ライフサイエンスコーパス: human retina

1 ogy of proximal and possibly also the distal human retina.

2 OT, RASSF3 and GNS] are all expressed in the human retina.

3 and to investigate retinal asymmetry in the human retina.

4 ents and blue light filters in the macula of human retina.

5 n how vasomotor function is regulated in the human retina.

6 e normal function of ON bipolar cells in the human retina.

7 was used to verify ZBED4 mRNA expression in human retina.

8 macaque retina, which is very similar to the human retina.

9 le degree of cellular plasticity in the aged human retina.

10 otensin II (Ang II) and its receptors in the human retina.

11 nanowires mimicking the photoreceptors on a human retina.

12 ganglion cells in the normal rat, mouse, and human retina.

13 noid constituting the macular pigment of the human retina.

14 tivity was determined in bovine, rabbit, and human retina.

15 cells undergo activation in the glaucomatous human retina.

16 , supports a photoreceptive role for CRY2 in human retina.

17 an primate (NHP) closely mirrors that of the human retina.

18 lls were isolated from papain-DNase-digested human retina.

19 mes more abundant than CRY1 throughout adult human retina.

20 lso cloned from rat, chicken, zebrafish, and human retina.

21 from a human AMD donor compared with healthy human retina.

22 OX-1 and COX-2 in the normal mouse, rat, and human retina.

23 receptor cells of the peripheral and central human retina.

24 cone photoreceptors of peripheral or central human retina.

25 nd splice variants of MYO3B expressed in the human retina.

26 both the rod and cone photoreceptors in the human retina.

27 -specific monoclonal antibodies in mouse and human retina.

28 mmunoreactivity (IR) in the rabbit, rat, and human retina.

29 ossibly present as early as mid-gestation in human retina.

30 as limited to the outer nuclear layer of the human retina.

31 es a profile of genes expressed in the adult human retina.

32 hotoreceptors are light-sensing cells in the human retina.

33 is showed that hDGK epsilon was expressed in human retina.

34 angement, and investigated its expression in human retina.

35 ining for CB1 receptors also was detected in human retina.

36 e insoluble interphotoreceptor matrix of the human retina.

37 of small Ras-like GTP-binding proteins from human retina.

38 asive measurement of macular pigments in the human retina.

39 compounds were present in the extracts from human retina.

40 ecause of the fewer number of S-cones in the human retina.

41 caca monkey, a widely accepted model for the human retina.

42 Fibronectin is synthesized in the adult human retina.

43 ative proteomics of ITM2B interactome of the human retina.

44 irst single-cell transcriptomic atlas of the human retina.

45 terization of a new macaque retina, and of a human retina.

46 ects lateral feedback to spared areas of the human retina.

47 al and temporal patterning of the developing human retina.

48 ons regulated by MR, are increased in GK and human retina.

49 m human pancreatic islets and the other from human retina.

50 ngle-cell transcriptomic maps of nondiseased human retina.

51 (NHP) retina is anatomically closest to the human retina.

52 ctional responses from neurons in the living human retina.

53 rate the pattern of M and L cones across the human retina.

54 of organoids to make improved models of the human retina.

55 ids were also detected in the RPE of healthy human retina.

56 nd parasol-magnocellular (M pathway) through human retina.

57 the cone photoreceptor mosaic in the living human retina.

58 tudy we aimed to characterize the A cells in human retina.

59 ividual nerve fibre bundles(5) in the living human retina.

60 confirm the presence of Bestrophin in normal human retina.

61 ar to A8 amacrine cells described in cat and human retina.

62 ng properties of P and M pathways across the human retina.

63 ssed in retinoblastoma and in the developing human retina.

64 n the Ca(V)1.4 transcripts isolated from the human retina.

65 mary initiator of visual transduction in the human retina.

66 was expressed in the photoreceptor layer of human retina.

67 pression was increased in diabetic mouse and human retina.

68 erve fiber layer and microvasculature of the human retina.

69 he molecular physiology and pathology of the human retina.

70 ion MRI of lamina-specific structures in the human retina.

71 nicotine by itself affects responses in the human retina.

72 but absent from the RPE monolayer in normal human retinas.

73 luminate likely CNTF impacts in degenerating human retinas.

74 n both the nuclear and cytosolic extracts of human retinas.

75 Immunohistochemistry localized ZBED4 in human retinas.

76 ARPP-32" is present in rat, cat, monkey, and human retinas.

77 ributing to disease progression in the aging human retinas.

78 ression profiles between normal and diseased human retinas.

79 ression of the USH2A gene in rat, mouse, and human retinas.

80 isms in organoids and for targeted repair in human retinas.

81 types have not been identified in primate or human retinas.

82 oung (13-14 years) and elderly (62-74 years) human retinas.

83 fatty acid composition similar to those from human retinas.

84 to the retinal ganglion cells of the rat and human retinas.

85 ion and localization of NOS-1 in the rat and human retinas.

86 labeling was detected with homogenates from human retinas.

87 retinal ganglion cells (RGCs) of rodent and human retinas.

88 sis of Stargardt disease and is evidenced in human retinas.

89 pression, leading to RGC senescence in adult human retinas.

90 A piece of well-fixed peripheral human retina (10 mm, 35 degrees nasal to the fovea) was

91 How the human retina accommodates mis-specified types and number

92 Humans retinas affected with age-related macular degener

93 ocalized by immunofluorescence microscopy in human retinas, aged 8.4 fetal weeks to adult.

94 In the human retina, all of the components for this circuit exi

95 nt in vitro and ex vivo model systems of the human retina allowed us to identify novel AAV variants c

96 B), we demonstrate that hOPSR and hOPSG from human retina also are O-glycosylated with full occupancy

97 novel DGK, which we designated DGKiota, from human retina and brain libraries.

98 his antibody reveals AIPL1 to be specific to human retina and cell lines of retinal origin (Y79 retin

99 ere, we show that FAT10 mRNA is expressed in human retina and identify rod PDE6 as a retina-specific

100 The choroid layer is a vascular layer in human retina and its main function is to provide oxygen

101 and L148/R from the published sequences for human retina and liver.

102 xpressed in distinct patterns throughout the human retina and ONH.

103 used to elucidate SPC enzyme activity within human retina and optic nerve head (ONH) tissues.

104 mRNA expression of the SPC family in the human retina and optic nerve head tissues was evaluated

105 n, localization, and activity of SPCs in the human retina and optic nerve head.

106 IL-8 protein expression was found in human retina and optic nerve.

107 q analysis revealed three transcripts in the human retina and relatively higher expression in S-cone-

108 Kir7.1 localized to human retina and retinal pigment epithelium and was espe

109 MS2 gene were both transcribed in rhesus and human retina and retinal pigment epithelium.

110 e found abundant expression of GLP-1R in the human retina and retinas from db/db mice.

111 In the human retina and RPE, the authors could not detect 27-hy

112 s could also be quantified in the bovine and human retina and RPE.

113 RNA derived from human retina and skin was analyzed and alternate 5' exon

114 tical differences are already present in the human retina and that retinal responses measured with el

115 concentrations in the fovea centralis of the human retina and their role in the prevention of age-rel

116 of the cryptochromes, CRY1 and CRY2, in the human retina and to correlate expression of these putati

117 Two human retina and two retinal pigment epithelium (RPE)/ch

118 that LOC387715/ARMS2 mRNA is detected in the human retina and various cell lines and encodes a 12-kDa

119 in the developing photoreceptor layer of the human retina and within the photoreceptors of the adult

120 Histopathology analysis of 3 specimens: 2 human retinas and 1 human ILM.

121 Carotenoids of a composite of 58 pairs of human retinas and a monkey retina were elucidated by com

122 to measure carotenoid levels in flat-mounted human retinas and eyecups and in experimental animal eye

123 Expression of FN-EDA in normal human retinas and PVR membranes was evaluated by immunoh

124 ence of Wilson and Menkes mRNAs in mouse and human retinas and retinal pigment epithelial cell lines.

125 s accumulation is conserved across mouse and human retinas and that the addition of HSPG binding to o

126 entially treatable photoreceptors across the human retinas and the rate of degeneration are not known

127 ly 20:1 in the foveal center (similar to the human retina) and only approximately 1.5:1 in the parafo

128 RGS 9 was isolated from a rat hypothalamus, human retina, and a human kidney (Wilm's) tumor.

129 nt carotenoids in quail retina are absent in human retina, and because of their different packaging (

130 f the timing of key events in the developing human retina, and in particular the factors critical for

131 by immunohistochemistry in cross sections of human retina, and its subcellular localization was deter

132 hese data provide a detailed analysis of the human retina, and show how scRNA-seq can provide insight

133 larities between the marmoset retina and the human retina, and the exceptionally small size of the mo

134 oreceptor activity of single cones in living human retina, and therefore, it may provide diagnostic o

135 In human retina, and those of cat and macaque, these high-r

136 aponica), for comparison with carotenoids in human retina, and to assess the effects of different sap

137 helium and choroid of light-responsive adult human retinas, and performed histochemistry.

138 We conclude that in human retina, antibodies against calretinin can be used

139 rtions of IMPDH1 transcripts and proteins in human retina are different from those in mouse retina.

140 Certain cells of the human retina are extremely sensitive to loss of function

141 Hereditary degenerations of the human retina are genetically heterogeneous, with well ov

142 addition, we show that hOPSR and hOPSG from human retina are recognized by jacalin, a lectin that bi

143 The predominant transcripts of IMPDH1 in human retina are the result of alternate splicing and al

144 ealizing the benefits of TPE for imaging the human retina arise from concerns about the high light ex

145 limit of quantification for 3'-oxolutein in human retina at a signal-to-noise ratio of 10 was 6 pg.

146 Histologic examination of six human retinas at 20-mum intervals from the temporal and

147 oscope and spectrally resolved images of the human retina based on 2-photon excitation (TPE) with nea

148 We found isoLG adducts in aged human retina but not in the retina of mice kept under di

149 SSIF(28) of hOPSR and hOPSG from extracts of human retina, but only after their O-glycans have been r

150 operties at the cellular scale in the living human retina, but remains challenging.

151 tential of this gene family expressed in the human retina, but the functional diversity created by th

152 lied hsp27 antibody enters neuronal cells in human retina by an endocytic mechanism.

153 nsors that loosely mimic the function of the human retina by asynchronously encoding per-pixel bright

154 hesized to function as an antioxidant in the human retina by inhibiting the peroxidation of long-chai

155 diameter punches of macula and midperipheral human retina by quantitative RT-PCR.

156 t was detected in rat brain, rat testis, and human retina by RT-PCR.

157 reefold decrease in HSC70 mRNA levels in the human retina by the eighth decade of life.

158 nalysis of their compartmentalization in the human retina, by both GAG chain type and sulfation patte

159 T), in Ca(v)1.4 channels typical of those in human retina: Ca(v)1.4 splice variants with or without e

160 of photoreceptors in the central part of the human retina (called the macula).

161 regulatory protein in the layer of ECM under human retina, called Bruch's membrane.

162 y a combination of large-scale sequencing of human retina cDNA clones and searches of expressed seque

163 ABArho1, two new variants were identified in human retina cDNA libraries.

164 We have cloned and characterized from a human retina cDNA library a mammalian ortholog of Drosop

165 Human retina cDNA library clones were arrayed at high de

166 ification of PhLP1 and the PhLOPs was from a human retina cDNA library, using a PCR product for libra

167 ared with control cultures by using a custom human retina cDNA microarray and were validated by quant

168 s for more efficient transduction of primary human retina cells and compared the top variants to the

169 able of high transgene expression in primary human retina cells.

170 of glycosaminoglycans (GAGs) in the healthy human retina, choroid, and sclera.

171 application to image quantitative BF of the human retina/choroid during rest and isometric exercise.

172 Robust BF of the unanesthetized human retina/choroid was detected.

173 MRI detected three layers within the human retina, consistent with MRI findings in rodent, fe

174 male and one female retina revealed that the human retina contains 7283 +/- 237 melanopsin-ir (0.63-0

175 ts and reading is the fact that both rat and human retinas convert bleach patterns into ganglion cell

176 In the normal human retina, COX-1 immunoreactivity is present in micro

177 In the normal human retina, COX-2 immunoreactivity is only present in

178 Cone packing density in the living human retina decreases as a function of age within the f

179 rx expression can promote differentiation of human retina-derived stem cells into light-sensitive pho

180 Proteomic analyses of the human retina detected expression and differential regula

181 table "developed" state at a rate similar to human retina development in vivo.

182 that there is still limited understanding of human retina development.

183 stages corresponding to hallmarks of native human retina development.

184 have been studied make conclusions about the human retina difficult.

185 The human retina does not replace lost or damaged neurons, u

186 o prominently detectable in the glaucomatous human retinas, downregulated CFH expression in retinal c

187 Cell death occurring in human retina during AMD, high IOP, and diabetic retinopa

188 and extent of neuronal reorganization in the human retina during normal aging.

189 characterization of the visual input to the human retina during normal head-free fixation.

190 us, midget and parasol ganglion cells in the human retina efficiently encode our visual environment.

191 I trial indicated that CNTF is safe for the human retina even with severely compromised photorecepto

192 roteins were then studied in isolated intact human retina (ex vivo) and cultured rat retinal cells (i

193 The patient's serum applied to normal human retina exhibited positivity in the inner nuclear l

194 howed aldose reductase immunoreactivity, and human retinas exposed to high glucose in organ culture i

195 In this study, we found that human retina expressed all GRKs except GRK4.

196 Magnetic resonance imaging (MRI) of the human retina faces two major challenges: eye movement an

197 In the adult human retina, fibronectin is present exclusively in the

198 rge animal model of diabetes relevant to the human retina for evaluation of vascular function is also

199 key epochs in the transcriptome dynamics of human retina from fetal day (D) 52 to 136.

200 ecessary to understand the marked changes in human retina from late gestation to early adulthood.

201 titative chromosomal conformation capture on human retinas from two male donors showed that the L/M e

202 al technologies to image cells in the living human retina, GCs remain elusive due to their high optic

203 array was constructed based on the predicted human retina gene expression profile according to expres

204 Embryonic human retina has a pool of precursors (CXCR4(+) and c-Ki

205 evelopmental sequence of plexiform layers in human retina has been characterized, the molecular steps

206 Human retina has limited regenerative power to replace c

207 mental animals; however, localization in the human retina has not been definitive.

208 udies from anesthetized feline, primate, and human retinas have revealed near-infrared fundus reflect

209 he finding that rods flanking laser burns in human retinas have sustained increases in bFGF immunorea

210 limited temporal dynamics compared with the human retina, hindering their overall performance and ad

211 In the human retina, identification of Ang II and its bioactive

212 e investigated possible extravasation in the human retina in acute migraine (n = 8) and cluster heada

213 non-human primate retina in vivo and in the human retina in vitro.

214 hing lutein from zeaxanthin in images of the human retina in vivo or in donor eye tissues has been ch

215 We studied patches of CNS myelin in human retina in vivo to determine the pattern of myelina

216 of tbdn-1 during adult homeostasis in normal human retinas, in a model of choroid-retina endothelial

217 oC), a novel microphysiological model of the human retina integrating more than seven different essen

218 analysis show that IMPG2 is processed in the human retina into multiple alternatively sized transcrip

219 roarrays, the authors show that aging of the human retina is associated with changes in patterns of g

220 n of gene expression variation in the normal human retina is attributable to identifiable biological

221 Aging of the human retina is characterized by progressive pathology,

222 isualization of microvascular changes in the human retina is clinically limited by the capabilities o

223 n in the sampling density of RGCs across the human retina is closely matched to the variation in the

224 A more complete knowledge of the human retina is crucial for counteracting the events tha

225 Furthermore, the human retina is devoid of myelin, but inflammation was d

226 e reactivity that the ASL-MRI detects at the human retina is dominated by the choroidal blood flow, a

227 Conversely, the human retina lacks rpgrip1b, and the constitutive transc

228 nomenclature system that is consistent with human retina layer designations to standardize murine OC

229 and 3-hydroxy-beta,epsilon-caroten-3'-one in human retina may be interconverted through a series of o

230 g near-infrared light sensitivity in a blind human retina may supplement or restore visual function i

231 uctive pathways for lutein and zeaxanthin in human retina, may therefore play an important role in pr

232 In both rat and human retinas, NOS-1 is expressed in the inner segments

233 ell cultures and sections of fetal and adult human retina, NRL is present in the nuclei of developing

234 ent carotenoids lutein and zeaxanthin in the human retina occurs early in life.

235 hRPCS were isolated from human retina of 14 to 18 weeks gestational age (GA) and

236 lity and high-resolution anatomic MRI of the human retina on a 3-Tesla (T) MRI scanner.

237 e show that these genes are expressed within human retina, optic nerve and trabecular meshwork and th

238 level in older compared with that in younger human retinas or RPE/choroids.

239 t of oxidative stress on the UPP in cultured human retina pigment epithelial cells.

240 he workflow allowed a detailed view into the human retina proteome highlighting new molecular players

241 The cone-dominant human retina resulting from NR2E3 mutations affords grea

242 of associations with common diseases of the human retina, retinal pigment epithelium and choroid and

243 Normal human retina revealed strongly labeled cone outer segmen

244 d PP7 was identified from cDNA produced from human retina RNA.

245 In mouse and human retina, rods greatly outnumber cones and consume m

246 In human retina, RP2 was localized to the plasma membrane o

247 cted with an approximately 80-kDa protein in human retina, RPE, kidney, and lung.

248 cripts (isoform A and isoform B) in MEFs and human retina-RPE-choroid samples (n = 83).

249 However, proteomic studies investigating on human retina samples are still rare.

250 dentified with high confidence (FDR < 1%) in human retina samples.

251 In the human retina, second-order processing of signals origina

252 -PCR clones derived from 5 fetal and 2 adult human retinas sequenced in our laboratory, revealed that

253 Immunohistochemistry studies in the human retina showed intense labeling of cone inner segme

254 Immunocytochemistry in human retina showed that CRX protein was not detected un

255 vel regulation of the ATPase activity of the human retina specific ATP binding cassette transporter (

256 trategy was used to isolate a 1381-base pair human retina-specific cDNA, human retinal gene 4 (HRG4),

257 In degenerate canine and human retinas, strong immunolabeling appeared in rod and

258 which comprise more than 80% of RGCs in the human retina, subserve high-acuity vision, and were prev

259 In primate and human retina such classification has so far, not been ap

260 earlier than L/M mRNA or protein across the human retina, suggesting that the two cone types differe

261 he cloning of GRK7 from rod-dominant pig and human retinas, suggesting that this kinase plays a role

262 ein (metabolite of lutein and zeaxanthin) in human retina suggests that lutein and zeaxanthin may act

263 a novel gene from pigment epithelium of the human retina that codes for a PEDF-binding partner, whic

264 of proteins upregulated in the glaucomatous human retina that exhibit many links to TNF-alpha/TNFR1

265 of chromatic and luminance processing in the human retina, the differences that exist between ERGs fr

266 The central region of the human retina, the fovea, provides high-acuity vision.

267 In the human retina, the most abundant mRNA isoforms are derive

268 ion of UMI-4C profiles we generated on adult human retina then allowed fine-mapping of the interactio

269 copy, and imaging mass spectrometry (IMS) to human retina tissue, we compared lipid profiles in ectop

270 l density and distribution of neurons in the human retina to aid in understanding human spatial visio

271 s data had shown CRX expression in the adult human retina to be photoreceptor-specific; however, we d

272 d from different regions of the dark-adapted human retina to evaluate localized rod function.

273 ducted a microarray-based analysis comparing human retina to hESC-derived retinal cells.

274 In macaque and human retina, two distinct populations of melanopsin cel

275 expression profiles were obtained from five human retinas, two livers, and the cerebral cortical reg

276 ar cells, as well as horizontal cells of the human retina, undergo extensive dendritic reorganization

277 el single-cell RNA sequencing (scRNA-seq) of human retinas using two independent platforms, and repor

278 In adult human retina, VEGF-like immunoreactivity (VEGF-IR) is fo

279 The distribution of Vn in the normal adult human retina was examined using antibodies to circulatin

280 An immortalized cell line obtained from human retina was investigated for the expression of know

281 onfirmatory immunohistochemistry staining in human retina was present in 12 of 14 samples (86%).

282 or RT-PCR from rat, chicken, zebrafish, and human retina, was performed to determine the sequence of

283 e the ability of tachyzoites to navigate the human retina, we developed an ex vivo assay, in which a

284 F) or vascular permeability factor, in adult human retina, we employed immunocytochemistry with doubl

285 To comprehensively profile the human retina, we performed single-cell RNA sequencing on

286 e loss of RPGR in the all-cone region of the human retina, we used Nrl(-/-) (neural retina leucine zi

287 racterize expression variation in the normal human retina, we utilized a custom retinal microarray to

288 ed from perifoveal and peripheral regions of human retina were found to be of high purity as indicate

289 dissociated Muller cells from the bovine and human retina were studied with the perforated-patch conf

290 High-resolution images of the human retina were successfully obtained with the MMOCT s

291 Vertical cryosections of human retinas were immunostained with antibodies specifi

292 o concurrently elicit ERG responses from the human retina which reflect processing in both chromatic

293 We targeted TRP channels to human retinas, which allowed the postmortem activation o

294 pic cultures of developing mouse, monkey and human retinas, which can be maintained for up to 2 weeks

295 of rhodopsin can be measured locally in the human retina with a widely available SLO.

296 encing to profile lesions from 11 postmortem human retinas with age-related macular degeneration and

297 g retina shares many cytologic features with human retinas with retinitis pigmentosa and provides an

298 c arrangement is also found across the adult human retina, with the notable exception that ChAT expre

299 With approximately 10(6) ganglion cells, the human retina would transmit data at roughly the rate of

300 However, in human retinas, ZBED4 was localized to cone nuclei, inner