1 SC) biology and function in the context of a
humanized mouse.
2 mor are implanted into an immunodeficient or
humanized mouse.
3 A
humanized mouse air-pouch model showed that intravenous
4 nhibited in vivo HIV-1 and SHIV infection in
humanized mouse and macaque models, respectively, includ
5 n immunodeficiency virus (SHIV) infection in
humanized mouse and macaque models, respectively, includ
6 sed an integrated approach of dynamic human,
humanized mouse and non-human primate models and samplin
7 Here we test a hematopoietically
humanized mouse as a potential in vivo model for biodosi
8 A
humanized mouse bearing the HLA-DR2 (DRA/DRB1*1501) prot
9 or (FcgammaR) dependence in vivo in FcgammaR
humanized mouse challenge models of EBOV disease.
10 eir in vivo persistence to that of syngeneic
humanized mouse-
derived CAR-T cells.
11 PR-Cas9-based saturation genome editing in a
humanized mouse embryonic stem cell line to determine th
12 ata support the potential utility of the BLT
humanized mouse for HIV-1 vaccine development but sugges
13 human breast tissue will be able to generate
humanized mouse glands within 3 months.
14 The hematopoietic
humanized mouse (
hu-mouse) model is a powerful resource
15 t human blood cells in the hematopoietically
humanized mouse in vivo environment recapitulated the ge
16 he early stages of acute co-infection in the
humanized mouse,
infection with HIV exacerbates the pro-
17 The
humanized mouse is one tool to bridge the gap between tr
18 Creation of this
humanized mouse is the first step toward development of
19 esponse between mice and humans, a PPARalpha-
humanized mouse line was generated in which the human PP
20 resent a characterization of the first Abcc1
humanized mouse line.
21 In the future, use of "
humanized" mouse lines, containing a human AHR or CYP1 a
22 Human gene expression levels in
humanized mouse livers were analyzed by qPCR and Nanostr
23 Despite complexities of the
humanized mouse,
marrow aplasia caused by TBI could be a
24 ncy in displacing FcepsilonRI-bound IgE from
humanized mouse mast cells and human basophils without t
25 In contrast, hGPRC6A(ICL3_KGKY) and
humanized mouse mGPRC6A(ICL3_KGKY) are retained intracel
26 L3_KGRKLP)), human (hGPRC6A(ICL3_KGKY)), and
humanized mouse (
mGPRC6A(ICL3_KGKY)) GPRC6A into human e
27 Using a
humanized mouse model (denoted Hu-mice) reconstituted wi
28 iNKT cells, we recently developed the first
humanized mouse model (hCD1d-KI) with human CD1d knocked
29 The new
humanized mouse model (Hu-NSG/alpha-Gal(null)) is design
30 lts in restoration of corneal thickness in a
humanized mouse model (Krt12(+/hL132P)) for MECD.
31 n of patient Th17 cells was illustrated in a
humanized mouse model and brain histology from a rebound
32 Two studies in this issue of the JCI use a
humanized mouse model and demonstrate that type I interf
33 t the rejection of islets of Langerhans in a
humanized mouse model and examined the mechanisms involv
34 CD34(-/lo)/CD38(+) immunophenotype in both a
humanized mouse model and primary patient samples, the r
35 Based on these principles, we developed a
humanized mouse model approach to diversify an anti-PD1
36 h tissue engineering, we sought to develop a
humanized mouse model based on the facile and ectopic im
37 Here, we describe the development of a
humanized mouse model based on the NOD-scid IL2rg(null)
38 Here, we established a
humanized mouse model by transplanting human induced plu
39 These findings demonstrate that a novel
humanized mouse model can help clinical translation of C
40 henotypically characterized a novel knock-in
humanized mouse model carrying the severe, MECD-associat
41 sion, prolong human skin graft survival in a
humanized mouse model comparably to autologous Tregs.
42 ervoir, we developed and characterized a new
humanized mouse model consisting of highly immunodeficie
43 A
humanized mouse model demonstrated that host skin-reside
44 Furthermore, the
humanized mouse model described here may prove valuable
45 f a potent and selective chemical tool and a
humanized mouse model described in this report should fa
46 Similar to humans, this
humanized mouse model developed a subset of CD8alphabeta
47 from embryonic progenitors in vivo, using a
humanized mouse model expressing human cytokines (MISTRG
48 Furthermore, a
humanized mouse model expressing MRGPRX4 in sensory neur
49 ates for the first time the application of a
humanized mouse model for functional analysis of human m
50 of loxP sites, we additionally enabled this
humanized mouse model for highly sophisticated studies i
51 Recent advances in the development of a
humanized mouse model for HIV-1 infection might provide
52 coronavirus (MERS-CoV) and development of a
humanized mouse model for MERS-CoV infection, which was
53 Here, we studied bone homeostasis in a
humanized mouse model for SCD.
54 is protocol describes our recently developed
humanized mouse model for studying HCV and other hepatot
55 viral surveillance and the relevance of this
humanized mouse model for the studies of HIV-1 pathobiol
56 hese studies demonstrate the utility of this
humanized mouse model for the study of human Treg ontoge
57 also block intrarectal HIV-1 infection in a
humanized mouse model in preliminary tests in vivo Our r
58 ive activity of human Treg in vitro and in a
humanized mouse model in vivo.
59 Here, we engineered a
humanized mouse model in which B cells expressed inferre
60 X chromosome dosage and sex hormones using a
humanized mouse model in which male or female NOD-SCID-b
61 We established a
humanized mouse model incorporating FLT3-ligand (FLT3-L)
62 This
humanized mouse model may be used to model the human imm
63 Our
humanized mouse model may thus be useful for preclinical
64 In a
humanized mouse model of acute HIV infection, venetoclax
65 Recently, we developed a
humanized mouse model of allergen-induced IgE-dependent
66 ll activation on pulmonary inflammation in a
humanized mouse model of allergic airway inflammation.
67 Importantly, using a
humanized mouse model of allergic asthma, we demonstrate
68 Furthermore, in a
humanized mouse model of allergy using PBMC-engrafted NO
69 In a chimeric
humanized mouse model of allograft rejection, medial imm
70 eated and used what we believe to be a novel
humanized mouse model of anaphylaxis that does not requi
71 to inhibit vascular allograft rejection in a
humanized mouse model of arterial transplantation.
72 In this study, we used a
humanized mouse model of arthritis in an attempt to dete
73 ivation of human Vgamma9Vdelta2 T cells in a
humanized mouse model of bacterial infection.
74 A preclinical
humanized mouse model of beta thalassemia major or Coole
75 nt of betaT in the gammabeta(0)/gammabeta(A)
humanized mouse model of betaT.
76 sts of anti-human GITR antibody MK-4166 in a
humanized mouse model of cancer mimicked many of the eff
77 modulator (CAM) GLP-26 in an immunocompetent
humanized mouse model of chronic HBV.
78 Here, using a
humanized mouse model of collagen-induced arthritis, we
79 A novel
humanized mouse model of Cooley's Anemia (CA) was genera
80 Here we describe a
humanized mouse model of COVID-19 that uses adeno-associ
81 We previously developed a
humanized mouse model of DF in which mice transplanted w
82 key features of cortical neurogenesis in the
humanized mouse model of DS (TcMAC21 of undetermined sex
83 on of full-length dystrophin expression in a
humanized mouse model of Duchenne muscular dystrophy (DM
84 ion will likely enhance HCV infection in the
humanized mouse model of HCV infection and replication.
85 We previously generated a
humanized mouse model of HD, Hu97/18, by intercrossing B
86 n mRNA, in patient cells and in a completely
humanized mouse model of HD.
87 To study this reservoir, we established a
humanized mouse model of HIV-1 infection and ART suppres
88 as a long-acting injectable monotherapy in a
humanized mouse model of HIV-1 infection, outperforming
89 When introduced into a
humanized mouse model of HIV-1 infection, these corecept
90 but significant decrease in GAS fitness in a
humanized mouse model of impetigo; the DeltafbaA mutant
91 732394 was shown to be highly effective in a
humanized mouse model of infection.
92 solated from aviremic individuals and in the
humanized mouse model of latency, combining dCA with ant
93 We established a
humanized mouse model of latent HIV infection by transpl
94 In our NOD/Scid IL-2Rgamma(null)
humanized mouse model of leukemia, control shRNA-transdu
95 vitro and suppress disease progression in a
humanized mouse model of lupus nephritis.
96 eir preventive potential was determined in a
humanized mouse model of mugwort pollen allergy.
97 Here, we describe the development of
humanized mouse model of MYC/BCL2-driven 'double-hit' ly
98 Finally, we developed a
humanized mouse model of Pseudomonas aeruginosa pneumoni
99 In a
humanized mouse model of pseudoxanthoma elasticum, we in
100 Using the knock-in
humanized mouse model of SCD and SCD patient blood, we s
101 ere with the development of nephropathy in a
humanized mouse model of SCD.
102 We bred Kcc1(M935K) mutant mice with a
humanized mouse model of sickle cell disease to directly
103 In a
humanized mouse model of sickle cell disease, the captur
104 and promoted rapid health deterioration in a
humanized mouse model of SM.
105 ation of nra leads to loss of virulence in a
humanized mouse model of superficial skin infection.
106 emonstrated in a murine melanoma model and a
humanized mouse model of triple-negative breast cancer,
107 to synergistic control of tumor growth in a
humanized mouse model of triple-negative breast cancer.
108 Using a
humanized mouse model of TSS and human cells, we herein
109 ed protection by IFN-alpha-treated Treg in a
humanized mouse model of xenogeneic graft-versus-host di
110 More important, in a preclinical
humanized mouse model of xenogeneic graft-versus-host di
111 This genetically
humanized mouse model opens new opportunities to dissect
112 Here, we use a
humanized mouse model overexpressing Tcf7l2, resulting i
113 This
humanized mouse model permits in vivo evaluation of immu
114 Thus, this
humanized mouse model permits preclinical testing of vac
115 Our establishment of this extensively
humanized mouse model phenotypically and functionally re
116 f Infectious Diseases summarizes work in the
humanized mouse model presented at an HIV Humanized Mous
117 The use of a
humanized mouse model provides a way of dissecting the r
118 al properties of these cells, we developed a
humanized mouse model reconstituted with human immune ce
119 This
humanized mouse model should be useful for studying immu
120 RT-PCR, lentiviral transduction, and in vivo
humanized mouse model studies demonstrated that malignan
121 or higher primates, we created a new triple-
humanized mouse model substituting human IL-4Ra, IL-4, a
122 s well, eliminating Ag-specific T cells in a
humanized mouse model system.
123 avi-Maharlooei and colleagues describe a new
humanized mouse model that allows direct investigations
124 ll lymphomas in a newly developed cord blood-
humanized mouse model that allows EBV-infected B cells t
125 Here, we describe a
humanized mouse model that can be used to detect latent
126 Here we report a genetically
humanized mouse model that incorporates a luciferase rep
127 mouse models and humans, we developed a new
humanized mouse model that mimics humans in that it lack
128 functional human dendritic cells (DCs) in a
humanized mouse model that mimics the human immune syste
129 Establishment of such a
humanized mouse model that mounts functional human DCs e
130 Here, we describe a
humanized mouse model that recapitulates fibrosis follow
131 Further, myelin internodes in a
humanized mouse model that recapitulates the human trans
132 Here we established a
humanized mouse model that reproduces features of acute
133 We show in a
humanized mouse model that such modified vectors were ab
134 stimulates regression of breast cancers in a
humanized mouse model through a mechanism involving CD4-
135 in vitro In this study, we used a cord blood-
humanized mouse model to compare the phenotypes of an EB
136 Halper-Stromberg et al. use a
humanized mouse model to demonstrate that broadly neutra
137 We developed a novel
humanized mouse model to evaluate in vivo human NK cell-
138 Here, we have used a
humanized mouse model to identify parasite factors impor
139 Here, we utilized a
humanized mouse model to recapitulate the low immunogeni
140 e recently used a newly developed cord blood-
humanized mouse model to show that EBV can cooperate wit
141 We generated a new
humanized mouse model to study HLA-restricted immune res
142 vious in vitro testing, here, we developed a
humanized mouse model to test cHBI efficacy in vivo.
143 er immunotherapy and provide a translational
humanized mouse model to test the lifespan, safety, and
144 The hMB
humanized mouse model underscores the synergy of MYC and
145 A
humanized mouse model was developed using Raji lymphoma
146 ociated with systemic lupus erythematosus, a
humanized mouse model was examined.
147 A
humanized mouse model was used to demonstrate that this
148 a highly sensitive and ecologically relevant
humanized mouse model was used to measure superficial sk
149 Using a
humanized mouse model we demonstrate that this missense
150 r fibrosis, we utilized a recently developed
humanized mouse model with autologous human immune and l
151 We have developed a cytokine-enhanced
humanized mouse model with greatly improved reconstituti
152 u-NSG/alpha-Gal(null) is the first available
humanized mouse model with such features.
153 In a
humanized mouse model, AA homozygous mice were similarly
154 ration and tubulogenesis, (b) in a PPARalpha-
humanized mouse model, activation of the receptor inhibi
155 In a genetically
humanized mouse model, active immunization with sE2 effi
156 to induce B cell lymphomas in the cord blood-
humanized mouse model, although the simultaneous loss of
157 lncRNAs can be successfully examined in the
humanized mouse model, and experimentally validate the p
158 In a
humanized mouse model, HLA-A2-specific CD3epsilon-TRuC T
159 Here we show our
humanized mouse model, huR83C, carrying the pathogenic G
160 In a
humanized mouse model, in vivo delivery of EPIC1-targeti
161 Here, we have used a new
humanized mouse model, in which both human fetal CD34(+)
162 hibits all preeclampsia-like features in the
humanized mouse model, including new-onset proteinuria,
163 roved the immunogenicity of the H7 HA in the
humanized mouse model, leading to a greater than 4-fold
164 Here, we describe a
humanized mouse model, named MaGIC for genes replaced, i
165 In a
humanized mouse model, NOTCH pathway disruption had stro
166 In a
humanized mouse model, ovarian tumors were treated with
167 ntly blocks tryptase enzymatic activity in a
humanized mouse model, reducing IgE-mediated systemic an
168 Ab513 mitigates thrombocytopenia in a
humanized mouse model, resolves vascular leakage, reduce
169 In the
humanized mouse model, T-cell infiltration into the sali
170 n an orthotopic patient-derived glioblastoma
humanized mouse model, the combined treatment with nanop
171 V in vitro and to human B cells in vivo in a
humanized mouse model, thus providing evidence that thes
172 Using a novel
humanized mouse model, we demonstrated that LSEVh-LS-F r
173 Here, using a pregnane X receptor (PXR)-
humanized mouse model, we found that co-treatment with R
174 By using in vitro approaches and a
humanized mouse model, we provide evidence for a causal
175 t irreversibly marks infected cells within a
humanized mouse model, which detects rare latently infec
176 antibody VRC01-N using a highly reproducible
humanized mouse model.
177 ells undergo tolerance, we developed a novel
humanized mouse model.
178 at requires Fcgamma receptor engagement in a
humanized mouse model.
179 rapeutic option in allergic diseases using a
humanized mouse model.
180 ponse and celiac disease-like pathology in a
humanized mouse model.
181 e, we aimed to corroborate our findings in a
humanized mouse model.
182 than HSPCs with lower levels of ARID3a in a
humanized mouse model.
183 munopathogenesis during HIV-1 infection in a
humanized mouse model.
184 thways in humans and co-regulated genes in a
humanized mouse model.
185 habetaT cells both in vitro and in vivo in a
humanized mouse model.
186 orally acquired listeriosis in a gnotobiotic
humanized mouse model.
187 y mediated superior antitumor responses in a
humanized mouse model.
188 te AHR and suppresses lung inflammation in a
humanized mouse model.
189 esulted in superior anti-tumor immunity in a
humanized mouse model.
190 preventing anaphylaxis is demonstrated in a
humanized mouse model.
191 tro and resulted in more severe disease in a
humanized mouse model.
192 effectively detects human immune cells in a
humanized mouse model.
193 gical patient-derived xenograft TNBC-bearing
humanized mouse model.
194 s in coculture system, 3D organoid model and
humanized mouse model.
195 drug pembrolizumab, a PD-1 inhibitor, in the
humanized mouse model.
196 ts less toxicity than anti-human CTLA-4 in a
humanized mouse model.
197 n fetal trophoblast cells, leads to FGR in a
humanized mouse model.
198 n marker expression were smaller than in the
humanized mouse model.
199 ting significant hematopoietic toxicity in a
humanized mouse model.
200 inistration, and HIV infection using the NSG
humanized mouse model.
201 pture and neutralize HIV-1 in vitro and in a
humanized mouse model.
202 activation, and allograft vasculopathy in a
humanized mouse model.
203 is in a hematopoietic stem cell-transplanted
humanized mouse model.
204 nt receptor expression and localization in a
humanized mouse model.
205 strains using immunoinformatics tools and a
humanized mouse model.
206 y image human immune responses in a relevant
humanized mouse model.
207 ction against HCV infection in a genetically
humanized mouse model.
208 a formation elicited by vascular injury in a
humanized mouse model.
209 Additionally, we employed a chimeric "
humanized" mouse model of HCV infection to demonstrate f
210 The '
humanized' mouse model enables strict comparison of the
211 In this study, we take advantage of a
humanized-mouse model to probe the contribution of APOBE
212 Humanized mouse models also continue to play their part.
213 SPA70 inhibits hPXR in human hepatocytes and
humanized mouse models and enhances the chemosensitivity
214 important step forward in the development of
humanized mouse models and particularly for the analysis
215 Humanized mouse models are based on the engraftment of h
216 These
humanized mouse models are becoming increasingly importa
217 Humanized mouse models are useful tools to understand pa
218 However, wild-type mice and all existing
humanized mouse models cannot be used to test the effica
219 However, existing
humanized mouse models cannot support development of hum
220 ts associated with non-human primate models,
humanized mouse models containing chimeric human livers
221 Here, we describe the major
humanized mouse models currently in use, and some recent
222 Host & Microbe, McHugh et al. (2017) develop
humanized mouse models for EBV/KSHV co-infection and ide
223 arvard Center for AIDS Research symposium on
humanized mouse models for HIV vaccine design.
224 d Infectious Diseases convened a workshop on
humanized mouse models for immunity in Bethesda, MD, on
225 ults offer a proof of concept for the use of
humanized mouse models for surrogate efficacy and histol
226 Humanized mouse models have become increasingly importan
227 Although
humanized mouse models have been developed by transplant
228 Various
humanized mouse models have been developed in efforts to
229 Improvements in
humanized mouse models have made them the preferred smal
230 Humanized mouse models have, over the past few years, se
231 nally, our findings highlight the utility of
humanized mouse models in interrogating therapeutic appr
232 The low efficiency of HCV replication in the
humanized mouse models is likely due to either the lack
233 A major limitation of current
humanized mouse models is that they primarily enable the
234 A major limitation with current
humanized mouse models is the development of graft-versu
235 ajor technological limitation of all current
humanized mouse models is the lack of mature and functio
236 Humanized mouse models lack adaptive immune responses bu
237 nt of CD19 CAR-T cells in both syngeneic and
humanized mouse models of B-acute lymphoblastic leukaemi
238 In conclusion, both porcinized and
humanized mouse models of heterotopic subcutaneous bronc
239 This Review summarizes the contribution that
humanized mouse models of HIV infection have made to the
240 Thus
humanized mouse models of HIV vaginal infection will all
241 ogeny, and it exhibits antiviral activity in
humanized mouse models of infection.
242 lly, the drug inhibited viral replication in
humanized mouse models of Rag2(-/-)gammac(-/-) with no t
243 immune-dependent responses in syngeneic and
humanized mouse models of telomerase-expressing cancers.
244 ceptor pathway to facilitate construction of
humanized mouse models on non-NOD genetic backgrounds.
245 In addition, we will discuss how
humanized mouse models such as the human skin xenograft
246 Clinical genetics and
humanized mouse models suggest that inhibiting CETP may
247 the basis for creating increasingly complex
humanized mouse models that could prove useful for study
248 We used
humanized mouse models to assess the infectivity of both
249 The new
humanized mouse models with a transplanted human immune
250 The improvement of
humanized mouse models with robust human immune cell rec
251 In
humanized mouse models, AL008 induced internalization of
252 the gut and colonic inflammation in vivo in
humanized mouse models, and altered effector T cells in
253 In
humanized mouse models, ApoC3 activated human monocytes
254 In
humanized mouse models, CAR-Ms were further shown to ind
255 human transgenes and additional mutations in
humanized mouse models, have expanded our opportunities
256 Recent advances in
humanized mouse models, in particular the humanized bone
257 nonhuman primates (NHPs), and HIV-1-infected
humanized mouse models, passive transfer studies in infa
258 Of the two current leading
humanized mouse models, the hu-HSC model is created by h
259 In
humanized mouse models, this CD161 mAb enhanced T-cell-m
260 Using several relevant
humanized mouse models, we demonstrate that TCR-transduc
261 enotypic and multi-omics data as well as two
humanized mouse models, we demonstrate the causal roles
262 Using PXR-
humanized mouse models, we recapitulated the RTV hepatot
263 Using both human and
humanized mouse models, we report that hyperglycemia-ind
264 ve Abs when those cells were introduced into
humanized mouse models.
265 mes using a panel of knockout and transgenic
humanized mouse models.
266 uct NRG or NSG mutant mice to facilitate new
humanized mouse models.
267 now confirmed the findings from the cat and
humanized mouse models.
268 er of limitations in the currently available
humanized mouse models.
269 ered insights into the development of future
humanized mouse models.
270 s, and this growth pattern was reproduced in
humanized mouse models.
271 inhibited the growth of human ccRCC in hPBMC-
humanized mouse models.
272 ary human hematopoietic progenitor cells and
humanized mouse models.
273 HIV infection comparably to well-established
humanized mouse models.
274 ent and function of NK cells in conventional
humanized mouse models.
275 obulin, prevented porcine islet rejection in
humanized mouse models.
276 ected, we used 3 different but complementary
humanized mouse models.
277 wn can control rejection of human tissues in
humanized mouse models.
278 In an effort to improve HLA-"
humanized" mouse models for type 1 diabetes (T1D) therap
279 dy has not only provided direct evidence in "
humanized" mouse models that soluble and membrane-restri
280 issue in NOD hosts during the generation of "
humanized" mouse models.
281 , we discuss recent efforts to generate new '
humanized' mouse models to better model human telomere b
282 Recently, several studies suggested that
humanized mouse or transgenic mouse expressing key HCV h
283 lls were assayed from both participants in a
humanized mouse outgrowth assay.
284 rum CSP inhibited liver-stage infection in a
humanized mouse/
P. falciparum challenge model.
285 Most significantly, when tested in
humanized mouse primary hepatocytes, TA inhibits hLRH-1
286 amma chain knockout-bone marrow-liver-thymus
humanized mouse provides a unique model for studying the
287 This "
humanized" mouse represents a potentially important mode
288 Compared with
humanized mouse results, we found transcriptionally simi
289 Thus, the
humanized mouse strain can be used to study the role of
290 as in virus infection models using FcgammaR
humanized mouse strains.
291 Humanized mouse studies determined the effective TAF dos
292 We have used a chimeric
humanized mouse system to model this arteriopathy in hum
293 Using a clinically relevant chimeric
humanized mouse system, we transplanted mice with human
294 osclerosis in a clinically relevant chimeric
humanized mouse system.
295 gen interphase has led to the development of
humanized mouse systems.
296 el small animal model of co-infection in the
humanized mouse to investigate how HIV infection disrupt
297 vitro colony formation and in vivo adoptive
humanized mouse transfers, indicate that eNePs are the e
298 In
humanized mouse tumor models, NC410 reduces tumor growth
299 of BA activation of MRGPRX4, we generated a
humanized mouse with targeted expression of MRGPRX4 in i
300 he humanized mouse model presented at an HIV
Humanized Mouse workshop in Boston, Massachusetts, in No