ライフサイエンスコーパス: homotrimer

1 active ecto-ATPase quaternary structure (the homotrimer).

2 rimers are identical in amino acid sequence (homotrimers).

3 iction enzymes but uniquely assembles into a homotrimer.

4 density in all three active sites of the MIF homotrimer.

5 ant CERT proteins containing the UVB-induced homotrimer.

6 endent of the presence of its N-terminal DBD homotrimer.

7 tein and forms a target membrane-inserted E1 homotrimer.

8 fusion loop and refolds to form a stable E1 homotrimer.

9 ll inserts into target membranes and forms a homotrimer.

10 kDa, which is consistent with it being an S homotrimer.

11 ein and induces the formation of a stable E1 homotrimer.

12 to proteolysis in the protease-resistant E1 homotrimer.

13 fic epitopes, and formation of the stable E1 homotrimer.

14 nactive monomer to the DNA-binding competent homotrimer.

15 s, resulting in the formation of a stable E1 homotrimer.

16 ated mass of 88 kDa, suggesting that it is a homotrimer.

17 1, which assembles into a large, multidomain homotrimer.

18 -coil interface with the other chains in the homotrimer.

19 n, Ara h 1 was shown to form a highly stable homotrimer.

20 ses establish that purified AcpS exists as a homotrimer.

21 tion-specific epitope and formation of an E1 homotrimer.

22 the purified OASS is either a homodimer or a homotrimer.

23 igase I undergoes self-association to form a homotrimer.

24 MvINS exists as a homotrimer.

25 or binding at the remaining two sites of the homotrimer.

26 me which bind equally to all subunits of the homotrimer.

27 0 ectodomain exists as an elongate, flexible homotrimer.

28 ng that its native conformation is that of a homotrimer.

29 h target liposome membranes, and form the E1 homotrimer.

30 ng the lack of efficient formation of the E1 homotrimer.

31 artilages and consists of a disulfide-linked homotrimer.

32 ntermolecularly disulfide-linked ecto-ATPase homotrimer.

33 te of unknown function between subunits of a homotrimer.

34 the SUN2 protein SUN domain, which reveals a homotrimer.

35 eractions, by axial rotation of the collagen homotrimer.

36 binds to the outside surface of the PabPCNA homotrimer.

37 protein that assembles as a pseudohexameric homotrimer.

38 all studies of collagen helices have been on homotrimers.

39 e uncharacteristic formation of proalpha1(I) homotrimers.

40 t nucleoplasmic NF7 exists primarily as free homotrimers.

41 ermined from the analysis of charge pairs in homotrimers.

42 without preactivation that unravels the CHP homotrimers.

43 ately 700 kDa, all of which were composed of homotrimers.

44 hat mediate membrane fusion usually exist as homotrimers.

45 tendency of the transmembrane helix to form homotrimers.

46 -tail-tendon homotrimers were similar to oim homotrimers.

47 , resulting in rings composed of five to six homotrimers.

48 p70 promoter when compared with HSF1 or HSF2 homotrimers.

49 sphatases, namely, that they may function as homotrimers.

50 rol, and sphingolipid and form highly stable homotrimers.

51 extensive post-translational modification of homotrimers.

52 d the kinetically trapped misfolded form are homotrimers.

53 lpha-helical and sufficient for formation of homotrimers.

54 copy dUTPases have been shown to assemble as homotrimers.

55 not cleave the C-propeptide of pro-alpha1(V) homotrimers.

56 contrast to the native molecule which forms homotrimers.

57 ike seed storage proteins that organize into homotrimers.

58 d for the ability of these molecules to form homotrimers.

59 h in response to lymphotoxin alpha (LTalpha) homotrimers.

60 -10 and CL-11, as opposed to CL-10 and CL-11 homotrimers.

61 ly linked F2 and F1 polypeptides that formed homotrimers.

62 and mechanical behavior between hetero- and homotrimers.

63 imer formation and simultaneously discourage homotrimers.

64 mposition due to varying amounts of residual homotrimers.

65 ntiparallel beta sheets and that they formed homotrimers.

66 stinct structural similarity to the resistin homotrimer, a small cytokine associated with obesity and

67 d embryonic survival suggest that alpha1(V)3 homotrimers, a rare collagen V isoform that occurs in th

68 cinomas are reported to contain alpha1(I)(3) homotrimers, a type I collagen isoform normally not pres

69 Ligation by PSTPIP1, which is also a homotrimer, activates pyrin by unmasking its PYD, thereb

70 turbidity most likely caused by formation of homotrimer aggregates.

71 smaller amounts of stable [pro alpha 1(I)]3 homotrimer also being formed.

72 s are believed to have evolved from the same homotrimer ancestor and they have substantial sequence h

73 ious studies have shown that the enzyme is a homotrimer and adopts a pinwheel shape.

74 y contacts of DIII-stem in the alphavirus E1 homotrimer and describe a sensitive and quantitative in

75 UT-B is a homotrimer and each protomer contains a urea conduction

76 actor 1 (HSF1) is converted to a DNA-binding homotrimer and is hyperphosphorylated.

77 CNA), a potential anticancer target, forms a homotrimer and is required for DNA replication and numer

78 LTalpha is secreted as a homotrimer and signals through two TNF receptors of 55-6

79 teraction of the protein subunits within the homotrimer and their interaction with the viral and targ

80 tumor necrosis factor receptors (TNFRs) as a homotrimer and via lymphotoxin beta receptor (LTbetaR) a

81 We design homotrimers and heterodimers that are stable above pH 6.

82 every natural amino acid, can evaluate both homotrimers and heterotrimers, and accounts for all poss

83 strated that EMILIN-3 forms disulfide-bonded homotrimers and higher order oligomers.

84 with a Mr indicative of the existence of SBP homotrimers and homodimers.

85 n Xenopus oocytes, we found that MEC-4 forms homotrimers and MEC-4 and MEC-10 form 4:4:10 heterotrime

86 nce, we studied interactions of alpha1(I)(3) homotrimers and normal alpha1(I)(2)alpha2(I) heterotrime

87 ExbB and ExbD complexes were homodimers and homotrimers and suggested that ExbB also interacted with

88 eratures revealed that microunfolding of oim homotrimers and wild-type heterotrimers occurs at simila

89 The transporter is a homotrimer, and each subunit contains a continuous membr

90 ce that NF7 is recruited to the nucleus as a homotrimer, and expression of several mutated forms of N

91 2 mutant was fully infectious, formed the E1 homotrimer, and had the wild-type pH dependence of infec

92 the characteristic stability of the starting homotrimer, and is free of lipid and other contaminants.

93 The inner membrane component AcrB is a homotrimer, and it has been postulated that the monomers

94 The enzyme is a homotrimer, and previous studies suggested that the acti

95 cherichia coli, AcrB, is known to exist as a homotrimer, and this construction is essential for drug

96 Homotrimers are further discouraged by reducing hydroxyp

97 m of chain assembly and why [pro alpha2(1)]3 homotrimers are not formed.

98 s in fibers from type I (as well as type II) homotrimers are not sensitive to pH between pH 6 and 7.5

99 Because the homotrimers are universally secreted by cancer cells and

100 y within this region, matrilin-2 will form a homotrimer as matrilin-1 does.

101 he left-handed beta-helix family and forms a homotrimer as the functional unit.

102 died in the past using collagen-like peptide homotrimers as a model system.

103 proline motifs to create optimal packing in homotrimer assembly distinct from classical trimeric coi

104 early phases of folding, but no longer after homotrimer assembly.

105 n purine nucleoside phosphorylase (PNP) is a homotrimer binding tightly to the transition state analo

106 SAT (a dimer of homotrimers) binds a maximum of two molecules of OASS (a

107 known as BlyS) was initially described as a homotrimer, but Liu and colleagues claim that it is a 60

108 droxylase 2 (PHD2) readily crystallises as a homotrimer, but with a sterically blocked active site.

109 In contrast, angiopoietin-1 forms some homotrimers, but predominantly exists in higher order mu

110 ther TNF superfamily ligands are noncovalent homotrimers, but the form under which CD40 exists in the

111 pological arrangement of monomers within the homotrimer by comparing atomic force microscopy (AFM) im

112 The chimeric A-NC1 peptide forms a homotrimer by itself, and a series of heterotrimers with

113 ssive addition of monomers to homodimers and homotrimers, can cause substantial amounts of protein to

114 tional alpha2 chains and formation of type I homotrimers cause severe bone pathology (osteogenesis im

115 ain by an alpha-1 chain, resulting also in a homotrimer collagen molecule.

116 f a section of mouse type I heterotrimer and homotrimer collagen molecules are developed to explore t

117 We found that at the same heating rate oim homotrimers completely denature at approximately 2.5deg.

118 The homotrimers completely replace the heterotrimers only in

119 induced the rapid formation of a stable CERT homotrimer complex in keratinocytes as determined by Wes

120 ositol-3-phosphate synthase (IP synthase), a homotrimer composed of a 68-kDa polypeptide in most mamm

121 The human copper transporter hCTR1 is a homotrimer composed of a plasma membrane protein of 190

122 YfkE forms a homotrimer, confirmed by disulfide crosslinking.

123 ive structure and convert to a highly stable homotrimer conformation during the fusion of the viral a

124 both the prefusion dimer and the postfusion homotrimer conformations.

125 The fiber protein is a homotrimer consisting of an N-terminal tail, a long shaf

126 rget membranes and refolds to a hairpin-like homotrimer containing a central core trimer and an outer

127 Human PNP is a homotrimer containing three tryptophan residues at posit

128 n purine nucleoside phosphorylase (PNP) is a homotrimer, containing three nonconserved tryptophan res

129 determined for the class I proteins, the E1 homotrimer contains the fusion peptide region responsibl

130 The homotrimer contains three high affinity ATP-binding site

131 n of MIF or the functional activities of MIF homotrimers could have therapeutic benefits during ocula

132 y more stable than the corresponding alanine homotrimer (deltaT(m) = 25 degrees C, deltadeltaG(unf) =

133 At the same, constant temperature, homotrimers denature approximately 100 times slower than

134 The crystal structure of the E. coli LpxA homotrimer, determined previously at 2.6 A in the absenc

135 The crystal structure of the E. coli LpxA homotrimer, determined previously in the absence of lipi

136 s results in secretion of collagen alpha1(I) homotrimer, diminished intracellular colocalization of c

137 iquitin to reside on the surface of the PCNA homotrimer, distinct from the position identified in the

138 pathology; for example, synthesis of 10-15% homotrimers due to a polymorphism in the alpha1(I) gene

139 the viral fusion peptide and forms a stable homotrimer during fusion.

140 fusion peptide loop and converts to a stable homotrimer during the fusion reaction.

141 mer to a highly stable, membrane-inserted E1 homotrimer (E1HT).

142 Within the context of the homotrimer, each H-NS1-64 protomer consists of three alp

143 Within a homotrimer, each monomer-monomer interface exhibits an a

144 stacked rings in the pore formed by the CTR1 homotrimer, each of which is required for maximal copper

145 al that in contrast to the heterotrimer, the homotrimer easily forms kinks and freely rotates with an

146 ystal structure of the Escherichia coli LpxD homotrimer (EcLpxD).

147 The approximately 84-kDa Pgp3 homotrimer, encoded on a cryptic plasmid, consists of gl

148 Deletion of Col1 homotrimers enhances T cell infiltration and enables eff

149 a stability comparable to that of a (POG)10 homotrimer even though D and K occur 20 times in the het

150 We observed the homotrimer fibers to be resistant to pericellular degrad

151 The aggregates promoted nucleation of homotrimer fibrils that served as seeds for mixed and he

152 The physiological importance of the homotrimer for chemotaxis was demonstrated with site-dir

153 s suggest that invasive cancer cells may use homotrimers for building MMP-resistant invasion paths, s

154 odel of collagen VIII assembly in which four homotrimers form a tetrahedron stabilized by central int

155 Thus, UVB-induced CERT homotrimer formation accounts, at least in part, for apo

156 However, both G91A membrane association and homotrimer formation had an acid-shifted pH threshold an

157 rity of CBF1 point mutants were deficient in homotrimer formation, proteolytic processing, and transp

158 ain of the CERT protein was required for the homotrimer formation, whereas neither the pleckstrin hom

159 association, but was essentially inactive in homotrimer formation.

160 order self-assembly but was dispensable for homotrimer formation.

161 a purification method for the E1 ectodomain homotrimer from the alphavirus Semliki Forest virus.

162 The crystal structure of the TgMIF homotrimer has been determined to 1.82 A, and although i

163 However, the [pro alpha 2(1)]3 homotrimer has not been detected, raising questions as t

164 and reconstituted fibers composed of type I homotrimers, heterotrimers and their mix.

165 positions was required to generate a stable homotrimer; however, the driving force for Smad2 self-as

166 eat and hydrogen peroxide to assemble into a homotrimer in a reversible and redox-regulated manner.

167 Pyrin exists as a homotrimer in an autoinhibited state due to intramolecul

168 imer or about the mechanism of action of the homotrimer in fusion.

169 We show that TcpB is a homotrimer in its crystallographic form as well as in so

170 ng ligand (TRAIL) protein is known to form a homotrimer in solution.

171 so demonstrated the dissociation of the PCNA homotrimer in the presence of NEIL1 and DNA, while small

172 The presence of the GDPDLd17 homotrimer in the viral baseplate structure involved in

173 The protein assembles into a propeller-like homotrimer in which each blade contains a GT-B-type glyc

174 We showed that LAMP-2A exists as a homotrimer in which the membrane-spanning helices wrap a

175 sent in healthy tissues, but the role of the homotrimers in cancer pathophysiology is unclear.

176 uration recombinant Scl proteins migrated as homotrimers in gel electrophoresis with and without SDS.

177 comparison, we report forces between type II homotrimers in reconstituted fibers.

178 wild type and mutant PCNAs were able to form homotrimers in solution and to sustain growth of a null

179 Modelling of E1 homotrimers in the post-fusion state predicts that ruhug

180 alpha1(VIII) and alpha2(VIII), that can form homotrimers in vitro and in vivo.

181 This coiled-coil domain forms a homotrimer, in both solution and crystal structure, and

182 rsion from a dimer on the virus surface to a homotrimer inserted into the host cell membrane.

183 tions resulting in formation of alpha1(I)(3) homotrimers instead of normal type I collagen cause mild

184 on by protrusion of extended E1-glycoprotein homotrimers into the target membrane.

185 Each subunit of the chalice-shaped homotrimer is composed of short amino and carboxy termin

186 Formation of the E1 homotrimer is critical to membrane fusion, but the mecha

187 ha2 chain, the hydroxyproline content of the homotrimer is higher than the heterotrimer, which may ac

188 he R-Smad/Smad4 heterotrimer over the R-Smad homotrimer is largely enthalpy driven, contributed by th

189 h concentration, formation of a proton-bound homotrimer is observed in the case of N-methylaziridine.

190 However, the cyclohexylalanine homotrimer is of comparable stability to the 2:1 complex

191 The structure of the homotrimer is that of a trimeric hairpin in which E1 dom

192 hypothesize that the lack of pro alpha 2(I) homotrimers is not due to the inability of the C-pro alp

193 In a homotrimer, it is impossible to determine whether the co

194 vation process involves the formation of HSF homotrimers, leading to high-affinity DNA binding.

195 ytokines, heterotrimer LT alpha 1 beta 2 and homotrimer LIGHT, and activates multiple signaling pathw

196 SEC indicated that all variants purified as homotrimers like the wild type.

197 iological unit is a 24-mer composed of eight homotrimers located at the corners of a cubic cage-like

198 ether LT alpha functions through an LT alpha homotrimer (LT alpha3) or LT alpha/beta heterotrimers.

199 alpha and beta subunits and is secreted as a homotrimer, LTalpha3.

200 I) chain capable of forming a triple-helical homotrimer not normally found in nature.

201 mes: ATCase, previously considered a Class C homotrimer, now falls into Class A, whereas the DHOase i

202 (3)) mice as well as artificial alpha1(I)(3) homotrimers obtained by refolding of rat-tail-tendon col

203 The homotrimers occur in fetal tissues, fibrosis, and cancer

204 diacylglycerol kinase (DAGK) functions as a homotrimer of 13 kDa subunits, each of which has three t

205 chromatography showed that the protein was a homotrimer of 34-kDa catalytic chains.

206 Procollagen VII is a homotrimer of 350-kDa pro-alpha1(VII) chains, each consi

207 Procollagen VII is a homotrimer of 350-kDa proalpha1(VII) chains.

208 Human copper transporter 1 (hCTR1) is a homotrimer of a 190-amino acid monomer having three tran

209 strated that only 2 equiv of AdoCbl bind per homotrimer of ATR and that binding of ATP to the vacant

210 ergy transfer to the PSII reaction center, a homotrimer of CP26 and a heterotrimer of CP26 and Lhcb3.

211 Each fiber is a homotrimer of gene product 8.5 (gp8.5) and consists of t

212 eficiency virus type 1 (HIV-1) function as a homotrimer of gp120/gp41 heterodimers to support virus e

213 bunits, UreA, UreB, and UreC, assembled as a homotrimer of individual UreABC heterotrimers (UreABC)(3

214 ngly suggest that this inactive complex is a homotrimer of mTERF.

215 The homotrimer of parallel, coiled coil alpha-helices contai

216 ace adjacent to the subunit interface of the homotrimer of PCNA in addition to the PIP-box binding ca

217 that Ski-(16-192) interacted directly with a homotrimer of receptor-regulated Smad protein (R-Smad),

218 cone photoreceptors and may correspond to a homotrimer of RHBDD2(L).

219 of the transmembrane 1 domain of the intact homotrimer of the integral membrane protein, diacylglyce

220 tween the viral and cellular membranes, is a homotrimer of three subunits, each containing two disulf

221 Both srf-4 and srf-5 formed E1 homotrimers of decreased stability compared to the homot

222 e formation of six-helix bundles (6HBs) from homotrimers of gp41, from which a number of synthetic pe

223 ment to host cells is mediated by 20-nm-long homotrimers of spike envelope protein S.

224 lear single quantum coherence experiments on homotrimers of the B peptide show trimer peaks which dis

225 imers of decreased stability compared to the homotrimers of the wild type and the srf-3 mutant.

226 Generation of the E1 homotrimer on fusion-incompetent membranes identified an

227 ate effects of a small fraction of alpha1(I) homotrimers on formation, properties, and remodeling of

228 rent for the three different subunits in the homotrimer, on the ligand-binding site.

229 mphocytes and functions as either a secreted homotrimer or a membrane-associated heterotrimer that in

230 e E1 conformational changes or the resulting homotrimer or about the mechanism of action of the homot

231 It exists as homotrimers or complexes containing multiple homotrimer

232 ASICs are formed as homotrimers or heterotrimers of several isoforms (ASIC1a

233 mbled from triple helices that can be either homotrimers or heterotrimers.

234 NMR and MMP kinetic studies of a series of homotrimer peptides that model type III collagen have be

235 The results show that homotrimer persistence length is half of that of the het

236 urs efficiently in recombinant pro-alpha1(V) homotrimers produced in 293-EBNA human embryonic kidney

237 peptide capable of spontaneous assembly as a homotrimer, producing a thermostable beta-trefoil archit

238 The Mt-CamH homotrimer purified from E. coli cultured with supplemen

239 milar to the wild-type, it does not form the homotrimer quaternary structure of the wild-type.

240 However, the formation of the H3A homotrimer required a much lower pH and showed reduced e

241 Col1 homotrimer results from epigenetic suppression of the Co

242 s because it is neutral (zwitterionic) while homotrimers should be destabilized because of charge rep

243 X-ray crystallographic analysis of the homotrimer showed that the design process had near-atomi

244 rs in solution, and 15 (four homodimers, six homotrimers, six homotetramers and one homopentamer) had

245 LIGHT is a homotrimer that activates proapoptotic and integrin-indu

246 pon exposure to mildly acidic pH and forms a homotrimer that appears necessary for fusion.

247 DarA is a homotrimer that binds three molecules of c-di-AMP, each

248 physiological stress, HSF1 is converted to a homotrimer that binds to its cognate DNA binding site wi

249 trate-bound LBD revealed a four-helix bundle homotrimer that had not been observed in bacterial chemo

250 tructure of a poplar cellulose synthase CesA homotrimer that suggests a molecular basis for cellulose

251 overmodified heterotrimers, and proalpha1(I) homotrimers that are compatible with normal skeletal gro

252 Piezos oligomerize as propeller-shaped homotrimers that are thought to locally curve the membra

253 Both BAFF and APRIL assemble as homotrimers that bind and activate several receptors tha

254 environmental factors result in synthesis of homotrimers that consist of three alpha1(I) chains.

255 g mutations at D50N or Y108F are secreted as homotrimers that fail to bind either TNF receptor and ar

256 VIII) or alpha2(VIII) assembled and secreted homotrimers that were stable in denaturing conditions an

257 xtensive contacts between E1 subunits in the homotrimer, the D188K mutant identifies an important "ho

258 ody (mAb) binding and forms an SDS-resistant homotrimer, the virus associates hydrophobically with th

259 rd the neighboring subunit of the functional homotrimer, thereby forming hydrogen bonds with Arg(104)

260 n-mouse hybrid trimers and truncated chicken homotrimers; this indicated that the mutant could assemb

261 , and each also formed high-molecular-weight homotrimers, thus supporting this model.

262 so found to interact directly with an R-Smad homotrimer to form a hexamer and with an R-Smad.Smad4 he

263 HSFs bind as homotrimers to conserved promoter DNA recognition sites

264 e in which E2 and E1 dissociate and E1 forms homotrimers, triggering fusion of the viral membrane wit

265 Homotrimer triple helices have different stability and l

266 tability and less efficient unwinding of the homotrimer triple helix at the collagenase cleavage site

267 centrifugation revealed that CMP-C36 forms a homotrimer under physiological conditions.

268 homotrimers or complexes containing multiple homotrimer units in plasma.

269 esponds to low pH to form the more stable E1 homotrimer via conformational changes different from tho

270 is, and suggest that Poldelta binds the PCNA homotrimer via its three subunits.

271 e here demonstrated that formation of the E1 homotrimer was efficiently triggered under low-pH condit

272 The preformed homotrimer was extremely stable to moderately harsh cond

273 Here, the E1 homotrimer was formed in vitro from either virus or solu

274 This homotrimer was further confirmed with size-exclusion chr

275 Once formed, the low-pH-induced E1 homotrimer was very stable and was only dissociated unde

276 The MMP-resistant homotrimers were produced by all invasive cancer cell li

277 es of changes in thermal stability of type I homotrimers were reported previously, but the results we

278 In this study, we found that these homotrimers were resistant to all collagenolytic matrix

279 microunfolding of artificial rat-tail-tendon homotrimers were similar to oim homotrimers.

280 as of infected mice, suggesting that the MIF homotrimers were the functionally active form of MIF.

281 ld be of general relevance.EIAV dUTPase is a homotrimer where each subunit folds into a twisted antip

282 human TRAIL leads to a disulfide bond-linked homotrimer which can be expressed at high levels as a se

283 This domain exists as a homotrimer, which is predicted to be self-associated thr

284 LT alpha exists in its soluble form as a homotrimer, which like TNF only binds the TNF receptors,

285 hCtr1 multimeric complex, consistent with a homotrimer, which was not observed following copper trea

286 bryonic kidney cells are able to form stable homotrimers, which are rapidly converted into smaller po

287 However, homotrimers, which by definition will contain glycine mu

288 ed to be in stable proximity within the DAGK homotrimer, while position 52 appears to be more distal

289 re of lambda exonuclease revealed a toroidal homotrimer with a central funnel-shaped channel for trac

290 HI0719 is a homotrimer with a distinct cavity located at the subunit

291 arlier studies have shown that ORF1p forms a homotrimer with an asymmetric dumbbell shape, in which a

292 RANKL self-associates as a homotrimer with four unique surface loops that distingui

293 Deglycosylation of the full-length homotrimer with peptide N-glycosidase-F under native con

294 ain self-assembles into an atypical expanded homotrimer with sparse monomer-monomer interfaces.

295 the three-dimensional structure of the DAGK homotrimer with the use of solution nuclear magnetic res

296 ary and sufficient to direct the assembly of homotrimers with correctly aligned triple-helices.

297 sfection with prolyl 4-hydroxylase generated homotrimers with stable pepsin-resistant triple-helical

298 (BtPNP) purine nucleoside phosphorylases are homotrimers with the catalytic sites located near the su

299 P2X7Rs are obligate homotrimers, with each subunit having two transmembrane

300 Elastase also cleaved the homotrimer within an E1 loop located near the fusion pep