ライフサイエンスコーパス: homozygous deletion

1 ve oncogenes or fragile sites ("unexplained" homozygous deletions).

2 mic alterations including amplifications and homozygous deletions.

3 table transgenic lines and mutant lines with homozygous deletions.

4 lines are superior for the identification of homozygous deletions.

5 n a specific area of common heterozygous and homozygous deletions.

6 occurrence of cancer gene amplifications and homozygous deletions.

7 al events, including 24 amplifications and 7 homozygous deletions.

8 s 96 genomic regions recurrently targeted by homozygous deletions.

9 nd include high-amplitude amplifications and homozygous deletions.

10 ated the genome landscape within unexplained homozygous deletions.

11 not translated, 4 were intronic, and 2 were homozygous deletions.

12 ions, some with high-level amplifications or homozygous deletions.

13 elocytic leukemia zinc finger (PLZF) protein homozygous deletions.

14 as project, 93 (21%) have KLLN hemizygous or homozygous deletions.

15 All of the putative homozygous deletions (10) and high-level amplifications

16 The homozygous deletion abolished U50 function in a colony f

17 Based on homozygous deletions affecting metabolic enzymes in 16 T

18 n cancer types and systematically screen for homozygous deletions, aiming to identify rare tumour sup

19 creased rates of LOH using the collection of homozygous deletion alleles of nonessential genes.

20 The odds ratio (OR) for p16INK4A homozygous deletion among alcohol consumers in the upper

21 ted over 50 sites (amplifications, potential homozygous deletion and gains or losses which extended o

22 ozygosity and copy number changes, including homozygous deletion and gene amplification, were similar

23 PTEN tumor suppressor was discovered by its homozygous deletion and other mutations in cancer.

24 evealed only minor expression differences in homozygous deletion and wild-type mice.

25 Then, we searched for homozygous deletions and amplifications in the tumor DNA

26 rs using approaches that can reliably detect homozygous deletions and amplifications.

27 (TSG) at 3p12, a region defined by hemi and homozygous deletions and functional analysis.

28 showing signatures of positive selection for homozygous deletions and identify candidate tumour suppr

29 Chromosomal abnormalities, including homozygous deletions and loss of heterozygosity, are amo

30 tative tumor suppressor genes by determining homozygous deletions and loss of heterozygosity.

31 We found homozygous deletions and mutations of MITOSTATIN gene in

32 polymorphisms in NQO1 (Pro187Ser) and GSTM1 (homozygous deletion) and asthma risk in children with hi

33 reduced in LKB1-null cell lines (mutation or homozygous deletion) and this partial degradation occurs

34 dies have shown that loss of heterozygosity, homozygous deletions, and abnormal expression of the FHI

35 ed and mapped regions of single-copy losses, homozygous deletions, and amplicons of various sizes in

36 s, 2p16/REL gains/amplifications, 19p13/CD70 homozygous deletions, and TP53 and MYC mutations.

37 ncers, including 8.1% heterozygous and 12.1% homozygous deletions, and were linked to advanced tumor

38 hat the genomic positions of the unexplained homozygous deletions are not randomly determined (P < 0.

39 Homozygous deletions are rare in cancers and often targe

40 , supports the hypothesis that hemizygous or homozygous deletions are responsible for the abnormal ex

41 DEAR1 undergoes loss-of-function mutations, homozygous deletion, as well as copy-number losses in mu

42 Mouse embryonic stem (ES) cells with a homozygous deletion at Acvr1 were used to generate chime

43 Genetic studies revealed a 175-kb homozygous deletion at chromosome 2q13, which encompasse

44 Genetic analysis revealed a homozygous deletion at the DNA level of 1758bp, predicte

45 In nine glioblastomas homozygous deletions at 1p36 were identified.

46 The finding of hemizygous or homozygous deletions at band 14 on chromosome 13 in a va

47 Homozygous deletions at DMBT1 repeat 2-4 to 2-7 were fou

48 ood by TaqMan and BioTrove assays identified homozygous deletions at the M1 and T1 loci of GST (GSTM1

49 a tendency to reduce the adverse effects of homozygous deletions by minimizing the number of genes r

50 In this study, we established CD47 homozygous deletion (CD47(-/-)) in human and mouse GBM c

51 The 178 unexplained homozygous deletions clustered into 131 genomic regions,

52 11,314 deletion, 5625 duplication, and 2746 homozygous deletion CNV regions (CNVRs).

53 s on the yeast whole-genome heterozygous and homozygous deletion collections and quantified the growt

54 ll prostate epithelium is inhibited by Grp78 homozygous deletion, corresponding with suppression of A

55 The prevalence of the homozygous deletion (del/del) genotype was 23%.

56 Next-generation sequencing identified homozygous deletions, deleterious mutations, or both in

57 ygous deletion or through adipocyte-targeted homozygous deletion, exhibited increased O-GlcNAc levels

58 Embryos produced by homozygous deletion females exhibit disorganized nuclei

59 eam reporter gene expression in strains with homozygous deletions for either gene, showing that each

60 However, DNA within homozygous deletions has higher flexibility.

61 There is evidence that homozygous deletion (HD) of chromosome 19p at the LKB lo

62 Biallelic or homozygous deletion (HD) of FOXO3 was detected in 8 of 3

63 d with 55 markers to identify new regions of homozygous deletion (HD) on chromosome 9p.

64 Detected aberrations include homozygous deletions, hemizygous deletions, copy-neutral

65 ic deletions in the tumor genome, especially homozygous deletions (HODs), have provided important pos

66 Here, we show that homozygous deletion (homozygous tm1a, tm1b, or tm1d alle

67 e recurrent region of loss contained a focal homozygous deletion in 11q24.2-q24.3 including the ETS1

68 defect led to the identification of a large homozygous deletion in FANCC, the first cancer cell line

69 f either, significantly predicted p16(INK4A) homozygous deletion in HNSCC.

70 The patient also harbored a homozygous deletion in IFNAR1 (IFNAR1*557Gluext*46), whi

71 th LOH in sporadic clear cell RCC as well as homozygous deletion in lung cancer.

72 s/ins)) as the primary disease locus while a homozygous deletion in MAP9 (MAP9 (del/del)) was later i

73 solated tRNALysCUU gene that was absent as a homozygous deletion in one of the parents.

74 iants were novel, including one multi-exonic homozygous deletion in OTOA.

75 ous studies have determined that mice with a homozygous deletion in the adapter protein p66(shc) have

76 The homozygous deletion in the cell lines was mapped to a 5.

77 ne that may cause GPR56 dysfunction, a 15-bp homozygous deletion in the cis-regulatory element upstre

78 ts do not exhibit any phenotype, whereas the homozygous deletion in the entire epiblast leads to panc

79 ith KS and their sister with nIHH harbored a homozygous deletion in the PROK2 gene (p.[I55fsX1]+[I55f

80 ng the c-myc and c-erbB-2 genes and apparent homozygous deletions in 3p21, 5q33, 8p23, 8p21, 9q34, 16

81 We identified 281 homozygous deletions in 636 cancer cell lines.

82 Here we identified 2,428 somatic homozygous deletions in 746 cancer cell lines.

83 4*1B and CYP3A5*3 variants and did not carry homozygous deletions in both GSTM1 and GSTT1 (denoted lo

84 However, most homozygous deletions in cancer genomes are unexplained.

85 Homozygous deletions in cancer genomes occur over recess

86 re, to elucidate further the pathogenesis of homozygous deletions in cancer, we investigated the geno

87 Hemizygous and homozygous deletions in cell lines/xenografts of prostat

88 (VEGFA) and 11q13 (FGF19/CNND1), as well as homozygous deletions in chromosome 9 (CDKN2A).

89 d adr-2, and characterize strains containing homozygous deletions in each, or both, of these genes.

90 Luca) region has been defined by overlapping homozygous deletions in lung and breast cancer cell line

91 elic losses and the discovery of overlapping homozygous deletions in lung and breast tumour-cell line

92 In particular, overlapping homozygous deletions in lung cancers have been identifie

93 gene, is a site of frequent heterozygous and homozygous deletions in many cancer cells and precancero

94 nto 131 genomic regions, 27 of which exhibit homozygous deletions in more than one cancer cell line.

95 We propose that homozygous deletions in such passenger genes can expose

96 Mice carrying homozygous deletions in the Ets-1 gene exhibited blunted

97 h known and novel genomic amplifications and homozygous deletions in these cancer samples.

98 Many homozygous deletions, including those that are in multip

99 competitive repopulation advantage, whereas homozygous deletion induces hematopoietic stem cell fail

100 es were analyzed for loss of heterozygosity, homozygous deletion, intragenic mutations, and promoter

101 Homozygous deletions, intragenic breaks, or microdeletio

102 Inactivation of tumour-suppressor genes by homozygous deletion is a prototypic event in the cancer

103 This EST mapping within the homozygous deletion is also expressed in HeLa cells, the

104 Hypothesizing that p16INK4A homozygous deletion is associated with tobacco and alcoh

105 The gene count within homozygous deletions is low compared with the rest of th

106 Among homozygous deletions, loci containing Rb1, CDKN2A/B, CSM

107 al response of both the reference strain and homozygous deletion mutant strain of CCC2, which encodes

108 r presenting with hyperlipidemia caused by a homozygous deletion mutation in CYP7A1.

109 We report a novel, homozygous, deletion mutation in a child of Nicaraguan d

110 These recurrent homozygous deletions occur either over tumour suppressor

111 For example, while CDKN2A homozygous deletions occur in a context of FGFR3-activat

112 PCR analysis further identified homozygous deletion of 11q13 sequences in a primary tumo

113 ysis revealed that all affected dogs share a homozygous deletion of 7.8 kb in the NHEJ1 gene.

114 ed a pool of 4,627 diploid strains each with homozygous deletion of a nonessential gene to identify t

115 owth factor (VEGF) stimulation with regional homozygous deletion of Alk1 induces severe dysplasia in

116 Although homozygous deletion of all three critical CDKN2A exons (

117 Homozygous deletion of ASF1A is seen in 10%-15% of certa

118 Homozygous deletion of beta1 integrins in the endotheliu

119 In the mouse, homozygous deletion of Bin1 causes developmental lethali

120 ssociated with pancreatic agenesis; however, homozygous deletion of both Gata4 and Gata6 is necessary

121 Mice with homozygous deletion of both TP53 and PIP4K2B were not vi

122 Delta11/Delta11)p53(+/-) mice that carried a homozygous deletion of Brca1 exon 11 and a p53 heterozyg

123 KRAS (73%), amplification of MYC (47%), and homozygous deletion of CDKN2A (40%) that are common in P

124 dren, in which there is frequent concomitant homozygous deletion of CDKN2A (five of seven cases).

125 During a study of SV40 in relation to homozygous deletion of CDKN2A in mesotheliomas, we becam

126 In contrast, expression of CD8 or CD62L, homozygous deletion of CDKN2A/CDKN2B, NOTCH1 and/or FBXW

127 We found that homozygous deletion of Chk1 immediately before carcinoge

128 In this regard, homozygous deletion of CK2alpha leads to embryonic letha

129 Mice harboring a homozygous deletion of Cyp24a1 (BVE(Cyp24a1-null)) exhib

130 ion was derived from study of knockout mice: homozygous deletion of dab2 results in early embryonic l

131 Mice with a homozygous deletion of DBH (Dbh-/-) have a selective and

132 gressive PDAC was observed in the setting of homozygous deletion of either p53 or p16(Ink4a), the lat

133 Homozygous deletion of Ets2 in p53 mutant mice resulted

134 Homozygous deletion of ETV4, using CRISPR/Cas9, led to g

135 in 3 of 20 ovarian tumor samples, as well as homozygous deletion of exon 2 in the lung adenocarcinoma

136 Genetic evaluation revealed a homozygous deletion of exon 21 in CARD11 as the underlyi

137 SRP to 2p24, where we identified an in-frame homozygous deletion of exon 5 in WDR35.

138 Meanwhile, FLPe-mediated homozygous deletion of exon 7 completely eliminated GBE

139 al muscular atrophy (age 16-65 years) with a homozygous deletion of exons 7, 8, or both, or with comp

140 FoxO1(3A/LXXAA), those with cardiac-specific homozygous deletion of FoxO1 (c-FoxO1(-/-)), and beclin1

141 tumors induced by the Neu (ErbB-2) oncogene, homozygous deletion of Gab2 in mice had only a modest ef

142 Homozygous deletion of Gad1 significantly reduced miniat

143 Homozygous deletion of GDE1 results in a buildup of inte

144 (HSC) and progenitor function in mice with a homozygous deletion of Gli1 (Gli1(null)).

145 We show that homozygous deletion of glycogen synthase kinase (GSK) 3b

146 Here, we report that homozygous deletion of Grp78 specifically in mouse prost

147 and breast cancer were more consistent with homozygous deletion of GSTM1 or GSTT1, the AAgenotype of

148 However, among subjects with homozygous deletion of GSTM1, carriers of a serine allel

149 Homozygous deletion of Hic1 in mice results in major dev

150 Mice with a homozygous deletion of Id4 (Id4(-/-)) have reduced body

151 naling and ADPKD cell proliferation in vitro Homozygous deletion of ILK in renal collecting ducts (CD

152 We demonstrate here that homozygous deletion of Ink4a-Arf bypasses the requiremen

153 Here we showed that homozygous deletion of Jmjd3 resulted in severe delay of

154 Homozygous deletion of Letm1 in mice resulted in embryon

155 Whereas homozygous deletion of LKB1 led to embryonic lethality,

156 Homozygous deletion of murine abi2 produced abnormal phe

157 cterized a mouse model with heterozygous and homozygous deletion of Mybphl.

158 In this study, we have shown that homozygous deletion of Nf1, the Ras GTPase gene underlyi

159 We further show that mice with homozygous deletion of Notch3 do not develop pulmonary h

160 ns in the known NPHP genes, particularly the homozygous deletion of NPHP1 at 2q13, have been identifi

161 , these alterations are most commonly due to homozygous deletion of p16(INK4a) and less commonly due

162 EWS-FLI1 fusion type, p53 mutation, and homozygous deletion of p16/p14ARF have each been shown t

163 Homozygous deletion of p16/p14ARF, and p53 mutations wer

164 To examine the effects of homozygous deletion of p190A, embryonic mammary buds wer

165 femoral artery mechanical injury, mice with homozygous deletion of p21Cip1 displayed accelerated pro

166 l injury was markedly increased in mice with homozygous deletion of p27(Kip1), characterized by promi

167 g Kras(G12D) activation with heterozygous or homozygous deletion of p53 (mean survival of 56 weeks vs

168 for distant metastases relative to mice with homozygous deletion of p53 or p16(Ink4a)/p19(Arf).

169 d mammary tumor formation in mice carrying a homozygous deletion of p53, uncovering a complex relatio

170 Homozygous deletion of PAPPA in mice leads to lifespan e

171 llele and mouse embryonic fibroblasts with a homozygous deletion of PERK exhibited attenuated phospho

172 Though homozygous deletion of Poldip2 is lethal, heterozygous m

173 Homozygous deletion of PSPHL was detected in 61% of CW c

174 Mice carrying homozygous deletion of Pten alleles developed widespread

175 Homozygous deletion of Pten causes embryonic lethality,

176 We report that homozygous deletion of PTEN in mammary epithelial cells

177 tion conditions, which was associated with a homozygous deletion of PTEN, the first reported in MM.

178 Previously, we showed that homozygous deletion of Rb in a prostate tissue recombina

179 Intriguingly, the homozygous deletion of ribosomal protein S6 kinase 1 (S6

180 iological roles of RINT-1, we found that the homozygous deletion of Rint-1 caused early embryonic let

181 generated mutant mice harboring alleles with homozygous deletion of ROCK1 (ROCK1(-/-)).

182 Consistently, homozygous deletion of Shp2 inhibited adipocyte differen

183 otes UVB-induced skin tumorigenesis, whereas homozygous deletion of SIRT1 suppresses skin tumor devel

184 In contrast, homozygous deletion of Sirt1 triggers cellular apoptotic

185 We found that specific homozygous deletion of Sox4 in the adult prostate epithe

186 Consequently, homozygous deletion of src homology 3 and cysteine rich

187 Homozygous deletion of SRC-3 in mice completely prevents

188 Homozygous deletion of survival of motor neuron 1 (SMN1)

189 Here we show that homozygous deletion of the aryl hydrocarbon receptor-int

190 sis in mice skin in vivo using mice with the homozygous deletion of the C-terminal transcriptional ac

191 Mice with homozygous deletion of the Cav-1 gene develop PH and rig

192 Mice with homozygous deletion of the coding sequence of KCNE1 have

193 Homozygous deletion of the cyclin D1 gene, enhanced expr

194 Homozygous deletion of the Efnb2 C-terminus caused abnor

195 Homozygous deletion of the EP1, EP2, or EP3 receptors di

196 We show that mice with homozygous deletion of the Ets transcription factor Erg

197 mouse embryo fibroblasts (MEF) or MEF with a homozygous deletion of the Gab1 gene (-/- MEF) with H(2)

198 Homozygous deletion of the gene encoding either receptor

199 T-ALL samples harbored either a mutation or homozygous deletion of the gene FBW7, a ubiquitin ligase

200 regulated by promoter hypermethylation or by homozygous deletion of the gene locus in certain cancers

201 tein, and chromosomal microarray confirmed a homozygous deletion of the group-specific component (GC)

202 Here we show that conditional homozygous deletion of the Hoxa cluster (Hoxa(-/-)) resu

203 We recently found that homozygous deletion of the insulin-degrading enzyme (IDE

204 Both heterozygous and homozygous deletion of the Lzts2-targeted allele in mice

205 Homozygous deletion of the MCM9 found in various cancers

206 Our results demonstrate that homozygous deletion of the Mdm4 RING domain results in p

207 Herein, we show that homozygous deletion of the miR-29a/b-1 bicistron results

208 further demonstrate that this loss is due to homozygous deletion of the miR-31-encoding gene that res

209 CRISPR-mediated homozygous deletion of the mouse ortholog of a noncoding

210 Homozygous deletion of the MRP1 gene in primary murine n

211 blood transplantation from donors carrying a homozygous deletion of the NKG2C gene.

212 with a mild form of JS were found to have a homozygous deletion of the NPHP1 gene identical, by mapp

213 In contrast, homozygous deletion of the NRC gene is embryonic lethal.

214 Moreover, homozygous deletion of the OLFM4 gene significantly corr

215 Homozygous deletion of the orthologous enhancer region i

216 Homozygous deletion of the p16(INK4a)/p14(ARF)/p15(INK4b

217 One somatic event in this pathway, homozygous deletion of the p16INK4A gene, is commonly ob

218 Mice with homozygous deletion of the plasminogen activator inhibit

219 nctional connectivity.SIGNIFICANCE STATEMENT Homozygous deletion of the Pten gene in neuronal subpopu

220 cancer-prone, heterozygous APC mutant mice, homozygous deletion of the Rad52 gene suppressed tumor g

221 ne genes and rescues the lethality caused by homozygous deletion of the RD histone locus.

222 blated by siRNA or chicken DT40 cells with a homozygous deletion of the RNF4 gene displayed increased

223 Herein, homozygous deletion of the Sirt1 gene in mice resulted i

224 of motor neuron (SMN) protein resulting from homozygous deletion of the SMN1 gene.

225 of acute myeloid leukemia (AML) in mice with homozygous deletion of the upstream regulatory element (

226 Mice with a homozygous deletion of this gene die at various time poi

227 ter region, while four (36%) had evidence of homozygous deletion of this region.

228 PR/Cas9, we created a transgenic line with a homozygous deletion of TpnC41C and compared its phenotyp

229 n and reduced apoptosis, in situ Conversely, homozygous deletion of TRAP1 delays prostatic tumorigene

230 endent homozygous frameshift mutations and a homozygous deletion of two exons in PIEZO2 that segregat

231 We now report that homozygous deletion of Ubiad1 is produced in knockin mic

232 when donor and recipient were mismatched for homozygous deletion of UGT2B17, a gene expressed in GVHD

233 gene (UNC5B(-/flox)) and mice with targeted homozygous deletion of UNC5B in kidney epithelial cells

234 in human colorectal cancer (CRC) cells with homozygous deletion of VEGF alleles to determine the pot

235 Indeed, homozygous deletion of Xrcc1 does not impair A-EJ of I-S

236 While homozygous deletions of 86 kb were achieved with up to 8

237 Large homozygous deletions of 9p21 that inactivate CDKN2A, ARF

238 All 22 cell lines examined showed homozygous deletions of 9p21.3, centering at the CDKN2A/

239 elated genes such as MYC, ID3, and DDX3X and homozygous deletions of 9p21/CDKN2A, whereas other cases

240 alyses showed that all affected patients had homozygous deletions of a single SNP (rs721575) and thei

241 rves of transgenic mice with heterozygous or homozygous deletions of APP.

242 fetal liver (FL) cells from mice containing homozygous deletions of both STAT5a and STAT5b genes (ST

243 expressing Cre-recombinase to generate focal homozygous deletions of Cbp in the nucleus accumbens (NA

244 Homozygous deletions of CDKN2A (9p21), PTEN (10q26), and

245 Somatic homozygous deletions of chromosomal regions in cancer, w

246 Homozygous deletions of chromosome 9p21 are known to tar

247 Homozygous deletions of exons 1 to 7 are predominantly s

248 ific alterations included amplifications and homozygous deletions of genes not yet implicated in epen

249 expressing Cre recombinase to generate focal homozygous deletions of Hdac3 in area CA1 of the dorsal

250 Of these deletions, 86 were homozygous deletions of known recessive cancer genes, 17

251 g nonsynonymous or splice site mutations and homozygous deletions of NER genes.

252 f nephronophthisis cases are caused by large homozygous deletions of NPHP1, but six genes responsible

253 K4c) often occurred in tumors also harboring homozygous deletions of p16(INK4a).

254 Homozygous deletions of recessive cancer genes and fragi

255 It is caused by homozygous deletions of STE20-related kinase adaptor alp

256 ulation of murine embryonic fibroblasts with homozygous deletions of the c-src, fyn, and yes genes fa

257 No homozygous deletions of the CFHR1 and CFHR3 genes, which

258 Recently, homozygous deletions of the chromosomal band 6q23, invol

259 ses their levels, we characterized mice with homozygous deletions of the IDE gene (IDE --).

260 e found 28% to 45% hemizygous and 15% to 57% homozygous deletions of the OLFM4 gene via fluorescence

261 Five homozygous deletions of tumour suppressor genes were con

262 that biallelic PTEN inactivation, by either homozygous deletion or deletion of one allele and mutati

263 Homozygous deletion or missense mutation in DJ-1 results

264 Homozygous deletion or mutation of the survival of motor

265 rvival motor neuron protein (SMN) due to the homozygous deletion or rare point mutations in the survi

266 d adenoid cystic carcinomas reported to have homozygous deletion or significant underexpression of AS

267 Together with point mutations, homozygous deletions or duplications in PARK2 are respon

268 ructural signatures that distinguish between homozygous deletions over recessive cancer genes and fra

269 Individuals were genotyped for a homozygous deletion polymorphism in the M1 gene loci of

270 A common homozygous deletion polymorphism of the GSTM1 gene elimi

271 Our study provides a genome-wide homozygous deletion profile in HG serous carcinomas, whi

272 s been identified in a 120-kb critical tumor homozygous deletion region (found in lung and breast can

273 a(2+)-channel complex, was identified in the homozygous deletion region of chromosome 3p21.3 in human

274 18 different ESTs localized adjacent to the homozygous deletion showed the presence of a transcript

275 o 18 kb) located on chromosome 22 and even a homozygous deletion smaller than 1 kb with high-resoluti

276 osteosarcoma model, we identified a somatic homozygous deletion specifically targeting Smpd3.

277 e that, whereas nuclear pore proteins of the homozygous deletion strain are devoid of O-GlcNAc, nucle

278 tive markers, we created approximately 3,000 homozygous deletion strains affecting 674 genes, or roug

279 all mice with Kras(G12D) activation and Pten homozygous deletion succumbed to cancer by 3 weeks of ag

280 Likewise, newly discovered PCR-validated homozygous deletions suggested candidate tumor-suppresso

281 r, the gene has not been reported to undergo homozygous deletion, suggesting that DICER1 is haploinsu

282 Application to clusters of unexplained homozygous deletions suggests that many are in regions o

283 eral loci, some containing large, inherited, homozygous deletions that are likely mutations.

284 -stage, sarcomatous histology and P16/CDKN2A homozygous deletion to be significant independent advers

285 ration of tobacco use, the OR for p16(INK4A) homozygous deletion was 1.3 (95% CI, 0.5-3.0) and 1.9 (9

286 rian aging phenotype of the Wv mice, whereas homozygous deletion was accompanied by a compensatory in

287 No homozygous deletion was detected at locus 74k in the 5'

288 n KLF5, and neither promoter methylation nor homozygous deletion was detected in any of the cell line

289 However, the homozygous deletion was significantly associated with un

290 reviously characterized loci, two regions of homozygous deletion were found, one near the PTPRD locus

291 Focal homozygous deletions were detected at 8p22, 10q23.31, 13

292 Homozygous deletions were detected in 51 genomic clones,

293 ach other, as irreversible mutations such as homozygous deletions were frequently not inherited from

294 Homozygous deletions were identified within the RPS6KA2

295 ere confirmed, and several potentially novel homozygous deletions were identified.

296 Except for the CDKN2A/B region, these homozygous deletions were not present in either SBT or L

297 s of amplifications and deletions, including homozygous deletions, were identified.

298 Some cancer cell lines have multiple homozygous deletions whereas others have none, suggestin

299 We have also observed a 5.7-kb homozygous deletion within this interval in HeLa cells (

300 Frequent allelic loss and homozygous deletions within chromosome 3p in human lung