ライフサイエンスコーパス: homozygote

1 m p.D519G (rs11558492; 15 heterozygotes, one homozygote).

2 est-risk genotypes (DR4-DQ8 heterozygotes or homozygotes).

3 (aHR = 3.9 [1.923-5.976], p < 0.0001 for the homozygotes).

4 = 0.04) and CFH risk alleles (P = 0.048 for homozygotes).

5 wer DNA methylation at CGI1 compared with GG homozygote.

6 to those found in the conditional Efnb2 null homozygote.

7 ed/collapsed forks compared to either single homozygote.

8 ent with the earlier age of seizure onset in homozygotes.

9 in PER3 (4) /PER3 (4) and PER3 (5) /PER3 (5) homozygotes.

10 d in the proband, but not in the other seven homozygotes.

11 e effect driven by 3 apolipoprotein epsilon4 homozygotes.

12 ies of probands identified ten additional TT homozygotes.

13 wing larger gains post-exercise than val(66) homozygotes.

14 ld potentially lead to disease if present as homozygotes.

15 omotor associative learning, compared to Val homozygotes.

16 directions and are neutral when combined in homozygotes.

17 tion that Fos is downregulated in diminuendo homozygotes.

18 istakenly calling heterozygotes as reference homozygotes.

19 eater absolute HbA1c reduction than T-allele homozygotes.

20 au and phosphorylated tau (p-tau) than Val66 homozygotes.

21 highest for GG homozygotes and lowest for AA homozygotes.

22 gnificantly higher and lower crossovers than homozygotes.

23 showed a discernible phenotype in individual homozygotes.

24 distinguishable from that of the conditional homozygotes.

25 that for placebo only in rs2832407 C-allele homozygotes.

26 with the largest reduction in variant allele homozygotes.

27 ans effects is to compare F1 hybrids with F0 homozygotes.

28 anced lung inflammation as a factor in ZZ-AT homozygotes.

29 nd myo-inositol/creatine ratios than APOE E3 homozygotes.

30 C42/IL6 decreases compared with major allele homozygotes.

31 cardiovascular disease when compared with TT homozygotes.

32 ed in IFNL4-DeltaG carriers but not IFNL4-TT homozygotes.

33 carriers, polymorphism carriers or wild-type homozygotes.

34 e carriers had less activation than A-allele homozygotes.

35 hrough adulthood, with increased severity in homozygotes.

36 B-TBOA (100 nm) mimicked the TauD changes in homozygotes.

37 p to 1.3 U/L in TA/TA homozygotes versus T/T homozygotes.

38 te infection rates separately, the resistant homozygote 119F/F genotype was significantly more associ

39 here were 14% to 16% of APOL1 variant allele homozygotes (2 copies of G1/G2) across cohorts.

40 For met/met homozygotes, 2 mA resulted in significantly poorer perfo

41 prospectively stratified by genotype (29 AA homozygotes, 27 carriers of at least 1 G allele) in a do

42 GM 3/17 heterozygotes, and lowest in GM 3/3 homozygotes (28.2, 19.0, and 8.1 microg/mL, respectively

43 T/T homozygotes (36% of participants) experienced a 51% MACE

44 CHOP protein was increased in homozygotes (384%).

45 type and heterozygous lenses but elevated in homozygotes (391%).

46 ere obtained for mutation carriers (95 Val66 homozygotes, 48 Met66 carriers).

47 al 4.1-5.2; p < 0.001) and epsilon4/epsilon4 homozygotes a 25.4 (20.4-31.2; p < 0.001) higher OR of A

48 Pro129/Pro129 homozygotes also showed greater placebo-induced mu-opioi

49 that although Pbx1 transcripts are higher in homozygotes, amounts of PBX1 protein are significantly d

50 suggested genetic interaction, as the triple homozygote and the Irf6; Esrp1 double homozygote were no

51 Haplotype analysis of 4 homozygotes and 11 heterozygotes for c.5461-10T-->C and

52 ater than the median duration (>14 years): 4 homozygotes and 17 compound heterozygotes (hereafter ref

53 1); in females, it was 14.0% for p.Cys282Tyr homozygotes and 2.3% for compound heterozygotes (p < 0.0

54 ate of HH in males was 24.4% for p.Cys282Tyr homozygotes and 3.5% for compound heterozygotes (p < 0.0

55 8/12 (66.7%) classified as severe were beta homozygotes and 7/8(87.5%) had alpha globin gene deletio

56 ls, only the prkdc mutant fish reproduced as homozygotes and also survived injury after cell transpla

57 0.001) and GBA mutations or variants (seven homozygotes and compound heterozygotes and 81 heterozygo

58 cognitive and motor performances, comparing homozygotes and compound heterozygotes who carry 2 PARKI

59 Among CASQ2 homozygotes and compound heterozygotes, clinical penetra

60 In contrast, hearts from homozygotes and heterozygotes showed normal morphology,

61 dian itch and VSS scores were highest for GG homozygotes and lowest for AA homozygotes.

62 NC1 result in perinatal lethal thrombosis in homozygotes and markedly increased VTE risk in heterozyg

63 ated with a high-iron phenotype in HFE C282Y homozygotes and may participate in hepcidin regulation.

64 r between preclinical mutation carrier Val66 homozygotes and Met66 carriers.

65 Loss-of-function homozygotes and other subjects genetically predicted to

66 f an association between rs12252 rare allele homozygotes and susceptibility to mild influenza (in pat

67 ant differences in mean age of onset between homozygotes and the minimal and moderate/strong impact g

68 ere were no differences between tff2(-/) (-) homozygotes and the wild type with regard to the dynamic

69 il assembly was minimally affected in mutant homozygotes, and isolated fibers displayed normal mechan

70 ntribute to the development of COPD in ZZ-AT homozygotes, and therefore merits further investigation.

71 e compared phenotypes between heterozygotes, homozygotes, and wildtypes.

72 ozygous, in a process we refer to as "forced homozygote approach".

73 Matr3(Gt-ex13) homozygotes are early embryo lethal, but Matr3(Gt-ex13)

74 ull homozygotes are live born, Bmp7(R-GFlag) homozygotes are embryonic lethal and have broadly reduce

75 While Bmp7 null homozygotes are live born, Bmp7(R-GFlag) homozygotes are

76 (WT) and gamma2(Y365/367F)+/- (HT) animals (homozygotes are not viable in utero), the expression lev

77 In Caucasians, C282Y HFE homozygotes are numerous, but they are only predisposed

78 G37S homozygotes are perinatal lethal, in contrast to the ear

79 by local ancestry and show that deleterious homozygotes arise at a higher rate when ROH overlap Afri

80 ygotes and 5.70 (95% CI, 4.66 to 6.97) among homozygotes, as compared with children who had the lowes

81 F, and TFR2 affect iron markers in HFE C282Y homozygotes at risk for hemochromatosis.

82 Among obese individuals, C-allele homozygotes at rs8192675 had a 0.33% (3.6 mmol/mol) grea

83 nfirmed greater (P = 0.003) efficacy for G:G homozygotes (%AUC difference = 43.7, 95%CL = 15.4, 72.1)

84 nce = 43.7, 95%CL = 15.4, 72.1) than for A:A homozygotes (%AUC difference = 6.5, 95%CL = -30.2, 43.2)

85 Specifically, val/val homozygotes benefited most from 1.5 mA tDCS on Visual WM

86 There were 493 Arg 389 beta(1) receptor homozygotes (beta(1)389 Arg/Arg) versus 547 Gly389 carri

87 GG homozygotes but not A-allele carriers showed strong gray

88 uencing confirmed that all SC plants were S1 homozygotes but not all S1 homozygotes were SC.

89 se palmitate uptake were markedly reduced in homozygotes but not heterozygotes for the Pro90Ser CD36

90 Homozygotes, but not heterozygotes, developed Parkinson

91 atistically enriched gene; one subject was a homozygote (c.362A>T [p.His121Leu]) and another a compou

92 heterozygote carriers (130/213), and 74% of homozygote carriers (43/58).

93 The corresponding HR for hetero- and homozygote carriers of the CYP2C19*17 allele were 1.02 (

94 .42) and 0.79 (CI 0.32-1.94) for hetero- and homozygote carriers, respectively.

95 e; heterozygote carriers: 81% [698/866]; and homozygote carriers: 86% [277/322]).

96 Compared with rs10455872 AA homozygotes, carriers of 1 or 2 G alleles were at increa

97 ession of B15 class I molecules than B15/B15 homozygote cells, presumably as a result of receiving ad

98 Relative to CASQ2 heterozygotes, CASQ2 homozygote/compound heterozygote genotype status in prob

99 individuals, including 36 CPVT probands (24 homozygotes/compound heterozygotes and 12 heterozygotes)

100 GBA homozygotes/compound heterozygotes had lower enzymatic a

101 d mortality compared to Asyn heterozygote or homozygote control mice.

102 5 years younger in the APOL1 variant allele homozygotes (Cox proportional hazards analysis, p value

103 d higher expression levels than minor allele homozygotes; decidual trophoblasts showed strong CXCR3 i

104 eu mutation were phenotypically normal while homozygotes demonstrated a dwarf phenotype.

105 e/ethnicity, age, sex, and burn size, the GG homozygotes demonstrated worse scarring (odds ratio 1.88

106 ddition, when reaching late adulthood, D673V homozygotes develop an evident bone-loss phenotype and s

107 between VS activation and WM, whereas the GG-homozygotes did not, suggesting that the effect of VS BO

108 In an outbred genetic background, Dnaaf2 homozygotes die after birth and have left/right defects

109 Homozygotes died perinatally, and E18.5 embryos exhibite

110 tex during failed-inhibition trials with Val homozygotes displaying elevated activation compared with

111 al FFA uptake was diminished in the Pro90Ser homozygotes during both suppressed and increased palmita

112 in heterozygotes compared with both types of homozygotes during cognitive engagement.

113 e2/e2 genotypes ('e2' carriers), 621 were e3 homozygotes ('e3' group), and 556 were e4/e3 (442) or e4

114 dults with varying doses of APOE4 - 20 APOE4 homozygotes (E4/E4), 20 heterozygotes (E3/E4) and 20 non

115 Adult D673V homozygotes exhibit dysplastic isthmus and reduced bone

116 es, subjects who were GA heterozygotes or AA homozygotes exhibited a decreased risk of gastric cancer

117 S408/9A homozygotes exhibited increased phasic, but decreased to

118 campal morphology at 2 weeks of age, and all homozygotes exhibited lethal tonic-clonic seizures by mi

119 Specifically, with low childhood stress, G homozygotes exhibited lower levels of negative emotional

120 Homozygotes experience deficiency in the lung concomitan

121 Remarkably, rs6008845 T/T homozygotes experienced a cardiovascular benefit from fi

122 None of four homozygotes expressed any signs of JBTS, and one of them

123 type 1 syndrome (CN1) in 28 UGT1A1 c.222C>A homozygotes followed for 520 aggregate patient-years.

124 ly high plasma HDL-C levels, we identified a homozygote for a loss-of-function variant, in which leuc

125 Postmortem human cortices homozygote for the minor rs17228616 allele showed AChE e

126 hy family members are either heterozygote or homozygote for the reference allele.

127 dentified the first PH3 patient with ESRD; a homozygote for two linked, novel missense mutations.

128 Homozygotes for ABCA1 mutations exhibited enhanced oral

129 y members, and unrelated individuals who are homozygotes for an AJ founder mutation.

130 ive mating disadvantage was detected in male homozygotes for both kdr/RDL-resistant alleles.

131 ymptomatic course of HSV-1 infection only in homozygotes for G1m3.

132 tory of childhood abuse and who were also GG homozygotes for rs110402 showed significant improvement

133 Homozygotes for the ancestral A allele had impairments i

134 We identified 1661 heterozygotes and 17 homozygotes for the E40K variant and 75 participants who

135 effect was measured by breeding and testing homozygotes for the expected in vivo loss-of-function ph

136 vel in the TC was associated with rs3857059; homozygotes for the minor allele showed significant high

137 Homozygotes for the PSC disease risk allele (AA) showed

138 Homozygotes for the risk allele produced more than four

139 ion, 62 healthy men from the cohort who were homozygotes for the TT or CC genotype of the FADS1 rs174

140 Minor allele homozygotes for the variant rs6128 were less likely to d

141 ble for hereditary essential tremor and that homozygotes for this allele develop Parkinson disease.

142 Eight patients were homozygotes for this mutation and 2 siblings were compou

143 tes through a recessive mode of inheritance (homozygote frequency = 0.15%, P = 4.5 x 10(-18), OR = 7.

144 that later stage trials selectively excluded homozygotes from consideration as varieties.

145 ortions of genotypes and the proline (Pro-P) homozygote groups between subsamples from different coun

146 ntrast, compared with T/T homozygotes, TA/TA homozygotes had 12% to 18% lower plasma ALT among the mo

147 fetal membranes, the rs2280964 major allele homozygotes had higher expression levels than minor alle

148 K40 homozygotes had markedly lower levels of triglycerides a

149 five carrying the Pro90Ser CD36 mutation (2 homozygotes had no CD36) and matched control volunteers.

150 ly 300 genes, whereas loss of Sema3d in null homozygotes had no major consequence and there was no ev

151 All three homozygotes had very low levels of LPL in the preheparin

152 These homozygotes had, on average, 46% higher MMA concentratio

153 fter administration of a thiopurine, whereas homozygotes have a 17% risk.

154 dementia, it is not yet known whether APOE2 homozygotes have a particularly low risk.

155 HIV-exposed seronegative KIR3DS1 homozygotes have a reduced risk of HIV infection.

156 However, adult homozygotes have an average testis weight that is around

157 No homozygotes have been reported for these changes in cont

158 infer that Reln(CTRdel)/Apoer2(null) double homozygotes have both receptor pathways disrupted.

159 balanced selection, where heterozygotes and homozygotes have higher and lower reproductive fitness,

160 showed that Reln(CTRdel)/Apoer2(null) double homozygotes have phenotypes akin to those of reeler muta

161 man bronchial epithelial cells) and in vivo (homozygote/homozygote bi-transgenic mice with CF).

162 ks are unclear in mostly undiagnosed p.C282Y homozygotes identified in community genotyping.

163 ional FUT2 enzyme, suggesting that FUT2 null homozygote (ie, nonsecretor) individuals may not be reco

164 The perinatal mortality (>80%) observed in homozygotes (Igf2r(I1565A/I1565A)) suggested that wild-t

165 We identified 22 rs12252_C homozygotes in 185 white non-Hispanic children.

166 controls, with higher frequency of GM 17/17 homozygotes in AD cases as compared with controls (19.8

167 lected by an under-representation of S-locus homozygotes in selfed progeny.

168 ons in G-allele carriers as compared with AA-homozygotes in the bilateral amygdala.

169 The rate of HFE c.845G>A (p.Cys282Tyr) homozygotes in the CRC group reinforces a previously rep

170 ively, causing considerable morbidity in the homozygotes in these populations.

171 MMA concentrations than methionine-encoding homozygotes in young adults with generally low MMA conce

172 e against any CVD pathology compared with e3 homozygotes, including CAA.

173 disease manifests in both heterozygotes and homozygotes, indicating a common collagen disorder impac

174 n trial in cognitively unimpaired APOE-e4/e4 homozygote individuals.

175 rmeability was reduced 3-fold in Tmc1 pD569N homozygotes, intermediate deficits being seen in heteroz

176 gB antibody levels were highest in GM 17/17 homozygotes, intermediate in GM 3/17 heterozygotes, and

177 ric plexus was observed only in all Ret null homozygotes, irrespective of the genotypes at Sema3d loc

178 a globin gene deletions in beta thalassaemia homozygotes is a significant factor in modulating diseas

179 We report that risk for T1D in HLA-DR3 homozygotes is increased significantly by a previously u

180 A8V mutation (heterozygote=KI-TnC-A8V(+/-); homozygote=KI-TnC-A8V(+/+)) were characterized by echoca

181 e to generate skeletal muscle-specific Brca1 homozygote knockout (Brca1KO(smi) ) mice.

182 ng embryonic development, we found that null homozygotes lacking any of the five different ribosomal

183 ausing neuropathic Gaucher's disease (GD) in homozygotes lead to aggressive cognitive decline in hete

184 estinal gene expression, loss of Ret in null homozygotes led to differential expression of approximat

185 In both heterozygotes and homozygotes, levels of calreticulin protein were increas

186 Consistent with this hypothesis, double homozygote lines combining introgression segments from t

187 Homozygote LRP6(R611C) (LRP6(mut/mut)) mice exhibited bo

188 od with severe motor impairments and whereas homozygotes manifest the disorder, heterozygotes are asy

189 Individuals carrying the homozygote MC1R risk haplotype looked on average up to 2

190 of Ret wild-type, null heterozygote and null homozygote mice at E12.5, birth and weaning were not inf

191 the corpus callosum of the Gnptab Ser321Gly homozygote mice compared to wild-type littermates, while

192 SNAP25Delta3 homozygote mice exhibited normal presynaptic inhibition

193 ma3d locus, and Sema3d null heterozygote and homozygote mice had normal intestinal innervation.

194 SNAP25Delta3 homozygote mice had various behavioral phenotypes, inclu

195 cumulation compared with wild type pigs, and homozygote MSTN mutant (MSTN(-/-)) pigs had apparent DM

196 s in the identification of the wild-type and homozygote mutant genotypes compared to pyrosequencing o

197 release cohort, survival was reduced in the homozygote mutant mice, revealing strong selection again

198 Among female p.C282Y homozygotes (n = 1596), there were 3 incident hepatic ma

199 Compared with FKBP5, GG homozygotes (N=118), A-allele carriers (N = 132) without

200 show by immunohistochemistry that, in del10 homozygotes, neural crest cells fail to infiltrate the d

201 old to 1.8-fold (p < 0.05) compared with DEL homozygotes not receiving PDE3i.

202 andem repeat polymorphism (VNTR) and for 6/6 homozygotes of SLC6A3 30 bp VNTR.

203 Homozygotes of the p.Glu257Lys variant in most persons a

204 s mice were more severely affected than null homozygotes on the same genetic background.

205 nts carried two variants in GJB2 or SLC26A4 (homozygote or compound heterozygote) and 10 of those inf

206 Homozygotes or compound heterozygotes for the R200W germ

207 nce or severity of NTDs in Apob or Lp mutant homozygotes or the loop-tail phenotype in Lp mutant hete

208 OR = 10.9, 95%CL = 2.4, 50.7) than among A:A homozygotes (OR = 0.8, 95%CL = 0.2, 3.2) with statistica

209 eduction revealed greater efficacy among G:G homozygotes (OR = 10.9, 95%CL = 2.4, 50.7) than among A:

210 ositive for genetic screening (heterozygote, homozygote, or compound heterozygote and mtDNA homoplasm

211 genotype had thinner choroids than low-risk homozygotes (P < 0.05).

212 st one trauma decreased the AAO only in 'SS' homozygotes (p = 0.001).

213 nd trauma score was observed only among 'SS' homozygotes (p = 0.002) but not among 'L' allele carrier

214 In striking contrast, in Magoh homozygotes, p53 loss fails to rescue interneuron number

215 0 years, the clinical duration in methionine homozygote patients appeared to be shorter than that see

216 12Gso homozygotes present urinary and vertebral defects very s

217 c and early postnatal development, S324Tfs*3 homozygotes produce predominantly the shorter wild-type

218 Rescued homozygotes raised on normal drinking water after weanin

219 In contrast, homozygote RDL susceptible mosquitoes (A/A296) were asso

220 rozygote males were more likely to mate than homozygote resistant (OR=2.36; P<0.001), suggesting a ne

221 nt fitness cost on the larval development as homozygote resistant larvae (CYP6P9a-RR) developed signi

222 Double homozygote resistant mosquitoes (RR/RR) significantly su

223 than heterozygote (OR = 2.04: P = 0.01) and homozygote resistant mosquitoes.

224 as further supported by the late pupation of homozygote resistant than susceptible mosquitoes (OR = 2

225 R)/RDL(S) were also more likely to mate than homozygote-resistant males (OR=2.58; P=0.007).

226 and multisystem disease in heterozygotes and homozygotes, respectively.

227 Minor allele homozygotes responded better and had fewer side effects

228 Common homozygotes responded better and had fewer side effects

229 notype, always represented by CGCG haplotype homozygotes, revealed an age-dependent heart rate-correc

230 638 - HTRA1 promoter SNP (P = 0.001) and GG (homozygote risk) genotype at rs10490924 (A69S) in LOC387

231 The AA (homozygote risk) genotype at rs11200638 - HTRA1 promoter

232 Three PPT1 homozygote sheep were generated by insertion of a diseas

233 S324Tfs*3 homozygotes show an abrupt onset of seizures at P15 that

234 Consistently, the variant allele homozygotes showed 8-fold lower odds for myocardial infa

235 Instead, AA homozygotes showed a blunted DA response in the nucleus

236 Specc1lDeltaC510/DeltaC510 homozygotes showed abnormal palate rugae but did not sho

237 Specifically, G homozygotes showed greater rVLPFC activation and had low

238 l 7 alpha-hydroxylase (CYP7A1-rs3808607) T/T homozygotes showed no LDL cholesterol lowering (mean +/-

239 pression analysis revealed that rs9517723 TT homozygotes showed significantly increased UBAC2 express

240 OPRM1 G carriers, compared with AA homozygotes, showed an overall reduction of baseline mu-

241 ice resulted in no viable offspring with the homozygote SM22-Cre: SCAP(flox/flox) genotype due to emb

242 ge 0-18 years), 208 (52%) showed sickle cell homozygote (SS) genotype, 113 (28%) showed sickle cell h

243 Additionally, minor allele heterozygote and homozygote subjects showed reduced cortisol and elevated

244 Compared with GG homozygotes, subjects who were GA heterozygotes or AA ho

245 nown in nature, overdominance is a result of homozygotes suffering from deleterious effects.

246 for the C121W mutation and was abolished in homozygotes, suggesting that loss of Nav alpha subunit m

247 so is clearly not a global null allele since homozygotes survive into adulthood.

248 both heterozygote (OR = 2.5; P = 0.012) and homozygote susceptible (L/L119) genotypes (OR = 2.10; P

249 zygote males were also more competitive than homozygote susceptible (OR=3.26; P=0.006), suggesting a

250 d significantly slower than heterozygote and homozygote susceptible mosquitoes (chi(2) = 11.2; P = 0.

251 CYP6P9a negatively impacts the fecundity as homozygote susceptible mosquitoes (CYP6P9a-SS) lay more

252 SLC35F3 risk-allele homozygotes (T/T) displayed decreased erythrocyte thiami

253 Relative to GG homozygotes, T carriers were characterised by earlier FM

254 In contrast, compared with T/T homozygotes, TA/TA homozygotes had 12% to 18% lower plas

255 ealed a higher 90-day mortality risk among T homozygotes than among C-allele carriers (p = 0.0144) ex

256 ring negative emotional word processing in G homozygotes than in A allele carriers (p(FWE corrected)

257 ffeine sensitivity were higher in 10R allele homozygotes than in carriers of the 9R allele.

258 binding for beta-endorphin compared with AA homozygotes that may contribute to individual difference

259 Among the 1294 male p.C282Y homozygotes, there were 21 incident hepatic malignancies

260 -guided attention declined with age in APOE4 homozygotes, this impairment may reflect early disease r

261 In lifetables projections for male p.C282Y homozygotes to age 75 years, the risk of primary hepatic

262 DS1(+) than KIR3DS1(-) NK cells from KIR3DS1 homozygotes to elicit anti-HIV functions such as CCL4, g

263 le were more than twice as likely as Thr 164 homozygotes to have uncontrolled, persistent symptoms du

264 lls may underlie the reduced risk of KIR3DS1 homozygotes to HIV infection.IMPORTANCE This study inves

265 p-regulation in PDE3A gene expression in DEL homozygotes treated with PDE3i was a cAMP response eleme

266 compared to AG heterozygotes whereas the AA homozygotes trended towards a protective effect against

267 PER3 (4) /PER3 (4) and 11 PER3 (5) /PER3 (5) homozygotes underwent morning light administration, whil

268 normal embryonic development of Mlkl(D139V) homozygotes until birth, and the absence of any overt ph

269 Finally, we identify a Finland enriched homozygote variant in the CRADD ID associated gene.

270 es in transferrin saturation levels (100% of homozygotes versus 37.5% of compound heterozygotes with

271 vels of plasma ALT of up to 1.3 U/L in TA/TA homozygotes versus T/T homozygotes.

272 The frequency of P1104A homozygotes was much higher in patients with TB (6/620,

273 at rs10063949 (G allele for heterozygote and homozygote) was associated with increased susceptibility

274 cant differences in offspring of rs174602 CC homozygotes (WAZ: -0.26 +/- 0.09 in the intervention gro

275 Among the thirteen TT homozygotes, we identified a previously unreported and s

276 triple homozygote and the Irf6; Esrp1 double homozygote were not observed.

277 and fertile, although slightly smaller, and homozygotes were born at lower frequency than expected,

278 diac structural alterations; in contrast, no homozygotes were detected at birth, suggesting a lethal

279 le, fertile and had a normal lifespan, while homozygotes were early embryonic lethal.

280 No Thr455 homozygotes were identified.

281 TSLPrs1898671 homozygotes were less likely to report topical calcineur

282 Moreover, the A-allele homozygotes were protected against stress-induced decrea

283 Hb S heterozygotes and alpha(+)thalassemia homozygotes were protected from severe malaria (odds rat

284 natal lethality and morphological defects in homozygotes were rescued by dietary myo-inositol.

285 d in population surveys, where only a few S1 homozygotes were SC.

286 SC plants were S1 homozygotes but not all S1 homozygotes were SC.

287 S940A homozygotes were viable and exhibited comparable basal l

288 ary airway epithelial cell cultures (F508del homozygotes) were used to determined ENaC activity (Ussi

289 n with the HLA haplotype DR3-DQ2, especially homozygotes, were found to be at high risk for celiac di

290 cription factor activity may be amplified in homozygotes, whereas it is buffered in heterozygotes.

291 risk for relapse to heavy drinking in the AA-homozygotes, whereas this effect could not be observed i

292 FAAH Pro129/Pro129 homozygotes, who constitute nearly half of the populatio

293 bjects with Chuvash polycythemia (VHL(R200W) homozygotes with constitutive upregulation of hypoxia-in

294 oad response was greater in lungs from ZZ-AT homozygotes with COPD, and was particularly found in pul

295 ome sequencing of DNA from 35 male HFE C282Y homozygotes with either markedly increased iron stores (

296 with mean CRP of 2.97 mg/L and major allele homozygotes with mean CRP of 4.11 mg/L.

297 Spermiogenesis is aborted in double homozygotes, with an absence of mature flagella on elong

298 igher mutation rate in heterozygotes than in homozygotes, with mutations occurring in closer proximit

299 dren with 2 FLG LOF alleles or TSLPrs1898671 homozygotes, with no significant difference observed bet

300 flies and flight ability is not restored in homozygotes, young heterozygotes fly well.