ライフサイエンスコーパス: human growth hormone

1 -kDa hPRLBP capable of binding both hPRL and human growth hormone.

2 cytosis, we used PC12 cells transfected with human growth hormone.

3 as determined by serum radioimmunoassay for human growth hormone.

4 in nor syntaxin 2 caused the cells to retain human growth hormone.

5 the minor loop disulfide at Cys182-Cys189 in human growth hormone.

6 97 is a linear peptide fragment derived from human growth hormone.

7 te-specifically glycosylated variants of the human growth hormone.

8 of aberrant splicing of transcripts encoding human growth hormone.

9 he location of metal-binding His residues of human growth hormone.

10 ive daily intramuscular doses of recombinant human growth hormone (0.15 mg rhGH/kg/day).

11 domly assigned to receive either recombinant human growth hormone, 0.1 mg/kg of body weight per day (

12 Specifically, human growth hormone 1, murine ribosomal protein S27, an

13 possible to prepare a long-acting analog of human growth hormone (191 amino acids), which is suitabl

14 lpha-2b, letrozole, Y-27632, octreotide, and human growth hormone, all delivered at clinically-releva

15 ms addressing the safety and tolerability of human growth hormone analogues.

16 ix D, similar to the first crossover loop in human growth hormone and granulocyte colony-stimulating

17 rombomodulin, as seen for the interaction of human growth hormone and insulin with their receptors.

18 maceutical products, such as erythropoietin, human growth hormone and interferons.

19 protein-protein complexes; barnase-barstar, human growth hormone and its receptor, subtype N9 influe

20 on and refolding of denatured and aggregated human growth hormone and lysozyme, and beta-lactamase in

21 2-K208A inhibited secretion of cotransfected human growth hormone and of noradrenalin.

22 side chains buried at the interface between human growth hormone and the extracellular domain of its

23 verage of a therapeutic protein, recombinant human growth hormone, and in detection of single amino a

24 n molecules within aggregates of recombinant human growth hormone are responsible for the rate-limiti

25 With the use of human growth hormone as a model protein, the potential o

26 In recent years, the use of recombinant human growth hormone as a therapeutic modality has great

27 By contrast, co-expression of Dyn/K44A with human growth hormone as an insulin secretory marker resu

28 beta2-microglobulin, immunoglobulin G1, and human growth hormone as model systems, we demonstrate th

29 Using human growth hormone as the encoded foreign Ag for immun

30 ing DNA from the baboon SP-A2 gene linked to human growth hormone, as reporter) containing TBEs, or w

31 C) demonstrated functional complexation with human growth hormone binding protein (hGHBp) to the diff

32 transplant, early institution of recombinant human growth hormone can promote growth.

33 sed by the use of biological materials (e.g. human growth hormone) contaminated with prions.

34 ottom-up method, for the characterization of human growth hormone degradation products.

35 he large intron of Fgf8 was found to enhance human growth hormone expressed from the Fgf8 promoter 3-

36 tein and cell specificity; newly synthesized human growth hormone expressed in AtT20 cells underwent

37 lubility with time, but albumin did not, and human growth hormone expressed in COS cells underwent le

38 sulted in long term (16 weeks) expression of human growth hormone following intracardiac, yet not int

39 s, increasing the intracellular half-life of human growth hormone from 90 min to 18 h.

40 ts S43D mutant on the regulated secretion of human growth hormone from PC12 cells.

41 Release of human growth hormone from syntaxin 1A-expressing cells w

42 Ca2+-dependent secretion of human growth hormone from transfected PC12 cells was tri

43 ng adenocarcinoma cells together with an SPA:human growth hormone fusion gene (255 base pairs of 5'-f

44 ed by comparing the expression of four Fabpl/human growth hormone fusion genes in multiple pedigrees

45 cific exon I.1 5' flanking DNA linked to the human growth hormone gene (hGH), as reporter, were intro

46 Human growth hormone gene (hGH-N) expression is activate

47 The human growth hormone gene (hGH-N) is regulated by a dist

48 s the mouse metallothionein promoter and the human growth hormone gene (MThGH).

49 ated from an empirical haplotype data set of human growth hormone gene 1.

50 The cDNA was linked to a fragment of the human growth hormone gene and in transgenic animal studi

51 The human growth hormone gene cluster is composed of five cl

52 olymorphism at the neighboring locus for the human growth hormone gene failed to support any role of

53 day C2C12 myotubes utilizing the therapeutic human growth hormone gene formulated in an optimal pepti

54 Transgenic mice generated with the human growth hormone gene fused to 800 bp of the mCC10 p

55 -flanking region of the HL gene fused to the human growth hormone gene were transfected in HepG2 cell

56 a nearby microsatellite polymorphism of the human growth hormone gene, supported a role of the ACE l

57 r in conjunction with sequences encoding the human growth hormone gene.

58 To rescue pancreatic expression, the human growth hormone genomic sequence was co-integrated

59 h adenoviral transduction, we have expressed human growth hormone (GH) as a model of regulated secret

60 y, we have detected mutations in IVS3 of the human growth hormone (GH) gene that affect a putative, h

61 Recombinant human growth hormone (GH) improves in vivo cardiac funct

62 Human growth hormone (GH) is widely used as an antiaging

63 Treatment with recombinant human growth hormone (GH) promotes longitudinal growth a

64 ells by measuring secretion of cotransfected human growth hormone (GH, a reporter for the regulated s

65 For some, like Turner syndrome, recombinant human growth hormone has become the standard of care.

66 Recombinant human growth hormone has been employed to ameliorate gro

67 A high-affinity variant of human growth hormone (hGH(v)) contains 15 mutations with

68 Mutations introduced into human growth hormone (hGH) (Thr175 --> Gly-hGH) and the

69 henylalanine (pAcF) at distinct locations in human growth hormone (hGH) allowed site-specific conjuga

70 It has previously been shown that a human growth hormone (hGH) analog, hGH-G120R, acts as a

71 ntal lactogen (hPL) is highly conserved with human growth hormone (hGH) and both hormones bind to the

72 Human growth hormone (hGH) and bovine neurophysin (bNP)

73 Using human growth hormone (hGH) and human leptin (hLeptin) as

74 allosteric dynamics by conducting studies on human growth hormone (hGH) and pyrin domain (PYD), and t

75 Remodeling of the interface between human growth hormone (hGH) and the extracellular domain

76 - optimized, high-affinity Site 1 variant of human growth hormone (hGH) and two copies of the extrace

77 the constitutive release of marker proteins human growth hormone (hGH) and vesicular stomatitis viru

78 n assay in PC12 cells expressing transfected human growth hormone (hGH) as a reporter protein.

79 Using PC12 cells that express transfected human growth hormone (hGH) as a secreted reporter protei

80 Human growth hormone (hGH) binds lactogenic or somatotro

81 he high affinity binding site (Site1) of the human growth hormone (hGH) binds to its cognate receptor

82 in adult skin and that keratinocyte-derived human growth hormone (hGH) can be produced, secreted, an

83 The five genes of the human growth hormone (hGH) cluster are expressed in eith

84 The human growth hormone (hGH) cluster contains five genes.

85 ach was applied to the high affinity site of human growth hormone (hGH) for binding to its receptor (

86 tivity in the high affinity site (site 1) of human growth hormone (hGH) for binding to its receptor.

87 urthermore, we found that over-expression of human growth hormone (hGH) from Syn1Cre results in a mal

88 e is situated between the pituitary-specific human growth hormone (hGH) gene and its locus control re

89 robust and tissue-specific activation of the human growth hormone (hGH) gene cluster in the pituitary

90 The human growth hormone (hGH) gene is controlled by a long-

91 High-level expression of the human growth hormone (hGH) gene is limited to somatotrop

92 An indirect immunoassay format with human growth hormone (hGH) immobilized on the self-assem

93 on from cells that are engineered to secrete human growth hormone (hGH) in response to stimulation by

94 have generated transgenic mice that express human growth hormone (hGH) in their bladder epithelium,

95 Excess circulating human growth hormone (hGH) in vivo is linked to metaboli

96 Human growth hormone (hGH) is a pituitary-derived endocr

97 The designed G120R mutant of human growth hormone (hGH) is an antagonist and can bind

98 Human growth hormone (hGH) is known to play a functional

99 contrast to rodent growth hormone loci, the human growth hormone (hGH) locus is regulated by a dista

100 The human growth hormone (hGH) minigene used for transgene s

101 The human Growth Hormone (hGH) multigene cluster contains fi

102 Derivatives of human growth hormone (hGH) of increasing size were produ

103 a Pax6 consensus binding site driving either human growth hormone (hGH) or Cre recombinase genes.

104 largely from its structural homology to the human growth hormone (hGH) receptor and known structure

105 The dimer assembly differs from that of the human growth hormone (hGH) receptor complex and suggests

106 e, consisting of the extracellular domain of human growth hormone (hGH) receptor, and the intracellul

107 ptor dimerization, except for studies of the human growth hormone (hGH) receptor.

108 cells was noted to transactivate the genomic human growth hormone (hGH) reporter construct in the abs

109 es of full-length and truncated NGF promoter-human growth hormone (hGH) reporter gene plasmids to inv

110 the human sMtCK gene ligated upstream of the human growth hormone (hGH) reporter gene.

111 Human growth hormone (hGH) stimulates somatogenic and la

112 rus (AAV) vectors, one encoding an inducible human growth hormone (hGH) target gene, and the other a

113 Recombinant human growth hormone (hGH) therapy in children with Prad

114 arison, we contrast IgG binding with that of human growth hormone (hGH) to its receptor (hGH-R) which

115 Here, using in vivo analysis of a human growth hormone (hGH) transgene locus, we report th

116 e rats were immunized with plasmids encoding human growth hormone (HGH) under the control of a cytome

117 ions, we examine the binding of a variety of human growth hormone (hGH) variants to the human growth

118 An injectable sustained-release form of human growth hormone (hGH) was developed by stabilizing

119 Ectopic human growth hormone (hGH) was highly expressed in MIP-C

120 Expression of human growth hormone (hGH) was targeted to growth hormon

121 trol of different promoters directed against human growth hormone (hGH) were constructed and infused

122 This result shows the similarity of hPRL to human growth hormone (hGH), a member of the same family

123 We utilized human growth hormone (hGH), a protein with a well define

124 o Rab11a-positive DFV, but virally expressed human growth hormone (hGH), a secretory protein, was pac

125 Human growth hormone (hGH), and its receptor interaction

126 s erythropoietin (EPO), interleukin-4 (IL4), human growth hormone (hGH), and prolactin (PRL) all form

127 was determined from the X-ray structures of human growth hormone (hGH), LIF, and G-CSF where the ali

128 FCS) to genetically conjoin a protein cargo, human growth hormone (hGH), to produce chimeras designed

129 to direct attachment of a secreted protein, human growth hormone (hGH), to the membranes of COS cell

130 The monomeric protein, human growth hormone (hGH), was fused to the N terminus

131 Signaling in the human growth hormone (hGH)-human GH receptor system is i

132 The human growth hormone (hGH)-receptor interaction was used

133 two-thirds of the contact side chains at the human growth hormone (hGH)-receptor interface have littl

134 the IL-3.IL-3 receptor complex based on the human growth hormone (hGH).hGH soluble receptor complex

135 ve investigated the weak self-association of human growth hormone (hGH, KD = 0.90 +/- 0.03 mM) at neu

136 Human growth hormone (hGH-N) expression in the pituitary

137 Activation of the human growth hormone (hGH-N) gene in pituitary somatotro

138 Expression of the human growth hormone (hGH-N) transgene in the mouse pitu

139 e of secretion of a nonglycosylated protein (human growth hormone [hGH]) that was secreted equally fr

140 ra-high-affinity receptor binding variant of human growth hormone (hGHv) that has been previously aff

141 and numerous recombinant products, including human growth hormone, human erythropoietin and granulocy

142 eased the effective detection sensitivity of human growth hormone in human urine using multiple react

143 ate its use to control circulating levels of human growth hormone in mice implanted with engineered h

144 ed by characterizing the interaction between human growth hormone in solution and the corresponding a

145 detected a trisulfide structure in methionyl human growth hormone in the major loop disulfide Cys53-C

146 ted in consistently high induction levels of human growth hormone in the presence of mifepristone whe

147 The efficacy of recombinant human growth hormone in the treatment of growth hormone

148 ministration of anabolic agents, recombinant human growth hormone, insulin, oxandrolone, or anticatab

149 ergy expenditure, muscle strength, and serum human growth hormone, insulin-like growth factor-I (IGF-

150 urothelium can secrete ectopically expressed human growth hormone into the urine, our data establish

151 Although recombinant human growth hormone is commonly used to treat the short

152 nd clinical testing of a monthly formulation human growth hormone is currently in progress.

153 Human growth hormone is now readily available and approv

154 Human growth hormone is reportedly used to enhance athle

155 Treatment with recombinant human growth hormone likely increases the IGF levels in

156 tion when inserted into the 5'-leader of the human growth hormone mRNA.

157 ion enhancing efficiency of CriticalSorb for human growth hormone (MW 22 kDa) was investigated in the

158 ization of disulfide linkages of recombinant human growth hormone (Nutropin), a therapeutic monoclona

159 leased four pulses of radiolabelled dextran, human growth hormone or heparin in vitro.

160 crosis factor (TNF)-alpha (both P<.002), and human growth hormone (P<.05).

161 ptic digest of bovine serum proteins or to a human growth hormone peptide digest at concentration rat

162 (DQA1*05, DQB1*02, DQB1*03:02 alleles), and human growth hormone (positive control).

163 lic bone disease, and the use of recombinant human growth hormone provide some hope for catch-up grow

164 ate following administration of biosynthetic human growth hormone (r-hGH) to short normal children.

165 f human growth hormone (hGH) variants to the human growth hormone receptor (hGHR) and the human prola

166 Two isoforms of the human growth hormone receptor (hGHR), which differ in th

167 y inhibiting the interaction of hGH with the human growth hormone receptor (hGHR).

168 ivation of human erythropoietin receptor and human growth hormone receptor and is supported by eviden

169 Comparison of the structure to that of the human growth hormone receptor, which belongs to a differ

170 a small set of contacts are crucial for the human growth hormone-receptor interaction.

171 ry marker resulted in a marked inhibition of human growth hormone release by glucose, KCl, and a comb

172 s significant reduction in high K(+)-induced human growth hormone release, the S43D mutant fails to i

173 erplasia induced by transgenic expression of human growth hormone-releasing hormone (GHRH) is signifi

174 Some antagonists of human growth hormone-releasing hormone (hGH-RH) synthesi

175 Antagonists of human growth hormone-releasing hormone (hGHRH) with incr

176 hypothesis, metallothionein promoter-driven, human growth hormone-releasing hormone (MT-hGHRH) transg

177 relationship scans of the active fragment of human growth hormone-releasing hormone, [Nle27]-hGHRH(1-

178 Nevertheless, the use of recombinant human growth hormone remains limited in patients with CR

179 others, the ultimate benefit of recombinant human growth hormone remains to be determined.

180 the human E-selectin promoter linked to the human growth hormone reporter gene (pE525-GH).

181 Stable transfection of ES cells, using a human growth hormone reporter gene, was employed to iden

182 -2038 to +15 of the rat LPH gene fused to a human growth hormone reporter gene.

183 cleotides -596 to +21 of Fabpl linked to the human growth hormone reporter, (ii) 4 additional copies

184 Benefits of recombinant human growth hormone (rhGH) alone or combined with gluta

185 t evidence concerning the use of recombinant human growth hormone (rhGH) as a potential therapy in ac

186 Pharmacologic doses of recombinant human growth hormone (rhGH) constitute another potential

187 uma center who were treated with recombinant human growth hormone (rhGH) for > or =7 days.

188 own to promote the absorption of recombinant human growth hormone (rhGH) from the gastrointestinal tr

189 Recombinant human growth hormone (rHGH) has been shown to increase m

190 The structural stability of recombinant human growth hormone (rhGH) has been studied by differen

191 method for the quantification of recombinant human growth hormone (rhGH) in serum has been developed

192 Recombinant human growth hormone (rhGH) reduces visceral adipose tis

193 Recombinant human growth hormone (rhGH) therapy is used in the long-

194 Administration of recombinant human growth hormone (rhGH) to critically ill adults in

195 out the cardiovascular safety of recombinant human growth hormone (rhGH) treatment in childhood have

196 d children during treatment with recombinant human growth hormone (rhGH), and to ascertain whether de

197 e previously shown that low-dose recombinant human growth hormone (rhGH), given to children after a s

198 e exogenous hormones estrogen or recombinant human growth hormone (rhGH).

199 ng the last decade, we have used recombinant human growth hormone (rhGH; 0.2 mg/kg/day s.q.) to succe

200 Somatropin (i.e., recombinant human growth hormone, rhGH) modified with the chelating

201 and growth retardation received recombinant human growth hormone (rHuGH) for 1 year.

202 1) is a potent, orally active agonist of the human growth hormone secretagogue (GHS) receptor.

203 domimetic 2 (BMS-317180) was discovered as a human growth hormone secretagogue (GHS).

204 tagogue, ghrelin, is a potent agonist at the human growth hormone secretagogue receptor 1a (hGHSR1a).

205 wide range of product variants in samples of human growth hormone secreted from Pichia pastoris.

206 were cotransfected with a plasmid encoding a human growth hormone secretion reporter along with eithe

207 ansfection analyses with plasmids in which a human growth hormone structural gene was under the contr

208 Low-dose recombinant human growth hormone successfully abates muscle cataboli

209 inserted the regulator GLp65 and a regulable human growth hormone target gene containing the 17-mer G

210 erved residues form a compact cluster in the human growth hormone tertiary structure.

211 uthors review the most important trials with human growth hormone that have been carried out recently

212 romoter is linked to the structural gene for human growth hormone that is biologically inactive (AF2-

213 ted efficacy and safety comparable to native human growth hormone therapy but with increased potency

214 Recombinant human growth hormone therapy of children with idiopathic

215 to recognize that the impact of recombinant human growth hormone therapy on adult height has not bee

216 Deciding when to pursue recombinant human growth hormone therapy to increase adult height is

217 ween antiepileptic drugs and the efficacy of human growth hormone therapy, and few data are available

218 delivered 1-mg payloads of human insulin and human growth hormone to the buccal cavity of swine withi

219 A recently designed human growth hormone/transferrin fusion protein (GHT) re

220 Expression of the MIS-human growth hormone transgene (MIS/GH) is restricted to

221 ted the expression of the collagen alpha1(I) human growth hormone transgene containing -2.3 kb of the

222 detected in a mixture containing 20 fmol of human growth hormone tryptic digest mixed with the bovin

223 studies with transgenic mice expressing the human growth hormone under the direction of 5' regulator

224 ensions containing aggregates of recombinant human growth hormone (up to 8.7 mg/ml) and 0.75 M GdmHCl

225 ess the role of dynamics for a high-affinity human growth hormone variant (hGHv) and the wild-type gr

226 Human growth hormone was targeted to and released from s

227 XTEN fusions to exenatide, glucagon, GFP and human growth hormone, we expect that XTEN will enable do

228 oluble, non-native aggregates of recombinant human growth hormone were formed by agitation in buffer

229 esence of an analogous metal-binding site in human growth hormone, which is located in the hydrophobi

230 genous CHGA and SCG2, as well as transfected human growth hormone, while SCG10 siRNA decreased the le

231 a naturally occurring C-terminal fragment of human growth hormone with therapeutic efficacy against i