ライフサイエンスコーパス: humanized

1 vious study, we isolated, characterized, and humanized a cross-reactive, neutralizing anti-F mAb (h5B

2 This stepwise process yielded a humanized AAV8 capsid (AAVhum.8) displaying nonnatural s

3 We anticipate that this humanized affinity-matured mAb will find application for

4 IMP761 is a LAG-3-specific humanized agonist Ab with immunosuppressive properties b

5 We then tested CLR01 in vivo in a humanized alpha-synuclein overexpressing mouse model; mi

6 To become humanized, an immune-deficient recipient is engrafted wi

7 sights into the development and selection of humanized animal antibodies and provide actionable infor

8 e-engineering, microfluidic organ-chips, and humanized animal systems.

9 antibody-drug conjugate (ADC) comprised of a humanized anti- Trop-2 antibody, conjugated with active

10 e discussed in this Review, including: fully humanized anti-CD20 and anti-CD19 monoclonal antibodies;

11 udy examines the feasibility of delivering a humanized anti-CD29 monoclonal antibody (OS2966) topical

12 Tumor uptake of the radiolabeled, humanized anti-GD2 antibody [(64)Cu]Cu-Bn-NOTA-hu14.18K3

13 Furthermore, SR-1 and clinical-grade humanized anti-human CD117 mAb, AMG 191, deplete normal

14 cle while the other group was treated with a humanized anti-IL-21R antibody (alphaIL-21R).

15 ouble-blind, placebo-controlled trial of the humanized anti-IL-5 antibody, reslizumab, (1.0 mg/kg IV)

16 Reslizumab is a humanized anti-IL-5 monoclonal antibody used as add-on m

17 Subsequently, the humanized antibody was de-immunized and site-specific mu

18 A humanized antibody, AK002, targeting Siglec-8 is undergo

19 Trem2(R47H) rats produce human-Abeta from a humanized-App rat allele because human-Abeta is more tox

20 nslation assays with wild-type bacterial and humanized bacterial ribosomes and of extensive antibacte

21 Cell-free translation assays with humanized bacterial ribosomes were used to optimize the

22 Caplacizumab, an anti-von Willebrand factor humanized, bivalent variable-domain-only immunoglobulin

23 ma, and eliminated lymphoma in a xenografted humanized bone marrow-liver-thymus mouse model.

24 The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) gr

25 gene along with the adjacent Borcs7 gene was humanized by syntenic replacement.

26 -/-)gamma(c)(-/-)CD47(-/-) C57BL/6 mice were humanized by the BLT method, infected with HIV-1(JR-CSF)

27 le useful pharmacologic interventions in the humanized C3 (C3(hu/hu)) mice.

28 ta3A) and wild-type (WT) EBV in a cord blood-humanized (CBH) mouse model.

29 A partially humanized CD105 neutralizing antibody, TRC105, inhibited

30 Subretinal delivery of EDIT-101 in humanized CEP290 mice showed rapid and sustained CEP290

31 ection.Methods: In this study, we describe a humanized-CFTR rat expressing the G551D variant obtained

32 intraperitoneal regimen of fluoxazolevir in humanized chimeric mice infected with HCV genotypes 1b,

33 with a humanized sialome (Cmah(-/-) mice) or humanized complement system (FH/C4b-binding protein tran

34 ure antibody therapy for NiV and HeV using a humanized cross-reactive mAb targeting the F glycoprotei

35 ogous expression, and actions of a synthetic humanized Delta(1)-KstD expressed in Hep3B and U-937 cel

36 e for the development of the 5A6 mAb and its humanized derivatives as a novel treatment against B cel

37 llular crosstalk in human BM, we established humanized ex vivo and in vivo niche models comprising AM

38 characterize structural changes in a native humanized Fab A33 antibody fragment, that correlated wit

39 In human post-mortem tissue and mouse models humanized for apolipoprotein E, we examined the impact o

40 -overexpressing primary human hepatocytes in humanized FRG mouse livers demonstrated active beta-cate

41 Accordingly, we engineered a humanized gene, hmTert, by knocking-in a 47-kilobase hyb

42 crobial community structure (P < .001), with humanized germ-free and antibiotic-treated groups overla

43 we modeled human interlaminar astrocytes in humanized glial chimeric mice by engrafting astrocytes d

44 C) loaded nanoparticles (NPs) to solution in humanized (hu) mice.

45 iRNA targeting human HTT (AAV5-miHTT) in the humanized Hu128/21 mouse model of HD.

46 embrane antigen (PMSA) and is comprised of a humanized IgG1 antibody site-specifically conjugated to

47 thods shared in detail can be applied to any humanized IgG1 mAb biotherapeutic for preclinical study

48 subclass switching studies, murine IgG2a and humanized IgG1 mAb variants controlled infection better

49 rolled infection better than murine IgG1 and humanized IgG1-N297Q variants.

50 Dupilumab is a humanized IgG4 monoclonal antibody that targets the IL-4

51 ng IL-26, which attenuate acute colitis in a humanized IL-26 transgenic mouse model.

52 Our study forms a strong basis for using humanized IL-27 toward the treatment of post-menopausal

53 gh ICOSL to control airway inflammation in a humanized ILC2 mouse model.

54 Humanized immune system immunodeficient mice have been e

55 etic-progenitors into the postnatal brain of humanized, immune-deficient mice results in context-depe

56 erived xenotransplantation model in cytokine-humanized immunodeficient "MISTRG" mice that provides ef

57 DSTP3086S is a humanized immunoglobulin G1 anti-STEAP1 monoclonal antib

58 We sought to characterize ARGX-117, a humanized inhibitory monoclonal antibody against complem

59 Using a humanized knockin (KI) mouse model and in vitro organoty

60 liver damage was observed in FRGN mice with humanized liver.

61 pression of genes in fatty acid oxidation in humanized livers through its interaction with RNA-bindin

62 2rg(-/-)/NOD (FRGN) mice to create mice with humanized livers.

63 l molecules (maraviroc and vicriviroc) and a humanized mAb (leronlimab)], are now being repositioned

64 GBR 830 is a humanized mAb against OX40, a costimulatory receptor on

65 We show that the affinity-matured and humanized mAb retains strong affinity and specificity to

66 BIIB059 is a humanized mAb that binds blood DC antigen 2 (BDCA2), a p

67 mab, sold under the brand name Avastin, is a humanized mAb that binds VEGF and blocks its binding to

68 use BIVV009 (Sutimlimab), a clinical stage, humanized mAb that specifically inhibits the CP-specific

69 Liver-humanized mice (LHM) are considered a promising model to

70 Single bNAbs protected humanized mice against infection but selected for resist

71 Generation of C1q humanized mice allowed for demonstration of the efficacy

72 f HCV replication in vitro and in coinfected humanized mice also reduced interferon signaling and, co

73 ere, we describe parallel efforts using both humanized mice and convalescent patients to generate ant

74 ee independent experiments in HIV-1-infected humanized mice and one pivotal experiment in simian-huma

75 s against P. falciparum asexual infection in humanized mice and prevented transmission to mosquitoes.

76 RT-suppressed bone-marrow-liver-thymus (BLT) humanized mice and rhesus macaques infected with HIV and

77 ong-term hematopoietic repopulating cells in humanized mice and rhesus macaques.

78 dy treatments for Ebola-one from genetically humanized mice and the other from a human survivor.

79 s study support the use of hematopoietically humanized mice as an in vivo model for screening of radi

80 zing plasma concentrations in HIV-1-infected humanized mice but elicited CD4-binding site mutations t

81 as recently reported to establish latency in humanized mice but not cause tumors.

82 Humanized mice can be used to better understand how the

83 Combined with single-cell genomics, humanized mice can facilitate functional precision medic

84 ng maternal-fetal transport in FcgammaR/FcRn humanized mice confirmed that only FcRn contributed to t

85 ral variants with greater fitness.IMPORTANCE Humanized mice constitute a useful model for studying th

86 er of TCR-grafted T cells into HBV-infected, humanized mice controlled HBV infection and virological

87 h CEA-TCB/CEA-4-1BBL in MKN-45 tumor-bearing humanized mice correlated with intratumoral CD8(+) T-cel

88 Humanized mice developing functional human T cells endog

89 eatment reactivated HIV-1 gene expression in humanized mice during suppressive cART.

90 Both murine transplant models and humanized mice engrafted with LV-modified HSCs show high

91 RNase 7 humanized mice exhibited marked protection from UPEC.

92 Notably, the humanized mice expressed both the full-length AS3MT that

93 al treated, virus-free animals to uninfected humanized mice fails to produce infectious progeny virus

94 la infections and demonstrate the utility of humanized mice for understanding the pathogenesis of a h

95 As a patient-derived xenograft (PDX) model, humanized mice functionally correlate putative mechanism

96 d-derived MSCs (hUC-MSCs) on tumor growth in humanized mice generated by the human adoptive transfer

97 Replicate humanized mice generated diverse and highly divergent re

98 cy.IMPORTANCE Advances in the development of humanized mice have raised the possibility of a small-an

99 We previously showed that humanized mice immunized with long-lived induced-dendrit

100 The optimal parameters for using humanized mice in preclinical CNS injury models need to

101 ted HIV-1 reservoirs under effective cART in humanized mice in vivo Interestingly, I-BET151 during su

102 of multiple clones of low abundance in these humanized mice mirrors the early phase of HTLV-1 infecti

103 Humanized mice receiving a SCI before or after stable en

104 y studying Borrelia burgdorferi infection in humanized mice reconstituted with human hematopoietic st

105 -only mice and bone marrow/liver/thymus-lung humanized mice substantially increase the number of huma

106 Administrating SF12 to HIV-1-infected humanized mice suppressed viremia and selected for virus

107 cation of iAs was much less efficient in the humanized mice than in wild-type mice.

108 Here we show by intravital microscopy in humanized mice that perturbation of the actin cytoskelet

109 Using humanized mice that were colonized with bacteria from th

110 This study sought to use humanized mice to extend these results to humans.

111 an optimal experimental framework for using humanized mice to help translate promising preclinical t

112 Karlinsey et al. (2019) combine TraDIS with humanized mice to identify genes required for early repl

113 Here, we describe the capacity of BLT humanized mice to mount broadly directed HIV-1-specific

114 mens from HEV-infected and ribavirin-treated humanized mice were analyzed using HEV antigen-specific

115 ed metabolites in tissues and excreta of the humanized mice were consistent with those reported in hu

116 mine these mechanisms, NOD/SCID IL-2 RG(-/-) humanized mice were either directly infected with HIV(AD

117 Humanized mice were infected with isogenic HIV molecular

118 Humanized mice were previously reported as a model for t

119 All humanized mice were stably colonized with O. formigenes

120 The use of humanized mice will allow us to use our knowledge of HIV

121 sis of plasma virus, that treatment of these humanized mice with a broadly neutralizing antibody, 10-

122 Finally, treatment of humanized mice with anti-Siglec antibody led to robust d

123 r-derived particles were infectious in liver-humanized mice with high RNA copy numbers detectable in

124 e fully suppressed viremia in HIV-1-infected humanized mice without selecting for resistant viral var

125 , (3) migration toward CXCL8 in vitro and in humanized mice, and (4) CXCR1, CXCR2, and CXCR4 expressi

126 g-like receptor B1 (LILRB1) transgenic mice, humanized mice, and genetically engineered HLA-G dimer,

127 t drugs in inhibiting vascular thrombosis in humanized mice, but neither causes serious bleeding, est

128 ion of HIV in almost all tissues analysed in humanized mice, including the lymph nodes, thymus, bone

129 n incorporated into bone marrow/liver/thymus humanized mice, lung implants are repopulated with autol

130 injection of hUC-MSCs in immune-deficient or humanized mice, respectively.

131 In humanized mice, the acquisition of ILC1 features by ILC3

132 When administrated in immune-humanized mice, the covalent PD-1(FSY) exhibited strikin

133 absence of the human Vlambda locus in these humanized mice, the dominance of Vlambda pairing with hu

134 In female humanized mice, we found that RPV LA inhibited vaginal t

135 In our humanized mice, we have shown downregulation of eukaryot

136 Humanized mice, which contain a human immune system, can

137 BLT (bone marrow-liver-thymus) humanized mice, which reconstitute a functional human im

138 ginal transmission of RPV-resistant HIV-1 in humanized mice.

139 ts were obtained in ART-treated HIV-infected humanized mice.

140 ent of IgG receptors (FcgammaRs) in FcgammaR-humanized mice.

141 st, and chronic phases of HIV-1 infection in humanized mice.

142 tent infectious reservoirs in HIV-1 infected humanized mice.

143 lowing therapy interruption in immune system-humanized mice.

144 and abolish ethanol-induced liver disease in humanized mice.

145 ttern of iAs metabolism in the wild-type and humanized mice.

146 viral evolution in the plasma compartment in humanized mice.

147 vitro by using flow cytometry and in vivo in humanized mice.

148 ogenesis in bone marrow, liver, thymus (BLT) humanized mice.

149 nfiltration and rejection by immune cells in humanized mice.

150 ity to deplete target cells in FcgammaR/FcRn humanized mice.

151 nsfer of treated lymphocytes into uninfected humanized mice.

152 In a humanized model of autoimmune thyroiditis, we investigat

153 Here, we report the first description of a humanized model of TBI and show that TBI places signific

154 tional status seen in this viral oncogenesis humanized model replicates observations obtained in the

155 This study provides a humanized model to study the crosstalk among HSPCs, leuk

156 n IRI and donor-specific antibodies by using humanized models and patient specimens.

157 emically induced, syngeneic, transgenic, and humanized models are discussed in order to provide conte

158 Humanized models enable us to overcome biologic differen

159 or aggression and demonstrating the value of humanized models for a better understanding of pediatric

160 Here we generate humanized models for Sonic Hedgehog (SHH)-subgroup MB vi

161 ere treated with a single 50-mg/kg dose of a humanized monoclonal anti-CD4 antibody; within 1 week, c

162 Neutralization of VEGF using humanized monoclonal antibodies such as Avastin, effecti

163 mediate hemolysis in vivo was inhibited by a humanized monoclonal antibody (mAb) that blocks IgG bind

164 RPC4046, a recombinant humanized monoclonal antibody against IL13, prevents its

165 carcinoma were treated with spartalizumab, a humanized monoclonal antibody against the programmed dea

166 Idarucizumab, a humanized monoclonal antibody fragment, reverses dabigat

167 GS-5745, a potent, highly selective humanized monoclonal antibody inhibitor of MMP9, has sho

168 Pembrolizumab is a humanized monoclonal antibody that blocks interaction be

169 Mepolizumab, a humanized monoclonal antibody that neutralizes IL-5 and

170 Tanezumab, which is a late-stage development humanized monoclonal antibody that targets NGF.

171 We evaluated the addition of bevacizumab, a humanized monoclonal antibody that targets vascular endo

172 Galcanezumab, a humanized monoclonal antibody to calcitonin gene-related

173 s an antibody-drug conjugate that combines a humanized monoclonal antibody, which targets the human t

174 mmunoprophylaxis of high-risk infants with a humanized monoclonal antibody.

175 Methods: A humanized monoclonal IgG antibody against the herpes sim

176 We first identified a humanized monoclonal IgG that has a high binding affinit

177 L3_KGRKLP)), human (hGPRC6A(ICL3_KGKY)), and humanized mouse (mGPRC6A(ICL3_KGKY)) GPRC6A into human e

178 Here we test a hematopoietically humanized mouse as a potential in vivo model for biodosi

179 or (FcgammaR) dependence in vivo in FcgammaR humanized mouse challenge models of EBOV disease.

180 ata support the potential utility of the BLT humanized mouse for HIV-1 vaccine development but sugges

181 t human blood cells in the hematopoietically humanized mouse in vivo environment recapitulated the ge

182 The humanized mouse is one tool to bridge the gap between tr

183 resent a characterization of the first Abcc1 humanized mouse line.

184 In contrast, hGPRC6A(ICL3_KGKY) and humanized mouse mGPRC6A(ICL3_KGKY) are retained intracel

185 The new humanized mouse model (Hu-NSG/alpha-Gal(null)) is design

186 Two studies in this issue of the JCI use a humanized mouse model and demonstrate that type I interf

187 Here, we describe the development of a humanized mouse model based on the NOD-scid IL2rg(null)

188 These findings demonstrate that a novel humanized mouse model can help clinical translation of C

189 ervoir, we developed and characterized a new humanized mouse model consisting of highly immunodeficie

190 A humanized mouse model demonstrated that host skin-reside

191 of loxP sites, we additionally enabled this humanized mouse model for highly sophisticated studies i

192 also block intrarectal HIV-1 infection in a humanized mouse model in preliminary tests in vivo Our r

193 eated and used what we believe to be a novel humanized mouse model of anaphylaxis that does not requi

194 ivation of human Vgamma9Vdelta2 T cells in a humanized mouse model of bacterial infection.

195 To study this reservoir, we established a humanized mouse model of HIV-1 infection and ART suppres

196 as a long-acting injectable monotherapy in a humanized mouse model of HIV-1 infection, outperforming

197 but significant decrease in GAS fitness in a humanized mouse model of impetigo; the DeltafbaA mutant

198 732394 was shown to be highly effective in a humanized mouse model of infection.

199 solated from aviremic individuals and in the humanized mouse model of latency, combining dCA with ant

200 We established a humanized mouse model of latent HIV infection by transpl

201 eir preventive potential was determined in a humanized mouse model of mugwort pollen allergy.

202 Finally, we developed a humanized mouse model of Pseudomonas aeruginosa pneumoni

203 Using the knock-in humanized mouse model of SCD and SCD patient blood, we s

204 avi-Maharlooei and colleagues describe a new humanized mouse model that allows direct investigations

205 Here, we describe a humanized mouse model that can be used to detect latent

206 mouse models and humans, we developed a new humanized mouse model that mimics humans in that it lack

207 functional human dendritic cells (DCs) in a humanized mouse model that mimics the human immune syste

208 Establishment of such a humanized mouse model that mounts functional human DCs e

209 Further, myelin internodes in a humanized mouse model that recapitulates the human trans

210 We show in a humanized mouse model that such modified vectors were ab

211 in vitro In this study, we used a cord blood-humanized mouse model to compare the phenotypes of an EB

212 u-NSG/alpha-Gal(null) is the first available humanized mouse model with such features.

213 In a humanized mouse model, AA homozygous mice were similarly

214 lncRNAs can be successfully examined in the humanized mouse model, and experimentally validate the p

215 ntly blocks tryptase enzymatic activity in a humanized mouse model, reducing IgE-mediated systemic an

216 tro and resulted in more severe disease in a humanized mouse model.

217 inistration, and HIV infection using the NSG humanized mouse model.

218 pture and neutralize HIV-1 in vitro and in a humanized mouse model.

219 activation, and allograft vasculopathy in a humanized mouse model.

220 antibody VRC01-N using a highly reproducible humanized mouse model.

221 thways in humans and co-regulated genes in a humanized mouse model.

222 te AHR and suppresses lung inflammation in a humanized mouse model.

223 However, wild-type mice and all existing humanized mouse models cannot be used to test the effica

224 A major limitation of current humanized mouse models is that they primarily enable the

225 immune-dependent responses in syngeneic and humanized mouse models of telomerase-expressing cancers.

226 In addition, we will discuss how humanized mouse models such as the human skin xenograft

227 Clinical genetics and humanized mouse models suggest that inhibiting CETP may

228 We used humanized mouse models to assess the infectivity of both

229 the gut and colonic inflammation in vivo in humanized mouse models, and altered effector T cells in

230 In humanized mouse models, ApoC3 activated human monocytes

231 In humanized mouse models, CAR-Ms were further shown to ind

232 human transgenes and additional mutations in humanized mouse models, have expanded our opportunities

233 Using PXR-humanized mouse models, we recapitulated the RTV hepatot

234 Thus, the humanized mouse strain can be used to study the role of

235 vitro colony formation and in vivo adoptive humanized mouse transfers, indicate that eNePs are the e

236 of BA activation of MRGPRX4, we generated a humanized mouse with targeted expression of MRGPRX4 in i

237 Despite complexities of the humanized mouse, marrow aplasia caused by TBI could be a

238 mor are implanted into an immunodeficient or humanized mouse.

239 In this study, we take advantage of a humanized-mouse model to probe the contribution of APOBE

240 exposed to glutamate and in capillaries from humanized mPGES-1 mice after SE.

241 approach by isolating brain capillaries from humanized mPGES-1 mice to study P-gp levels.

242 -pembrolizumab was further investigated in a humanized murine model.

243 idated by the x-ray structure of a partially humanized mutant of E. coli DHFR (N23PP/G51PEKN).

244 autosis by ouabain, a cardiac glycoside, in humanized Na+,K+-ATPase-knockin mice reduced I/R injury.

245 rain by deleting its extracellular domain of humanized NC16A (termed DeltaNC16A mice).

246 duce the human Skin and Immune System (hSIS)-humanized NOD-scid IL2Rgamma(null) (NSG) mouse and Sprag

247 y potentially new anti-HIV Abs, we exploited humanized NOD-scid IL2rgamma(null) mice systemically inf

248 eukocytes for early biodosimetry triage from humanized NOD-scid-gamma (Hu-NSG) mice and non-human pri

249 In this study, we established a diabetic humanized NOD-scidIL2Rgamma(null) (NSG) mouse model of T

250 ted significantly milder hemotoxicity in the humanized NOD/SCID mouse model engrafted with red blood

251 ro-benzene-sulfonic-acid model of colitis in humanized NOD/scid/gamma mice.

252 We report here that humanized, non-Fcgamma receptor (FcgammaR)-binding monoc

253 ir biodistribution in athymic nude, NSG, and humanized NSG mice bearing human epidermal growth factor

254 y concentrations are reduced by ~3.5-fold in humanized NSG mice).

255 ia alternata model of allergic asthma and in humanized NSG mice.

256 ic monoclonal antibodies (mAbs) are based on humanized or human IgG1, 2, or 4 subclasses and engineer

257 ddressed in the future by using pigs to grow humanized organs with lower potential for immunological

258 sustain human hematopoiesis was evaluated in humanized ossicle models.

259 BT-MSCs failed to form a proper BM niche in humanized ossicle models.

260 susceptibility to mammary cancer, we used a humanized p53 mouse model, homozygous for either P72 or

261 the efficacy and safety of pembrolizumab, a humanized PD-1-blocking antibody, at a dose of 200 mg ev

262 f effector cell degranulation when using the humanized RBL-SX38 cell model and that multivalency can

263 nes will facilitate development of effective humanized recombinant antivenom.

264 Omalizumab, a humanized recombinant monoclonal anti-IgE antibody, prov

265 me injection of AAV9-M7.8L RNAi in 3-day-old humanized regulatory light chain mutant transgenic mice

266 For RNase 7 in vivo studies, we developed humanized RNase 7 transgenic mice, subjected them to exp

267 n and immune system components into a single humanized rodent model could provide a platform for stud

268 opathogenesis has been separately studied in humanized rodent models developed with human lymphoid ti

269 hSIS-humanized rodents demonstrate the development of human f

270 We then immune humanized RRGS animals with human peripheral blood monon

271 s: In vivo imaging of the lung in transgenic humanized SCD mice and in vitro imaging of SCD patient b

272 ving events following hypoxia/reperfusion in humanized SCD mice.

273 cultured normal and IPF fibroblasts and in a humanized SCID mouse model of IPF employing both short i

274 thogenesis, whereby RNA-editing targets in a humanized sCJD mouse model were confirmed in pathologica

275 mosozumab, approved by the FDA in 2019, is a humanized sclerostin-neutralizing antibody (Scl-Ab) indi

276 multidrug-resistant gonococci in mice with a humanized sialome (Cmah(-/-) mice) or humanized compleme

277 (also known as "RTH258" and "ESBA1008") is a humanized, single-chain variable fragment (scFv) antibod

278 cardiac and lung transplant models, and in a humanized skin transplant model.

279 the early phase of allograft rejection in a humanized skin transplantation model in mice reconstitut

280 signaling can delay allograft rejection in a humanized skin transplantation model.

281 Five days postchallenge, SP-A KO and humanized SP-A2 223K/K mice had persistent eosinophilia

282 Wild-type, SP-A knockout (SP-A KO) and humanized (SP-A2 223Q/Q, SP-A2 223K/K) C57BL/6 mice were

283 The humanized TBC1D24G501R fly model exhibits sustained acti

284 Humanized TCR/HLA-transgenic allergy mice were treated i

285 tudy revealed a novel approach to engineer a humanized telomerase gene in mice, achieving a milestone

286 g a milestone in creating a mouse model with humanized telomere homeostasis.

287 In this study, we humanized three parent low affinity allergic response in

288 The model can be further humanized through the engraftment of human hematopoietic

289 We generated humanized transgenic (TG) mice containing all the intron

290 IC) assays of skin samples from hamsters and humanized transgenic mice (Tg40h) at different time poin

291 In this study, we establish a humanized transplantation model of PD that better recapi

292 In liver-humanized uPA/severe combined immunodeficient (SCID)/bei

293 A humanized version (huPMN310) compared favorably to other

294 ves: We hypothesized that a rat expressing a humanized version of CFTR and harboring the ivacaftor-se

295 sequent generation of optimized chimeric and humanized versions of these antibodies has paved the way

296 ma nanobodies (VHH) from naive and synthetic humanized VHH phage libraries that specifically bind the

297 he development of lung fibrosis in SCID mice humanized with IPF lung fibroblasts.

298 Co-crystal structures with beta2 humanized yeast proteasomes visualize protein-ligand int

299 Engineering chimeric, "humanized" yeast ribosomes for ES9S reveals that an evol

300 While the 'humanized' yeast grew in the absence of adenine, it did