ライフサイエンスコーパス: how

1 We also determine how 14-3-3 relieves the negative regulatory effect of AT

2 Here, we investigate how a benzene motif influences the photoinduced electroc

3 Herein, we describe how a biomimetic synthesis of bruceol, a pentacyclic mer

4 largest ubiquitin ligase subtype and reveal how a defined architecture within a disordered region co

5 al for survival in humans as in animals, but how a desire is translated into the decision that an act

6 These findings explain how a distinctive ubiquitin-like protein alters the func

7 How a dysfunction of GABAergic cortical interneurons int

8 We applied this approach to examine how a fungal pathogen affected the assembly processes st

9 lial cells in the colitis response and shows how a highly conserved chromatin remodeling factor has a

10 Overall, these data show how a member of the human skin microbiome can be useful

11 It also shows, more broadly, how a nutritional constraint can drive predators towards

12 ot only provide new mechanistic insight into how a unique collagen fragment may regulate ovarian canc

13 We also review how access to these substrates has now enabled biochemic

14 It is not known how activating ESR1 mutations may alter the predictive v

15 how the larger substrate is accommodated and how active site residues have changed to recognize N-cit

16 In this Review, we summarize how adult reproductive function can be shaped by childho

17 s from idiosyncratic variation and analyzing how age patterns change over time and across birth cohor

18 nts and phagocytic targets have demonstrated how altering the actomyosin cytoskeleton affects phagocy

19 To understand how an accessory subunit (CoREST) enables a chromatin en

20 These findings reveal how an interaction between cells in different EMT states

21 pancreatic ductal adenocarcinoma (PDAC), yet how and when obesity contributes to PDAC progression is

22 nding variation and de novo mutations; shown how antagonistic pleiotropy and temporally varying selec

23 However, how apoptotic caspases regulate GC B cell fate has not b

24 gional ecosystem devastation, we demonstrate how 'Arctic Dimming' can explain the circumpolar 'Diverg

25 ions; and provided important case studies of how assortative mating can evolve and facilitate speciat

26 cal studies that deepen our understanding of how bacterial cell wall enzymes cooperate to build a mat

27 We explored how bacterial community composition and underlying ecolo

28 watching joint actions, directly influencing how beautiful and enjoyable we find these interactions,

29 with mortality, but there is no consensus on how best to assess abdominal adiposity.

30 How best to project data across single-cell atlases is a

31 Investigating how binocular disparity is processed in the mouse visual

32 We examined how birth size and growth in infancy and childhood were

33 freely-moving mice, we explored whether and how burst propensity relates to pyramidal cell heterogen

34 It is incompletely understood how cancer cells escape NK cell surveillance.

35 Yet our understanding of how cancer cells sense and convert mechanical stimuli in

36 ranscription induce genomic instability, but how cells respond to the R loop-associated genomic stres

37 anding of the genetic and temporal nature of how cells respond to them is poorly established.

38 We summarize recent work illuminating how cerebrospinal fluid (CSF) regulates brain function.

39 We present how chamber background pressure affects energetic proton

40 In addition, we suggest how changes in the association of lipid-binding caveolar

41 ide a global-scale meta-analysis to quantify how changes in the diversity of organic matter derived f

42 However, we know little about how changes in winter snowfall will affect ecosystem pro

43 In this commentary, we discuss how choice of conference location-choosing less expensiv

44 scovered NSC-BV communication route explains how circulatory neurogenic mediators are 'sensed' by NSC

45 Despite numerous studies examining how CodY controls gene expression directly or indirectly

46 we constructed a robust framework to predict how complex network behavior in DCvNs emerges from the c

47 tary systems is fundamental to understanding how cone-mediated vision is sustained in vivo.

48 However, it is currently unknown whether or how conformational biases within the disordered ensemble

49 trasting implications for efforts to predict how consumers will respond to climate change and other e

50 intermediates broadly and for understanding how copper active sites achieve activation of strong C-H

51 structural data, we propose a mechanism for how CsMAF1 represses Pol III transcription and how phosp

52 cross five closely related species to assess how CTCF binding patterns stably fixed by evolution in e

53 We demonstrate how current economic and social systems can adapt to exi

54 in axon growth and guidance is to understand how cytoplasmic signaling modulates the cytoskeleton to

55 osphatase-mediated desensitization; however, how degradation events regulate BCR functions in GCs is

56 nitrate, moisture and plants; we investigate how differences in the soil microbiome due to antecedent

57 A new study reveals how differences in tubulin populations between two relat

58 The structure and assembly of SGs and how different components contribute to their formation a

59 analysis provide unprecedented insight into how different DNA sequences select distinct compositions

60 Here, we highlight how different microrobots, ranging from tailor-made moti

61 In this review, we summarize how different spectroscopic approaches have shed light o

62 ulations and analytical results, we explored how different types of habitat modifications (that augme

63 Our study provides a paradigm describing how differential responses to regulatory inputs generate

64 llustrate the longevity of legacy scales and how disequilibrium compounds persist long after treatmen

65 However, it is unclear how distinct structural features of the two PA2G4 isofor

66 break (DSB) repair pathways in human cells, how DNA repair failures can lead to human disease, and h

67 How do we learn about what to learn about?

68 ductivity measurements (Lp(r) ), we examined how drought-induced changes in anatomy and hydraulic pro

69 Here we show how dualities can enhance the symmetries of a dynamical

70 y annotated in the human genome and describe how each class is assigned a standardised nomenclature.

71 consensus on the relevance of REA, including how each of these measures should be used in different s

72 Our work provides a mechanism for how early clonal dynamics imprint the hierarchy of T cel

73 xtremely challenging, and it is thus unclear how eco-evolutionary dynamics drive the evolution of con

74 By contrast, an understanding of how effectors manipulate nonimmunity pathways is only be

75 At excitatory synapses, how endogenous AMPARs, NMDARs, and mGluRs are co-organiz

76 the second law of thermodynamics that states how entropy must increase.

77 These observations were analogous to how Escherichia coli encountering cell stress and nutrie

78 eptor substrates bind in the active site and how ethambutol inhibits arabinosyltransferases by bindin

79 Here we investigated how excitatory and VIP inhibitory cells in layer 2/3 of

80 However, little is known about how excitatory-inhibitory balance is defined at most syn

81 In this Perspective we explain how executable computational models meet this need.

82 How extracellular matrix contributes to tissue morphogen

83 f cutaneous wound healing with discussion on how extracellular matrix proteins and hypoxia can be uti

84 in vivo This work provides new insight into how flaviviruses control pathogenesis and mosquito trans

85 together, our results provide insights into how FOXA1 mutations perturb its function to dictate canc

86 We further demonstrate how fragmentation of THF-doped DOM in APPI resolved subt

87 gy transfer (smFRET) experiments, we studied how frameshift-inducing stem-loops from E. coli dnaX mRN

88 To understand how fruits regulate flowering in polycarpic plants, we f

89 How functional assembly of presynaptic active zones is c

90 udo-nitzschia multistriata Here, we describe how functional genomics and reverse genetics have contri

91 which cannot be directly measured, and (iv) how g(m) responds to long- and short-term changes in gro

92 collection of papers offers perspectives on how G-E interplay operates contingently within and again

93 (gamma-TuRC) has been identified, precisely how gamma-TuRC nucleates a MT remains poorly understood.

94 tomatic tissue from eye bank donors to probe how gene expression changes precede disease; and (iii) T

95 highlight experimental data that illustrate how genetic mutations drive telomere shortening and dysf

96 n algae and offer potential explanations for how green plants adapt to extreme environments.

97 sulfation pattern, allowing us to determine how heparanase recognizes HS substrate and selects a fav

98 However, little is known about how HIV-1 latency affects their function.

99 Our studies help elucidate how HSV gE/gI and US9 promote the assembly of virus part

100 nd biodiversity models to assess whether-and how-humanity can reverse the declines in terrestrial bio

101 suggested that there may be similarities in how humans and DCNNs interpret these seemingly nonsense

102 ional magnetic resonance imaging to describe how humans select predictors that might be most relevant

103 ntly reported connectomes helps characterize how information is transmitted and processed across a ra

104 How integrin binding under shear stress mechanosignals a

105 To address how interactions between four key TFs contribute to cis-

106 We sought to determine how it could influence the gut environment in ICP to alt

107 is applied in various examples demonstrating how it might be used to cross-validate and compare in vi

108 synthesis of the existing data on the MT and how it relates to CVD.

109 A pressing question is to understand how large-scale cross-linking mass spectrometry (XL-MS)

110 ing net rates of CO(2) assimilation, (ii) on how leaf biochemical and anatomical factors influence g(

111 However, little was known about how leptin acts in the NTS neurons to inhibit food intak

112 Understanding how leukocytes are produced and how they contribute to a

113 However, how LMP2A signaling contributes to tumorigenesis remains

114 We seek to understand how locomotor synergies change during development and tr

115 These data provide an explanation for how low levels of Beclin 1 facilitate tumor proliferatio

116 In this Review, we discuss how machine learning can aid early diagnosis and interpr

117 gy related genes (gHFI) determines which and how many somatic mutations (sM) must occur for malignant

118 k curves were used to draw conclusions about how many years earlier patients with diabetes reach the

119 This helps to explain how mass cell suicide can evolve, as any small benefit t

120 hich may provide some clues to understanding how melatonin protects against Abeta, and that choice of

121 This study reveals how memory effects stymied the locomotion of a diversity

122 To understand how menthol activates the channel, we docked menthol to

123 e not fully understood, nor is it understood how microstructure and mechanics change with onset and p

124 e FXR1 condensates in muscle development and how mis-splicing promotes disease.

125 We also show how more challenging variants of rubazonic acid are effi

126 his function, a mechanistic understanding of how Msp1 extracts its substrates is still lacking.

127 cleoids within the mitochondrial matrix, but how mtDNA nucleoids are formed and regulated within cell

128 Our model also includes the perception of how much the individual is going to retain from her coop

129 c titanosaurs, its peculiar morphology shows how much these animals changed during growth and has imp

130 Overall, these results shed light on how mucus impacts P. aeruginosa behavior, and may inspir

131 gen sensors in freely moving rats to examine how naloxone-HCl and naloxone-methiodide, the latter whi

132 of cancer and other diseases and demonstrate how nanobiosensors could enhance the performance of conv

133 In this study, we investigated how natural interstrain variation in the amino acid sequ

134 How natural photonic systems manage light scattering and

135 However, it remains unclear how neocortex maintains this asynchronous spiking regime

136 However, how neuronal activity regulates synaptic vesicle recycli

137 g cheetahs (Acinonyx jubatus) to demonstrate how new insights into the socio-spatial organization of

138 However, the precise mechanism of how NF2 mediates upstream signals to regulate the Hippo

139 To better understand how NTRs work, we performed the first comprehensive inve

140 Our work provides insight into how nuclei and spatial system dimensions can control loc

141 lters the functions of its targets, and show how numerous NEDD8-dependent interprotein interactions a

142 In this review, we discuss how OCM impacts the translation apparatus (composed of r

143 henotype of future generations-can influence how organisms cope with environmental change.

144 Here, we investigated how pairs of chimpanzees (Pan troglodytes) solved a prob

145 pair failures can lead to human disease, and how PARP inhibitors have emerged as a novel clinical the

146 We discuss how PDNET can be used to predict contacts, distance inte

147 reproduce the spectroscopy data and explain how periodic microstructures play a critical role in the

148 tudy provides a foundation for understanding how pharmacologically diverse and clinically essential d

149 ectric point of the macromolecules and study how phase diagrams depend on pH.

150 w CsMAF1 represses Pol III transcription and how phosphorylation controls this process.

151 Here, we show a molecular mechanism of how plants can sense parasitic Cuscuta.

152 However, it is not fully understood how plants control light-dependent FAS regulation to mee

153 How plasticity can contribute or hinder adaptation to di

154 We sought to understand how portable current ONT analysis methods are.

155 To understand how PRD suppresses lymphomagenesis, we introduced the ca

156 The goal of our study was to understand how predators influence the ability of range-shifting pr

157 d stimulus information in sensory areas, but how prior knowledge modulates processing higher up in th

158 It has been demonstrated how process signatures from the PAT tools across various

159 d histone surfaces to comprehensively assess how proteins recognize nucleosomes.

160 orption of additional active ingredients and how quickly systemic exposure exceeds 0.5 ng/mL as recom

161 We provide a proof-of-concept to show how Raman spectroscopy can be used to identify the types

162 Furthermore, we provide an overview of how ratcheted processivity emerges from pulsed events, a

163 study not only deepened our understanding of how ratio-sensing is achieved in yeast GAL metabolic reg

164 change mitigation, yet little is known about how reactive Fe and Al minerals affect C cycling in rest

165 of behavioral tasks, raising the question of how recorded activity relates to theoretical models.

166 Here, we investigate how reinforcement learning and selective attention inter

167 can generate NCE contingencies while guiding how research might better anticipate and account for the

168 Understanding how RGF1 regulates the development of the root meristem

169 s a uniquely advantageous model for studying how RNA triggers disease because: (i) Affected tissue is

170 espectively) is well accepted; it is unknown how robust this dichotomy is under inflammatory conditio

171 Our understanding of how rotavirus (RV) subverts host innate immune signaling

172 Here, we report how Runx1 is specifically upregulated at the injury site

173 mation and provide mechanistic insights into how SARAH domain-mediated interactions influence Hippo p

174 a new generation to take a look back, to see how science has and hasn't changed.

175 However, how seipin regulates adipocyte development and function

176 Our experiments show how selection can enhance evolvability by enhancing robu

177 ighlights the need for a clear assessment of how sex ratios of organisms with TSD are affected.

178 we use a coevolutionary model to illustrate how shifts in the magnitude of anorexia (e.g., via drugs

179 nd analyse data where available, to consider how size affects the primary components of viral fitness

180 Our analysis demonstrates how small-scale experimental data can be leveraged to de

181 es to provide a high level of protection and how SMC might be improved.

182 occurs, and in particular, to shed light on how social cognition supports, and is supported by, encu

183 atmosphere, and it is critical to understand how soil greenhouse gas (GHG) emissions and uptake will

184 Here, we set out to examine how song-generating circuits may be influenced early in

185 etween neighbouring groups in non-humans for how space is used and shared.

186 limate change may help refine projections of how species and biotic communities will respond to futur

187 Understanding how species have responded to past climate change may he

188 ies of patients with MS and animal models of how specific cytokines produced by autoreactive CD4 T ce

189 How sphingolipid synthesis is regulated to fulfill these

190 This study showcases how strain can be used to modulate the hydrogen absorpti

191 scuss GLUT4 sorting in different species and how studies of CHC22 have identified new routes for GLUT

192 The mechanism underpinning how substitutions in this position modulate inhibitor ef

193 cause complete loss of NHE6 expression, but how subtler missense substitutions or nonsense mutations

194 There are limited data on how such anomalies affect deaths from injuries.

195 fied, categorized, and analyzed to determine how supervisors affect autonomy of residents.

196 Herein, we present our results showing how surface-passivated gold nanoparticles behave as synt

197 NINJA will enable studies of how T cells respond to defined neoantigens in the contex

198 Specifically, we understand little about how taxonomic and functional diversity contributes to th

199 the regulation of 2OGDDs in normal cells and how that regulation is corrupted in cancer.

200 kes it a unique tissue(1-4), but whether and how the absence of nutrient supply regulates chondrogene

201 Our models explain how the activation of pyramidal cells or PV(+) cells can

202 These results demonstrate how the activity of VGLUTs can be coordinated with large

203 response (DDR) pathways, it remains unknown how the APE2 gene is altered in the human genome and whe

204 However, how the binding of multiple factors at any given locus i

205 biology in the 21st century is to understand how the brain adapts with experience.

206 How the brain orchestrates this integration process has

207 Our findings are crucial for understanding how the brain regulates information flow across senses t

208 ion of transcription on chromosome arms, yet how the cell regulates nuclear and chromatin-associated

209 How the combined activity of these different components

210 How the convergence of combinatorial inputs to principle

211 This study demonstrates how the costs of barrier crossings in prevailing winds c

212 The study showed how the developed approach can be used to study the hete

213 Here, we examine how the distinct motor programs of the nematode C. elega

214 These structures show how the donor and acceptor substrates bind in the active

215 ual figures, we have a poor understanding of how the early visual system contributes to figure-ground

216 ld contribute to the better understanding of how the fungus is able to facilitate wood decay and nutr

217 copy and density functional theory to reveal how the generation of S-vacancies within MoS(2) nanopart

218 ergent organisms, and in the second, we show how the heterogeneity of autism mechanisms in humans can

219 FigC N-citrylornithine decarboxylase reveals how the larger substrate is accommodated and how active

220 or visual processing, but also shed light on how the mammalian brain computes stereopsis.

221 This critical review discusses how the need for reduced clinical turnaround times has i

222 rane in osmotic energy conversion and reveal how the oxidation of BP influences power generation.

223 relevant examples emphasize the diversity in how the proteinaceous environment control reactivity of

224 We survey how the recent developments in genetics are beginning to

225 control, thus, it is important to understand how the reduction of this scavenger guild influences the

226 Cryo-ET reveals how the shape of the helical membrane tube arises from t

227 al environmental conditions or fully address how the spatial arrangement of habitat patches (and resu

228 Our results illustrate how the timing, size, and duration of putative local tra

229 Thus, we have identified how the Toxoplasma effector GRA15 affects cell-autonomou

230 UBE2K-Ub and UBE2K-Ub(2) complexes and show how the UBA domain can alter the position of a polyubiqu

231 anism of enhanced cooperativity demonstrates how the widespread phenomenon of enzyme polymerization c

232 Understanding how their synthesis is regulated is crucial to revealing

233 Here, we focus on how these 'cue-locked' neurons exhibited a variety of am

234 otic use, we have learned a great deal about how these 'miracle' drugs work.

235 ecent data have provided novel insights into how these ABO effects are modulated and have highlighted

236 of the specific consequences of actions, but how these are implemented in the brain is poorly underst

237 echnology, analysis of current research into how these changes reflect neurodegenerative pathology, a

238 Our results show how these chromatin parameters act together to produce d

239 To understand how these compounds alter T cell function, we assessed t

240 We discuss how these errors have affected downstream analyses and g

241 rrelating ontogeny with function, as well as how these findings can be translated to human DCs and th

242 Here, we study how these multiple FLC paralogues determine vernalizatio

243 We also provide mechanistic insights into how these novel cyclotides interact with and permeabiliz

244 in the cytoplasm of infected cells; however, how these pathogens are able to compartmentalize their l

245 It remains unclear how these pathways interact to contribute to contextual

246 tra-individual consistency, we then examined how these physiological measures relate to survival and

247 To explain how these problems develop, the neuroimmune network hypo

248 How these processes are coordinated has remained a myste

249 We further discuss how these properties contribute to intestinal developmen

250 How these regions and their interactions with brain-wide

251 It is currently unclear whether and how these repulsive and attractive biases interact durin

252 How these structural and functional brain changes may re

253 dition, this review provides perspectives on how these tools can be applied to specific research fiel

254 How these two forcings affect the seasonal intensity and

255 o be central to suppressing aggregation, but how they affect substrate conformations remains poorly u

256 her national immunology societies to discuss how they and their members responded following the emerg

257 onsidering the types of items purchased (and how they are disposed of).

258 nderstanding how leukocytes are produced and how they contribute to atherosclerosis and its complicat

259 structures of Abeta oligomers, which reveal how they form lipid-stabilized pores that might disrupt

260 Individuals differ in how they learn from experience.

261 rs already exist among these progenitors and how they may behave differently during inflammation.

262 g to the cause of this syndrome and consider how they might be modified or inhibited.

263 the immunosuppressive B7 family members, yet how they regulate and coordinate alphabeta and gammadelt

264 hromatids has made it difficult to determine how they topologically interact in replicated chromosome

265 perception of sponge cakes and demonstrates how this approach can be used to improve the sensory per

266 This review concludes with a perspective on how this fundamental knowledge might inform future clini

267 inputs from distal regulatory elements, yet how this is achieved remains poorly understood.

268 cular mechanism of CD81 cholesterol sensing, how this relates to HCV entry, and CD81's function as a

269 ity of life (VRQoL), but it is still unclear how this relationship varies with age across the VI spec

270 How this resistance is mediated is poorly understood, pa

271 rom the shift pattern change, and to explore how this shapes wellbeing.

272 gether, these data provide a mechanism as to how TIH, prevalent in people with impaired glucose metab

273 these networks, yet the mechanisms governing how tissue specificity of their function is achieved are

274 processivity emerges from pulsed events, and how tissue-level mechanics are the coordinated output of

275 In this Perspective, we first discuss how to achieve atomically precise NCs and determine thei

276 ur aim is to spur further dialogue regarding how to assess and address patient activation in kidney d

277 Our work provides a guideline on how to assess doping effects in COFs and highlights the

278 l challenges and provide our perspectives on how to bridge the phenotype-genotype gap.

279 lable evidence and potential alternatives on how to establish tau positivity (T+) for multiple tau-im

280 We illustrate how to extend the platform to model specific virus types

281 This article provides helpful guidance on how to have meaningful conversations about serious illne

282 s on many different factors, and we consider how to make these choices based on different scales of b

283 Research is needed to understand how to monitor immune response to vaccines in immunosupp

284 day, the planet again faces the challenge of how to provide people with clean water.

285 The ability to decide whether, when and how to try is central to human learning.

286 des a window through which we can understand how tree size and traits shape growth responses to droug

287 Our work highlights, at a biochemical level, how tumor-initiating ETS translocations result in reprog

288 Here, we determine how two extragenic CREs that are prominent in epithelial

289 olution, pressure-based approach to describe how two fishes, bluegill sunfish (Lepomis macrochirus Ra

290 Thus, understanding how variants of IFI16 and AIM2 contribute to periodontal

291 butes to expression of the locus and suggest how variation in these SEs may contribute to human disea

292 teractions with vesicle trafficking to probe how various processes might affect polarity site movemen

293 bitats accounting for phylogeny and then ask how vulnerability varies under four warming scenarios: +

294 How VZV establishes, maintains and reactivates from late

295 to decipher heterogeneity in T2D and detail how we and others are applying approaches developed for

296 discuss the implications of our findings for how we think about the current communication environment

297 e, we categorize human diseases according to how well they can be recapitulated by animal models and

298 flowering time variation have reconstructed how, when, and where polygenic evolution of phenotypic p

299 mutants display variable PCP defects; thus, how Wnts regulate PCP remains unresolved.

300 to both cancer and wound healing and discuss how wounding, as in biopsy and surgery, might positively