ライフサイエンスコーパス: homotrimeric

1 The homotrimeric (41,184-Da subunit) phosphonopyruvate decar

2 are 28 known types of collagen that can form homotrimeric (AAA) or heterotrimeric (AAB and ABC) compo

3 The conformation of the homotrimeric AcrB remains the same when the surrounding

4 ort the hypothesis that all Scl proteins are homotrimeric and cell wall-anchored.

5 Both proteins are homotrimeric and center about a long alpha-helix, featur

6 Acid-sensing ion channels (ASICs) form both homotrimeric and heterotrimeric ion channels that are ac

7 ASIC proteins can form both homotrimeric and heterotrimeric ion channels.

8 Both homotrimeric and heterotrimeric type I collagen molecule

9 CaiT is a homotrimeric antiporter that exchanges l-carnitine (CRN)

10 Here, we describe a branched homotrimeric aptamer with three-fold rotational symmetry

11 GltPh, a homotrimeric aspartate transporter from Pyrococcus horik

12 However, homotrimeric assemblies have always remained the most th

13 We apply this method to design two homotrimeric assemblies, Tet4 and TP1, with tetrahedral

14 hows that CD70 adopts a classical TNF ligand homotrimeric assembly to engage CD27 receptors in a 3:3

15 In this motif, a coiled coil (formed by homotrimeric association of the N-terminal regions of th

16 Homotrimeric bacterial collagen proteins with a Gly-to-A

17 Type XVIII collagen is a homotrimeric basement membrane molecule of unknown funct

18 The discovery of a discretely folded homotrimeric betabetaalpha motif (BBAT1) was recently re

19 ns, and comparison of the heterotrimeric and homotrimeric C-pro structures and stability.

20 ember CD27 on naive CD8(+) T (Tn) cells with homotrimeric CD70 on antigen-presenting cells (APCs) is

21 o-hArgI-C(PEG-20K)); (ii) engineering of the homotrimeric Co-hArgI into a linked, monomeric 110kDa po

22 A metal-assembled homotrimeric coiled coil based on the GCN4-p1 sequence h

23 , whereas its N-terminal segment forms long, homotrimeric coiled coils linking the OM to the PG layer

24 omprises two, noncovalent, heterodimeric and homotrimeric coiled-coil bundles.

25 te that N36(Mut(e,g)) acts by disrupting the homotrimeric coiled-coil of N-terminal helices in the pr

26 importance of considering all three sites of homotrimeric collagen as independent interaction surface

27 ss force sensitive than the proteolysis of a homotrimeric collagen model peptide, consistent with stu

28 inding sequences have been identified in the homotrimeric collagen types II and III, however, it is u

29 xyl-terminal non-collagenous domain (NC2) of homotrimeric collagen XIX forms a stable trimer and subs

30 kDa, indicating that the protein exists as a homotrimeric complex in solution.

31 An application is illustrated with a 95 kDa homotrimeric complex of the acyltransferase protein, Lpx

32 o the mitochondrial matrix, where it forms a homotrimeric complex organized in a doughnut-shaped stru

33 Moloney murine leukemia virus (MoMuLV) is a homotrimeric complex whose monomers consist of linked su

34 They reveal that CbpF forms a stable homotrimeric complex whose N-terminal part of the extrac

35 croscopy analyses reveal their assembly into homotrimeric complexes in vitro in which each CesA proto

36 hereas most TNF receptors normally form only homotrimeric complexes, the preligand assembly domains i

37 Oxidative HAOs have a homotrimeric configuration with the monomers covalently

38 and size exclusion chromatography suggest a homotrimeric configuration.

39 Here, we report the homotrimeric crystal structure of 2OST from chicken, in

40 lex has a four-layered structure composed of homotrimeric discs of PaaF and PaaG.

41 The homotrimeric DNA replication protein proliferating cell

42 proliferating cell nuclear antigen (PCNA), a homotrimeric DNA sliding clamp and polymerase processivi

43 r (HSF) is the only known sequence-specific, homotrimeric DNA-binding protein.

44 The homotrimeric enzyme Mt-Cam from Methanosarcina thermophi

45 Complete inhibition of the homotrimeric enzyme occurs at one mole of inhibitor per

46 nithine transcarbamoylase (OTC), a cytosolic homotrimeric enzyme of yeast, do not require CCT action.

47 ull-length (763-aa) M. smegmatis PNPase is a homotrimeric enzyme with Mg(2+)*PO(4)-dependent RNA 3'-p

48 oliferating cell nuclear antigen (PCNA), the homotrimeric eukaryotic sliding clamp protein, recruits

49 collagenous substrates, we have constructed homotrimeric, fluorogenic triple-helical peptide (THP) m

50 provides a rationale for the prominence of a homotrimeric form of type I procollagen (alpha1 trimer)

51 e have determined the crystal structure of a homotrimeric fragment from ACRP30 at 2.1 A resolution.

52 cally and therapeutically active recombinant homotrimeric fragment of human lung surfactant protein D

53 tic administration of rfhSP-D, a recombinant homotrimeric fragment of human SP-D comprising the alpha

54 Thrombospondin 1 (TSP1) is a homotrimeric glycoprotein composed of 150-kDa subunits c

55 Influenza hemagglutinin (HA), a homotrimeric glycoprotein crucial for membrane fusion, u

56 high affinity to thrombospondin-1 (TSP-1), a homotrimeric glycoprotein that is a potent inhibitor of

57 bular "head" domain of hemagglutinin (HA), a homotrimeric glycoprotein.

58 neutralizing antibody responses than did the homotrimeric gp140s.

59 identity) that can adopt two very different homotrimeric helical bundle conformations-one short (~66

60 ichia coli diacylglycerol kinase (DAGK) is a homotrimeric helical integral membrane protein in which

61 to bias the self-assembly into collagen-like homotrimeric helices that are capable of fibrillogenesis

62 and (4S-Flp-4R-Flp-Gly)7 do not form stable homotrimeric helices, mixtures of these two peptides for

63 , even compared to the already slow rates of homotrimeric helices.

64 ix stability have been performed on collagen homotrimeric helices.

65 Homotrimeric hemagglutinin (HA) is one of the major spik

66 The homotrimeric HIV-1 envelope glycoprotein (Env) undergoes

67 n E synthase 1 (mPGES-1) is an alpha-helical homotrimeric integral membrane inducible enzyme that cat

68 ics of membrane insertion and folding of the homotrimeric integral membrane protein diacylglycerol ki

69 due to poor packing within PodA's obligatory homotrimeric interfaces.

70 The homotrimeric iron protein contains a covalently bound fe

71 ge is crucial for tissue remodeling, but its homotrimeric isoform is resistant to all collagenases.

72 The homotrimeric isoform of type I collagen, which consists

73 The homotrimeric ligand tumor necrosis factor alpha (TNFalph

74 ng crevices between pairs of monomers of the homotrimeric ligand.

75 upon binding to their cognate receptors in a homotrimeric manner.

76 udies to map the oligomeric interface of the homotrimeric membrane protein diacylglycerol kinase (DAG

77 Homotrimeric MIF levels correlated with the severity of

78 aturing experiments result in heterotrimeric/homotrimeric mixtures.As the proportion of hydroxyprolin

79 em was developed for bacterial production of homotrimeric model polypeptides.

80 amino acid residues, we generated a complete homotrimeric molecular model of PpCESA5 using a combinat

81 resents the opportunity to create a matching homotrimeric molecular recognition element that is perfe

82 lambda Exonuclease is a toroidal homotrimeric molecule and this quaternary structure is a

83 Both BLyS and APRIL have been described as homotrimeric molecules, a feature common to members of t

84 Human peroxidasin 1 is a homotrimeric multidomain peroxidase that is secreted to

85 GltPh from Pyrococcus horikoshii is a homotrimeric Na(+)-coupled aspartate transporter.

86 rfhSP-D, containing homotrimeric neck and lectin domains, was expressed in E

87 ith respect to ORF1p, a coiled coil-mediated homotrimeric nucleic acid chaperone that can form tightl

88 thesizing unique molecular identifiers using homotrimeric nucleotide blocks provides an error-correct

89 acterized KsHDH as a covalently cross-linked homotrimeric octaheme protein as found for HAO and HAO-r

90 Collagen triple helices can be homotrimeric or heterotrimeric, and while some types of

91 ng, right-handed, parallel beta-helix of the homotrimeric P22 tailspike adhesin exhibits predominantl

92 structure with a similar architecture to the homotrimeric PCNA DNA-binding clamp.

93 assemble into a protein ring resembling the homotrimeric PCNA of humans but with three unique protei

94 We found that a triple-helical, homotrimeric peptide mimetic of a putative alpha2beta1 b

95 d, this monomer was used for the design of a homotrimeric peptide mimic that we termed [PKT16](3), wh

96 main A3 bound to a collagen type III-derived homotrimeric peptide.

97 stitutions for Gly in these Gly-Pro-Hyp-rich homotrimeric peptides shows a significant correlation wi

98 The homotrimeric PII signal transduction protein of Escheric

99 viously generated the stable and ultrapotent homotrimeric Pittsburgh inhalable Nanobody 21 (PiN-21).

100 Tumor necrosis factor (TNF)-alpha, a homotrimeric, pleiotropic cytokine, is secreted in respo

101 The homotrimeric PNPase engages RNase E on the periphery of

102 tual fusion process involves a switch from a homotrimeric prehairpin intermediate conformation, consi

103 replication proteins such as the ring-shaped homotrimeric proliferating cellular nuclear antigen (PCN

104 F-alpha) exists in its functional state as a homotrimeric protein and is involved in inflammation pro

105 mers, respectively, cis-CaaD appears to be a homotrimeric protein as assessed by gel filtration chrom

106 of diacylglycerol kinase (s-DAGK), a 40 kDa homotrimeric protein having nine transmembrane segments.

107 oliferating cell nuclear antigen (PCNA) is a homotrimeric protein that functions as a sliding clamp d

108 Apo2L/TRAIL is a homotrimeric protein that interacts with five receptors:

109 P22 tailspike is a homotrimeric protein that is prone to aggregation via mi

110 The structure reveals a homotrimeric protein that resembles TNF with receptor-bi

111 onal methodology to design a self-assembling homotrimeric protein with [Fe(Bpy-ala)3](2+) complexes a

112 , the crystal structure of SsRidA revealed a homotrimeric protein with active sites at the interface

113 In eukaryotes the ring-shaped homotrimeric protein, proliferating cell nuclear antigen

114 nB and GlnK represent a widespread family of homotrimeric proteins (GlnB-K) that bind and respond to

115 entially expressed on the heterotrimeric and homotrimeric proteins.

116 The protein adopts a homotrimeric quaternary structure built around a central

117 The homotrimeric quaternary structure of TNFalpha is essenti

118 Viral hemagglutinin is a homotrimeric receptor, and thus, tri- or oligovalent lig

119 PCNA is a homotrimeric ring-shaped sliding DNA clamp that can faci

120 oliferating cell nuclear antigen (PCNA) is a homotrimeric, ring-shaped protein complex that functions

121 nd endonuclease activities, while ORF1p is a homotrimeric RNA-binding protein with poorly understood

122 al methods to delineate the mechanism of the homotrimeric RND-type proton/drug antiporter AcrB, the a

123 he homodimeric Escherichia coli beta and the homotrimeric Saccharomyces cerevisiae proliferating cell

124 The symmetrical shape of the homotrimeric SARS-CoV-2 spike protein presents the oppor

125 Loss-of-function mutations in the homotrimeric serine protease HTRA1 cause cerebral vascul

126 PII proteins are small homotrimeric signal transduction proteins that regulate

127 duplication of an ancestral gene encoding a homotrimeric single-repeat protein.

128 The homotrimeric sliding clamp proliferating cell nuclear an

129 l nuclear antigen (PCNA), the subunit of the homotrimeric sliding clamp, in which the rev6-1 mutation

130 ors, including herpes simplex virus UL42 and homotrimeric sliding clamps such as proliferating cell n

131 h contain substitutions that destabilize the homotrimeric sliding DNA clamp.

132 erves as an initial interaction site for the homotrimeric spike (S) protein of SARS-CoV-2 to facilita

133 have probed the conformational space of the homotrimeric Spike from SARS-CoV-2.

134 The homotrimeric splice variant ASIC1a has been implicated i

135 ed with P. aeruginosa, MIF is primarily in a homotrimeric state.

136 A stable homotrimeric structure for the transmembrane domain (TM)

137 a(beta)(alpha) peptide that forms a discrete homotrimeric structure in solution, was evaluated with 1

138 Additional evidence for the homotrimeric structure of MIF under native solution cond

139 p21-based PCNA antagonist, we exploited the homotrimeric structure of PCNA and developed multivalent

140 blished that the sec180e complex is a stable homotrimeric structure which assembles prior to secretio

141 HtrA2 forms a homotrimeric structure, with each subunit composed of pr

142 Glutamate transporters have a homotrimeric subunit structure with a large central wate

143 n of Apo-2L (amino acids 114-281) exhibits a homotrimeric subunit structure.

144 MTAP is a ubiquitously expressed homotrimeric-subunit enzyme critical to polyamine metabo

145 edominantly as dodecamers consisting of four homotrimeric subunits each.

146 Hemagglutinin (HA) is a homotrimeric surface glycoprotein of the influenza virus

147 f Hsp47 in its free form and in complex with homotrimeric synthetic collagen model peptides, each com

148 he interactions between the 180 kDa wildtype homotrimeric tailspike protein of the bacteriophage P22

149 herichia coli bacteriophage HK620 is a large homotrimeric tailspike that cleaves the O18A1 type O ant

150 P22 tailspike is a homotrimeric, thermostable adhesin that recognizes the O

151 In contrast to all previously characterized homotrimeric TNF family members, the mouse GITRL crystal

152 Homotrimeric TNF superfamily ligands signal by inducing

153 and is activated by RANK ligand (RANK-L), a homotrimeric, TNF-like cytokine.

154 In contrast to homotrimeric transporters of the RND (resistance-nodulat

155 In wild-type homotrimeric transporters, the glutamate concentration d

156 wever, most synthetic systems have addressed homotrimeric triple helices.

157 collagenous substrates, we have constructed homotrimeric triple-helical peptide (THP) models of the

158 Of interest, fCECs predominantly secreted homotrimeric type I collagen, [alpha1(I)](3), with heter

159 to the alpha-helical transmembrane domain of homotrimeric type I integral membrane protein, influenza

160 alpha1(I)(2)alpha2(I) heterotrimers, unlike homotrimeric types II and III.

161 nd the broadest efficacy was achieved with a homotrimeric version of the 75-residue angiotensin-conve

162 n of invasive cancer cells on the surface of homotrimeric versus normal (heterotrimeric) type I colla

163 heterotrimeric structures based on published homotrimeric X-ray data.