems.

149 of the ring-opened product of N-hexanoyl- l-homoserine lactone are determined at 0.95 and 1.4 A reso

150 mall diffusible molecules, specifically acyl-homoserine lactones, are produced by P. aeruginosa to pr

151 rum-sensing systems, ain and lux, using acyl homoserine lactones as signaling molecules.

152 systems (Sin, Tra, and Mel) that use N-acyl homoserine lactones as their quorum-sensing signal molec

153 C3193 produce 3-oxo-C8-HL (N-3-oxooctanoyl-l-homoserine lactone) as the major AHL analog as well as l

154 to quorum sensing inhibitor (QSI) - a N-acyl homoserine lactone autoinducer antagonist - and then dos

155 es that bind in place of the native acylated homoserine lactone autoinducer, provided that they stabi

156 x reactions to some irritants including acyl-homoserine lactone bacterial quorum-sensing molecules, w

157 Many bacteria are capable of acyl-homoserine lactone-based or peptide-based intraspecies q

158 Our analysis revealed that acyl-homoserine lactone-based quorum sensing controls the exp

159 wn to be positively regulated by an N-acyl-L-homoserine lactone-based quorum sensing system, but oper

160 ous virulence factors, by N-3-oxododecanolyl homoserine lactone binding to the quorum sensing recepto

161 ly formed product from N-(3-oxododecanoyl)-L-homoserine lactone; both the N-acylhomoserine and its no

162 e catalyzes the hydrolysis of N-hexanoyl-(S)-homoserine lactone but not the (R) enantiomer.

163 requires the quorum-sensing signal butanoyl-homoserine lactone, but other factors are also required

164 CviI synthesizes the autoinducer C(10)-homoserine lactone (C(10)-HSL), and CviR is a cytoplasmi

165 long with its cognate autoinducer, N-butyryl homoserine lactone (C(4)-HSL), regulates gene expression

166 ctones (AHLs), such as butanoyl and hexanoyl homoserine lactones (C(4)- and C(6)-HSLs), as well as N-

167 -homoserine lactone (C8-HSL), and N-decanoyl-homoserine lactone (C10-HSL).

168 The bacterial molecule N-3-oxo-dodecanoyl-l-homoserine lactone (C12) has critical roles in both inte

169 owed that the bacterial N-(3-oxo-dodecanoyl) homoserine lactone (C12) selectively impairs the regulat

170 ing molecules, including N-(3-oxododecanoyl)-homoserine lactone (C12), for intercellular communicatio

171 g- and short-chain AHLs, N-3-(oxododecanoyl)-homoserine lactone (C12-HSL) and N-butyryl homoserine la

172 RhlI catalyses the synthesis of N-butanoyl homoserine lactone (C4) and RhlR is a transcription fact

173 xoproducts but retained wild-type N-butanoyl homoserine lactone (C4-HSL) levels.

174 phase, epithelial cell contact, and butanoyl homoserine lactone (C4-HSL), a quorum sensing signaling

175 )-homoserine lactone (C12-HSL) and N-butyryl homoserine lactone (C4-HSL), on cell viability and mucus

176 growth, addition of the RhlI product butyryl-homoserine lactone (C4-HSL), or bacteria that produce C4

177 oserine lactone (3OC12-HSL) and N-butanoyl-l-homoserine lactone (C4-HSL), to control production of ex

178 ion by a large excess of exogenous N-butyryl homoserine lactone (C4-HSL).

179 the diet, reduce the levels of N-hexanoyl-l-homoserine lactone (C6-HSL) and N-(3-oxo-hexanoyl)-l-hom

180 rly effective alkanoyl acyl-HSL N-hexanoyl-L-homoserine lactone (C6-HSL) required the continued prese

181 type B. thailandensis synthesizes N-hexanoyl-homoserine lactone (C6-HSL), N-octanoyl-homoserine lacto

182 oli and a candidate autoinducer N-octanoyl-L-homoserine lactone (C8-HSL) has been calculated in solut

183 noyl-homoserine lactone (C6-HSL), N-octanoyl-homoserine lactone (C8-HSL), and N-decanoyl-homoserine l

184 SUPB145, was restored by 1 microM N-octanoyl homoserine lactone (C8-HSL).

185 However, other homoserine lactones can elicit LasR-dependent quorum-sen

186 ododecanoyl-homoserine lactone and N-butyryl-homoserine lactone, can both enter eukaryotic cells and

187 QS in P. aeruginosa involves two acyl-homoserine-lactone circuits, LasI-LasR and RhlI-RhlR.

188 al signals, most of which belong to the acyl-homoserine lactone class.

189 Exposure of this strain to exogenous N-acyl-homoserine lactone counteracts this adhesion phenotype.

190 on of mRFP1 with ahlI, which exhibits N-acyl homoserine lactone-dependent transcriptional activity, a

191 We show that two other homoserine lactone derivatives are also capable of actin

192 haride, rhamnolipids, lipopeptides, and acyl-homoserine-lactones-do not trigger LORE-dependent respon

193 -homoserine lactone and n-(3-oxo-dodecanoyl)-homoserine lactone, exhibited marked attenuation of viru

194 n density by utilizing members of the N-acyl homoserine lactone family as inducers and a transcriptio

195 the esaR gene and responds to exogenous acyl-homoserine lactone for derepression.

196 on factor, QscR, bound to N-3-oxo-dodecanoyl-homoserine lactone from the opportunistic human pathogen

197 ate group onto the gamma-carbon, affording L-homoserine lactone (HSL) and 5'-methylthioadenosine (MTA

198 nsing system consisting of TraR and its acyl-homoserine lactone (HSL) ligand.

199 g systems that produce and detect fatty acyl-homoserine lactone (HSL) signals.

200 Interestingly, exogenously added C(4)-homoserine lactone (HSL), but not 3-oxo-C(12)-HSL, resto

201 mutants, which do not respond to 3-oxo-C(12)-homoserine lactone (HSL)-mediated QS, exhibit reduced vi

202 monas aeruginosa secrete N-(3-oxododecanoyl)-homoserine lactone (HSL-C12) as a quorum-sensing molecul

203 Acyl-homoserine lactones (HSLs) serve as quorum-sensing signa

204 tor QscR responds to a variety of fatty acyl-homoserine lactones (HSLs), including N-3-oxododecanoyl-

205 three-dimensional structure of the N-acyl-l-homoserine lactone hydrolase (AHL lactonase) from Bacill

206 tivator A (AiiA) is a metal-dependent N-acyl homoserine lactone hydrolase that displays broad substra

207 The N-acyl- l-homoserine lactone hydrolases (AHL lactonases) have attr

208 des the quorum-sensing receptor for N-acyl-l-homoserine lactone in Escherichia coli.

209 Furthermore, N-(3-oxo-dodecanoyl)homoserine lactone induced distension of mitochondria an

210 icient in the synthesis of a diffusible acyl-homoserine lactone inducer remain repressed for EPS synt

211 sa's main QS molecule, N-(3-Oxododecanoyl)-L-homoserine lactone, induces candidal resistance to fluco

212 oof of concept, we characterize a set of Lux homoserine-lactone-inducible genetic devices with differ

213 ydra to specifically modify long-chain 3-oxo-homoserine lactones into their 3-hydroxy-HSL counterpart

214 Signaling via acyl-homoserine lactones is the paradigm for QS in Proteobact

215 We identify mutants that alter which homoserine lactones LasR detects.

216 Although acyl-homoserine lactone levels in cultures of this strain are

217 n 11.2 kDa antiactivator, modulates the acyl-homoserine lactone-mediated autoinduction of Ti plasmid

218 ent recently published reports indicate that homoserine lactone-mediated quorum sensing regulates the

219 Many Proteobacteria use acyl-homoserine lactone-mediated quorum-sensing (QS) to activ

220 we provide evidence that N-(3-oxo-dodecanoyl)homoserine lactone-mediated signaling does not require t

221 These findings suggest that N-(3-oxo-acyl)homoserine lactones might be recognized by receptors of

222 The acyl-homoserine lactone molecular species (AHLs) produced by

223 , in the presence of 1-100 nM exogenous acyl-homoserine lactone molecules has been quantified.

224 ction of Pig and Car is controlled by N-acyl homoserine lactone (N-AHL) quorum sensing, with synthesi

225 AHLs synthesized via YenI: N-(3-oxodecanoyl)homoserine lactone, N-(3-oxododecanoyl)homoserine lacton

226 cell-to-cell signals, N-(3-oxododecanoyl)-L-homoserine lactone, N-butyryl-L-homoserine lactone, and

227 and rhlI genes, impairing the production of homoserine lactones necessary for quorum-sensing, an imp

228 onstrate that the QSSM N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL) from P. aeruginosa blocks pro

229 sing (QS) signal molecule 3-oxo-dodecanoyl-L-homoserine lactone (OdDHL) is produced by the opportunis

230 enzyme that hydrolyzes the ester bond of the homoserine lactone of N-acyl homoserine lactone (AHLs).

231 In contrast, other acylated homoserine lactones of different chain lengths did not a

232 s on the production of a N-(3-oxohexanoyl)-L-homoserine lactone (OHHL) quorum sensing (QS) signal.

233 nsing (QS) signal molecule, 3-oxo-hexanoyl-l-homoserine lactone (OHHL), and (ii) the intracellular 'a

234 ing signalling molecule, N-(3-oxohexanoyl)-L-homoserine lactone (OHHL).

235 the signalling molecule, N-(3-oxohexanoyl)-l-homoserine lactone (OHHL).

236 the quorum sensing molecule (N-3-oxohexanoyl-homoserine lactone; OHHL) and PCWDEs.

237 anding of the effects of N-(3-oxo-dodecanoyl)homoserine lactone on host cells and its role in persist

238 the quorum-sensing signal N-3-oxooctanoyl- l-homoserine lactone (OOHL) and a C-terminal domain that b

239 raR requires the pheromone N-3-oxooctanoyl-L-homoserine lactone (OOHL) for biological activity, and i

240 ires its cognate autoinducer N-3-oxooctanoyl-homoserine lactone (OOHL) for resistance of proteolysis

241 he presence of the autoinducer 3-oxooctanoyl-homoserine lactone (OOHL).

242 the autoinducer pheromone N-3-oxooctanoyl-l-homoserine lactone (OOHL).

243 nts from A. tumefaciens (i.e. 3-oxooctanyl-l-homoserine lactone [OOHL]) synthesized by the TraI prote

244 N-3-oxo-tetradecanoyl-l-homoserine lactone (oxo-C14-HSL) primed plants for enhan

245 The yenI(+) EHEC produces oxo-C6-homoserine lactone (oxo-C6-HSL) and had a significant re

246 signal synthase, which produces p-coumaroyl-homoserine lactone (pC-HSL) and RpaR, which is a pC-HSL-

247 ynthesized quorum-sensing signal p-coumaroyl-homoserine lactone (pC-HSL).

248 gulated by the quorum-sensing signal, N-acyl homoserine lactone, plant signals, an assortment of tran

249 ssor of Pig and Car when levels of N-acyl- l-homoserine lactones, produced by SmaI, are low.

250 n secretion profile and increased N-butanoyl homoserine lactone production and influenced several quo

251 transcriptional activator TraR and its acyl-homoserine lactone quormone N-(3-oxo-octanoyl)-L-homoser

252 Acyl-homoserine lactone quorum sensing appears to be a system

253 rkholderia thailandensis contains three acyl-homoserine lactone quorum sensing circuits and has two a

254 in, which appears to bind and sequester some homoserine lactone quorum signals, resulting in the inab

255 aeruginosa utilizes two interconnected acyl-homoserine lactone quorum-sensing (acyl-HSL QS) systems,

256 The acyl-homoserine lactone quorum-sensing (QS) systems of these

257 thelium and is activated in response to acyl-homoserine lactone quorum-sensing molecules secreted by

258 yet another subtle regulatory layer for acyl-homoserine lactone quorum-sensing signal-responsive tran

259 c bacterium Pseudomonas aeruginosa uses acyl-homoserine lactone quorum-sensing signals to coordinate

260 Vibrio fischeri possesses two acyl-homoserine lactone quorum-sensing systems, ain and lux,

261 There are two interrelated acyl-homoserine lactone quorum-sensing-signaling systems in P

262 ession, resulting in increased N-(butyryl)-l-homoserine-lactone quorum sensing signal and decreased E

263 xy-4(1H)-quinolone and N-(3-oxododecanoyl)-l-homoserine lactone reporter assays, showing that Fap fib

264 l-homoserine lactone and respond to butanoyl-homoserine lactone, respectively.

265 the cps cluster are significantly more acyl-homoserine lactone responsive than genes located towards

266 n is the founding member of a family of acyl-homoserine lactone-responsive quorum-sensing transcripti

267 eived through binding to LuxR-type, acylated-homoserine-lactone-responsive transcription factors.

268 Although the acyl-homoserine lactone responsiveness of both proteins is th

269 ion of the lasI mutant with 3-oxo-dodecanoyl homoserine lactone restores pel transcription to the wil

270 Because acyl-homoserine lactones serve as quorum-sensing molecules fo

271 Acyl-homoserine lactones serve as quorum-sensing signals for

272 The LasI-generated 3-oxododecanoyl-homoserine lactone serves as a signal molecule for QscR.

273 d the bacterial signaling molecule 3-oxo-C12-homoserine lactone, showing the necessity for cholinergi

274 QscR uses the LasI-generated acyl-homoserine lactone signal and controls a specific regulo

275 I and LasR, which generate a 3-oxododecanoyl-homoserine lactone signal and respond to that signal, re

276 transcriptional regulator that responds to a homoserine lactone signal to activate expression of acut

277 In such a system, binding of an acyl-homoserine lactone signal to its cognate transcriptional

278 ng signals for many Proteobacteria, and acyl-homoserine lactone signaling is known to control coopera

279 olone signal (PQS), which interacts with the homoserine lactone signaling pathway.

280 nd the glyoxylate bypass are induced by acyl-homoserine lactone signaling.

281 P. aeruginosa uses at least two N-acyl l-homoserine lactone signals and three homologous LuxR-typ

282 were not deficient in production of acylated homoserine lactone signals or catalase activity.

283 any Gram-negative bacteria involves acylated homoserine lactone signals that are perceived through bi

284 Along with their cognate acyl-homoserine lactone signals, the quorum sensing regulator

285 converse bidirectionally by exchanging acyl-homoserine lactone signals.

286 LasI is an acyl-homoserine lactone synthase that produces a quorum-sensi

287 ene, which is co-transcribed with the N-acyl-homoserine-lactone synthase gene cinI, is required to fu

288 to discovering inhibitors of LuxI-type acyl-homoserine lactone synthases.

289 L were found to efficiently hydrolyze N-acyl homoserine lactones that mediate quorum sensing in many

290 N-(3-oxo-dodecanoyl) homoserine lactone, the autoinducer of the Pseudomonas a

291 ssion system, whereas in the absence of acyl homoserine lactones, the protein is expressed into insol

292 kers of the effects induced by N-(3-oxo-acyl)homoserine lactones, the secreted products of a number o

293 lactonase catalyzing the hydrolysis of acyl-homoserine lactones; these molecules are involved in Gra

294 es, with low efficiency, lactones other than homoserine lactones, thus preceding the detoxifying func

295 P. aeruginosa releases N-(3-oxo-dodecanoyl) homoserine lactone to suppress host immunity for its own

296 t greatly influenced by addition of butanoyl-homoserine lactone to the biofilm growth medium.

297 Compound 12b, 3-oxo-12-phenyldodecanoyl-L-homoserine lactone, was identified as a lead compound wi

298 reased amounts of rhamnolipids and N-butyryl homoserine lactone were detected in the biofilm effluent

299 n of the AinS-generated pheromone N-octanoyl homoserine lactone, which may account for the previously

300 hat recognizes the naturally-occuring N-acyl homoserine lactone with high affinity.