ライフサイエンスコーパス: human ES cell

1 the induction of KDR(+) PDGFRa(+) CPCs from human ES cells.

2 were morphologically indistinguishable from human ES cells.

3 aling is required to sustain self-renewal of human ES cells.

4 of FGF signaling to support self-renewal of human ES cells.

5 sion of NO signaling components in mouse and human ES cells.

6 ed shortly thereafter by their derivation of human ES cells.

7 k of autoregulatory and feedforward loops in human ES cells.

8 hlighted known differences between mouse and human ES cells.

9 stablished for mouse ES cells work poorly in human ES cells.

10 e development of homologous recombination in human ES cells.

11 ansplantation of neural precursor cells from human ES cells.

12 ession shortly after induction of each TF in human ES cells.

13 Furthermore, human ES cell and iPS cell differentiation to cerebral c

14 is hypermethylated and largely repressed in human ES cells and derived trophoblast cell lines, as we

15 and H3K27me3) of ChIP sequencing datasets in human ES cells and eight pairs in murine ES cells, and p

16 of cortical neuroepithelial stem cells from human ES cells and human iPS cells was dependent on reti

17 3 gene signature transcriptionally resembles human ES cells and in vitro cultured GBM stem cells, and

18 the self-renewal mechanism between mouse and human ES cells and simplify the culture of hESCs.

19 surface markers and genes that characterize human ES cells, and maintain the developmental potential

20 Increasingly, human ES cells are being considered for their potential

21 s recombination is an essential technique if human ES cells are to fulfill their promise as a basic r

22 These results depict human ES cells as a source of transplantable neural prec

23 tion of these factors at promoter regions in human ES cells, Boyer et al. demonstrate frequent promot

24 tlas of regulated targets of TFs (ART-TF) in human ES cells by combining data on TF binding with data

25 mpared gene expression profiles of mouse and human ES cells by immunocytochemistry, RT-PCR, and membr

26 Although efficient methods for production of human ES cells by somatic nuclear transfer must be devel

27 What is less widely appreciated is that human ES cells can also form the extra-embryonic tissues

28 These results demonstrate that human ES cells can be selectively directed to a neural r

29 Human ES cells can proliferate without a known limit and

30 o, in contrast to their murine counterparts, human ES cells cannot be cloned efficiently from single

31 Here we report feeder-independent human ES cell culture that includes protein components s

32 e midbrain DA neuron phenotype in murine and human ES cell cultures.

33 Our results with mouse and human ES cells demonstrate an increase in Nkx2.5 and myo

34 reakthroughs in somatic nuclear transfer and human ES cell derivation have produced a flurry of new a

35 lls but is not sustained during conventional human ES cell derivation protocols.

36 corporation of defined numbers of MPs within human ES cell derived EBs, down to 1 MP per EB.

37 provide a foundation for similar studies in human ES cells derived from sickle cell patients.

38 onstrated endothelial differentiation within human ES cell-derived aggregates using VEGF loaded MPs.

39 Surface-modified scaffolds were seeded with human ES cell-derived cardiomyocytes and cultured in vit

40 ansplantation into the neonatal mouse brain, human ES cell-derived neural precursors were incorporate

41 of chemical leads in secondary assays using human ES cell-derived neurons.

42 in human embryonic stem (ES) cells and four human ES-cell-derived lineages, we uncover extensive chr

43 Here, we generated human ES cells designed to conditionally express heteroz

44 Human ES cells differ from mouse ES cells and the specif

45 Here we demonstrate that human ES cells differentiate to hematopoietic precursor

46 ly, GO also improves, in addition to murine, human ES cell differentiation to blood cells.

47 Finally, in differentiating human ES cells, endodermal markers were more efficiently

48 Selection for CD34(+) cells derived from human ES cells enriches for hematopoietic colony-forming

49 nce of acetylated histone H3K56 (H3K56ac) in human ES cells (ESCs) correlates positively with the bin

50 Haploid human ES cells exhibited typical pluripotent stem cell c

51 , STELLAR and OCT4, whereas undifferentiated human ES cells expressed these genes along with the germ

52 CNT could aid efforts to generate autologous human ES cells for regenerative applications, as donated

53 Ability to transfer foreign genes into human ES cells has potential relevance for the developme

54 High, stable transfection efficiencies in human ES cells have been difficult to achieve, and, in p

55 Significant differences between mouse and human ES cells have hampered the development of homologo

56 from several mammalian species, but haploid human ES cells have yet to be reported.

57 Human ES cells (hESC) exposed to bone morphogenic protei

58 tion of a unique stem cell phenotype by both human ES cells (hESCs) and induced pluripotent stem cell

59 ntrol of self-renewal and differentiation of human ES cells (hESCs) remains a challenge.

60 to identify cardiovascular progenitors from human ES cells (hESCs) that can functionally integrate i

61 e two routes to generate nontransgenic naive human ES cells (hESCs).

62 20q11.21, including three genes expressed in human ES cells, ID1, BCL2L1 and HM13, occurred in >20% o

63 The necessity of examining human ES cells in culture, coupled with the wealth of ge

64 two factor-induced human iPS cells resemble human ES cells in pluripotency, global gene expression p

65 results demonstrate that differentiation of human ES cells into EBs in vitro results in formation of

66 in combination with the success in deriving human ES cell-like induced pluripotent stem (iPS) cells

67 rons derived from a new APP(Swe/Swe) knockin human ES cell line.

68 ocumented and recent research has shown that human ES cell lines can be derived in vitro, this review

69 on profiles showed that the five independent human ES cell lines clustered tightly together, reflecti

70 Recently, human ES cell lines have been established that can be us

71 We describe the derivation of two new human ES cell lines in these defined culture conditions.

72 At present, large-scale culturing of human ES cell lines is problematic and provides substant

73 The gene expression patterns of human ES cell lines showed many similarities with the hu

74 in H1 cells was similar to that of two other human ES cell lines tested (line I-6 and clonal line-H9.

75 the successful isolation and maintenance of human ES cell lines with a normal haploid karyotype.

76 mors, we compared the expression profiles of human ES cell lines, human germ cell tumor cell lines an

77 This was achieved by coating MPs with human ES cell lysate and centrifugation of specific rati

78 nsfer dissociation (ETD) to characterize the human ES cell phosphoproteome.

79 The in vitro differentiation of human ES cells provides an opportunity to better underst

80 Although haploid human ES cells resembled their diploid counterparts, the

81 Now, the advent of human ES cells sets the stage for more applied pursuits

82 Furthermore, EpiSC and human ES cells share patterns of gene expression and sig

83 We demonstrate that, like human ES cells, skin fibroblast-derived iPS cells have t

84 When this approach was applied to the human ES cell system, similar phenomena were observed.

85 ch, based on the physical characteristics of human ES cells, that we used to successfully target HPRT

86 Human ES cells thus provide a tool for studying the diff

87 This approach can be applied to human ES cells to correct the sickle mutation as well as

88 The use of human ES cells to derive early human trophoblast is part

89 Neural differentiation of human ES cells to NPs is concurrent with a threefold ele

90 ranscriptional profiles of three pluripotent human ES cells to those of isolated inner cell mass (ICM

91 superfamily, induces the differentiation of human ES cells to trophoblast.

92 ferentiated hematopoietic cells derived from human ES cells under these conditions also express norma

93 quantified the abundances of these codes as human ES cells undergo differentiation to reveal strikin

94 insights into transcriptional regulation of human ES cells, we have identified OCT4, SOX2, and NANOG

95 Finally, human ES cells were transduced by lentiviral vectors and

96 We expect that haploid human ES cells will provide novel means for studying hum

97 The ability to generate human ES cells without the destruction of ex utero embry