ライフサイエンスコーパス: host defense

1 h as thyroid hormone biosynthesis and innate host defense.

2 response in mice and humans and compromises host defense.

3 ring lung surface tension but also in innate host defense.

4 in part by symbiotic cooperation with innate host defense.

5 y in vivo as well for IL-1beta-enhanced skin host defense.

6 and pathways involved in effective antiviral host defense.

7 dant circulating leukocyte, are critical for host defense.

8 quired for efficient nutrient absorption and host defense.

9 dies of IEIs can unveil key requirements for host defense.

10 ing of bacterial pathogenesis and vertebrate host defense.

11 between fine-grained tissue organization and host defense.

12 ve macrophage functions toward antimicrobial host defense.

13 cus, impaired Ifng response, and compromised host defense.

14 r DQ2-restricted viral epitopes, relevant to host defense.

15 cellular inflammatory responses and mediate host defense.

16 imulated antiviral genes, is a vital part of host defense.

17 ow that these CD4(+) T(RM) cells can promote host defense.

18 ls that are critical for gut homeostasis and host defense.

19 n genetics and environment in the context of host defense.

20 es and play a role in tissue homeostasis and host defense.

21 ion and tissue injury, as well as anti-viral host defense.

22 ing a possible role in niche competition and host defense.

23 egrating inflammatory and microbial cues for host defense.

24 s a role in inflammation, atherogenesis, and host defense.

25 ion to coordinate inflammatory responses and host defense.

26 ate immune cells that play critical roles in host defense.

27 llustrate the importance of cell movement in host defense.

28 hesis from its precursor l-citrulline blunts host defense.

29 critical effector function of MAIT cells in host defense.

30 tor 5 (IRF5) is essential for the control of host defense.

31 an adjuvant to boost inflammasome-dependent host defense.

32 es for the absence of apoptosis in antiviral host defense.

33 e inflammasome activation, thereby affecting host defense.

34 genes [ISGs]) that are integral to antiviral host defense.

35 the importance of avSGs in RNase L-mediated host defense.

36 -presenting cells and perform their roles in host defense.

37 (Treg) cells maintains immune tolerance and host defense.

38 llergy-like type 2 immunity in antibacterial host defense.

39 l to investigate the role of transferrins in host defense.

40 ial homeostasis, including solute uptake and host defense.

41 ellularly without encountering extracellular host defenses.

42 ic actions of nutritional immunity and other host defenses.

43 ize essential cellular processes to suppress host defenses.

44 his interaction plays in viral infection and host defenses.

45 ultiple roles in regulating inflammation and host defenses.

46 e effects of both type I and II IFN-mediated host defenses.

47 enhance its resistance to antimicrobials and host defenses.

48 trained immunity-based strategies to improve host defenses.

49 ting from parasite endogenous metabolism and host defenses.

50 an confer resistance to both antibiotics and host defenses.

51 growth, dissemination, and the countering of host defenses.

52 from the extracellular environment including host defenses.

53 ones play a role in surviving intracellular host defenses.

54 nisms to infection as well as to mount early host defenses.

55 infection dynamics, capable of orchestrating host defense according to the status quo of infection.

56 G protein-coupled receptors contribute to host defense across the animal kingdom, transducing many

57 nto large nanomachines that execute distinct host defense activities against a wide variety of microb

58 immune responses, IgE antibodies, and MCs in host defense against a pathogenic bacterium.

59 e data therefore implicate CIITA and CD74 in host defense against a range of viruses, and they identi

60 Therefore, although providing host defense against bacteria, PC:CRP-induced inflammati

61 rmine whether IL-17D has a role in mediating host defense against bacterial infections, we studied i.

62 l bactericidal activities and is pivotal for host defense against bacterial pathogens.

63 explored the role of platelets in antifungal host defense against C. albicans PBMCs were stimulated w

64 for IL-17A produced by gammadelta T cells in host defense against C. difficile infection.

65 Yet, T cell-mediated inflammation and host defense against Citrobacter rodentium were not impa

66 control of lysosome function broadly impacts host defense against diverse viral and microbial pathoge

67 ties to define nonredundant requirements for host defense against EBV infection.

68 ates innate and adaptive immunity leading to host defense against enteropathogenic bacterial infectio

69 nhibit intestinal inflammation and establish host defense against enteropathogens.

70 nd identify a critical role for caspase-8 in host defense against eukaryotic pathogens.

71 timulation by commensal C. albicans improves host defense against extracellular pathogens, but with p

72 inflammatory response by macrophages during host defense against fungal challenge.

73 ll carbohydrate beta-1,3-glucan, is vital to host defense against fungal infections.

74 induced NF-kappaB could profoundly influence host defense against fungal pathogens.

75 the enigmatic cytokine IL-17F contributes to host defense against fungi.

76 Host defense against IA relies on lung-infiltrating neut

77 -17-producing gammadelta T cells in neonatal host defense against infection and provide a mechanistic

78 by the innate immune system is essential for host defense against infection and tissue homeostasis.

79 l killer (NK) cells, which are implicated in host defense against infection with herpesviruses, inclu

80 racellular traps (NETs) are important in the host defense against infection, but they also promote in

81 hat play a crucial role in the regulation of host defense against infection.

82 (PANoptosis) and plays an essential role in host defense against influenza A virus (IAV) infection.

83 ts indicate that exposure to dry air impairs host defense against influenza infection, reduces tissue

84 To ascertain whether IL-26 contributes to host defense against intracellular bacteria, we studied

85 nate immune sensors of DNA are essential for host defense against invading pathogens.

86 testinal epithelial autophagy is crucial for host defense against invasive pathogens, and defects in

87 echanism by which L-selectin participates in host defense against Klebsiella pneumoniae-induced pulmo

88 RIPK3-MLKL pathway in nonimmune cell-derived host defense against Listeria invasion, which is mediate

89 and whether such AwM play a critical role in host defense against M. tuberculosis infection.

90 ogical and pathological processes, including host defense against microbial infections, anti-tumor im

91 nd caspase-11 (caspase-1/-4/-5/-11)) mediate host defense against microbial infections, processing pr

92 crucial role in regulating inflammation and host defense against microorganisms in the intestine.

93 ortant for activation of immune cells during host defense against Mycobacterium tuberculosis.

94 crophage-FABP4 has a novel role in pulmonary host defense against P. aeruginosa infection by facilita

95 ith type 2 immunity, allergic reactions, and host defense against parasite infections.

96 d adaptive immunity genes that contribute to host defense against pathogenic viruses such as herpes v

97 that AIM2 plays essential roles not only in host defense against pathogens but also in inflammatory

98 nfluence of peptidoglycan N-deacetylation on host defense against pathogens, we investigated the viru

99 Programmed cell death contributes to host defense against pathogens.

100 optosis, necroptosis) is an integral part of host defense against pathogens.

101 ons, but they also play an important role in host defense against pathogens.

102 highlights the role of CD28 costimulation in host defense against poxvirus infections.

103 ld identify novel host factors important for host defense against S. aureus.

104 form physicians and enhance understanding of host defense against SARS-CoV-2.

105 ) cells are induced by pathogens and promote host defense against secondary infections.

106 in infection substantially improved systemic host defense against secondary SA infections in mice.

107 ating memory cells were required for optimal host defense against skin VV infection.

108 une responses in vivo and is a suppressor of host defense against systemic fungal infection.

109 d that nociceptor neurons critically mediate host defense against the bacterial pathogen Salmonella e

110 jasmonic acid and salicylic acid to control host defense against this pathogen.

111 hat RNase 7 has a role in kidney and bladder host defense against UPEC and establish a foundation for

112 r of necroptosis, has been implicated in the host defense against viral infection primary in immune c

113 IFNs (IFN-alpha and -beta) are important for host defense against viral infections.

114 Interferons (IFNs) represent an important host defense against viruses.

115 tic investigation of previously understudied host defenses against a major crop plant pathogen.

116 e been many recent advances in understanding host defenses against common fungi, this work illuminate

117 Additionally, the critical host defenses against gammaherpesvirus reactivation, vir

118 Host defenses against infection by this pathogen are poo

119 ognition of intracellular peptidoglycans and host defenses against Listeria monocytogenes.

120 conventional and innate-like T (iT) cells in host defenses against M. marinum remain unclear.

121 reveal that GBP2 is an important mediator of host defenses against murine norovirus.

122 Host defenses against pathogens are energetically expens

123 to infection sites is a fundamental step in host defenses against the frequent human pathogen group

124 cluding the p53 and pRB pathways, or disrupt host defenses against viral infections, including interf

125 iral activity and are important mediators of host defenses against viral infections.

126 lipidation that may mediate cell-autonomous host defense, an unanticipated mechanism that is distinc

127 OR kinase activity, increased LC3-associated host defense and anti-microbial peptide production in th

128 ll immune responses, during both anti-fungal host defense and autoimmunity.

129 idney to identify unique proteins related to host defense and bacterial pathogenesis.

130 from pathogens or host cells to function in host defense and cell clearance.

131 H(2)O(2) that plays a critical role in both host defense and chronic inflammation.

132 ufficiency of TRPV1(+) neuron activation for host defense and demonstrate the existence of functional

133 tified to regulate inflammatory responses in host defense and disease development.

134 mmunological mechanisms contributing to both host defense and disease following viral infection of th

135 Macrophages play an essential role in host defense and display remarkable plasticity in switch

136 arkedly impacts TB outcome by affecting both host defense and drug metabolism.

137 F) and rifabutin (RFB), resulting in altered host defense and drug metabolism.

138 rstanding of how resident AMs participate in host defense and have broader implications in the defens

139 ns in the small intestine that contribute to host defense and homeostasis.

140 dogenous mediators and mechanisms pivotal in host defense and homeostasis.

141 ced NADP (NADPH) oxidase plays a key role in host defense and immune regulation.

142 We propose that harnessing mast cells' host defense and immunomodulatory properties via the act

143 ) signals could enhance macrophage antiviral host defense and improve clinical outcomes in hypercapni

144 is cell death pathway has been implicated in host defense and in the pathology of inflammatory diseas

145 Monocytes play a key role in host defense and inflammation and are critical for contr

146 de receptor 2 (FPR2) plays a crucial role in host defense and inflammation, and has been considered a

147 Antibodies are key to cutaneous host defense and inflammation.

148 ymphoid cells (ILCs) play important roles in host defense and inflammation.

149 eutrophil function in which a combination of host defense and inflammatory complications are prominen

150 ate lymphoid cells (ILC2s) are implicated in host defense and inflammatory disease, but these potenti

151 ium plays an important role in wound repair, host defense and is involved in the immunopathogenesis o

152 and recruited macrophages contribute to both host defense and pathology.

153 aling has also been associated with impaired host defense and resistance to the development of inflam

154 ofessional phagocytes that are essential for host defense and tissue homeostasis.

155 nnate lymphoid cells (ILCs) are critical for host defense and tissue repair but can also contribute t

156 remarkable plasticity that is essential for host defense and tissue repair.

157 Interferon gamma (IFN-gamma), critical for host defense and tumor surveillance, requires tight cont

158 ) T cell-mediated memory responses, limiting host defense and vaccine responses.

159 his clinically significant microbe to bypass host defenses and cause invasive disease.

160 e activated by pathogen effectors to trigger host defenses and cell death.

161 is widely known that cigarette smoke damages host defenses and increases susceptibility to bacterial

162 gocyte NADPH oxidase plays a crucial role in host defenses and inflammatory reaction.

163 highlights the importance of synergy between host defenses and the necessity of evaluating the contri

164 er opportunity for gaining new insights into host defenses and their evolution in an important lab mo

165 oduced as part of the oxidative burst during host defenses and under molluscan hypoxia, we propose th

166 tionary struggle to overcome their microbial hosts' defenses and must adapt in unconventional ways to

167 arrier cells are proposed to be critical for host defense, and airway epithelial cell capacity for IF

168 play critical roles in lung homeostasis and host defense, and are central to the pathogenesis of a n

169 functions, such as chemotaxis, phagocytosis, host defense, and the regulation of MC functions at the

170 nding of how IL-22 regulates homeostasis and host defense, and we discuss the IL-22 pathway as a ther

171 food composition on colonization resistance, host defenses, and the infection process as well as the

172 ) of unirradiated mice were characterized as host defense antibacterial effector cells.

173 Furthermore, host defense antimicrobial peptides and small-molecule p

174 beetle life cycles whereas drought-weakened host defenses appear to have been a distant secondary dr

175 activation of Ty3/Gypsy retrotransposons and host defense are controlled by master meiotic regulators

176 roduction of inflammatory mediators dictates host defense as well as tissue injury.

177 e did not cooperatively impair antimicrobial host defenses, as mice given combined IL-17A and TNF-alp

178 ppression of gene expression associated with host defense at 10 dpi but followed by an apparent activ

179 ion elicited type 17 responses and augmented host defense at adjacent, unstimulated skin through a ne

180 gammadelta T cells play a major role in host defense at mucosal sites and are known to respond r

181 Dissecting the interactions between WNV and host defenses both informs basic molecular virology and

182 (ROS) by NADPH oxidase that are crucial for host defense but can lead to tissue injury when produced

183 Rationale: Complement is crucial for host defense but may also drive dysregulated inflammatio

184 Neutrophil recruitment is not only vital for host defense, but also relevant in pathological inflamma

185 s exert innate-like effector function during host defense, but whether MP CD4(+) T cells are function

186 s, in part due to the counteraction of these host defenses by viral accessory proteins.

187 ce and their macrophages, demonstrating that host defense can employ varying components of several ce

188 paradoxical role of neutrophils and NETs in host defense, chronic inflammation, and tissue disrepair

189 drive aberrant Mphi activation and impaired host defense contributing to IBD pathogenesis.

190 ted inflammasome activation, cell death, and host defense during IAV infection, opening additional av

191 Myeloid LKB1 is important for local host defense during Klebsiella pneumonia by maintaining

192 te immunity and its link to inflammation and host defense encompasses diverse areas of biology, rangi

193 n group A streptococcus (GAS) encounters the host defense factor calprotectin (CP) during infection.

194 Tetherin is a host defense factor that physically prevents virion rele

195 We identify that commensals aid in host defense following infection with a neurotropic viru

196 ng protein fibrinogen has been implicated in host defense following Staphylococcus aureus infection,

197 se gene duplication, augmenting their innate host defense function against helminths and snake enveno

198 s regulating the induction, maintenance, and host defense functions of CD4(+) T(RM) cells.

199 ic signatures in genes that are critical for host defense functions.

200 tween lung dysbiosis, mortality, and altered host defense gene expression, supporting a role for lung

201 vore-associated loss of the gastrointestinal host defense gene NOX1 could be related to a reduced gut

202 nfection to investigate the role of CXCL1 in host defense, granulopoiesis, and neutrophil mobilizatio

203 Intrinsic host defense immunity is a specialized innate immunity c

204 We demonstrated that not only host defense immunity, but also pro-cancerous immune cel

205 We investigated the role of FABP4 in host defense in a murine model of Pseudomonas aeruginosa

206 e lung injury and contribute to dysregulated host defense in CF lung disease.

207 cues the impairments in neutrophil-dependent host defense in Cxcl1 (-/-) mice.

208 d epithelial cells of the gut to orchestrate host defense in homeostasis and following Salmonella inf

209 Effective initial host defense in the lung is associated with mild symptom

210 ation, we found that pDCs were essential for host defense in the presence of normal neutrophil and Mo

211 suggest that Mtb may benefit from declining host defenses in the lung mucosa of the elderly.

212 tasis, they are also crucial in development, host defense, inflammation, and tissue repair.

213 ile disease tolerance is a known strategy of host defense, its role in noninfectious diseases has bee

214 a T cells, not previously implicated in DENV host defense, killed infected targeted DCs and contribut

215 uces neutrophil infiltration and compromises host defense, leading to overwhelming bacterial infectio

216 This parasite-driven host defense limits Toxoplasma replication while maintai

217 In addition to their role in host defense, mast cells contribute to a number of chron

218 (GTPase) Rab32 coordinates a cell-intrinsic host defense mechanism that restricts the replication of

219 These findings identify a host defense mechanism that uses QSMs as an "Achilles he

220 ing in the intestine represents an important host defense mechanism to avoid inappropriate responses

221 s that allow microbial pathogens to overcome host defense mechanisms and cause disease in a host.

222 ding of how gut microbial metabolites affect host defense mechanisms and identify candidate pathways

223 borreliae require the ability to escape from host defense mechanisms, in particular complement.

224 ne causes lung inflammation and can suppress host defense mechanisms, including impairing macrophage

225 llergic and immunologic diseases, as well as host defense mechanisms, it is unsurprising that omalizu

226 AhR sensing of TB drugs modulates host defense mechanisms, notably impairs phagocytosis, a

227 sights into how CFTR dysfunction impairs key host defense mechanisms, such as mucociliary clearance a

228 lly colonize their hosts by manipulating the host defense mechanisms, which is accompanied by major t

229 ility and resistance to many antibiotics and host defense mechanisms.

230 ter understanding microbial pathogenesis and host defense mechanisms.

231 ibit autocrine type I IFN signaling to evade host defense mechanisms.

232 essor vasopressin on the immune response and host defense.Methods: Leukocytes from six to nine donors

233 ontribute to immune dysregulation and impact host defense.Objectives: To investigate effects of norep

234 Host defense of the epidermis and dermis involves the in

235 ompted us to investigate its effect on other host defense parameters, and inhibition study revealed a

236 H69 cleavage is antagonized by the 3 major host defense pathways defined by the pmk-1, fshr-1, and

237 We identified and experimentally verified host-defense pathways induced by Spn during invasive dis

238 that human enteric alpha-defensin 5 (HD5), a host defense peptide important for intestinal homeostasi

239 pathogen-induced expression of an amphibian host defense peptide modulates plant innate immunity and

240 AG-30/5C is an angiogenic host defense peptide that activates human mast cells (MC

241 Diversity of alpha-helical host defense peptides (alphaHDPs) contributes to immunit

242 ino acids can be incorporated into synthetic host defense peptides (HDPs) to modulate their susceptib

243 Host defense peptides (HDPs), also known as cationic ant

244 We have previously demonstrated that host defense peptides (HDPs), short peptides that are ke

245 lly those intended to mimic the structure of host defense peptides (HDPs).

246 secrete mucus, airway surface lining fluid, host defense peptides, and antioxidants and express inna

247 cytokines IL-1alpha, IL-1beta, and TNF, and host defense peptides.

248 reased synergy in combination with synthetic host-defense peptides DJK-5 and IDR-1018 under host-like

249 Host-defense peptides have drawn significant attention a

250 AMPs with minimal cross-resistance to human host-defense peptides remains limited.

251 mote their own systemic movement and disrupt host defense processes.

252 ers in both gene regulation (eukaryotes) and host defense (prokaryotes).

253 -deficient mice showed a higher level of the host defense protein lactotransferrin in BAL fluid.

254 sponse to lipopolysaccharide (LPS), multiple host defense proteins, including interferon-inducible gu

255 g bacterial dissemination via proteolysis of host defense proteins.

256 including the presence of iron-sequestering host-defense proteins.

257 phages (AM) play pivotal roles in modulating host defense, pulmonary inflammation, and tissue injury

258 species with likely homeostatic functions in host defense, regulation of microbial communities, and w

259 of CD4 T(RM) cells and their contribution to host defense remain elusive.

260 its contribution to macrophage functions and host defense remains to be delineated.

261 ulatory T cells are sufficient for the rapid host defense required to eliminate Kp.

262 mmune sensor of nucleic acids that regulates host defense responses and development.

263 IL-17 family cytokines are critical to host defense responses at cutaneous and mucosal surfaces

264 ytoplankton mortality, little is known about host defense responses.

265 ns initiate signaling cascades that activate host defense responses.

266 cells (MCs) have been shown to contribute to host-defense responses in certain bacterial infections,

267 eflect the ability of rare lineages to evade host defenses, specifically antiviral RNA interference (

268 asing evidence indicates that tolerance is a host defense strategy against pathogens as widespread an

269 ulation of membrane cholesterol content as a host defense strategy.

270 gene transfer to counter evolving bacterial host defenses; such arms race dynamics should lead to di

271 n during pneumococcal pneumonia by promoting host defenses, suggesting AnxA1-based peptides as a nove

272 esponses during pathogen attacks, and robust host defense suppression by pathogen effector proteins i

273 ct macrophage polarization and contribute to host defense/susceptibility toward infection.

274 eactivation might be necessary and potent to host defense system readiness for damage control of tumo

275 al, salivary protein that is involved in the host defense system.

276 -associated epitopes are often recognized by host defense systems, wall deficiency provides a plausib

277 gen, secretes numerous effectors to modulate host defense systems.

278 tion implicating multiple pathways including host defense, telomere maintenance, signaling, and cell-

279 Autophagy is a powerful host defense that restricts herpes simplex virus-1 (HSV-

280 However, acquired or genetic disruptions to host defense that tip the balance in favor of EBV can ha

281 tory factor (MIF) is an upstream mediator of host defense that up-regulates the expression of pattern

282 activity and mucociliary transport, two key host defenses that protect the lung.

283 Innate immunity contributes to host defense through all cell types and relies on their

284 g infection but also a critical component of host defense through modulation of the innate immune res

285 Viral infection triggers host defenses through pattern-recognition receptor-media

286 rucial for a variety of processes, including host defense, tissue repair, the pathogenesis of inflamm

287 local type 17 immune response that augmented host defense to C. albicans and S. aureus.

288 by reductions in barrier function, impaired host defense to pathogens, and exaggerated inflammatory

289 role of these nerves in the coordination of host defenses to Citrobacter rodentium.

290 pathogenic bacterial metabolites, triggering host defenses to control the infection.

291 ired pathogen, but the mechanisms underlying host-defense to MRSA remain poorly understood.

292 hrough the subversion of endothelial amyloid host-defense to promote a lung endothelial-derived cytot

293 tions, ranging from oxygen transportation to host defense, to injury repair.

294 nse through microbial dysbiosis or defective host defense toward invasive intestinal bacteria can res

295 feron (IFN)-alpha/beta or IFN-lambda induces host defense transcriptional signatures and inhibits ZIK

296 PGLYRP4, a secreted, innate mediator of host defenses, was found to limit early inflammatory pat

297 major proinflammatory mediator important in host defense, whereas resolvins (Rvs) are produced durin

298 Ifng-as1 full-length transcript and impaired host defense, while allowing proper chromatin structure.

299 tyrate might represent a strategy to bolster host defense without tissue damaging inflammation and (2

300 Eosinophils and neutrophils are critical for host defense, yet gaps in understanding how granulocytes