ライフサイエンスコーパス: human

1 Neanderthal sequences segregating in modern humans.

2 families have been scarcely investigated in humans.

3 egions that are separated by 500-residues in humans.

4 ving influenza virus-induced inflammation in humans.

5 patterns in the internal organs of deceased humans.

6 hares many conserved genes and pathways with humans.

7 m contributes to figure-ground processing in humans.

8 ated to reducing PTSD symptom development in humans.

9 division in organisms ranging from yeast to humans.

10 most common single gene familial diseases in humans.

11 he potential to cause zoonotic infections in humans.

12 uzii, ultimately increasing its contact with humans.

13 asting plasma glucose in both obese mice and humans.

14 l corollaries of sex-biased brain anatomy in humans.

15 ) associated with variants of these genes in humans.

16 herapeutic options for sinonasal diseases in humans.

17 F-alpha and is not associated with increased human-Abeta levels and AD pathology.

18 protein, and block the interaction with the human ACE2 receptor.

19 o native and venomous agent X (VX)-inhibited human AChE, here we created seven uncharged acetamido bi

20 Human actions are causing concurrent shifts in CO(2) , t

21 explicitly includes the combined effects of human activities and fire regimes.

22 ly assessing Pb emissions directly linked to human activities.

23 aggregates extracted from cell cultures and human AD brain tissues, demonstrating the ability of the

24 iruses, we modeled the inactivation of three-human adenovirus and two bacteriophages-MS2 and phiX174-

25 rved plasma silver concentrations in healthy human adults.

26 As humans age, hematopoietic stem cells (HSCs) occasionally

27 In humans, age-related changes in personality occur in a no

28 Here, Abi1 knockdown by shRNA reduced human airway smooth muscle cell migration, which was res

29 viral life cycle in three-dimensional (3-D) human airway tissues.

30 PFGE was performed on 38 human and 10 puppy isolates; PFGE patterns did not relia

31 ion has been neglected by research comparing human and machine behavior, and that it should be essent

32 into nanocomplexes at the plasma membrane of human and mouse arterial myocytes.

33 wo different mouse xenograft models and four human and mouse cell lines we examined in vitro cisplati

34 nd generated STING-noninteracting mutants of human and mouse TRIFs.

35 es that manage bodily excreta within coupled human and natural systems.

36 tic ratios revealed sterols originating from human and nonhuman sewage sources.

37 However, recent evidence in human and rodent chronic sleep restriction (CSR) studies

38 nt correlation between the detected level of human and SARS-CoV-2 nucleic acids.

39 illustrate a particular relationship between humans and carnivores during the MIS5-4 Still Bay and Ho

40 specificity is a hallmark for adaptation to humans and evolution toward a transmittable virus.

41 ith increased incidence of diabetes, both in humans and in animal models.

42 ble the exploration of biotin trafficking in humans and its use as a research tool for diagnostic ima

43 sses the disconnect in biotin levels between humans and mice, and explains the failure of potent biot

44 d aspects of sex-biased brain development in humans and mice, and shed light on the consistency, cand

45 ies virus (RABV), is a fatal encephalitis in humans and other mammals, which continues to present a p

46 intermediate host, leading to infections in humans and other mammals.

47 igin of diverse biological species including humans and proteomic data to classify breast cancer tumo

48 Chronic stress in both humans and rodents induces a robust downregulation of ne

49 ct of EDCs causing adverse health effects in humans and wildlife has led to the development of scient

50 Recent evidence from human newborns and non-human animals has challenged the primary role assigned t

51 Targeting Fn-EDA in human aortic SMCs suppressed the synthetic phenotype and

52 developing immune system.(1)(,)(2) However, humans are unique among primates in that we consume high

53 e thus a valuable resource for investigating human astrocyte function and dysfunction in health and d

54 ously, we demonstrated PCSK6 upregulation in human atherosclerotic plaques associated with smooth mus

55 The selected genes were either from human BC studies (n = 294) or from within canine mammary

56 d by the fact that our methods for measuring human behavior are typically developed and validated for

57 mice (10 animal/sex/group) along with their human blood compatibility.

58 association of Cd and smoking exposures with human blood DNA methylation (DNAm) profiles.

59 hundred times less abundant than glucose in human blood.

60 s are the main cytotoxic killer cells of the human body to eliminate pathogen-infected or tumorigenic

61 Recombinant human bone morphogenetic protein 2 (rhBMP-2) is an osteo

62 ptible to the rs6971 genetic polymorphism in human brain and heart samples.

63 epresentation of temporal information in the human brain needed to form episodic memories.

64 In RNA-Seq analyses of human brain samples from the NYGC ALS cohort, truncated

65 However, human brain sampling complexities limit the explanatory

66 tion than lower processing levels, as in the human brain, activity in low-level visual areas should e

67 In human breast cancer cell lines and 4T1 mouse mammary tum

68 Pulsed magnetic field exposure of human breast cancer cells that express a sialic-acid ric

69 en each of these miRNAs was transfected into human breast cancer MDA-MB-231 cells.

70 The Wnt signaling pathway triggers human BTSC proliferation in vitro and influences PBG hyp

71 ling is essential to prevent OPC in mice and humans, but the individual roles of its ligands, IL-17A,

72 caution that opportunistic blood feeding on humans by sylvatic Ae. malayensis may occasionally contr

73 rotein in pathologically affected vessels of human CADASIL-affected brains.

74 plied on WGS data to determine the source of human campylobacteriosis, the geographical origin of div

75 Cancer elimination in humans can be achieved with immunotherapy that relies on

76 ow the heterogeneity of autism mechanisms in humans can be broken down by functional groups and trans

77 tumour spheroids formed from two established human cancer cell lines (HCT116 and CAL27) to single and

78 nd evaluation of their activity against five human cancer cell lines.

79 In both C. elegans and human cancer cells, ether-lipid synthesis protects again

80 exhibits cytotoxic activity against various human cancer cells, killing SW48 colon cancer cells in p

81 ve G-quadruplex ligand that, when studied in human cancer cells, proved to be able to stabilize both

82 studies, particularly in genomic studies of human cancer.

83 well-known oncoprotein overexpressed in most human cancers, we show that FBXL16 stabilizes C-MYC by a

84 pment, and homeostasis, and are disrupted in human cancers.

85 Experiments were conducted in isolated human cardiomyocytes and trabeculae.

86 Synthetic pigment and pigmented human cartilage tissue both showed hydroquinone-resembli

87 is allowing repression of rat macrophages by human CD47-positive cells.

88 lpha,beta-methylene)diphosphate (AOPCP) with human CD73, we designed a series of novel monophosphonat

89 e in target cell killing by freshly isolated human CD8(+) T cells, which represent a challenging but

90 urate 21-plex quantification of labeled K562 human cell line protein digests via single-shot nanoLC-M

91 ese viruses are restricted to replication in human cells and tissues, making them difficult to study

92 tor of fetal gamma-globin gene expression in human cells by repressing BCL11A transcription.

93 and non-invasive method of isolating viable human cells present at the site of skin wounds.

94 proteins together promote MVA replication in human cells to levels that are comparable to titers in c

95 double-strand break (DSB) repair pathways in human cells, how DNA repair failures can lead to human d

96 owever, here we found that when expressed in human cells, two highly homologous HSP70s, HSPA1A and HS

97 activity on rat P2X2 receptors expressed in human cells.

98 s of DS, involving trisomy of all or part of human chromosome 21 or orthologous mouse genomic regions

99 We further report the cryoEM structure of human CMG bound to the replisome hub AND-1 (CMGA).

100 Moreover, human cohort data have revealed differential DNA methyla

101 is, video analysis, video summarization, and human-computer interaction.

102 rotein (SP) family of chromatin 'readers' in humans consists of SP100, SP110, SP140, and SP140L.

103 The human corpus callosum exhibits substantial atrophy in ol

104 roscopy (SR-XRF), gadolinium was detected in human cortical bone tissue.

105 polymerization-based regulation employed by human CTP synthase 2 (CTPS2).

106 Human cytomegalovirus (HCMV) causes a lifelong infection

107 l as how these findings can be translated to human DCs and their progenitors.

108 Conjugation of recombinant human deoxyribonuclease I (rhDNase) to polyethylene glyc

109 Human dermal fibroblasts were used as comparator cells.

110 Proportionally, countries with a low UNDP human development index (HDI) faced a greater burden of

111 ews regarding the role of animal products in human diets.

112 how variation in these SEs may contribute to human disease and altered immunity.

113 n cells, how DNA repair failures can lead to human disease, and how PARP inhibitors have emerged as a

114 f loss-of-function mutations associated with human disease.

115 ogical stress has adverse effects on various human diseases, including those of the cardiovascular sy

116 l to the etiology of a wide range of serious human diseases, such as Alzheimer's disease and prion di

117 Human disturbances alter the functioning and biodiversit

118 hallenging because of low bacterial and high human DNA abundances.

119 Interestingly, human DNA polymerase eta (poleta) proficiently incorpora

120 e fovea and peripheral retina of seven adult human donors.

121 lts on Database of Interacting Protein (DIP) Human, Drosophila, Escherichia coli (E. coli), and Caeno

122 Using monkey and human electrophysiology data, we show here that attracto

123 sequencing on zebrafish, chicken, mouse, and human embryos.

124 ascular endothelial cells and an established human endothelial cell line, we investigated the role of

125 n equivalently vetted inventory of bona fide human enhancers.

126 troduced interactions is directly related to human environmental modifications and is accelerating, h

127 ceptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) are the

128 Therefore, we characterized the human ERICH3 gene functionally and identified ERICH3 mRN

129 Loss of ZNF410 in adult-type human erythroid cell culture systems and xenotransplanta

130 human HUDEP2 erythroid cell line and primary human erythroid cultures.

131 ly occurring estrogen estetrol and Selective Human Estrogen-Receptor Partial Agonists are being evalu

132 Humans exert dramatic influences upon the environment, c

133 The human FBN1+ FAP cell subtype is novel and a correspondin

134 ta, and dye tracer tests provide evidence of human fecal contamination in the private wells studied,

135 s belonging to 1-2 mum structures in primary human foreskin fibroblasts or mouse bone marrow-derived

136 NA expression levels of ST6GAL-I and SOX9 in human gastric epithelial cells correlated positively wit

137 ynamic behavior whereby Tfh cells migrate in human GC and highlight the heterogeneity of GC for Tfh c

138 The human gene catalogue is essentially complete, but we lac

139 nformation they can convey in the context of human genetics.

140 unknown how the APE2 gene is altered in the human genome and whether APE2 is differentially expresse

141 ssing the HTLV-1 oncogene Tax, driven by the human granzyme B promoter (Tax(+)), develop osteolytic t

142 ing the biological characterization of these human groups, especially regarding the Mid-UP period (MU

143 as isolated during functional screening of a human gut metagenomic library using Lactococcus lactis M

144 Studies in experimental models and humans have identified 9 highly interconnected hallmark

145 inhibitors that discriminate between the 11 human HDAC isoforms.

146 pharmaceutical compounds toward safeguarding human health and ecosystems on a global scale.

147 aquifers poses significant environmental and human health concerns.

148 Extreme heat adversely affects human health, productivity, and well-being, with more fr

149 In the setting of human health, understanding metabolic changes within bac

150 e electrophysiological properties in failing human heart ventricles have not been examined for a circ

151 s node (SAN) is the primary pacemaker of the human heart, and abnormalities in its structure or funct

152 sion tomography-computed tomography scans in human hearts.

153 e hexamers to generate free amino acids from human hemoglobin and are drug targets for the design of

154 The human hepatocyte growth factor receptor (c-MET) signalin

155 emonstrate that DCLK1-overexpressing primary human hepatocytes formed spheroids in suspension culture

156 Human herpesvirus-6 (HHV-6) A and B are ubiquitous betah

157 pattern of SCGN immunostaining in the adult human hippocampal formation (DG, CA1, CA2, CA3, subiculu

158 We examined preparatory coding in the human hippocampus and mPFC, two regions that are importa

159 ctivation by inhibition" using bacterial and human HtrA proteases as models.

160 t F cells and non-F cells (A cells) from the human HUDEP2 erythroid cell line and primary human eryth

161 Our data show human IgM affects C. neoformans morphology in vitro and

162 nd can play a critical role in the spread of human ignited wildfires.

163 g of electrophile-sensitive cysteines in the human immune proteome remains limited.

164 ion for the CDC intermedilysin, bound to the human immune receptor CD59 in a nanodisc model membrane.

165 The ongoing spread of human immunodeficiency virus (HIV) has driven novel inte

166 , Philadelphia identified an outbreak of new human immunodeficiency virus (HIV) infections among pers

167 However, the impact on transmission of human immunodeficiency virus (HIV) is uncertain.

168 coli dnaX mRNA and the gag-pol transcript of Human Immunodeficiency Virus (HIV) perturb translation e

169 luated the feasibility of daily and nondaily human immunodeficiency virus (HIV) preexposure prophylax

170 ptomic data with new data from a prospective human immunodeficiency virus (HIV)-negative UK cohort of

171 AH) is overrepresented in People Living with Human Immunodeficiency Virus (PLWH).

172 We estimated human immunodeficiency virus incidence and incidence rat

173 Chronic inflammatory diseases including human immunodeficiency virus infection, psoriasis, rheum

174 n vitro and suggest that the hypothesis that human immunoglobulins may affect C. neoformans virulence

175 The forests of the HRL have experienced low human impact and still constitute large tracts of contig

176 performance, and inhibiting eye movements in humans impaired navigation precision.

177 Using human induced pluripotent stem cell (iPSC)-derived neuro

178 as assessed in HL1 murine cardiomyocytes and human induced pluripotent stem cell-derived cardiomyocyt

179 DNMT3A was knocked out in human induced pluripotent stem cells by CRISPR/Cas9gene

180 e, we report the directed differentiation of human iPSCs into airway basal cells ("iBCs"), a populati

181 VSG in humans is a complex procedure and includes peri-operativ

182 In a context-aware blind evaluation by human judges, CUBBITT significantly outperformed profess

183 y ascorbic acid was accomplished in cultured human keratinocyte stem cells to show similar Ca(++)-ind

184 s in podocalyxin (PODXL) are associated with human kidney disease.

185 is study, we show that MVs isolated from the human lactic acid commensal bacteria Pediococcus pentosa

186 sity and are slow to recover if destroyed by human land uses (e.g., tillage agriculture, plantation f

187 e whether, when and how to try is central to human learning.

188 d an age-associated increase in stiffness in human lenses that was directly correlated with levels of

189 which creates a neoepitope presented by the human leukocyte antigen with the A2 serotype (HLA-A2) th

190 The human lineage is marked by a transition in hand use, fro

191 We describe a specific example of a gAP in humans linked to individual differences in the response

192 ctroencephalography (EEG) in male and female human listeners to examine potential effects of hearing

193 hermore, CRISPR-mediated knockout of FN3K in human liver cancer cells altered the abundance of redox

194 eases they transmit claim at least a million human lives every year globally.

195 The ontogeny of airway macrophages (AMs) in human lung and their contribution to disease are poorly

196 syncytial virus (RSV) infection in mouse and human lung is associated with oxidative injury and patho

197 O- and glycosphingolipid-glycans from total human lungs, along with histological analyses of IAV bin

198 Vpr-dependent rescue of HIV-1 replication in human macrophages from inhibition by cGAMP, the product

199 hese botanical dispersals need not have been human mediated(7).

200 The human-mediated spread of exotic and invasive species oft

201 y employed to treat infections in animal and human medicine.

202 provide evidence that primary FCRL4-bearing human memory B cells are constitutively bound to IgA.

203 ations suggest that lifetime trajectories of human-microbial relationships could differ from those of

204 e genes characterized by biofilm-forming and human-microbiome-influenced environments with correspond

205 domain and neighboring first brace helix of human MLKL with nanomolar affinity.

206 Built upon the common human mobility metrics, we construct a Social Distancing

207 thermore, an RA-responsive gene signature in human monocytes correlates with an immunosuppressive TME

208 a ubiquitous commensal fungus that colonizes human mucosal tissues and skin, can become pathogenic, c

209 In this report, a procedure for collecting human mucus has been described.

210 The human nasal passages host a distinct community of microb

211 rganoid engineering are expanding the use of human neuronal models in vitro.

212 phagy as a mechanism to reduce tau burden in human neurons and, from a small-molecule screen, identif

213 hology and IST1 localization in iPSC-derived human neurons.

214 Human neutrophils are critical for the innate immune res

215 Recent evidence from human newborns and non-human animals has challenged the

216 ver that majority of miR-21-5p isolated from human non-small cell lung cancer (NSCLC) tissue possesse

217 es revealed distinct genetic architecture of human NP and AF compartments and identified 2,196 differ

218 nct, osteogenically-committed BMSC subset in human OA trabecular bone.

219 es containing internal temporal structure to humans of either sex and male macaque monkeys.

220 alpha-tubulin peptides in the background of human olfactory neurosphere-derived stem (ONS) cell matr

221 remarkable microbial diversity found within humans, our ability to link genes to phenotypes is based

222 t two cryo-electron microscopy structures of human PAC in a high-pH resting closed state and a low-pH

223 3T, Panc-1, and Panc-28 cells and samples of human pancreatic intraepithelial neoplasia (PanIN), alon

224 Human papillomavirus-16 cleared significantly slower tha

225 We exposed human participants to auditory cues that predicted the l

226 hippocampus, performing the same task as the human participants.

227 The human pathogen Chlamydia trachomatis targets epithelial

228 The human pathogen Vibrio cholerae typically exists as a cur

229 -stranded DNA (ssDNA) in a manner similar to human PC4, the prototype of PC4-like proteins, which pla

230 Tumor models of human PCa epithelia with CAF expanded similarly in mice

231 documenting the importance of S-acylation in human physiology and disease.

232 dard deviations (RSD) between the cycles for human plasma samples were 0.84-6.6%.

233 ons of 75 compounds previously identified in human plasma samples with annotations generated by three

234 that comprise dopamine neurons derived from human pluripotent stem cells, which have several advanta

235 ence of its causal agent, SARS-CoV-2, in the human population remains mysterious, although bat and pa

236 herpesviruses, infecting the majority of the human population.

237 s a need for reference genomes from multiple human populations to avoid potential biases.

238 ual speech evokes a positive response in the human posterior superior temporal gyrus, enhancing the e

239 r UPR induction in murine myeloblast 32D and human promyelocytic NB4 cells.

240 ieves state-of-the-art accuracy of 99.15% on Human protein reference database (HPRD) dataset and also

241 on the metabolic activity and morphology of human pulmonary endothelial cell monolayers.

242 The inoculation of a human rabbitized (FdltB(r)) strain demonstrated its capa

243 ponses induced by intravenous heroin at low, human-relevant doses.

244 stigations of antiviral activity against the human respiratory syncytial virus were carried out for s

245 Using primary human retinal vascular endothelial cells and an establis

246 he ability of dysbiotic Pg-strains to invade human-retinal pigment epithelial cells(ARPE-19), their s

247 rapid binding (in the order of seconds) with Human Salivary alpha-amylase (HSA) and Porcine Pancreati

248 A is essential, and reuptake failure worsens human seizures.

249 l magnetic resonance imaging to describe how humans select predictors that might be most relevant.

250 004 wt % of the total protein in 1:4 diluted human serum or 0.024 wt % of the total protein from brea

251 sion of culture-a feature that songbirds and humans share.

252 that mouse nighttime sleep, analogous to the human siesta, is a "hard-wired" property gated by specif

253 and Il2rg deficiency with the expression of human signal regulatory protein alpha, a negative regula

254 ed immunodeficient Rat Rag-/- Gamma chain-/- human signal regulatory protein alpha-positive (RRGS) ra

255 Human skin contains a population of memory T cells that

256 Here we describe an ex vivo cultured human skin explant model in which we have characterized

257 the time-consuming purification of LCs from human skin.

258 Thus, TMR in human sleep transcends global action by selectively prom

259 o reflect novel forms of social hierarchy in human societies, and, by providing an efficient short-cu

260 onstrate that environmental geometry affects human spatial memory in a similar manner to rodent grid-

261 n was to establish a method for isolation of human stem cells from the PDL and gingiva, multilineage

262 ocystis subtype 4 (ST4) cysts, isolated from human stool samples.

263 r conducting these experimental studies with human strains.

264 Consistent with prior experimental and human studies, GFAP, was highest at 6 h post-injury, whi

265 In this first-in-human study, low- intensity collimated ultrasound-guided

266 ural recordings from electrodes implanted in human subjects and showed that activations emerge sponta

267 es a potential treatment option for managing human SUDV infection.

268 One hundred nine human surgical right atrial specimens were evaluated.

269 Evidence is accumulating that humans synchronize these nonverbal expressions and the p

270 ng data, we develop a quantitative theory of human T cell dynamics compatible with the statistical la

271 Here we show that primary mouse and human T cells engage in macropinocytosis that increases

272 been suggested as the underlying gene for a human T1D associated region on chromosome 21.

273 AKT-KI(+/+) mice, expressing the pathogenic human Tau mutant (hTau-P301L), the hTau S199 phosphoryla

274 Overexpression of human TET catalytic domains (hTETCDs) from the TET famil

275 d for in vitro selection against recombinant human TfR1 ectodomain (rh-TfR1-ECD) followed by in vivo

276 le applications of high-performance SDRC for human thermal comfort in buildings.

277 diverse natural reservoir, posing a risk to humans through the occasional emergence of novel strains

278 ations threatens the health and longevity of humans throughout the world.

279 ccus pneumoniae can cause disease in various human tissues and organs, including the ear, the brain,

280 Here, we functionally characterized human TMEM165 by heterologously expressing it in budding

281 We demonstrate that Notch activation in human tonsil-derived stage 3 (CD34(-)CD117(+)CD94(-)NKp8

282 e-wide association studies (GWAS) of complex human traits in the UK Biobank has not been investigated

283 that are associated with gene expression and human traits.

284 casionally contribute to bridge sylvatic and human transmission cycles.

285 In both murine and human tumor cells, HOTAIR-sbid impaired the ability of H

286 Human tumors with exonuclease domain mutations in the ge

287 es with an immunosuppressive TME in multiple human tumors.

288 Human tyrosinase (hsTYR) is the key enzyme ensuring the

289 iants (V1, V2) of murine UHRF1 (mUHRF1) with human UHRF1 (hUHRF1).

290 d then compared these networks with those in humans using connectivity fingerprinting.

291 deling healthy and pathological aging of the human vasculature represents an unresolved experimental

292 entified thus far to regulate members of the human Vdelta1 population and discuss what players are in

293 ansducing phosphoantigen-mediated signals to human Vgamma9Vdelta2 T cells.

294 has a zoonotic origin and was transmitted to humans via an undetermined intermediate host, leading to

295 hed host transcripts could generate chimeric human-viral mRNAs with coding potential.

296 that parallel associated health benefits in humans, we propose C15:0 as a potential essential fatty

297 shown to improve cognition in animals or in humans, whereas benzodiazepines were linked to increased

298 ted B cells [ABCs]) is increased in mice and humans with infections or autoimmune diseases.

299 ehavioral outcomes in DS mouse models and in humans with Ts21.

300 G-protein-coupled receptors like the human Y(1) receptor (hY(1)R) are promising targets in ca