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1 andom location (so-called KO-plus-transgenic humanization).
2 mouse IgG3 mAb is lost upon chimerization or humanization.
3 aluable insights into the optimization of IF humanization.
4 two potential modes of adaptation to histone humanization.
5 rine lungs and spleens indicating successful humanization.
6 facilitate further antibody optimization and humanization.
7  2.5-A resolution and used as a template for humanization.
8 rent and random location; KO-plus-transgenic humanization.
9 f immunodeficient mouse strains suitable for humanization.
10  animals with a notion that such mAbs bypass humanization.
11 ts were allowed to heal on naive mice before humanization.
12 e changes necessary to regain activity after humanization.
13 and also suggest a possible means of enzyme "humanization."
14                               We present the humanization, affinity maturation, and epitope mapping o
15                    A method for simultaneous humanization and affinity maturation of monoclonal antib
16 uld not be identified by sequential in vitro humanization and affinity muturation strategies.
17 the fields of antibody engineering, antibody humanization and CAR-T cell therapy.
18                                We report the humanization and characterization of monoclonal antibody
19 the Ebola virus now provides a framework for humanization and development of a postexposure immunothe
20  the immunogenicity of rodent antibodies via humanization and generation of antibodies in transgenic
21 he TKO hu-PBMC mouse model not only supports humanization and HIV-1 infection but also has a delayed
22 gn strategy could be applied during antibody humanization and library design for in vitro display met
23   Advances in antibody technologies, such as humanization and robust methods for human antibody gener
24                          Here, we report the humanization and testing of these antibodies for clinica
25 Here, we present data on the identification, humanization, and in vitro pharmacology of an antidote f
26 ovides a detailed description of our genetic humanization approach, and the companion paper reports t
27 stant regions intact, using a unique in situ humanization approach.
28 rparts at the same genetic location (in situ humanization), but such efforts involved laborious proce
29                                        Liver humanization by intrasplenic injection of human hepatocy
30     Removal of foreign amino acid content by humanization can lower the immunogenic risk of the thera
31 l in which combined human liver and cytokine humanization confer enhanced human erythropoiesis and RB
32 oach (i) provides a rapid route for antibody humanization constraining the content of original mouse
33  and prior experience conducting research in humanization contexts may reduce costs and time spent, a
34 ht chain Ig loci, by far the largest genetic humanizations ever described.
35 an effective replacement for trial-and-error humanization experiments, producing similar results in a
36                                              Humanization had as a consequence that efficacy studies
37 notransplantation with human immune systems (humanization) has been problematic because C57BL/6 SIRPa
38                     Heretofore, most genetic humanizations have involved disruption of the endogenous
39  of concept for the emerging appreciation of humanization in synthetic biology for human health.
40 nimal immunization and also commonly require humanization in the case of therapeutic applications.
41             One important example of genetic humanization involves mice humanized for their Ig genes,
42 e development of a new strategy for antibody humanization is described.
43 ther the primacy of gender categorization in humanization is more likely to be a culturally specific
44                                              Humanization is normally carried out in a largely trial-
45                   mAb discovery is rapid and humanization is straightforward, establishing the utilit
46                Hu-mAb (humanness scoring and humanization) is freely available to use at opig.stats.o
47  of its high affinity and its high degree of humanization, JC-7U IgG1 is an excellent drug candidate
48                                        Liver humanization led to reprogrammed diurnal gene expression
49  in the CDRs, which are typically avoided in humanization methods.
50          Here, we describe the isolation and humanization of a potent monoclonal antibody cross-neutr
51                                              Humanization of a potent neutralizing mouse anti-human I
52 Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse
53 y technology, we recently reported the first humanization of a rabbit monoclonal antibody.
54                                   Hence, the humanization of ABC transporters in mice has become a ma
55 activation of GP130 in human hepatocytes, or humanization of an Il6 allele in recipient mice, substan
56                                          The humanization of animal model immune systems by genetic e
57                                          The humanization of animals is a powerful tool for the explo
58 bilities come moral concerns about the moral humanization of animals, especially when it comes to the
59  platforms, a rapid and reliable process for humanization of antibodies from nonhuman sources is requ
60 y either exogenous catestatin replacement or humanization of Chga mice.
61                                              Humanization of E06 was carried out by converting over 6
62   Here we demonstrate marked effects of this humanization of Foxp2 on learning and striatal neuroplas
63                                   Microbiota humanization of germ-free mice with fecal samples from t
64                                              Humanization of germ-free mice with pre-LFD feces caused
65          Improvement of affinity, as well as humanization of GNC92H2, would be advantageous in immuno
66 phism in vivo, we performed targeted genomic humanization of mice by using CRISPR/Cas9 (clustered reg
67 kb of a tailored Trp53 locus, as well as for humanization of mice using 116 kb and 180 kb human ACE2
68 it immune repertoires for the generation and humanization of monoclonal antibodies that bind with str
69                          Here, we report the humanization of mouse 38C2 based on rational design guid
70 hain variable regions (VH), is important for humanization of mouse antibodies.
71             This approach was applied to the humanization of mouse mAb LM609 that is directed to huma
72 designed combinatorial V gene libraries, the humanization of mouse monoclonal antibody LM609 directed
73              In this report, we describe the humanization of muMAb VEGF A.4.6.1. by site-directed mut
74                                              Humanization of NSG mice with pediatric thymus was succe
75    More recently, efforts have turned to the humanization of other animal species such as the rat, wh
76                                          The humanization of rabbit antibodies, however, has not been
77  a dramatic, unexpected discovery during the humanization of rbt4A11 where, two variants of humanized
78                                              Humanization of rhLCV with EBV gp350 also confers suscep
79 rived from mice bearing human Ig transgenes, humanization of rodent Abs, or phage libraries.
80 ural information and computational tools the humanization of rodent antibodies for clinical use often
81              In addition, we determined that humanization of SCID mice following engraftment and vasc
82  provides a framework for further design and humanization of shark IgNARs.
83               We have applied this method to humanization of the anti-vascular endothelial growth fac
84 es, such as cocaethylene, and for additional humanization of the antibody.
85  goal of this study was to determine whether humanization of the As3mt gene confers a human-like patt
86                                We report the humanization of the glycosylation pathway in the yeast P
87                                  Physiologic humanization of the hematopoietic stem cell niche proves
88                                              Humanization of the HRS-3 scFv coupled with the 4-1BB sp
89  themes emerged: 1) a feeling of support, 2) humanization of the medical system, 3) an opportunity fo
90                              In situ genetic humanization of the mouse Cbln2 enhancer drives increase
91 r findings have significant implications for humanization of the mouse IgG1 currently in clinical tri
92 ecifically mutated to increase the degree of humanization of the nanobody VHH-B11.
93                                   Homozygous humanization of TPO led to increased levels of human eng
94        In this review, the immune and tissue humanization of various species is presented with an emp
95 ies, especially as they relate to potential "humanization" of host animals.
96 ell-binding antibodies, these data show that humanization offers a significant reduction in immunogen
97                                     Antibody humanization often requires the replacement of key resid
98 tibody-derived antibody sequence used during humanization, only the CDR3 region from a murine antibod
99                                              Humanization procedures aim to produce antibody therapeu
100 hus overcoming the major drawback of current humanization procedures, the requirement to construct an
101 ut these systems involve a long and variable humanization process, are expensive, and require the use
102         The best available methods for liver humanization rely on cell transplantation into immunodef
103                                              Humanization significantly changed the murine intestinal
104 cells and stromal cells occurs 2 weeks after humanization, so investigators should expect to observe
105                                    The novel humanization strategy described here provides a robust a
106 ndogenous epithelium with subsequent stromal humanization takes 1 month.
107 highly successful in the clinic, all current humanization techniques have potential limitations, such
108            We previously developed the ultra-humanization technology "Augmented Binary Substitution"
109            The best available model of liver humanization, the uroplasminogen-activator transgenic mo
110 lassifiers to develop a novel, computational humanization tool, Hu-mAb, that suggests mutations to an
111 for very large, in situ, and precise genetic humanization using large compound bacterial artificial c
112 e to HCV entry in vitro, we attempted murine humanization via a genetic approach.
113                This study examines how ultra-humanization, via CDR germlining, is facilitated while m
114 because of the manner in which their genetic humanization was carried out.
115  immunodeficiency virus, type 1 disease, its humanization was desired to minimize the potential for i
116                                              Humanization was performed by adoptive transfer of human
117                          For rabbit antibody humanization, we then used a selection strategy that com
118                                          For humanization, we transplanted pooled feces from healthy,
119                                      Genetic humanization, which involves replacing mouse genes with
120  translational roadblock, by combining liver humanization with AAV receptor (AAVR) ablation, renderin
121 tive microbiome, were germ free, or received humanization without pretreatment or received sham gavag

 
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