ライフサイエンスコーパス: host defence

1 he localization of immune cells, to optimize host defence.

2 in the pathogenesis of atopic dermatitis and host defence.

3 ways that are directly relevant to the human host defence.

4 umoniae infection, HVEM is also required for host defence.

5 of microbes, whether to promote mutualism or host defence.

6 t targeting HVEM with agonists could improve host defence.

7 gen infection and for establishing effective host defence.

8 iew of the immune system and its function in host defence.

9 ptides (AMPs) and other mechanisms of innate host defence.

10 oteases in the interaction with human innate host defence.

11 I interferons and other genes important for host defence.

12 of epithelial-derived defensins in mammalian host defence.

13 rial products in this region is critical for host defence.

14 d disease; and the roles of efferocytosis in host defence.

15 ce for the importance of natural products in host defence.

16 SNOs) are central to signal transduction and host defence.

17 has revealed new and important insights into host defence.

18 ral to both innate and adaptive immunity for host defence.

19 portant role in allowing B. cepacia to evade host defence.

20 lineages are recognised; each has a role in host defence.

21 potent regulator of the cellular response in host defence.

22 at they have an important underlying role in host defence.

23 portals of bacterial entry, are important to host defence.

24 e common in arthropods, often functioning in host defence.

25 after AMI, particularly related to impaired host defence.

26 both cell-autonomous and non-cell-autonomous host defence.

27 ch suggests a role for PMR in anti-bacterial host defence.

28 death process that is crucial for antiviral host defence.

29 allergic inflammation, tissue protection and host defence.

30 tion, trigger immune signalling pathways for host defence.

31 sting that extrusion of NETs is important in host defence.

32 ruses, appears to have adapted to evade this host defence.

33 direct and indirect effects on pathogens and host defence.

34 ncluding cell proliferation, development and host defence.

35 innate immunity that plays pivotal roles in host defence.

36 24 h, p=0.0032) without being detrimental to host defence.

37 pneumococcal pneumonia without compromising host defence.

38 uently validate for their role in antifungal host defence.

39 analysis has suggested their involvement in host defence.

40 22 and IL-23 are able to restore the mucosal host defence.

41 immune system with roles in inflammation and host-defence.

42 ing in strong selection for the evolution of host defences.

43 exploit cognitive and sensory limitations in host defences.

44 properties to facilitate persistence despite host defences.

45 virulence factor which functions to subvert host defences.

46 s to the ability of the spirochaete to evade host defences.

47 er the cytoplasm of plant cells and suppress host defences.

48 ns in nutrient availability as well as plant host defences.

49 he importance of this system for survival to host defences.

50 creted protein may protect the parasite from host defences.

51 microbial virulence apparently by modulating host defences.

52 g Salmonella against oxygen radical-mediated host defences.

53 organisms to resist antimicrobial drugs and host defences.

54 may include survival factors that counteract host defences.

55 by secreting effectors that manipulate plant-host defences.

56 man reservoirs and are triggered by impaired host defences.

57 teract bacterial infection and strengthening host defences.

58 cues evolved by the parasites to subvert its host defences.

59 lymeric protein hydrogel for protection from host defences.

60 tially biased positions to promote effective host defence(2,3).

61 lasia in the intestinal mucosa, and elevated host-defence ability against an intestinal bacterial pat

62 the amino sugars as a harbinger of potential host defence activation, and suppresses the expression o

63 Activation of the inflammasome provides host defence against aspergillosis(2,3), which is a majo

64 ding protein (LBP), which are central to the host defence against bacteria, and cholesteryl ester tra

65 OS) produced by phagocytes are essential for host defence against bacterial and fungal infections.

66 lergic and autoimmune disorders, and optimal host defence against bacterial and parasitic infections

67 We investigated the role of mast cells in host defence against bacterial infections using a well c

68 s (AMPs) represent a key component of innate host defence against bacterial pathogens.

69 mechanism for activating this pathway in the host defence against C. albicans remains unknown.

70 n-22 (IL-22) is considered indispensable for host defence against Citrobacter rodentium, with 100% mo

71 studies indicate that STING is essential for host defence against DNA pathogens such as HSV-1 and fac

72 acute peritonitis that is indispensable for host defence against early systemic bacterial spread and

73 rophage mannose receptor is not essential to host defence against fungal pathogens, as previously tho

74 lls best known for their role in allergy and host defence against helminth parasites.

75 The host defence against helminths such as Nippostrongylus b

76 ytokines and receptors have central roles in host defence against infection and development of inflam

77 led pro- and anti-inflammatory responses for host defence against infection and disease states.

78 complement system is a recognized pillar of host defence against infection and noxious self-derived

79 ndicate that one of the functions of IL-3 in host defence against infection is to expand populations

80 ation by macrophages is an essential part of host defence against infection.

81 ant protein (SP)-A and SP-D, are involved in host defence against infectious and allergenic agents vi

82 cyte-derived intestinal MPs in ILC3-mediated host defence against intestinal infection.

83 h1 response, which is critical for effective host defence against intracellular pathogens.

84 ropriate inflammatory responses critical for host defence against invading pathogens or tumours.

85 Th2 immunity is a primary host defence against metazoan pathogens and two of the i

86 ogen species (RNS) play an essential role in host defence against Mycobacterium tuberculosis (MTB) in

87 t allergic immunity has an important role in host defence against noxious environmental substances, i

88 gnificant role in inflammation, allergy, and host defence against parasitic helminths.

89 Inflammasomes are important for host defence against pathogens and homeostasis with comm

90 Innate immunity is the first line of host defence against pathogens.

91 reveals the critical importance of LUBAC in host defence against pathogens.

92 Three perioperative factors impair host defence against recurrence during cancer surgery: t

93 dritic cells, respectively, is essential for host defence against SARS-CoV-2.

94 ZBP1 mediates host defence against some viruses(6,7,9-14) by sensing v

95 that T(H)17 cells have an important role in host defence against specific pathogens and are potent i

96 lymphocytes are believed to be important in host defence against the human immunodeficiency virus (H

97 distinct effector functions best suited for host defence against the invading pathogen.

98 conserved T-cell receptor and contribute to host defence against various microbial pathogens.

99 -mediated antiviral responses are central to host defence against viral infection.

100 duction of cytokines, which are important in host defence against virus infections to both RSV and rh

101 change in community composition might affect host defences against Bd.

102 While theoretical models on the evolution of host defences against disease have been widely studied,

103 ne response that are normally concerned with host defences against infection can, under some circumst

104 on immune cells, which also plays a role in host defences against infection.

105 present useful targets in the modulation of host defences against viral pathogens.

106 on and immunity has uncovered a new angle of host-defence against pathogen assault.

107 sites including the lungs and contribute in host-defence against pathogens, but little is known abou

108 ibiotics, new antimicrobials, and optimizing host defences among the most likely to improve the care

109 terleukin (IL)-17 (T(H)17), are critical for host defence and autoimmunity.

110 CD4(+) T cells are critical for host defence and autoimmunity.

111 challenges of the infectious process such as host defence and bacterial products.

112 viruses manipulate these processes to impair host defence and enhance viral fitness remains unclear.

113 Although complement is crucial to host defence and homeostasis, its inappropriate or uncon

114 protein interaction networks are integral to host defence and immune signalling pathways, which are o

115 ctions, and suggest a potential role in both host defence and immunopathology.

116 and IL-17, might have essential functions in host defence and in the pathogenesis of autoimmune disea

117 scavenger receptors play important roles in host defence and in the regulation of acquired immunity.

118 Our results show that p38 may influence host defence and inflammation by maintaining the balance

119 recently emerged as important regulators of host defence and inflammation(1-4).

120 ion of the complement system to non-specific host defence and maintenance of homeostasis is well appr

121 and CD4+ T cells plays an important role in host defence and mucosal homeostasis, thus it is importa

122 al drivers of rhythms in traits underpinning host defence and parasite offence are largely unknown.

123 cytokine production as a means to dampen the host defence and promote viral pathogenesis.

124 ation of eosinophils, which are important in host defence and the pathogenesis of allergies and asthm

125 innate immune effector system that mediates host defence and tissue homeostasis.

126 Innate lymphoid cells (ILCs) contribute to host defence and tissue repair but can induce immunopath

127 ngly acknowledged to play important roles in host defence and tissue repair.

128 have far-reaching consequences for immunity, host defence and tumorigenesis.

129 he nature of virulence, host susceptibility, host defence and, ultimately, the origin of phytopathoge

130 charide that also confers resistance to many host defences and antibiotic treatments.

131 that are delivered into host cells, counter host defences and co-opt host cell functions for their o

132 w insights into how parasitic weeds overcome host defences and could potentially contribute to the de

133 ssion is associated with ever-shifting virus-host defences and counterdefences.

134 his pattern likely resulted from both weaker host defences and greater adaptation by parasites to inf

135 aliva and intestinal content that counteract host defences and help to accommodate and metabolize the

136 ensive polysaccharide capsule, which impedes host defences and is absolutely required for fungal viru

137 neuroimmune axis in the meninges can enhance host defences and potentially produce treatments for bac

138 ellular ubiquitin ligase complex to overcome host defences and promote virus production.

139 he ModA2 phasevarion in adaptation to innate host defences and reveal an additional microenvironmenta

140 sed on the co-evolutionary arms race between host defences and the parasites that attempt to circumve

141 er of virulence genes required to circumvent host defences and/or acquire nutrients in the host.

142 influence of host taxonomy, host life stage, host defence, and host geographical distance on communit

143 that C. auris is a strong inducer of innate host defence, and identify possible targets for adjuvant

144 sis is critical for digestive physiology and host defence, and is often dysregulated in gastrointesti

145 ned by reproductive trade-offs as well as by host defences, and illustrate how cooperative and parasi

146 s, bacterial parasites cooperate to overcome host defences, animals breed cooperatively, and humans a

147 ted with roles in reproduction, immunity and host defence appear to be under diversifying positive se

148 Host defences are often accompanied by programmed cell d

149 interactions impact meningeal antibacterial host defences are unclear.

150 o the broad benefits of trained immunity for host defence but has also suggested potentially detrimen

151 t that coordinates inflammatory responses in host defence but is pathogenic in autoimmunity.

152 elimination provides an additional layer of host defence, but no virulence mechanisms that target th

153 (RNS) function as powerful antimicrobials in host defence, but so far little is known about their bac

154 gene product in plant-microbe interaction or host defence, but the fact that all the transcripts were

155 nocytes play a crucial role in antimicrobial host defence, but the mechanisms by which they protect t

156 ate immune system is absolutely required for host defence, but, uncontrolled, it leads to inflammator

157 sensory neurons (nociceptors), also aids in host defence by alerting organisms to the presence of po

158 Native host defence by Cas12a employs cis cleavage, which can b

159 eukaryotic counterparts, TtAgo functions in host defence by DNA-guided DNA interference.

160 st-growing intracellular Salmonella overcome host defence by reprogramming macrophage polarization.

161 d enteropathogen, evades this GSDMB-mediated host defence by secreting IpaH7.8, a virulence effector

162 dapt to diverse environments and/or to evade host defences by antigenic variation.

163 hat potentially allows the organism to evade host defences by antigenic variation.

164 tite motif (TRIM) proteins mediate antiviral host defences by either directly targeting viral compone

165 , adrenaline may also serve in favour of the host defences by lowering antimicrobial peptide resistan

166 ptors, advances in chemotaxis, subversion of host defences by pathogens, adaptation to high salt, com

167 Staphylococcus aureus subverts host defences by producing a collection of virulence fac

168 factor is an adenylate cyclase that impairs host defences by raising cellular cAMP levels.

169 at the antimicrobial conditions generated by host defences can accelerate the generation of genome re

170 n that gingival bleeding and infiltration of host defence cells are symptoms of periodontal infection

171 Whereas acute inflammation is critical for host defence, chronic inflammation contributes to tumori

172 plants as responsible for detoxification of host defence compound 2-benzoxazolinone.

173 vading pathogens and for initiating cellular host defence countermeasures, which include the producti

174 These results directly link the initial host defence defect to the loss of CFTR, an anion channe

175 ection and fine-tuned adaptations to enhance host defence during pregnancy and early life.

176 tory cytokine IL-17A to regulate the vaginal host defences during infection.

177 For example, the herbicide atrazine affects host defences (e.g. resistance and tolerance) of the amp

178 include proteins which function to modulate host defences either through proteolysis, post-translati

179 pecificity correlated with their response to host defences: escalating traits largely affected genera

180 Neutrophils are critical to host defence, executing diverse strategies to perform th

181 protect its replicating genomes by excluding host defence factors(2-4).

182 w ecological feedbacks generate diversity in host defence focussing on when polymorphism can evolve w

183 tabolome, modifying the immunomodulatory and host defence functions of bile.

184 This defect in host defence has generally been ascribed to the immaturi

185 loss of CFTR function first disrupts airway host defence has remained uncertain.

186 are an important native component of innate host defence in mice and provide protection against necr

187 undant function, and is required for mucosal host defence in the lung.

188 ntimicrobial peptide important in epithelial host defence in the small intestine.

189 s well as improved strategies for augmenting host defence in this vulnerable population.

190 tive small-molecule ion channels can restore host defences in cystic fibrosis airway epithelia via a

191 ay surface liquid pH, and impair respiratory host defences in people with cystic fibrosis(1-3).

192 Human pathogenic Yersinia resist host defences, in part through the expression and delive

193 r 17 (TH17) cells are critically involved in host defence, inflammation, and autoimmunity.

194 e essential function of the immune system in host defence is best illustrated when it goes wrong; und

195 The requirement for FADD in mammalian host defence is evocative of innate immune signalling in

196 notion that humoral immunity contributes to host defence is unproven.

197 conserved molecules of pathogens that elicit host defences known as pattern-triggered immunity (PTI).

198 ected by metagenomic analysis, and modulated host defence, leading to reduced Vibrio cholerae coloniz

199 Dendritic cells serve a key function in host defence, linking innate detection of microbes to ac

200 employs plethora of mechanisms to hijack the host defence machinery for its successful survival, prol

201 ic neonatal pathogen represents an important host defence mechanism against infection in neonates.

202 ndent necrotic pathway that has emerged as a host defence mechanism against murine cytomegalovirus.

203 Collectively, our data suggest a key host defence mechanism against S. Typhimurium infection

204 urst, effectively masking the impact of this host defence mechanism.

205 Therefore, as a part of the host-defence mechanism, the mucus could also be responsi

206 tions in pathogenesis by blocking non-immune host defence mechanisms and acting as a relatively non-i

207 cause biofilms notoriously resist killing by host defence mechanisms and antibiotics.

208 o the ability of M. tuberculosis to overcome host defence mechanisms and grow in a mammalian host.

209 have evolved diverse strategies to overcome host defence mechanisms and to redirect host metabolism

210 several orders of magnitude lower, and their host defence mechanisms are substantially more effective

211 Since host defence mechanisms can be costly, individual hosts

212 erated a strategy to efficiently escape from host defence mechanisms during reactivation from latency

213 ons of years, during which time a variety of host defence mechanisms has evolved.

214 Understanding of anti-candida host defence mechanisms in the vagina has developed slow

215 release of dsRNA into the cytoplasm triggers host defence mechanisms(9), dsRNA viruses retain their g

216 Pathogens use effectors to suppress host defence mechanisms, promote the derivation of nutri

217 d novel insights into effector secretion and host defence mechanisms, there remain many unanswered qu

218 Here, as pathogens often subvert host defence mechanisms, we hypothesized that this might

219 the relationship between sleep dynamics and host defence mechanisms, with a focus on cytokine respon

220 which are necessary to avoid or overcome the host defence mechanisms.

221 actors at its disposal) and the integrity of host defence mechanisms.

222 llularly, thereby helping the virus to avoid host defence mechanisms.

223 lps the bacilli to overcome the onslaught of host defence mechanisms.

224 Here we report that the host defence molecule NOD1 regulates IL-18 processing in

225 Nitric oxide (NO) is an important host defence molecule that varies its immune stimulatory

226 gress in understanding the function of these host defence molecules in intestinal physiology.

227 + F treatments expression of genes encoding host defence molecules including DEFbeta4A, DEFB103A, LC

228 growing evidence that microbes contribute to host defences of plants and animals.

229 The effect of elicitors associated with host defence on betacyanin accumulation in Amaranthus ma

230 e conserved structures that also function in host defence, pain, organ protection and tissue remodell

231 fective in neutralizing this RAB32-dependent host defence pathway in mice.

232 the potential synergy between this cationic host defence peptide (CHDP) and the current TB drugs and

233 The host defence peptide cathelicidin (LL-37 in humans, mCRA

234 Previous studies demonstrated that the host defence peptide human beta-defensin 2 (HBD2) preven

235 Firstly, the host defence peptide LL-37 induces tolerance by triggeri

236 fungal antibiotic plectasin is a eukaryotic host defence peptide that blocks bacterial cell wall syn

237 we report the de novo design of a synthetic host defence peptide that targets a specific pathogen by

238 Cathelicidin, an antimicrobial host defence peptide, is induced by infection and inflam

239 ted that Par37 displays characteristics of a host defence peptide.

240 increase (P < 0.05) in the production of the host-defence peptide (HDP), BD2.

241 Cationic host defence peptides (CHDP), also known as antimicrobia

242 Host defence peptides (HDPs) are critical components of

243 athelicidins are innate immune antimicrobial host defence peptides and have antiviral activity agains

244 esist or tolerate a variety of antimicrobial host defence peptides and proteins.

245 The identification of the host defence peptides as target effectors in the innate

246 Structural knowledge of how host defence peptides impair cell wall synthesis will li

247 The multifunctional host-defence peptides (HDPs) cathelicidins play crucial

248 hat of the active sub-units of, for example, host-defence peptides and p53.

249 innate immune receptors cooperate to mediate host defence: phagocytic receptors, such as the mannose

250 however, the role that biological rhythms in host defences play in defining this pattern remains larg

251 g with a variety of proteins affiliated with host defence, programmed cell death and innate immunity

252 rring susceptibility to this major pulmonary host defence protein.

253 ance to the antibacterial effects of a human host defence protein.

254 tify human neutrophil elastase (NE) as a key host defence protein: NE degrades Shigella virulence fac

255 n to identify protein complexes that contain host defence proteins and pathogenicity factors.

256 by outcompeting some pathogens or modulating host defence provided by the gut barrier and intestinal

257 ogen-derived effector and are perceived by a host defence receptor.

258 t is perceived via direct interaction with a host defence receptor.

259 Angiogenins are a family of host defence-related ribonucleases, of which at least on

260 of Udorn does not (effectively) inhibit this host defence response in human monocytes.

261 cells of the innate immune system to mount a host defence response to infection, they must recognize

262 cant side effects such as suppression of the host defence response.

263 d in clearance of ROS, thus anticipating the host defence response.

264 est in the epidermal layer, fail to suppress host defence responses and fail to induce non-host resis

265 ate hosts, trematode parasites down regulate host defence responses by interfering with key signal-tr

266 y the fungus, and for the rapid induction of host defence responses in an incompatible reaction.

267 perturb cellular homoeostasis, resulting in host defence responses in the form of cytokine release a

268 associated molecular products, TLRs activate host defence responses through their intracellular signa

269 Interleukin (IL)-1 is a mediator of host defence responses to inflammation and injury, inclu

270 IL-1 mediates host defence responses to local and systemic disease and

271 TLRs can directly induce innate host defence responses, but the mechanisms of TLR-mediat

272 mst12 mutant also failed to elicit localized host defence responses, including papilla formation and

273 en linked to the activation of intracellular host defence signalling pathways.

274 ful drivers of both the strength and type of host defence strategies against parasites.

275 of the ecology and evolution of alternative host defence strategies.

276 Our work further suggests that multiple host-defence strategies as a potential explanation for t

277 , the evolutionary history of this DNA-based host defence strategy is unclear.

278 role in resistance to non-oxidative mucosal host defences such as anti-microbial peptides.

279 ruses express proteins to evade non-specific host defences such as complement, interferons and the in

280 inflammation, impact cell competition-based host defences, suggesting that their effect on tumour ri

281 rane decoration may enable them to evade the host defence system and colonize the subgingival space.

282 ucociliary clearance (MCC) is a major airway host defence system that is impaired in patients with sm

283 While these stresses serve as part of a host defence system, V. cholerae has evolved resistance

284 e been implicated in pathogen evasion of the host defence system.

285 remodelling pathway probably extends beyond host defence systems, as several other biologically acti

286 lasmid anti-defence systems employ to escape host defence systems.

287 Despite multiple layers of host defence, TEs actively shape mammalian-specific deve

288 crease in Paneth-cell-mediated antimicrobial host defence that compromised dendritic cell recruitment

289 ate immune cells important for the immediate host defence, they can differentiate into memory NK cell

290 ults reveal a critical role for cryopyrin in host defence through bacterial RNA-mediated activation o

291 forming proteins that play critical roles in host defence through pyroptosis(1,2).

292 or (OF) is an adenylate cyclase that impairs host defences through a variety of mechanisms including

293 Bacterial pathogens must suppress host defences to cause disease.

294 al nitrooxidative stress response suppresses host defences to facilitate the growth and development o

295 clearly establish that MCs may contribute to host defences to Leishmania in a differential manner, by

296 Host defences to microorganisms rely on a coordinated in

297 nd host, leading to the intricate balance of host defence versus parasite survival.

298 en as an adaptation of the parasite to evade host defence: we show that the coordination necessary fo

299 ue characteristics involved in circumventing host defences, which significantly contribute to their v

300 exert non-overlapping roles in antimicrobial host defence, with antibodies targeting pathogens in the