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1 d in 18% of participants, most commonly with housekeeping (48%) and transportation (36%) and least co
2 ases containing the a3-subunit, but not the "housekeeping" a1-subunit, were isolated bound to actin.
3 f enhanced migratory, vasculoprotective, and housekeeping activities, as well as profound suppression
5 Using mutagenesis analysis, we separated the housekeeping activity of IRE1alpha at MAMs from its cano
6 onstrates the importance of proteolysis as a housekeeping activity that removes outgoing factors from
13 to increase exposure to PBDEs and that good housekeeping and personal hygiene practices may reduce e
14 These experiments yielded 37 peptides from housekeeping and structural proteins (i.e., GroEL, EF-TU
16 riches for context-specific transcripts over housekeeping and/or structural RNA, and it preserves the
19 thway which plays a crucial role in cellular housekeeping by internalization, transport, sorting and
20 first time that AGGF1 activates autophagy, a housekeeping catabolic cellular process, in endothelial
22 ology categories were overrepresented, while housekeeping cellular functions were mainly transcriptio
23 genome and involved in regulation of either housekeeping/cellular maintenance genes or liver-specifi
25 indicates that such recruitment of cellular housekeeping components is a common feature used to inte
26 lular localization relative to the ancestral housekeeping desaturase may have allowed proto-SAD5's re
27 ansport, and mutations in the ubiquitous and housekeeping dynamin 2 (DNM2) have been associated with
30 that interact with different core promoters: housekeeping enhancers (hkCP) and developmental enhancer
33 ndings suggest that rather than serving as a housekeeping enzyme, MS has a broad and dynamic role in
34 hosphatase 1 (dCTPase) is a nucleotide pool "housekeeping" enzyme responsible for the catabolism of c
35 Although traditionally considered metabolic housekeeping enzymes because of their ability to detoxif
40 binding protein profilin is believed to be a housekeeping factor that maintains a general pool of una
41 allows for a reversible sigma-switching from housekeeping factors to alternate sigma-factors when the
42 6S RNAs function through interaction with housekeeping forms of RNA polymerase holoenzyme (Esigma(
43 all RNA that binds within the active site of housekeeping forms of RNA polymerases (e.g. Esigma(70) i
45 In conclusion, seafood consumption, higher housekeeping frequency, and foam mattress were associate
46 curtains and carpets at home, mattress type, housekeeping frequency, and television use was also coll
47 r whether defects in this well characterized housekeeping function cause the specific degeneration of
49 degradation of mitochondria, is an important housekeeping function in eukaryotic cells, and defects i
50 GTP dysregulation occurs, revealing a vital housekeeping function of (p)ppGpp; in fact, loss of (p)p
52 fferocytosis is recognized as a constitutive housekeeping function of macrophages, these data indicat
54 hese results, we suggest that SOD1 carries a housekeeping function that maintains ROS levels below a
56 tious disease, but also are involved in host housekeeping functions and can suppress allergic disease
57 during senescence: early down-regulation of housekeeping functions and metabolic processes followed
59 netic states across cell types correspond to housekeeping functions and stimulus response, respective
60 We find that the coordinated regulation of housekeeping functions and tissue-specific gene expressi
61 t nonhost resistance mechanisms and pathogen housekeeping functions are conserved at deeper phylogene
62 ciples likely coordinate differentiation and housekeeping functions during progenitor cell differenti
63 genes but also the coordinated adaptation of housekeeping functions from a metabolically active, prol
64 that have been thought primarily to subserve housekeeping functions in cells-ribosomal RNAs, transfer
66 but instead are often involved in essential housekeeping functions that are highly conserved across
67 veal that NF-Y regulates not only genes with housekeeping functions through cell type-invariant promo
69 t protein homologues; instead, they affected housekeeping functions, such as signal recognition parti
71 al binding events are enriched at genes with housekeeping functions, while distal binding events inte
84 g copies) and RNA transcripts from the GAPDH housekeeping gene (5.45 ng total mouse embryonic stem ce
85 there was no amplification of CRX; only the housekeeping gene (GAPDH) demonstrated amplification.
86 nching holes to deliver cholesterol-modified housekeeping gene (Gapdh) siRNA to the mouse ear skin.
87 Among children positive for the P falciparum housekeeping gene (PF08_0085; ubiquitin-conjugating enzy
89 xpression domains in C(3), including typical housekeeping gene expression patterns in various tissues
91 which dominantly inherited mutations in the housekeeping gene GARS, which encodes glycyl-tRNA synthe
95 , and CRISPR/cas) is its ability to cleave a housekeeping gene mRNA after being activated by a cancer
96 ii) tightly bind a structured fragment of a housekeeping gene mRNA, and iii) cleave it with efficien
97 or a gene therapy DNA machine that cleaves a housekeeping gene only in the presence of a cancer-causi
102 the core promoter -270GC-rich box of PIGM, a housekeeping gene, disrupts binding of the generic trans
103 -function mutations in the widely expressed, housekeeping gene, GARS The mechanisms underlying select
106 s suggest a surprising potential role for a 'housekeeping' gene in fine-tuning the development of an
107 y after photobleaching implied modulation of housekeeping-gene pulse strength occurs at the level of
108 agent was characterized by sequencing of six housekeeping genes (16S rRNA, ftsZ, gltA, groEL, ribC, a
109 free CpG island from the human HNRPA2B1-CBX3 housekeeping genes (A2UCOE) effectively prevents transge
110 ly 25% of expressed genes that are essential/housekeeping genes (e.g. RNA synthesis and splicing).
112 Diabrotica undecimpunctata howardi (Barber), housekeeping genes (HKG), beta-actin (Actin), beta-tubul
116 as developed based on the sequences of eight housekeeping genes (ppa, pgm, gyrB, gmk, glyA, atpA, arc
117 ic proteins, but also repress a small set of housekeeping genes - such as those encoding lactate dehy
118 displays binary behavior, strongly expressed housekeeping genes altered the magnitude of their transc
119 erol (gpd1) caused a prolonged repression of housekeeping genes and a delay in gene activation at ind
120 those of four major gastric proteins and two housekeeping genes and comparable to the level of pepsin
121 an expanded eight gene version based on six housekeeping genes and two 'putative virulence' genes (e
122 , our analysis reveals that the locations of housekeeping genes are closely associated with cross-tis
123 ly bipartite organization in which conserved housekeeping genes are concentrated in syntenic gene-ric
124 We previously reported that specialized and housekeeping genes are differentially regulated via de n
128 DR) approach, which employs stably expressed housekeeping genes as references to eliminate platform-s
129 s-related genes, and are reduced to encoding housekeeping genes as well as a protease subunit (clpP)-
130 ulation of a large number of genes including housekeeping genes as well as actively regulated genes.
132 spect to tissue weight or mRNA levels of the housekeeping genes B2M or GAPDH, were over-expressed in
134 ve to either: tissue weight or levels of the housekeeping genes beta-2 microglobulin (B2M) and glycer
135 a set of randomly chosen genes, and a set of housekeeping genes broadly conserved in eukaryotes.
138 e groEL gene, and multilocus sequencing of 7 housekeeping genes confirmed the presence of a common st
140 promoter regions of some of the most active housekeeping genes during interphase in human cells, but
141 rom positive controls, negative controls and housekeeping genes embedded in the nCounter system.
142 To search for the internal references, 10 housekeeping genes from a gut transcriptome of a wood-fe
143 ely removes highly expressed but nonspecific housekeeping genes from lens tissue expression profiles,
144 sponds to different functional classes, with housekeeping genes having few contacts, and dosage-sensi
145 such GAPs generated so far bear mutations in housekeeping genes important for parasite development in
146 interacts with transcriptional regulators at housekeeping genes in somatic cells is not well understo
147 or, to mechanistically dissect how essential housekeeping genes like TFR1 successfully balance the op
148 scription factors, effectors, and supportive housekeeping genes required for establishing and propaga
149 In this study, expression profiles of 16 housekeeping genes selected from C. maculata were cloned
151 rase III is highly conserved and transcribes housekeeping genes such as ribosomal 5S rRNA, tRNA and o
152 f bacterial communities by the sequencing of housekeeping genes such as that encoding the small subun
153 +)CD8(+) stage involved a global shutdown of housekeeping genes that is rare among cells of the immun
154 by a process that may be common among other housekeeping genes that reside in large regulatory domai
155 is brings about global repression and allows housekeeping genes to be expressed in all cells of the b
156 typing utilizing eight chromosomally located housekeeping genes to obtain information about species a
157 After in silico analysis, a final set of 7 housekeeping genes was selected (dnaA, metS, recA, tufA,
158 bolic functions, while mRNA levels for these housekeeping genes were low in cells at the bottom of th
160 lity to find tissue- and cell line-optimised housekeeping genes without any prior bias, that again in
161 g improved reference genes over the cohort ('housekeeping genes') typically used for normalisation in
162 thermore, we present 692 uniformly expressed housekeeping genes, 43% of whose human orthologs are als
163 omains of early embryonic development genes, housekeeping genes, and constitutive regulatory elements
165 how that mOTUs, which are based on essential housekeeping genes, are demonstrably well-suited for qua
166 and IB), atpD (type II), and recA (type III) housekeeping genes, as well as a Fic family toxin gene (
167 11 H. ducreyi loci, including virulence and housekeeping genes, augmenting published data sets with
168 levels affect the polyadenylation levels of housekeeping genes, but not of p21 and c-fos genes, whic
169 leotide polymorphism (SNP) approach for nine housekeeping genes, characterizing penA alleles, and ant
170 al activation across cell lines, enriched in housekeeping genes, functionally related to fundamental
171 iption start site on many of the most active housekeeping genes, including genes encoding translation
172 o been shown to affect expression of E. coli housekeeping genes, including H-NS, a global regulator t
173 e to convergent losses of photosynthesis and housekeeping genes, making them excellent systems for st
174 II plays a role in incrementally increasing housekeeping genes, proportionate to the increase in hea
175 s, especially to conserved regions of common housekeeping genes, such as actin, alpha/beta-tubulin, a
176 biotic-producing functions and depleted from housekeeping genes, suggesting that they have a role in
177 MLST) scheme, comprised of seven single-copy housekeeping genes, to genetically characterize Trichomo
178 ched for the insulator binding protein CTCF, housekeeping genes, transfer RNAs and short interspersed
179 ion partners of functional fusions are often housekeeping genes, whereas the 3' fusion partners are e
198 ys are spatially proximal to one another and housekeeping-genes tend to be proximal to several other
199 for at least one daily-living activity, with housekeeping, grocery shopping, and laundry being the ac
202 ichia coli, this process requires either the housekeeping Isc or the stress-induced Suf pathway.
204 n remain problematic, due to the absence of "housekeeping" kinases and the obvious fallacy of the ass
205 ggravates the loss of RNA polymerase II from housekeeping loci, which apparently do not accumulate at
208 em, where it probably constitutes a baseline housekeeping mechanism and a first line of defence again
209 st chaperone gene expression is an essential housekeeping mechanism and provides a roadmap for defini
210 ted by TiO(2) nanoparticles and autophagy, a housekeeping mechanism that removes damaged cellular con
212 nous ZnT8 from a basal level to 32.5% of the housekeeping Na(+)/K(+) ATPase on the cell surface, ther
213 in silico studies therefore reveal a set of housekeeping noncoding RNAs of interest both in terms of
216 llular constituents is critical for cellular housekeeping, nutrient recycling, and various aspects of
217 eep loss, suggesting that it may promote the housekeeping of heavily used and strong synapses in resp
218 of all specialized genes, while sparing the housekeeping ones, and, thus, attenuated pathological hy
219 Transcriptome analyses often have focused on housekeeping or tissue-specific genes or on gene coexpre
220 olism, demonstrating that a core gene in the housekeeping pathway of pterin biosynthesis has been coo
221 s mutated in IBMFS frequently participate in housekeeping pathways, which are important for cell grow
223 ts, quantitates adduct levels relative to a "housekeeping peptide", and annotates modifications based
225 2alpha activity in the generation of a basal housekeeping PI3P pool and in the control of membrane re
230 TFIIB is constitutively bound to all paused, housekeeping, promoters, whereas de novo recruitment of
231 We use this probe to measure kinase and housekeeping protein activities, separately or simultane
233 stable isotope-labeled standard peptides (or housekeeping protein peptides), but quantitation using w
234 election on the transferrin receptor TfR1, a housekeeping protein required for iron uptake and the ce
236 t cells requires its binding to an essential housekeeping protein, translation elongation factor Tu (
239 etases (aaRSs) have long been viewed as mere housekeeping proteins and have therefore often been over
240 s the major route of initiation of mRNAs for housekeeping proteins and thus, the bulk of protein synt
241 e trends were maintained for subsets of only housekeeping proteins and when moving from exomes of 1,0
243 at they have retained typical structural and housekeeping proteins found in nematocysts of jellyfish,
245 own that the expression level of such common housekeeping proteins is, in fact, dependent on various
246 athway involved in some cases recruitment of housekeeping proteins through gene duplication and their
247 ecursors for the synthesis of peptidoglycan, housekeeping proteins, and virulence factors in bacteria
248 he synthesis of the peptidoglycan cell wall, housekeeping proteins, and virulence factors of bacteria
250 mRNAs encoding ribosomal proteins and other 'housekeeping' proteins tending to have shorter tails.
252 dels successfully increased the inclusion of housekeeping reactions, which are often lost in models b
253 were categorized as constitutively expressed housekeeping, regulated homeostatic, or dynamic early st
259 in Gram-negative bacteria has a more global housekeeping role, prompting our investigation to determ
261 ssemblies that have probably served cellular housekeeping roles for at least one billion years, ances
262 ass E sortase (SavSrtE) annotated to perform housekeeping roles in Streptomyces avermitilis Biochemic
264 t to be ubiquitously expressed and to serve 'housekeeping' roles in controlling protein homeostasis.
265 he crl gene has two overlapping promoters, a housekeeping, RpoD- (sigma(70)) dependent promoter, and
268 ma factor activity from competition with the housekeeping sigma factor for RNA polymerase and allows
269 nscription from the rrn promoter by both the housekeeping sigma factor holoenzyme (Esigma(70) ) and t
270 we analyzed the promoter specificity of the housekeeping sigma factor RpoD to promoters encoding pre
271 dependent upon a consensus sequence for the housekeeping sigma factor SigA and an A+T-rich upstream
275 gh rRNA transcription activities or when the housekeeping sigma(70) was sequestered, and was only sig
276 (Eco) 6S RNA interacts specifically with the housekeeping sigma(70)-holoenzyme (Esigma(70)) and plays
285 ve pili on the cell surface modulated by the housekeeping sortase are among the notable highlights.
287 known adhesion-related proteins, such as the housekeeping sortase responsible for covalently linking
289 ral biofilms, that genetic disruption of its housekeeping sortase SrtA generates exceedingly long pil
290 xically, we discovered that depletion of the housekeeping sortase SrtA was lethal for Actinomyces ori
294 how coordination between differentiation and housekeeping states can be achieved by interconnected re
295 ched for specific transcription factors, non-housekeeping status, and genomic and 3D conformational p
297 ences in stability between developmental and housekeeping transcripts, although strongly induced RNAs