ライフサイエンスコーパス: hookworm

1 nts in targeting parasitic roundworms (e.g., hookworms).

2 dren coinfected with Schistosoma mansoni and hookworm.

3 t doses comparable with its known effects on hookworm.

4 ng efficacy against Ascaris lumbricoides and hookworm.

5 dren coinfected with Schistosoma mansoni and hookworm.

6 Albendazole is the drug of choice against hookworm.

7 that has previously been isolated from adult hookworms.

8 rotein extracts of adult Ancylostoma caninum hookworms.

9 parasite fecundity in hamsters infected with hookworms.

10 lp in devising new drugs or vaccines against hookworms.

11 represent new potential drug targets against hookworms.

12 prevalence of elephantiasis (16.7% to 5.3%), hookworm (10.3% to 1.9%), roundworm (34.5% to 2.3%), and

13 ndividuals infected with M. perstans but not hookworm, 2.33 (95% CI, 1.47-3.69); for individuals infe

14 h Schistosoma japonicum (15.6%, P = .03) and hookworm (22.0%, P = .05) were significantly lower among

15 (30.8%, P = .02) and for those infected with hookworm (31.8%, P = .0002).

16 Common maternal infections were hookworm (45%), Mansonella perstans (21%), Schistosoma m

17 prevalence of elephantiasis (12.6% to 4.6%), hookworm (7.8% to 0%), roundworm (33.5% to 6.1%), and wh

18 le alone significantly reduced prevalence of hookworm (8.1% to 1.3%), roundworm (28.4% to 0.9%), and

19 Pyrantel-oxantel significantly reduced hookworm (93.4% to 85.2%), roundworm (22.8% to 1.4%), an

20 endazole significantly reduced prevalence of hookworm (94.0% to 71.8%), roundworm (62.0% to 1.4%), an

21 in vitro and in vivo data indicate that the hookworm A. ceylanicum is a particularly sensitive and u

22 We estimate that the prevalence of hookworm, A lumbricoides, and T trichiura among school-a

23 the data in space and estimate risk of with hookworm, A lumbricoides, and T trichiura over a grid of

24 We hypothesize that hookworms actively manipulate the host immune response t

25 Hookworms, aggressive, blood-feeding, intestinal nematod

26 ble egg antigen and SmTAL2) or somatic adult hookworm (AHW) antigens either decreased after treatment

27 terior secretory glands of the dog-infecting hookworm Ancylostoma caninum and the human-infecting hoo

28 , from the blood-feeding stage of the canine hookworm Ancylostoma caninum and vaccinated dogs with th

29 The hematophagous hookworm Ancylostoma caninum produces a family of small,

30 The dog hookworm Ancylostoma caninum secretes an astacin-like me

31 vel glutathione S-transferase from the adult hookworm Ancylostoma caninum, and its possible role in p

32 e similarity to Ac-GST-1, a GST from the dog hookworm Ancylostoma caninum.

33 m AcAP5, its homologue isolated from the dog hookworm Ancylostoma caninum.

34 Hamsters were infected with the hookworm Ancylostoma ceylanicum and vaccinated with the

35 e report two x-ray crystal structures of the hookworm Ancylostoma ceylanicum DAF-12 ligand binding do

36 tic threadworm Strongyloides stercoralis and hookworm Ancylostoma ceylanicum have highly dissimilar o

37 Ancylostoma caninum and the human-infecting hookworm Ancylostoma ceylanicum, and BmK1, the C-termina

38 bitory Factor (MIF) has been cloned from the hookworm Ancylostoma ceylanicum.

39 ) has been used to model infections with the hookworm Ancylostoma ceylanicum.

40 41-kDa glycoprotein isolated from the canine hookworm (Ancylostoma caninum), binds to the I domain of

41 41-kD glycoprotein isolated from the canine hookworm (Ancylostoma caninum), is a beta2 integrin anta

42 rin-binding protein isolated from the canine hookworm (Ancylostoma caninum).

43 -transmitted helminths Ascaris lumbricoides, hookworm (Ancylostoma duodenale and Necator americanus),

44 vidual infection with Plasmodium falciparum, hookworm (Ancylostoma duodenale and/or Necator americanu

45 eases of the major blood-feeding nematodes - hookworms (Ancylostoma spp. and Necator americanus) and

46 (Ascaris lumbricoides, Trichuris trichiura, hookworm [Ancylostoma duodenale and Necator americanus],

47 testinal brush border membrane of the canine hookworm, Ancylostoma caninum, contains aspartic proteas

48 Unlike other hookworms, Ancylostoma ceylanicum infects both humans an

49 Oxantel pamoate had low efficacy against hookworm and A. lumbricoides.

50 eatest risk of infection with P. falciparum, hookworm and E. histolytica/dispar, as well as co-infect

51 ng the development of new methods to control hookworm and human immunological diseases.

52 effective elimination strategy for targeting hookworm and liver and intestinal fluke infections throu

53 Maternal hookworm and M. perstans infections were associated with

54 47-3.69); for individuals infected with both hookworm and M. perstans, 1.85 (CI, 1.24-2.76).

55 4+ cell counts were highest in subjects with hookworm and Mansonella perstans infection.

56 Hookworm and Mansonella perstans infections were associa

57 tion to modulate the host immune response to hookworm and other parasites.

58 s), 5 potential pan-intestinal (whipworm and hookworm) and 6 pan-Phylum Nematoda (intestinal and fila

59 e site of infection by a parasitic helminth (hookworm) and gluten-dependent inflammation in humans wi

60 50 were infected with T. trichiura, 443 with hookworm, and 293 with A. lumbricoides.

61 lumbricoides, 1% with T. trichiura, 2% with hookworm, and 39% with G. duodenalis.

62 g Ascaris lumbricoides, Trichuris trichiura, hookworm, and Giardia duodenalis among children born to

63 treatment in children with afebrile malaria, hookworm, and Schistosoma haematobium infection.

64 ed helminthiases - ascariasis, trichuriasis, hookworm, and strongyloidiasis - in addition to the inte

65 transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura) are widespread and of

66 prior to and following infection with human hookworms, and following challenge with escalating doses

67 en administered as a mucosal vaccine against hookworm anemia.

68 represent a useful strategy for controlling hookworm anemia.

69 in parasite survival and the pathogenesis of hookworm anemia.

70 ed risk of wheeze, and IgG4 to somatic adult hookworm antigen with a reduced risk of HDM-SPT sensitiv

71 e vaccination of hamsters with soluble adult hookworm antigens emulsified in alum led to partial prot

72 infected animals following stimulation with hookworm antigens was partially restored in the presence

73 IgG1, and IgG4 responses to schistosome and hookworm antigens, including the allergen-like proteins

74 educed host lymphoproliferative responses to hookworm antigens.

75 In humans, hookworms appear to impair memory and other forms of cog

76 Hookworms are a leading cause of anemia in developing co

77 of anemia control in schoolchildren in whom hookworms are endemic, and should be complemented with s

78 Hookworms are hematophagous nematodes capable of growth,

79 Hookworms are human parasites that have devastating effe

80 Hookworms are one of the most prevalent and important pa

81 th infections, ascariasis, trichuriasis, and hookworm, are common clinical disorders in man.

82 Soil-transmitted helminths (hookworm, Ascaris lumbricoides, and Trichuris trichiura)

83 or soil-transmitted helminth infections (ie, hookworm, Ascaris lumbricoides, Trichuris trichiura) wit

84 s shown to confer partial protection against hookworm-associated growth delay without a measurable ef

85 The hookworm-associated immunodepression may have important

86 at AceKI plays a role in the pathogenesis of hookworm-associated malnutrition and growth delay, perha

87 ified in alum led to partial protection from hookworm-associated pathology in the absence of reductio

88 ctor Xa inhibitory activity is predictive of hookworm bloodfeeding capabilities in vivo.

89 s with Ac-ASP-1 also exhibited reductions in hookworm burden in the muscles.

90 Hookworm burden reductions from Ac-ASP-1 immunization we

91 -ASP-1-vaccinated mice also resulted in lung hookworm burden reductions.

92 ma responses were negatively associated with hookworm burden, decreasing by 18 pg/mL for each increas

93 eductions in fecal egg counts and intestinal hookworm burden.

94 ogel elicited 32 and 39% reductions in adult hookworm burdens (P < 0.05) following N. americanus larv

95 otection is manifested by reductions in lung hookworm burdens at 48 h postchallenge.

96 sitive association between P. falciparum and hookworm but no association between P. falciparum and Sc

97 as as follows: for individuals infected with hookworm but not M. perstans, 1.53 (95% confidence inter

98 ts and excretory/secretory products of adult hookworms but not the infective third stage larvae.

99 uld represent a potential mechanism by which hookworms can regulate gluten-induced inflammation and m

100 Hookworms cause a major neglected tropical disease, occu

101 one in six, people worldwide are infected by hookworms causing gastrointestinal blood loss and iron d

102 num (Ac-ASP-1) results in protection against hookworm challenge infections.

103 accine candidates were evaluated in a rodent hookworm challenge model, resulting in up to 98% and 99%

104 After 24 months, prevalence of hookworm changed from 18.6% (95% CI 13.9-23.2) to 13.8%

105 Plasmodium-hookworm coinfection exhibits marked age dependency and

106 , and consequences of Plasmodium species and hookworm coinfection in rural communities in Uganda.

107 Prevalence of Plasmodium-hookworm coinfection was 15.5% overall and highest among

108 Since the 1990s, the major approach to hookworm control has been morbidity reduction in school-

109 lel efforts to develop new and complementary hookworm control tools, such as new anthelmintic drugs (

110 the potential for selectively inhibiting the hookworm cytokine as a means of reducing parasite surviv

111 a-responsive myeloid cells promote repair of hookworm-damaged lung tissue, because LysM(Cre)TGF-betaR

112 nt study was designed to determine whether a hookworm-derived recombinant neutrophil inhibitory facto

113 that severe dietary iron restriction impairs hookworm development in vivo but that moderate iron rest

114 Hookworm disease is among the leading causes of iron-def

115 involved and understand the epidemiology of hookworm disease.

116 h A. ceylanicum and followed for evidence of hookworm disease.

117 are promising candidates as vaccines against hookworm disease.

118 of worker productivity are diminished during hookworm disease.

119 iron deficiency anemia are the hallmarks of hookworm disease.

120 er mammals, providing a laboratory model for hookworm disease.

121 llular traps (NETs), but whether they target hookworms during skin infection is unknown.

122 Heritability for hookworm egg count was 17% before treatment and 25% afte

123 ignificantly greater in children with > 2000 hookworm eggs/g feces at baseline.

124 Our findings highlight the importance of hookworm elimination and suggest that finer tuned spatia

125 d the antibody responses of individuals from hookworm endemic areas of Brazil and China against the m

126 significant proportion of the population in hookworm-endemic areas had increased levels of IgE to Na

127 c studies in adults and children residing in hookworm-endemic areas were conducted to assess the prev

128 improving birthweight and infant survival in hookworm-endemic regions.

129 ers that were orally vaccinated with soluble hookworm extract (the latter animals were also resistant

130 moral immune responses against soluble adult hookworm extracts and excretory-secretory products that

131 rarosaniline, showed a significant impact on hookworm fecundity in vivo.

132 cinated dogs were significantly smaller than hookworms from control dogs.

133 -Ac-CP-2 antibodies were bound to the gut of hookworms from vaccinated dogs, which suggests that thes

134 Characterization of this first hookworm genome sequence identified genes orchestrating

135 demonstrate a postgenomic application of the hookworm genome sequence.

136 Sequencing hookworm genomes and finding which genes they express du

137 Hookworm glutathione S-transferases (GSTs) are critical

138 iron absorptions in the afebrile malaria and hookworm groups were 12.9% and 32.2% (P < 0.001) before

139 79.1% and 88.0% in the afebrile malaria and hookworm groups with no significant differences pre- and

140 ptide antigen, and the parent protein in the hookworm gut.

141 in fecal egg counts and the number of female hookworms in vaccinated dogs.

142 acilitate the specific study of bloodfeeding hookworms in vivo without prior exposure of the host to

143 d at least one stool nematode, most commonly hookworm (in 9.2%).

144 Hookworms infect over 400 million people, stunting and i

145 Although blood-feeding hookworms infect over a billion people worldwide, little

146 We find that hookworm-infected hamsters were fully capable of detecti

147 However, hookworm-infected hamsters were impaired in detecting a

148 As controls, hookworm-infected hamsters were treated with the anthelm

149 inimidyl ester-positive lymphocytes from the hookworm-infected vaccinated group were reduced by 50% r

150 s expressing IFNgamma were reduced following hookworm infection (23.9%-11.5%; P = .04), with correspo

151 ng shoes was associated with reduced odds of hookworm infection (OR 0.29, 95% CI 0.18-0.47) and infec

152 es (OR 0.62, 95% CI 0.44-0.88), but not with hookworm infection (OR 0.80, 95% CI 0.61-1.06).

153 5% confidence interval [CI], 1.03-2.14), and hookworm infection (OR, 1.77; 95% CI, 1.22-2.55) were th

154 e association between Plasmodium-species and hookworm infection among preschool-aged children (odds r

155 s highlight the importance of neutrophils in hookworm infection and a potential conserved mechanism o

156 Hookworm infection and gluten exposure were associated w

157 Hookworm infection appeared to modify the relationship b

158 s with tribendimidine against moderate/heavy hookworm infection are needed.

159 Mortality was lower in subjects with hookworm infection at enrollment.

160 risk of wheeze was independently reduced by hookworm infection by an odds ratio of 0.48 (95% CI 0.24

161 Other molecular mechanisms of hookworm infection cause a systematic suppression of the

162 In school-age children, hookworm infection does not produce inflammation or incr

163 Thus, coincident hookworm infection exerts a profound inhibitory effect o

164 g human immunity to both schistosomiasis and hookworm infection has been associated with IgE response

165 These data demonstrate that human hookworm infection in a laboratory mammal results in a s

166 of an effective recombinant vaccine against hookworm infection in humans.

167 t loss and anemia) of Ancylostoma ceylanicum hookworm infection in Syrian golden hamsters of the outb

168 Predisposition to human hookworm infection in this area results from a combinati

169 ficant role for host genetics in determining hookworm infection intensity has also been shown, but th

170 In multivariate analyses, hookworm infection intensity was the strongest explanato

171 Hookworm infection is a major cause of anemia and malnut

172 Human hookworm infection is a major cause of anemia and malnut

173 Hookworm infection is a major cause of iron deficiency a

174 Hookworm infection is associated with growth delay and i

175 Together, these data demonstrate that hookworm infection is associated with impaired function

176 escence-activated cell sorting revealed that hookworm infection is associated with reduced percentage

177 Predisposition to heavy or light human hookworm infection is consistently reported in treatment

178 Our data show that, although hookworm infection leads to a minor increase in microbia

179 Treatment of hookworm infection neither affected inflammation biomark

180 Experimental hookworm infection of the trial subjects resulted in mai

181 sed to determine the impact of A. ceylanicum hookworm infection on host cytokine responses and lympho

182 To determine the role of coincident hookworm infection on responses at steady-state and on M

183 so we examined the influence of experimental hookworm infection on the predicted outcomes of escalati

184 We also found that hookworm infection resulted in reproducible reductions i

185 demonstrate that the presence of coincident hookworm infection significantly diminished both spontan

186 infective larvae (L3) in a controlled human hookworm infection trial and followed for 52 weeks.

187 iron restriction mediates susceptibility to hookworm infection using the hamster model of Ancylostom

188 In addition, hookworm infection was associated with a significantly r

189 1.34; 95% CI, 1.05-1.71; 20 studies), while hookworm infection was associated with a significantly s

190 Additionally, coincident hookworm infection was associated with increased adaptiv

191 Predisposition to heavy or light hookworm infection was observed, with a phenotypic corre

192 h P. falciparum infection, but the effect of hookworm infection was seen only in the absence of M. pe

193 Hookworm infection was undetectable after 1 year.

194 CRs against hookworm infection were 57% (moxidectin) and 56% (iverme

195 However, in infants of mothers with hookworm infection, albendazole treatment reduced interl

196 s observed among children without detectable hookworm infection, but no association was observed amon

197 Hookworm infection, in contrast, was associated with exp

198 lopment of NTD vaccines, including those for hookworm infection, schistosomiasis, leishmaniasis, and

199 As part of on-going efforts to control hookworm infection, The Human Hookworm Vaccine Initiativ

200 ring chronic helminth infection; at least in hookworm infection, this suppression may protect against

201 viduals with LTB with or without concomitant hookworm infection.

202 but not IL-4-driven Type 2 responses during hookworm infection.

203 SP-2-specific IgE likely induced by previous hookworm infection.

204 ency anemia that is the clinical hallmark of hookworm infection.

205 on the risk of an individual harboring heavy hookworm infection.

206 anti-ASP-2 IgE levels and the risk of heavy hookworm infection.

207 important new tool for the control of human hookworm infection.

208 -1 is a possible drug and vaccine target for hookworm infection.

209 are efficacious vaccines in animal models of hookworm infection.

210 of Australia who were suffering from endemic hookworm infection.

211 weight loss and anemia caused by a secondary hookworm infection.

212 immunity and restricts lung injury following hookworm infection.

213 Hookworm infections and tuberculosis (TB) are coendemic

214 These results suggest that hookworm infections have an immunomodulatory effect by i

215 pathogenesis by allowing the study of adult hookworm infections in a species with well-characterized

216 ty of ascending tribendimidine doses against hookworm infections in African school-aged children, key

217 hamsters (i.e., those with neither previous hookworm infections nor treatment) were also vaccinated.

218 he effect of concurrent (active) and treated hookworm infections on the immunogenicity of vaccination

219 species for examining host immunity to human hookworm infections.

220 interbirth intervals, whereas infection with hookworm is associated with delayed first pregnancy and

221 Where hookworm is heavily endemic, deworming programs can impr

222 ustainability of benzimidazole deworming for hookworm is of concern because of the variable efficacy

223 er third-stage Ancylostoma caninum infective hookworm larvae (L3) or alum-precipitated recombinant An

224 animals with living irradiated, third-stage hookworm larvae (L3), we examined the antibody responses

225 rotein 2 (Na-ASP-2) is secreted by infective hookworm larvae on entry into human hosts.

226 TP-1 is critical for the invasion process of hookworm larvae, and moreover, that antibodies against t

227 was found to be highly toxic to early stage hookworm larvae.

228 tion with third-stage Ancylostoma ceylanicum hookworm larvae.

229 l protect against asthma, but infection with hookworm may reduce the risk of this disease.

230 The relative bioactivities of human and hookworm MIF proteins were compared using in vitro assay

231 alyses pave the way for the controlled human hookworm model to accelerate drug and vaccine efficacy s

232 s aimed at defining mechanisms through which hookworms modulate the host cellular immune response.

233 ing a full-length GST protein from the human hookworm Necator americanus (and designated Na-GST-1, Na

234 The hookworm Necator americanus establishes infections of im

235 that the excretory/secretory products of the hookworm Necator americanus inhibited eosinophil recruit

236 The hookworm Necator americanus is the predominant soil-tran

237 in secreted by infective larvae of the human hookworm Necator americanus, has been solved to resoluti

238 Trials using helminths like hookworm (Necator americanus) or porcine whipworm (Trich

239 The human hookworm, Necator americanus, is a parasite that infects

240 One exception is infection with the human hookworm, Necator americanus, where virtually no protect

241 sent in other nematodes, including the human hookworm, Necator americanus, which also evaded NETs in

242 infection with the blood-feeding intestinal hookworm, Necator americanus.

243 l established that infection with the rodent hookworm Nippostrongylus brasiliensis induces a strongly

244 y and anamnestic immunity against the rodent hookworm Nippostrongylus brasiliensis.

245 Employing a rodent model of infection with hookworm (Nippostrongylus brasiliensis), we characterize

246 Using a murine hookworm, Nippostrongylus brasiliensis, we observed neut

247 non-poultry based livestock farming and for hookworm (OR 2.42, CI 1.56-3.75), malaria (OR 2.00, CI 1

248 nfection intensity, types of worms (ascaris, hookworm, or trichuris), risk of bias, cluster versus in

249 rculosis, and HIV, and co-infections between hookworm, P. falciparum and E. histolytica/dispar, were

250 Hookworm-P. falciparum coinfection and M. perstans-P. fa

251 ages and egg/larval stages of both the human hookworm parasite Ancylostoma ceylanicum and the free-li

252 ation factor Xa has been identified from the hookworm parasite Ancylostoma ceylanicum using reverse t

253 es of purified recombinant Cry5B against the hookworm parasite Ancylostoma ceylanicum, a bloodfeeding

254 for the control of lung injury caused by the hookworm parasite Nippostrongylus brasiliensis and for t

255 d cell expansion, and host resistance to the hookworm parasite Nippostrongylus brasiliensis Collectiv

256 nd iii) enhances type 2 immunity against the hookworm parasite Nippostrongylus brasiliensis.

257 Here we study the impact of a human hookworm parasite, Ancylostoma ceylanicum, on cognition

258 Hookworms, parasitic nematodes that infect nearly one bi

259 ons of these molecular mechanisms to chronic hookworm parasitism and host clinical outcomes.

260 development of larvae into egg-laying adult hookworms (patency) coincided with a switch to Th2 predo

261 AWT to mice may further our understanding of hookworm pathogenesis by allowing the study of adult hoo

262 nd vaccine targets and should help elucidate hookworm pathogenesis.

263 Hookworm, Plasmodium, and Schistosoma infections contrib

264 lt worms, suggesting a biologic role for the hookworm platelet inhibitor in vivo.

265 This protein, named the hookworm platelet inhibitor, has an estimated molecular

266 ide treatment was more effective in reducing hookworm prevalence and intensity than school-based trea

267 Hookworm prevalence was 8% versus 11% (RR 0.55, 95% CI 0

268 The primary outcome was community hookworm prevalence, assessed at 12 and 24 months throug

269 spite reductions in S. mansoni intensity and hookworm prevalence, intensive MDA had no effect on atop

270 io, 0.19), ascaris (prevalence ratio, 0.06), hookworm (prevalence ratio, 0.07), or trichuris (prevale

271 Hookworms produce a vast repertoire of structurally and

272 es in the tautomerase sites of the human and hookworm proteins.

273 tigen-specific antibody responses, and adult hookworms recovered from the intestines of vaccinated do

274 responses to AHW antigen and protection from hookworm reinfection were observed in this sample of sch

275 ect of ivermectin on the morbidity caused by hookworm-related cutaneous larva migrans in patients in

276 Hookworms remain major agents of global morbidity, and v

277 een cloned from adult Ancylostoma ceylanicum hookworm RNA.

278 most important of these interactions is the hookworm's interruption of nutrient acquisition by the h

279 sequence identified genes orchestrating the hookworm's invasion of the human host, genes involved in

280 , but the protein was detected only in adult hookworm somatic extracts and excretory/secretory produc

281 his is the first anticoagulant cloned from a hookworm species for which humans are recognized permiss

282 t virulence factors from related Ancylostoma hookworm species may have significant implications for h

283 ortant therapeutic target in human parasitic hookworm species that infect more than 600 million peopl

284 These parasites, which include two hookworm species, Ancylostomaduodenale and Necator ameri

285 el and albendazole affected schistosome- and hookworm-specific humoral responses differently from tho

286 ly one organism is endemic; schistosome- and hookworm-specific responses were not associated, and the

287 Results: Schistosoma mansoni, hookworm, Strongyloides stercoralis, and Mansonella pers

288 ng capabilities between these two species of hookworm, suggesting that factor Xa inhibitory activity

289 tor localized to the subcuticle of the adult hookworm, suggesting that it has a potential in vivo rol

290 es between hamsters and humans infected with hookworms, suggesting that hamsters will be a useful ani

291 d higher CRs and egg reduction rates against hookworm than the monotherapy arms.

292 fection with Nippostrongylus brasiliensis, a hookworm that infects the lung and intestine.

293 Dogs and cats are hosts to hookworms that may cause zoonotic disease, most notably,

294 nowledge of the molecular mechanisms used by hookworms to survive for extended periods in the human h

295 rts to control hookworm infection, The Human Hookworm Vaccine Initiative has identified candidate vac

296 rugs (e.g. tribendimidine) and a recombinant hookworm vaccine.

297 Trichuris and hookworm were rarely detected, resulting in imprecise ef

298 Bloodfeeding hookworms, which currently infect over a billion people

299 Soil-transmitted nematodes (STNs), namely hookworms, whipworms, and ascarids, are extremely common

300 The soil-transmitted helminths or nematodes (hookworms, whipworms, and Ascaris) are roundworms that i