ライフサイエンスコーパス: hub

1 PN2 comprised 10 hub regions with intra-hemispheric connections in HCs.

2 PN1 comprised 10 hubs in HCs, RRMS and PPMS but did not include the right

3 The network included 2 hubs and 43 spokes with 12 803 consults performed during

4 ory segment, a variable linker region, and a hub domain, which is responsible for oligomerization.

5 PeriLC(VGLUT2) neurons are a hub between hunger and thirst that specifically controls

6 The canonical Wnt pathway serves as a hub connecting diverse cellular processes, including bet

7 These data identify HDAC3 as a hub coordinating multiple aspects of epidermal barrier a

8 l such STEM society committees to serve as a hub for a growing community of practice.

9 1 (L1) interneurons have been proposed as a hub for attentional modulation of underlying cortex, but

10 erefore, our work identifies astrocytes as a hub for controlling inhibition in cortical circuits, pro

11 pecific cell types, revealing TSK cells as a hub for intercellular communication.

12 endoplasmic reticulum (ER) serves both as a hub for maturation of secreted proteins and as an intrac

13 , our findings suggest that ringer acts as a hub for microtubule regulators that relays cellular stat

14 ated target genes identify this complex as a hub for repressing both master regulators of reproductiv

15 ropils, suggesting that the lACA serves as a hub for thermo- and hygrosensory circuitry.

16 ant expression of IGFBP2 in cancer acts as a hub of an oncogenic network, integrating multiple cancer

17 lobacter crescentus, where it functions as a hub protein that recruits multiple regulatory proteins f

18 complex organization, and reveals it to be a hub that is able to coordinate autonomic and behavioral

19 echanism that explains how hyperpolarizing a hub cell results in widespread inhibition of islet elect

20 Especially the amygdala is a hub for giving an emotional flavor to personal memories.

21 We propose that ASAP1 is a hub protein for dynamic protein-protein interactions in

22 s (MSNs) from the nucleus accumbens (NAc), a hub of the brain's motivation system.

23 ge loop structures and provide evidence of a hub-like structure that colocalizes genes involved in ri

24 t from the paraventricular thalamus (PVT), a hub for cortical, sensory, and limbic information, to th

25 depends on its orientation with respect to a hub acting as a source, even if the link in question is

26 es (ILFs) constitute steady-state activation hubs containing group 3 innate lymphoid cells (ILC3) tha

27 regulatory segment bind to the CaMKII-alpha hub and break it into smaller oligomers.

28 omplex heterogeneity, synergistic alphaalpha-hub:ligand folding, accessory binding sites, and supramo

29 ble by the characteristics of the alphaalpha-hub fold, including supersite properties, dynamics, vari

30 nctions, and complexes across the alphaalpha-hubs are described and compared to provide a unified des

31 Combined, the members of the alphaalpha-hubs are ideal models for deconvoluting signal fidelity

32 group of folded hub domains, the alphaalpha-hubs, was defined based on a shared alphaalpha-hairpin s

33 Land-use intensity strongly altered hub identity and module composition in both habitats, sh

34 We describe an anatomic hub (a couplon) formed by sodium channel clusters and su

35 Detected gene hubs and hub sub-networks were integrated by signature loci assoc

36 )/CaM sensitivity depended on the kinase and hub domains.

37 erties of structural covariance networks and hub regions.

38 in the characterization of key pathways and hub genes that might be further used as markers to impro

39 transitions between developmental stages and hub genes in co-expression modules.

40 ovide insights via co-expression modules and hubs, alternative forms of computational modelling shoul

41 ht temporoparietal junction, but not another hub of the social brain (dorsomedial PFC), increased the

42 Our results suggest that AVA are hub neurons where sensory inputs from threat and reward

43 ial smooth muscle fibers to converge around 'hubs' which serve as positional landmarks.

44 e multienzyme molecular machines that act as hubs for post-transcriptional regulation of gene express

45 t the body; (b) that multiple sites acted as hubs for HIV dissemination but that blood and lymphoid t

46 We identified NFKBIA and ARG1 as hubs in the networks and 3 groups of interacting key nod

47 n addition, regions which were considered as hubs differed between groups.

48 Mitochondria function as hubs of plant metabolism.

49 developed transportation infrastructures as hubs of HIV dispersal.

50 at Sac1 might be a component of the assembly hub for VRCs, likely in collaboration with the co-opted

51 in the highly connected network core between hub genes, but that GLIDE's global embedding measure add

52 dock spontaneously at the interface between hub subunits, trapping large fluctuations in hub structu

53 new class of structural linear motif-binding hub proteins (LMB-hubs) with key common features.

54 l interplay between a key nucleosome binding hub and a histone modification that underlies the diseas

55 ates a highly competitive nucleosome binding hub and establishes universal principles of nucleosome r

56 licate the glyoxylate cycle as a biochemical hub linking multiple metabolic pathways to stimulate rip

57 hondria are well established as bioenergetic hubs for generating ATP but have also been shown to regu

58 ncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulato

59 ia balance their dual role as a biosynthetic hub as well as a center for cellular respiration.

60 ure, yet significant reorganisation of brain hubs that formed parts of a wider rich-club collective.

61 networks in OCD, and reorganization of brain hubs.

62 indicative of altered distribution of brain hubs.

63 ed care by neurologists, physician-led care, hub and spoke models incorporating stroke telemedicine (

64 This analysis identifies a mesenchymal cell hub coordinating the LAM disease phenotype.

65 The endoplasmic reticulum is a cellular hub of lipid metabolism, coordinating lipid synthesis wi

66 ndoplasmic reticulum (ER), the main cellular hub of lipid biosynthesis and the entry site for the sec

67 d in vivo downregulation of STAT3, a central hub associated with GBM progression.

68 or triacylglycerol storage and are a central hub for fatty acid trafficking and signaling in cells.

69 ycin (TOR) has been established as a central hub for integrating external and internal metabolic cues

70 a maize NIN-like protein ZmNLP5 as a central hub in a molecular network associated with N metabolism.

71 ng and the pluripotency network as a central hub in cancer formation.

72 nother transcription factor, PU.1, a central hub in the AD gene network.

73 The huntingtin gene (Htt) is a central hub in the regeneration transcriptome; deletion of Htt s

74 The p53 and MDM2 proteins form a central hub in this pathway that receives stressful inputs via M

75 roperties in the ventral pallidum, a central hub of reward circuits, that differ between mice that ga

76 RO and clearly establish DMVs as the central hub for viral RNA synthesis and a potential drug target

77 most prominent in the striatum, the central hub of the basal ganglia.

78 al topology of reaction spaces, with central hub molecules involved in multiple reactions, requires a

79 ucosyltransferase (UGGT) 1 and 2 are central hubs in the chaperone network of the endoplasmic reticul

80 g step, and finally found six mostly changed hub genes including KIF14, CDK1, AURKA, LCN2, TGM1, and

81 n centre in the Jalpha array and a chromatin hub for interactions between Valpha and Jalpha genes.

82 At regional CO(2) collection hubs, emissions of 40 MtCO(2)/yr can be avoided within 1

83 eated a table describing a network of common hub metabolites and how they are biochemically connected

84 these fields, as promoted through the common hub of RL, has facilitated paradigm shifts that relate m

85 e hypothesis that motif V is a communication hub for this energy transduction.

86 tified Motif V as a potential "communication hub" for this energy transduction pathway.

87 f NCM cell types as major cell-communication hubs.

88 ry holders marked and defended communication hubs (CHs) in the core area of their territories.

89 the formation of heterologous communication hubs in which tumor cell-derived factors modify the cros

90 the formation of heterologous communication hubs in which tumor cell-derived factors modify the cros

91 The formation of new communication hubs connecting CECs and LSECs included the hepatocyte g

92 ngagement of category-specific computational hubs in the ventral visual stream with the distributed c

93 Well-connected hub genes with heart-specific expression targeted by emb

94 e strongly organized around highly connected hubs.

95 and the identification of highly connected "hub" (or "leader") cells and of follower populations sub

96 uorides (SASFs) as a new class of connective hub in concert with a diverse selection of click-cycload

97 where nutrient signaling pathways constitute hubs integrating information from multiple aging-related

98 ively fewer second-order nodes and contained hubs.

99 the fronto-limbic circuitry as a convergence hub for emotional dysregulation.

100 reward-related activation in one of the core hubs of the brain reward system (the ventral striatum),

101 The PPC is considered to be a cortical hub for multisensory integration, working memory, and pe

102 ANCE STATEMENT The spinal cord is a critical hub for processing somatosensory input, yet which spinal

103 The ventral hippocampus (vHPC) is a critical hub in networks that process emotional information.

104 ATEMENT The anterior cingulate is a critical hub in prefrontal networks through connections with func

105 circuit, has been identified as the critical hub responsible for fear responses related to stress cop

106 etics, are increasingly emerging as critical hubs for intracellular signaling.

107 SPI-Birds acts as a data hub and a catalogue of studied populations.

108 To control CP1-3, dedicated hubs integrate the antagonistic mitogenic and DNA damage

109 loration of graph measures in the determined hub regions showed that efficiency of six regions differ

110 to those formed by intrinsically disordered hub proteins in other kingdoms.

111 r revealed that these proteins have distinct hub and bottleneck properties in the brain protein inter

112 dered a complex integration and distribution hub for sensorimotor information.

113 ory areas are thought to act as distribution hubs, transmitting information about the external enviro

114 Consistent with PLN acting as a dynamic hub in the control of Ca(2+) handling, our results ident

115 chain LC8 as a canonical example of dynamic hub proteins to develop a conceptual residue-level frame

116 eviously uncharacterized Pax7-bound enhancer hub that regulates the essential myosin heavy chain clus

117 y exclusive manner documenting that enhancer hubs impinging on MYC detected in large cell populations

118 pothesis postulates that specially equipped "hub" or "leader" cells within the beta-cell network driv

119 Thus, DiNeR successfully extracted hub regulators and discovered well-known risk genes.

120 ng to task goal, consistent with a "flexible hub" mechanism for cognitive control.

121 Recently, a new group of folded hub domains, the alphaalpha-hubs, was defined based on a

122 oluting signal fidelity maintained by folded hubs and their interactions with intrinsically disordere

123 lop a conceptual residue-level framework for hub-partner interactions and functions.

124 apause development and an important role for hub genes in the evolution of transcriptional divergence

125 role of the nucleus reuniens as a functional hub for exchanging and processing memories.

126 racteristics when compared to the functional hub and diverse club regions.

127 pproach identified 35 metabolite and 34 gene hubs with the most network correlations.

128 Detected gene hubs and hub sub-networks were integrated by signature l

129 ovascular regional public service healthcare hub demonstrate a significantly longer time from symptom

130 dy from a regional public service healthcare hub in Milan included all consecutive patients with STEM

131 Finally, DiNeR highlights hubs in the resultant differential network as key TFs as

132 dehydrogenase type 12 (HSD17B12) as a human hub of the very-long-chain fatty acid (VLCFA) synthesis

133 e has emerged as the central immunometabolic hub of the macrophage.

134 re Complex (NPC) has emerged as an important hub for processing various types of DNA damage.

135 numerous auditory nuclei and is an important hub for sound processing.

136 ted control of the nucleolus as an important hub linking acetyl-CoA fluctuations to cellular stress r

137 ent plants have been identified as important hubs for small particulate plastic, down to the nanomete

138 hub subunits, trapping large fluctuations in hub structure.

139 prevent hospitals from becoming independent 'hubs' of SARS-CoV-2 transmission, and illustrate how, wi

140 Our findings position ILFs as key inductive hubs for regional immunity in the human intestine, and t

141 signalling system can act as an information hub by multiplexing information arising from multiple si

142 SER becoming an opportunity and information hub that helps to fill resource gaps.

143 reviously recognized as a signal-integrating hub for NLRP3 activation in response to many stimuli and

144 7, is widely recognised as a key integration hub for cell growth and intracellular stress signals ups

145 e (RNAP)(3-11), forming a signal-integration hub for co-transcriptional regulation that includes tran

146 onnected enhancers (HICE) act as integration hubs orchestrating differentiation by the formation of t

147 Like other integration hubs, it contains repeated neurochemical motifs with dis

148 s indicate that CsoS2 acts as an interaction hub to condense Rubisco and enable efficient alpha-carbo

149 roteins comprising a few highly interactive "hubs" such as parvalbumin and calmodulin.

150 onstrated robust congeneric and intergeneric hubs but significantly fewer cytokine-bacterial connecti

151 e that the Tkv receptor is internalized into hub cells from the MT-nanotube surface and subsequently

152 d Tkv internalization from MT-nanotubes into hub cells both resulted in an overabundance of Tkv prote

153 The ventral pallidum (VP) is a key hub in the reward system that encodes the hedonic aspect

154 n of systems-wide signaling defects in a key hub of the DMN.

155 duced decreases in amygdala perfusion, a key hub of the OT central circuitry, are explained entirely

156 The precuneus (PreC; Brodmann area 7), a key hub within the default mode network (DMN) displays amylo

157 udalis) and the centromedial amygdala as key hubs for flexibly integrating valence information into d

158 rgency appears related to dysfunction in key hubs implicated in the integration of cognitive control

159 imulus-dependent, cognition overlap with key hubs of the default mode network (DMN) that become compr

160 nding of the function of the identified KIRC hub genes could provide deep insights into the molecular

161 create more unity through a common knowledge hub linking academia, industry, healthcare providers and

162 increased connectivity in frontal and limbic hubs over time, children with PME showed increased conne

163 LMB-hubs have structural plasticity yet conserved interfaces

164 tural linear motif-binding hub proteins (LMB-hubs) with key common features.

165 f the ventral tegmental area (VTA), the main hub of the brain reward system, remains only partially c

166 e RE has been suggested to represent a major hub in reciprocal hippocampal-prefrontal communication.

167 on within the restrosplenial cortex, a major hub of the DMN.

168 The human claustrum, a major hub of widespread neocortical connections, is a thin, bi

169 ddition to functional changes in these major hubs of tactile information processing, whisker stimulat

170 China are concentrated in key manufacturing hubs, including the Yangtze River Delta, Pearl River Del

171 Many hub brain regions that control this network were identif

172 ysregulated FFL networks, we found that many hub nodes (12 out of 30 for SE and 8 out of 32 for NSE)

173 ontrols in global normalized graph measures, hubs, or modularity structure of the pain matrix and the

174 hippocampal system, the brain's major memory hub, has been studied in people with epilepsy or Alzheim

175 tamine, and NAD(+), representing a metabolic hub that may balance the levels of core nitrogen and car

176 icating this conserved and central metabolic hub in life span regulation.

177 amycin complex 1 (mTORC1) is a key metabolic hub that controls the cellular response to environmental

178 e localization of GLUT8 at a major metabolic hub (the late endosomal/lysosomal interface) and its reg

179 Mitochondria are essential metabolic hubs that dynamically adapt to physiological demands.

180 potential after disturbance of metacommunity hub species with core structural and functional roles fo

181 identify a miRNA network composed of 8 miRNA hubs and 54 target genes.

182 n the core of SWI/SNF, acting as a molecular hub.

183 After validation in multiple databases, most hub genes remained significant.

184 Most hubs of this network were associated with ABA signalling

185 trich ciliates, which is a localized, motile hub that traverses the macronucleus while replicating DN

186 al role of the yolk sac as a multifunctional hub for haematopoiesis, germ cell development and nutrit

187 we validated the role of a predicted network hub gene using the Arabidopsis system.

188 We found that the network hub gene Bcat1 and seven other co-regulated MMnet genes

189 Network hubs' strengths were compared with HCs.

190 tribution of low- and high-frequency network hubs, implying that they constitute distinct CFC mechani

191 e normal inhibitory self-coupling of network hubs in both antero-mesial temporal lobes, with developm

192 esults suggest that disconnection of network hubs led to a less efficient network, which in turn may

193 ng RNAs, share RNP networks and that network hubs define functional sites in these RNAs.

194 Within the networks, hub miRNAs, miR-29b-3p, miR-17-5p, and miR-20a-5p, were

195 s GLP-1Rs and functions as a neuroanatomical hub connecting the nucleus tractus solitarius (NTS), the

196 ed AR formation through upregulation of nine hub regulators, including a jasmonate signaling pathway

197 chamber network, we show that the top 10% of hub rumor echo chambers contribute to propagation of 24%

198 Although this distinguishes some features of hub protein/partner interactions, the increasing literat

199 otoablation, has confirmed the importance of hub cells as possible pacemakers.

200 he reversible head-to-tail polymerization of hub proteins into filaments that are cross-linked by dim

201 us literature reporting the vulnerability of hub regions to neurological disease, as well as provide

202 necting the kinase domains to the oligomeric hubs of the holoenzyme.

203 length one and two which contain at least on hub node, and they are related to the eigenvector centra

204 efficiency was less critically dependent on hubs.

205 Oncological hub-and-spoke program was planned in 29 departments, but

206 The oncological hub-and-spoke program did not work adequately.

207 the vmPFC appeared to be central 'nodes' or hubs of the fatigue network.

208 le of the helicase as the central organizing hub.

209 We show that genes that form stable E-P hubs have less cell-to-cell variability in gene expressi

210 The MDM2-p53 hub is one of the hubs most highly connected to other si

211 mically and topologically specific pacemaker hub that determines the emergent properties of the SCN t

212 d the ongoing development of organ perfusion hubs.

213 negative regulator of a posttranscriptional hub involved in mRNA half-life regulation of cancer-rela

214 VI - highlighting these regions as potential hubs for multimodal cortical influence.

215 Compared with HCs, MS patients had preserved hub number, but some hubs exhibited reduced strength.

216 ome of which project to a key presympathetic hub, the rostral ventrolateral medulla (RVLM).

217 dvanced river civilizations, and a principal hub of the Silk Roads over a period of more than 2,000 y

218 cleus accumbens (NAc) is a reward processing hub sensitive to acute sleep deprivation.

219 Notably, ANKRD30B, a promising hub gene, was significantly hypermethylated in blood and

220 chorismate-tyrosine pathway as a regulatory hub controlling the supply of the aromatic head group fo

221 ngs establish the endodermis as a regulatory hub coordinating microbiota assembly and homeostatic mec

222 eries highlight the lysosome as a regulatory hub for cellular and organismal homeostasis, and an attr

223 point previously identified as a regulatory hub in Sth1, suggesting that large conformational change

224 model by which Cav1 is a central regulatory hub for tumor-stroma interactions through a novel exosom

225 tructure of human CMG bound to the replisome hub AND-1 (CMGA).

226 a vasoprotective nanobarrier and responsive hub.

227 cted the Euclidean distance to the retrieved hub, which was reinstated in HC.

228 -2012) and observe the emergence of shipping hubs in the Arctic where the cumulative risk of non-nati

229 mucosal barriers indicates that a signaling hub coordinates the interaction between environmental cu

230 nes (SEF), is proposed to act as a signaling hub that negatively regulates mitogenic signaling pathwa

231 induced by RNase L as an antiviral signaling hub to coordinate the RNA ligands with cognate receptors

232 follow and understand this complex signaling hub is desirable.

233 enes (STING) acts as a cytoplasmic signaling hub of innate immunity that is activated by host-derived

234 system is emerging as an important signaling hub that modulates the response to nutritional signals,

235 is largely driven by the metabolic signaling hub, mammalian target of rapamycin complex 1, and the do

236 e roles of the multifunctional PIF-signaling hub.

237 Mitochondria are signaling hubs in eukaryotic cells.

238 trafficking, ion transfer, and as signaling hubs.

239 cell populations serve as crucial signaling hubs to maintain epidermal communication.

240 terotrimeric G proteins, two major signaling hubs in eukaryotes, independently relay signals across t

241 se that NF-kappaB is an important signaling 'hub' that suppresses the reprogramming of Muller glia in

242 st variety of bile acids and is a signalling hub in the liver-bile acid-microbiota-metabolism axis(1-

243 on, adipose tissue functions as a signalling hub that regulates systemic metabolism through paracrine

244 The evening complex is a major signalling hub and a core component of the plant circadian clock(2,

245 ered, multidimensional MAPK7/MMP9 signalling hub in primary bone cancer metastasis that is clinically

246 patients had preserved hub number, but some hubs exhibited reduced strength.

247 oseness, degree and a new metric, the source/hub ratio.

248 Creating community-specific hubs (such as ours, COMADRE for animal demography, etc.)

249 Stabilized hubs presage the site of the manubrium blastema, whose g

250 ear to converge towards an oxidative stress "hub" affecting parvalbumine interneurones (PVI) and thei

251 We define ATP6AP1 as a structural hub for V(o) complex assembly because it connects to mul

252 Our work identifies a structural "hub," formed by the association of several Sth1 domains,

253 The hub role of the right anterior insula (AI) has been emph

254 The hub transcripts were identified for REA (LRRFIP1, RCAN1

255 sive interactions between the kinase and the hub domains, even in the presence of a 30-residue linker

256 PI networks were analyzed with MCODE and the hub genes chose from the PPI networks were verified by O

257 ntroduce a topological characterization, the hub-set-orientation prevalence of a link, which indicate

258 The nucleus accumbens (NAc), considered the hub of reward circuitry, is comprised of two medium spin

259 phosphorylation allows it to destabilize the hub, producing smaller assemblies that might reassemble

260 ed a previously uncharacterized role for the hub domain as an allosteric regulator of kinase activity

261 n the direction of propagation away from the hub core of the graph.

262 includes substantial contributions from the hub domain.

263 k in question is several steps away from the hub itself.

264 In the inferior colliculus (IC), the hub of the central auditory pathway, molecular markers f

265 By identifying the hub rumor echo chambers (in terms of connectivity to oth

266 Our integrated analysis illustrated the hub genes involved in KIRC tumorigenesis, shedding light

267 ube surface and subsequently degraded in the hub cell lysosomes.

268 localize to distinct adjacent regions in the hub, which specifically regulate and implement DNA trans

269 notubes (MT-nanotubes) that project into the hub cells, serving as the platform for niche signal rece

270 rface of MT-nanotubes, where it receives the hub-derived ligand Decapentaplegic (Dpp).

271 o 10 germline stem cells (GSCs) surround the hub, a cluster of somatic cells that organize the stem-c

272 Our numerical results show that the hub-set-orientation prevalence of a link strongly correl

273 transferred from the remote hospital to the hub hospital, only 14 (8.2%) of all remote hospital pati

274 altered brain morphometry in OCD, while the hub findings point to OCD-related alterations in traject

275 sory neurons, synaptic-like contacts are the hubs of a 2-site receptor.

276 we show several examples how changes in the hubs linkage effects the degree-degree correlations and

277 The MDM2-p53 hub is one of the hubs most highly connected to other signalling pathways

278 cores are related by the connectivity of the hubs, we show several examples how changes in the hubs l

279 its average orientation with respect to the hubs of a graph.

280 measured based on the connectivity with the hubs.

281 how that the connections with and within the hubs can be used to define different networks cores.

282 degree based on the connectivity within the hubs.

283 pend on the connectivity with and within the hubs.

284 These hub molecules were validated by an independent dataset.

285 These hubs have prognostic value and are likely integral to tu

286 How these hubs cross-talk has been a long-standing question, but a

287 We investigate how these hubs of ecosystem services facilitate socio-ecological c

288 Stabilization of these hubs, and associated expression of Wnt6, depends on the

289 and only offloaded searches to and from this hub network onto an interactive webserver capable of vis

290 ller glia into proliferating MGPCs and this 'hub' coordinates signals provided by reactive microglia.

291 etylation and presumably expression of three hub regulators, PuWRKY51, PuLBD21 and PuIAA7.

292 ted this data as a publicly accessible track hub, enabling researchers to explore this data set easil

293 ies diversity was similar between both trade hubs with a small subset of species dominating the compo

294 t that systematic studies of other fin trade hubs within Mainland China and stronger law-enforcement

295 Golgi network (TGN) is a central trafficking hub where secretory, vacuolar, recycling, and endocytic

296 ties such as hospitals, schools, and transit hubs.

297 f this organelle in autophagy as a transport hub supplying various components of autophagosome format

298 x is recognized as being a central transport hub in the cell, with a critical role in endocytic traff

299 by gene co-expression network analysis where hub genes were identified as main drivers of invert suga

300 ivations via a wireless signal to a wireless hub divided by a previously validated estimate of the nu