ライフサイエンスコーパス: hot spot

1 on identified as potential electrocatalytic "hot spots".

2 e nanocarriers and creating the enhancement "hot spots".

3 locations between the gold nanoparticles or "hot spots".

4 icating these areas as future food security 'hot spots'.

5 re released, with littoral zones acting as a hot spot.

6 romatic region serves as a secondary binding hot spot.

7 ial location of molecules within a plasmonic hot spot.

8 ive tumor cells within a subjectively picked hot-spot.

9 rticularly abundant in ocean N(2)O-producing hot spots.

10 il domain to the active site via a series of hot spots.

11 used for the identification of conservation hot spots.

12 led receptors occurs preferentially at these hot spots.

13 mbination in the genomes with cold spots and hot spots.

14 bridges, resulting in the formation of SERS hot spots.

15 ion marks at mammalian meiotic recombination hot spots.

16 stone modifications and DNA accessibility at hot spots.

17 ively bind C3b near ligand-guided functional hot spots.

18 s SAR exploration to map GPCR-ligand binding hot spots.

19 he composition of antibody-binding energetic hot spots.

20 and by hospital referral region to identify hot spots.

21 preader which is significant for eliminating hot spots.

22 s concentrated as interlineage recombination hot spots.

23 for the determination of these recombination hot spots.

24 an electron microprobe could account for the hot spots.

25 ntial fine-scale heterogeneity at individual hot spots.

26 strategies for these vulnerable biodiversity hot-spots.

27 devices through the formation of nanoscopic hot-spots.

28 l areas forms several European air pollution hot-spots.

29 hoods were 0.88 times as likely to live in a hot spot [95% CI (confidence interval): 0.80-0.97; P = 0

30 Guided by these hot spots, a library of drug-like macrocycles was docked

31 entified in 277 patients revealed that those hot spots account for 68.5% of patients (37 of 54) with

32 Together, these data provide a model for hot spot activation in which HELLS and PRDM9 form a pion

33 one acetylation marks are necessary for both hot spot activity and crossover resolution.

34 ce in HT29 cells significantly impairs Li(+) hot spot activity.

35 replication and that these changes occur in hot spots along the HRSV genome.

36 pplications as they support abundant E field hot spots along their surface and within their open inte

37 +)=O) and induces irreversible oxidation of "hot-spot" amino acids, including betaCys-93.

38 dynamics of a critical tropical biodiversity hot spot and provide guidance for future regulation of t

39 a major determinant of meiotic recombination hot spots and acts through sequence-specific DNA binding

40 Both the Li(+) hot spots and cell migration are blocked in HT29 cells b

41 f greenhouse gas (GHG) fluxes, also known as hot spots and hot moments.

42 d the evolutionary turnover of recombination hot spots and its consequences, we mapped DSB hot spots

43 mplex, with strong dependence on hydrophobic hot spots and networks of water-mediated hydrogen bonds.

44 We identified three hot spots and obtained 6 X-ray co-structures, giving a h

45 PRDM9 function together to open chromatin at hot spots and provide access for the DNA double-strand b

46 SERS and TERS, including the concept of SERS hot spots and the plasmonic nanostructures necessary for

47 ir remarkable thermal conductivity minimizes hot spots and thermal gradients.

48 engthening subsidence produced a mesospheric hot-spot and caused extreme enrichment of photochemicall

49 on that partially occludes the three binding hot-spots and suggest a facile transition to an open sta

50 en structural mimicry and a crucial peptide "hot spot" and demonstrate its role, along with the MHC,

51 to identify ERV progenitors, recombinational hot spots, and segments that are always replaced, never

52 Hot spots are a small set of residues that contribute mo

53 Punctate Li(+) hot spots are clustered in the lamellipodial leading edg

54 Recombination hot spots are decorated by a unique combination of histo

55 tering substrates with spatially homogeneous hot spots are developed.

56 Three major hot spots are discovered in remote binding areas: Asp81,

57 of gamma radiation levels are provided, and hot spots are discussed.

58 In this technique, hot spots are formed by drying up a microvolume drop of

59 The hot spots are identified by FTMap, a computational analo

60 In contrast, Li(+) hot spots are not evident in a poorly migrating colon ca

61 formed between adjacent Ag-nanorods, where "hot spots" are generated.

62 e institutions, two in a region considered a hot spot (area of high prevalence) for COVID-19.

63 ng, Shanggao, Jing'an and Gao'an county were hot spots areas.

64 nique to provide extremely dense and regular hot spot arrays for highly sensitive surface-enhanced Ra

65 s and the identification of novel structural hot spots as targets for pharmacological intervention.

66 rustule surface, which provides high density hot spots as well as strongly coupled optical resonances

67 ce-enhanced Raman spectroscopy (SERS) active hot spots associated with gold nanoparticle oligomers is

68 lity loci for prostate cancer, including the hot spot at 8q24.

69 This led to our discovery of a mutational hot spot at HBoV1 capsid position 590 that accumulated i

70 d upwelling that ascends beneath the Reunion hot spot at the time of the Deccan eruptions.

71 s were derived for hydrophobic alpha-helical hot spots at positions i, i + 3, and i + 7.

72 late organic matter (POM) induces diagenetic hot spots at the sediment-water interface (SWI).

73 We identify the formation of strong hot spots between all particles as the main mechanism fo

74 TCR binding necessitates hot-spot burial, yielding high energetic penalties that

75 ts, mostly protein kinases, also have strong hot spots but show no correlation between affinity and l

76 HELLS is recruited to hot spots by PRDM9 and is necessary for both histone mod

77 on are directed to a subset of genomic loci (hot spots) by sequence-specific binding of the PRDM9 pro

78 how conserved and selective PDE interaction hot spots can accommodate the large diversity of chemica

79 ulation of population inversion at plasmonic hot spots can be spatially modulated by the diffractive

80 h charge carriers transferred from plasmonic hot spots can drive chemistry.

81 decreased protection of this major amyloid "hot spot" can trigger protein misfolding.

82 Thus, mtCU "hot spots" can be formed at the cardiac muscle mitochond

83 hat reduced protection of the major amyloid "hot spot", combined with the structural integrity of the

84 ify the antibodies' epitope as an 'antigenic hot spot' critical for virus entry.

85 ty in real time by the appearance of lithium hot spots detected by confocal microscopy.

86 fies an important functional capsid surface "hot spot" dictating receptor attachment, transduction ef

87 Initiation of chemical reactions occurs at hot spots due to energy localization at sites of porosit

88 to influence the locations of recombination hot spots during meiosis by sequence-specific DNA bindin

89 oorly understood, is access to recombination hot spots during meiosis.

90 (SERS) substrate with a thermally inducible hot spot effect for sensitive measurement of Raman-activ

91 optimized particle gaps to produce inducible hot spot effects on thermal shrink.

92 were explored for the creation of inducible hot spot effects.

93 ntionally druggable, but reaching additional hot spots enables improved pharmaceutical properties.

94 receptors/transcription factors in trans to hot spot enhancers serves as an effective biological str

95 ed) or was even cost saving for travelers to hot spots, especially if travelers were previously unvac

96 helial denudation regeneration are exudation hot spots evoking asthma-like features, including recrui

97 binding and whether other nucleosome binding hot-spots exist remain unclear.

98 Sequencing of hot spot exons in CNTNAP2 led to discovery of a 5 bp ins

99 tions between individual buyers and specific hot spots explain the disproportionate impacts of some a

100 The human 16p11.2 gene locus is a hot spot for copy number variations, which predispose ca

101 often in females than males, it represents a hot spot for SAS, offering a refuge for recessive male-b

102 no clear evidence that the X chromosome is a hot spot for sexually antagonistic variation.

103 A particular hot spot for such oxidative attack on chromosome 15 has

104 We find Australia to be a global hot spot for variability, with semi-arid ecosystems in t

105 in specific genomic islands, which represent hot spots for BGC acquisition.

106 e River, further confirming these regions as hot spots for biodiversity in Europe, where successful l

107 ortant roles in carbon sequestration and are hot spots for biodiversity.

108 s show that gamma-secretase presents several hot spots for either orthosteric or allosteric inhibitio

109 Also conserved to varying extents are hot spots for interactions with hydrophobic ligands, lip

110 d microenvironments that make them potential hot spots for prebiotic biochemistry.

111 asmic reticulum (ER) and other membranes are hot spots for protein-mediated lipid transport between t

112 nces at polymerization interfaces, which are hot spots for sequence divergence between tubulin isofor

113 stern Russia, Europe, and the WUS emerged as hot spots for snow droughts, experiencing ~2, 16, and 28

114 d by policymakers when identifying important hot spots for the conservation of biodiversity in the Am

115 dicating that these sequence elements act as hot spots for the formation of CNVs.

116 precipitated iron(III) (oxy)hydroxides, are hot spots for the removal and redissolution of iron, ass

117 1 eV, suggesting the carbon also serves as a hot-spot for the dissociation of water molecules in wate

118 ch and two adjacent surfaces are the primary hot-spots for nucleosome disk interactions, whereas near

119 terminants of ASFV variability are potential hot-spots for recombination.

120 The intercalated disc (ID) is a "hot spot" for heart disease, as several ID proteins have

121 graphic screening identified three distinct "hot-spots" for fragment binding within the NRF2 binding

122 g is used to detect specific binding sites ("hot spots") for cholesterol on K(+) channels with charac

123 t targeting high-cost Medicare patients (ie, hot spotting) for cost containment efforts would be a po

124 n countries formed a cluster of high values (hot-spots) for stillbirth and 13 countries formed a clus

125 ates locally enhanced electromagnetic field 'hot spot', formed at the junctions and interstitial crev

126 se patterns of riparian zone in the cold and hot spots found that land-use patterns had an important

127 In an iterative process, hot-spot-guided docking, characterization of inhibition

128 Winter polar hot-spots have been observed on other planets, but detec

129 y high reproducibility due to the absence of hot spots, high durability due to no oxidization, and hi

130 dentify and classify interfacial residues as Hot-Spots (HS) and Null-Spots (NS).

131 nt system: in silico active site mapping for hot spot identification to guide rational structure-base

132 tein-ligand interactions in three energetic "hot spots" identified by fragment screening.

133 o-scale simulations are required to quantify hot spot ignition and growth and to develop models for m

134 Here, we present a multimodal hot-spot imaging approach using an innovative high-densi

135 tial-volume effects (PVEs) degrade signal in hot-spot imaging techniques such as amyloid PET.

136 ts had been deployed, identified a pollution hot spot in a rapid and economical manner.

137 or LtpM, which is encoded in a recombination hot spot in L. pneumophila Paris.

138 modified landscapes (HMLs) in a biodiversity hot spot in South America.

139 Spatial analysis revealed high-risk hot spots in Borneo, the central Amazon and the Congo Ba

140 lly determine the role of diverse structural hot spots in conferring host cell binding and ligand bin

141 sistance profiling of the chemotype revealed hot spots in conserved hydrophobic positions of the RABV

142 d human genetic disorders and/or defined CNV hot spots in epilepsy.

143 ot spots and its consequences, we mapped DSB hot spots in four major subspecies of Mus musculus with

144 arge nonequilibrium deformations at discrete hot spots in lipid vesicles and thus inducing an overall

145 show that the recombinogenic cores of active hot spots in mice harbor several histone H3 and H4 acety

146 high frequency of interlineage recombination hot spots in nonstructural protein 9 (NSP9) and in the G

147 high frequency of interlineage recombination hot spots in nonstructural protein 9 (NSP9) and the GP2

148 ent regions that were reported as regulatory hot spots in some kinases and thus are potential target

149 We identified and structurally verified hot spots in the interface between RHOGAPs and RHO prote

150 uggest that variation of numerous structural hot spots in the ligand binding pocket of Epa proteins i

151 The research hot spots in the period from 1976 to 2016 were identifie

152 cated the existence of age-related glycation hot spots in the plant proteome.

153 a-camera images and a nephron model revealed hot spots in the proximal renal tubules.

154 Our structures reveal cryptic druggable hot spots in the shallow inhibitor binding site of MraY

155 CpG dinucleotides are the main mutational hot-spot in most cancers.

156 n these areas and poses this connection as a hot-spot in the circuits involved in reactivation of fea

157 a potential strategy to identify structural hot-spots in proteins as targets for pharmacological res

158 t this region may represent a recombination "hot spot" in CoV genomes.

159 s study was to determine the feasibility of "hot spotting" in elective surgical populations.

160 nanoscale deformations can form 'electrical hot spots' in the sensing channel which reduce the charg

161 loiting the lightning rod effect, or plasmon hot spots, in anisotropic (nonspherical) metal nanoparti

162 I, at discrete regions in the genome coined "hot spots." In mammals, meiotic DSB site selection is di

163 omplex" hot spot structure with four or more hots spots, including some strong ones.

164 ed Volatile Organic Compound (VOC), the main hot spot is noticed over the city Atyrau, the oil capita

165 One of these hot-spot is the residential district of Ostrava Radvanic

166 ntification of high-cost patients, known as "hot spotting," is well developed in medical populations,

167 durability due to its strong dependence on "hot spots", large photothermal heat generation, and easy

168 e nanostar side, likely due to the combined "hot spot + lightening-rod" effects.

169 (and often random) distribution of surface "hot spots" limits its routine clinical use.

170 Atlas is a systematic collection of binding hot spots located at the above ten sites in 4910 structu

171 provide a multitude of applications, such as hot-spot management, nonequilibrium hot-carrier generati

172 ng footprint, the identification of binding 'hot spots' may facilitate the design of receptor mimic t

173 Thus, the sites of glycation hot spots might be defined by protein structure that ind

174 ts, together with a focus on a small peptide hot spot, might place limits on peptide antigen cross-re

175 rR) as specific bridging molecules in a SERS hot-spot model.

176 ot spot structure, i.e., three or fewer weak hot spots, must use larger compounds that interact with

177 erfering-RNAs, capable of targeting four p53 hot-spot mutants which represent ~20% of all p53 mutatio

178 show in this study that the lamin A p.R482W hot spot mutation prevents adipogenic gene expression by

179 ormal DNA samples and identified a recurrent hot-spot mutation (c.1712A>G; p.Gln571Arg) in the enhanc

180 due to PPAR gamma gene amplification or RXRA hot-spot mutation (S427F/Y) drives 20-25% of human bladd

181 In summary, this study revealed that a hot-spot mutation in EZH1 is the second most frequent ge

182 K CRISPR cells we found that one deleterious hot-spot mutation increased chromosome instability in a

183 We show that SRSF2 Pro95 hot spot mutations elicit enhanced mRNA decay, which is

184 experimentally interrogate cancer-associated hot-spot mutations localizing within the endogenous huma

185 oparticle-bacterial cellulose substrate and "hot spot"-normalized surface-enhanced Raman scattering (

186 eoning industry has occurred in biodiversity hot spots, notably in the tropical forests of South Amer

187 To identify drivers of this effect at a hot spot of antiandrogenicity in the German river Holtem

188 It is a known hot spot of retroviral tagging insertion and a fusion pa

189 ynthetic gene clusters are embedded in local hot spots of 3D contacts that segregate cluster regions

190 s observed latitudinal gradients and coastal hot spots of [Formula: see text]O flux and reveals a vig

191 bution across the biofilm, with concentrated hot spots of c-di-GMP.

192 In particular, hot spots of charge storage are identified.

193 Hot spots of dopaminergic drive notably include cortical

194 of mechanobiologists because these sites are hot spots of epithelial tension.

195 These analyses reveal hot spots of fluctuations that set the stage for large-s

196 cal anion species localized in the plasmonic hot spots of individual gold nanosphere oligomers, corro

197 There are two hot spots of intrusion, one in the Luzon Strait and the

198 ypomethylation and detecting hypomethylation hot spots of LTRs and LINEs.

199 diment composition, and vegetation influence hot spots of P retention throughout small agricultural s

200 The observed hot spots of variation in the attenuated viruses have th

201 Although hot spots of variation were identified in spike and nucl

202 n from coarse-to-fine grain sizes promoted a hot-spot of organic matter degradation and biomass growt

203 Re-configured INs were hot-spots of differential interactions, whereby MYOD bin

204 ng behaviour interact to create predictable "hot spots" of fear on the reef where herbivores withhold

205 ighly inhomogeneous distributions, creating "hot spots" of MP.

206 RAS, and do not affect the three mutational "hot spots" of RAS.

207 n estuarine resident with several localized "hot-spots" of abundance.

208 ing mode of the side chains of alpha-helical hot spots, offering a new class of small-molecule alpha-

209 In this way, we defined a theta hot spot on a group level and investigated whether proxi

210 an NMR complex structure revealed a binding hot spot on CXCL12 that normally interacts with the I4/I

211 Western blotting analysis detected hot spots on 67-kDa proteins in pork meat and cat dander

212 Compared to the extensive studies of the hot spots on protein-protein interfaces, the hot spot re

213 ng antibodies target four spatially distinct hot spots on RTA, which we refer to as epitope clusters

214 on of previous efforts in mapping functional hot spots on the bile acid scaffold, we here demonstrate

215 to exhibit binding modes focused more toward hot spots on the HLA surface and exhibited a greater deg

216 We find hot spots on the plasma membrane, at least partially def

217 te" and provides a means to block all three "hot spots" on (Ca)S100B, which will impact next generati

218 erely focusing incident sunlight into small "hot spots" on a photothermally active desalination membr

219 However, only a few cells work as 'hot spots' on the sorption of Pb NPs.

220 ing points of locally enhanced heat flux or "hot spots." One conclusion is that the fraction of heat

221 Identifying hot spots or areas of high environmental contributions u

222 f plasmonic applications based on individual hot spots or ensembles of hot spots with high uniformity

223 idues within the amyloid core IAPP region as hot spots or key residues of its cross-interaction with

224 The first one (possibly associated to hot spots or whole Fermi sheets) has a strong mass enhan

225 fted in a manner designed to produce either "hot spot" or "widespread" striatal innervation.

226 of neighborhoods with significantly higher (hot spots) or lower (cold spots) rates of surgery.

227 mount antigen-specific T cell responses to "hot spot" p53 mutations that in some cases are shared am

228 model of Li-Fraumeni syndrome harbouring the hot-spot p53R172H mutation described an elevated level o

229 n anti-gp70 V1V2 scaffold (V1V2) and anti-V2 hot spot peptide (V2 HS) antibody responses and reduced

230 gher affinity than allele A bound A-specific hot spots, perhaps explaining why the former is dominant

231 nology for the simultaneous detection of two hot-spot PIK3CA mutations (E545 K and H1047R) in circula

232 s film-forming foams (AFFFs) has resulted in hot spots polluted with poly- and perfluorinated alkyl s

233 in highly similar recognition of an apical 'hot-spot' position in the peptide with tolerance of sequ

234 Both well-established hot spot prediction methods and new approaches to analyz

235 binding region serves as the primary binding hot spot, preferably binding small tertiary amines.

236 was detected for many markers, sometimes as hot spots present in different populations.

237 nt-resistance mutations occur in the dynamic hot spots recently identified to be responsible for imat

238 s revealed that it fits into the hydrophobic hot spot region of the accessible surface of WW1.

239 ounds that interact with surfaces beyond the hot spot region to achieve acceptable affinity.

240 and contributes to enlarging a "hydrophobic hot spot" region on the WW1 domain.

241 to engage a polymorphic, positively charged "hot-spot" region that is almost exclusive to the alpha1-

242 advocated in recent Paris agreement, several hot spot regions experiencing highest droughts are ident

243 randomly distributed, but there are certain hot spot regions.

244 Several genetic hot spots regulating a large number of transcript level

245 Regarding SO(2) the major hot spots relate to regions with high population and lar

246 ibody, a HCDR3 tryptophan binds similarly to hot spot residue Phe(279) Mutation of this HCDR3 Trp res

247 ed at these conserved contact and activation hot-spot residue positions.

248 We identify three hot spot residues (Galphas/Galphaq-Gln-384/Leu-349, Gln-

249 tional model, iPNHOT, to effectively predict hot spot residues on protein-nucleic acids interfaces.

250 hot spots on protein-protein interfaces, the hot spot residues within protein-nucleic acids interface

251 The prediction of the hot-spot residues within the target peptide through comp

252 roaches; here, we predict the binding poses, hot-spot residues, and binding affinity differences of a

253 he AgNPs and inducing the formation of SERS "hot spots" responsible for SO(2) signals enhancement.

254 This hot spot seems to be highly characteristic for PTFL.

255 with an oligonucleotide representing a known hot spot sequence and report the structure here.

256 rom the iNOS DINNN hot loop and the AGRP RFF hot spot sequence yielded novel and potent ligands of th

257 leotide representing a known PRDM9c-specific hot spot sequence, and compared the structure with that

258 Use of a dual hot-spot signal-amplification strategy based on AuNP-AgN

259 ions, transport the suspended cells toward a hot-spot site of the chip, for rapid concentrating and p

260 This hot-spot site was identified by an experimental approach

261 other chromatin features needed for meiotic hot spot specification are largely unknown.

262 nefit from bRo5 drugs if they have "complex" hot spot structure with four or more hots spots, includi

263 Finally, targets with "simple" hot spot structure, i.e., three or fewer weak hot spots,

264 es insertion of Ty1 elements upstream of the hot spot SUF16 tRNA locus and abolishes the interaction

265 all molecule to the additional alpha-helical hot spots suggests that the decoration of this series of

266 e consistent with age-related changes in SHM hot-spot targeting.

267 These observations reveal a hot spot that is located 41 +/- 12 degrees east of the s

268 a second active upwelling below the Comores hot spot that likely contributed to the region of partia

269 idue belongs to 1 of the 2 mosaic mutational hot spots that face each other in the core of the NLRP3

270 contamination is often concentrated in toxic hot spots that need to be identified locally.

271 getic epitope by determining the interfacial hot-spot that dominates the binding affinity for an anti

272 during the initiation stage of the Hawaiian hot spot, the fate of this plateau is unclear.

273 mulation occur within three global carbonate hot spots: the Western Pacific Ocean, Eastern Indian Oce

274 ing the degradation machinery at specific ER hot spots to enable efficient protein quality control.

275 n the stem region of TGGAA repeat DNA act as hot spots to facilitate the transition between the two c

276 binding pockets of additional alpha-helical hot spots to produce potent small-molecule inhibitors fo

277 Dynamic properties of the Li(+) hot spots, turning on and off, are confirmed by time-lap

278 Local groundwater hot spots under city centers and under industrial areas

279 A hot spot was localized in the farm, which corresponded t

280 antom study, the diameter of the most active hot spot was reduced by 24% in the dual gated images com

281 nal convergence of hydrophobic alpha-helical hot spots was revealed by analyzing alpha-helix-mediated

282 Several antibody-binding hot spots were identified in ZIKV immunogenic antigens,

283 The histidine oxidation hot spots were identified, which include conserved histi

284 Intralineage recombination hot spots were not as concentrated as interlineage recom

285 Also, intralineage recombination hot spots were scattered across the genome between Chine

286 AID deamination occurs predominantly at WRC hot spots (where W is A or T and R is A or G) and that t

287 focuses on the characterization of the Mcl-1 hot-spots which are related to four hydrophobic pockets

288 ng several conserved and variable structural hot spots, which were implicated in mediating functional

289 h Hawaii, Samoa, and Iceland but not beneath hot spots whose OIB yield normal (182)W and homogeneousl

290 Allele C was found to bind a C-specific hot spot with higher affinity than allele A bound A-spec

291 destination-specific Riskexposure, including hot spots with active measles outbreaks; the percentage

292 ased on individual hot spots or ensembles of hot spots with high uniformity and improved controllabil

293 bipyridine molecules, localized in plasmonic hot spots within individual gold nanosphere oligomers.

294 substrate in vivo Two reproducible small-RNA hot spots within the 3' UTR/sfRNA of the wild-type virus

295 m that recapitulates the distribution of HIV hot-spots within T-cells.

296 mechanism and a possible role of plasmonic "hot spots" within the metal nanostructures, remain poorl

297 ambiguous identification of phosphorylation "hot spots" within virion proteins.

298 ities of all possible variants and find the "hot-spot" within the limit of experimental time.

299 ard cues through the recruitment of hedonic 'hot spots' within the brain's reward circuitry.

300 r possible impact to human health in similar hot-spots worldwide.