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1 drug delivery vehicles through the vitreous humor.
2 iably high ESBA105 concentrations in aqueous humor.
3 ance of nutritional support from the aqueous humor.
4 tration and protein concentration in aqueous humor.
5 olite concentrations in aqueous and vitreous humor.
6 n D(3) were detected in aqueous and vitreous humor.
7 are difficult to determine in human vitreous humor.
8 lony-forming units per milliliter of aqueous humor.
9 c polymerase chain reaction (PCR) in aqueous humor.
10 ansforming growth factor-beta in the aqueous humor.
11 echanical properties of the natural vitreous humor.
12 e critical for the production of the aqueous humor.
13 ated and wild-type myocilin into the aqueous humor.
14 and sufficient for up-regulation by vitreous humor.
15 LM are the peripheral retina and/or vitreous humor.
16 duced pressure-dependent drainage of aqueous humor.
17 ls that separate the cornea from the aqueous humor.
18 vobiocin (0.1 mM) was present in the aqueous humor.
19 d leukocytes within the aqueous and vitreous humors.
20 (64 days), amniotic fluid (38 days), aqueous humor (101 days), cerebrospinal fluid (9 months), breast
21 eyes was not different for both the vitreous humor (13,600 vs. 15,000 ng/day/mL; P = 0.73) and retina
22 re ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after
24 isms were found to predict time to recovery: humor, acting out, emotional hypochondriasis, and projec
25 studies conducted with adults indicate that humor activates specific brain regions, including the te
26 ccumbens in younger participants, indicating humor activation intensity changes during development.
27 ion of regulatory T cells (Tregs) by aqueous humor (AH) and identified TGF-beta as a critical factor.
28 TGFbeta(2)) is often elevated in the aqueous humor (AH) and trabecular meshwork (TM) of patients with
31 concentration of ANGPTL7 protein in aqueous humor (AH) from patients with glaucoma and control patie
32 enzyme-linked immunosorbent assay in aqueous humor (AH) obtained from human donor eyes (POAG and norm
34 of MRP4 in human TM (HTM) cells and aqueous humor (AH) outflow pathway was determined by RT-PCR, imm
35 arising from increased resistance to aqueous humor (AH) outflow through the trabecular meshwork is a
36 The effects of neuromedin U (NMU) on aqueous humor (AH) outflow were determined in enucleated porcine
37 s from the resistance to drainage of aqueous humor (AH) produced by the ciliary body in a process req
40 uveitis patients, positive for RV in aqueous humor analysis (polymerase chain reaction [PCR] and/or G
42 leukin (IL)-6 and IL-8 levels in the aqueous humor and a concomitant approximately twofold (P < 0.001
43 secretion of mutant myocilin in the aqueous humor and by decreasing intracellular accumulation of my
44 pears to antagonize the formation of aqueous humor and cause an inhibition of both F(c) and F(u), des
45 NF-alpha, CCL-2/MCP-1, and ICAM-1 in aqueous humor and CCL-2/MCP-1 and ICAM-1 levels in retina were s
48 te via soluble agents present in the aqueous humor and implicate Best2 as a critical mediator of that
49 d on elevated levels in glaucomatous aqueous humor and its ability to induce extracellular matrix (EC
50 ular adhesion molecule-1 (ICAM-1) in aqueous humor and retina and nuclear translocation of nuclear fa
51 ncentrations were determined in the vitreous humor and retina for 31 days (on days 2, 8, 15, 22, and
52 and drug content quantified in the vitreous humor and retina-choroid tissue by high-performance liqu
53 between levels of IL-6 and MMP-2 in aqueous humor and the axial lengths of the eye globes (IL-6, bet
54 ug levels were observed in both the vitreous humor and the retina-choroid even on day 21 after diclof
55 form (hDE-117) was maintained in the aqueous humor and the target tissue (iris-ciliary body) up to 24
56 ulate pressure-dependent drainage of aqueous humor and thus intraocular pressure (IOP) are unknown.
58 and comparing myocilin levels in the aqueous humor and trabecular meshwork of Tg-MYOC(Y437H) mice.
60 , a single dose of DPT-GFX sustained aqueous humor and vitreous humor drug levels during the 24-hour
61 ygen species (ROS) production in the aqueous humor, and caused greater CE cell loss, including loss o
62 re capable of protecting the cornea, aqueous humor, and crystalline lens of rabbits from UV-induced p
65 roughout the eye, including cornea, vitreous humor, and retina, suggesting a coordinated protective r
66 liver, spleen, kidney, brain, lung, vitreous humor, and vena cava in comparison to untreated controls
67 r anterior segment of human eyes and aqueous humor antioxidant levels of ascorbate (AsA) and total re
68 munosuppressive molecules within the aqueous humor (AqH) are thought to preserve ocular immune privil
70 aracterized the metabolic profile of aqueous humor (AqH) of patients with HLA-B27-associated AAU (B27
71 ed when the disease was at its peak; aqueous humor (AqH) was collected from one eye, and the other ey
72 LPS injection, eyes were enucleated, aqueous humor (AqH) was collected, and the number of infiltratin
76 in which secretion and absorption of aqueous humor are circumferential around and through the iridoco
77 e of psychosocial factors such as the use of humor as a coping style and the level of health care pro
79 soactive peptide that is elevated in aqueous humor as well as circulation of primary open angle glauc
82 giogenic factors upregulated in PDR vitreous humor besides VEGF, thus inhibiting their biological act
84 scularized structure located in the vitreous humor between the posterior surface of the lens and neur
85 t myocilin was not secreted into the aqueous humor but accumulated in the ER of the trabecular meshwo
88 d therapeutic drug concentrations in aqueous humor can be achieved for long-term (i.e., 28 days) prot
90 ter efficacy with significantly less aqueous humor cells and lower vitreous opacity scores (p<0.05).
94 factor (VEGF) concentrations in the aqueous humor decreased (P = 0.0003), whereas the concentrations
96 er treatment with IFN-gamma, porcine aqueous humor, dexamethasone, or a calcium ionophore in cells pr
98 cal diseases including muscle, membrane, and humor disorders; optic nerve damage; and eyelid affectio
102 the result of abnormal resistance to aqueous humor drainage is a major contributing, and the only pre
103 cular pressure (IOP) due to impaired aqueous humor drainage is a major risk factor for the developmen
104 nterior chamber angle containing the aqueous humor drainage tissue in situ were imaged by TPEF to loc
105 acterized by increased resistance to aqueous humor drainage, elevated IOP, optic nerve degeneration a
107 DPT-GFX sustained aqueous humor and vitreous humor drug levels during the 24-hour study, with a t(1/2
108 -alpha is elevated in the cornea and aqueous humor during allograft rejection and anterior uveitis.
113 he correlation between parameters of aqueous humor dynamics and the influence of CCT in healthy volun
117 he tissues and cells specialized for aqueous humor dynamics in zebrafish show conservation with that
119 near correlations between individual aqueous humor dynamics parameters and pachymetry were evaluated
122 eir glaucoma medication before their aqueous humor dynamics study measurements at baseline and the 3-
123 ensive ophthalmic examination before aqueous humor dynamics study measurements, including fluorophoto
124 The interplay between parameters of aqueous humor dynamics suggests possible autoregulatory mechanis
126 molecular and cellular mechanisms of aqueous humor dynamics using this species, the authors have char
129 s having a mechanoregulatory role in aqueous humor dynamics, with eNOS induction at elevated IOPs lea
130 clude fibrillar degeneration of the vitreous humor, early-onset cataract, minute crystalline deposits
131 o humor, suggesting these regions may form a humor-essential neural network already present in childh
132 ide (NO) increases the rate at which aqueous humor exits the eye; however, the involvement of soluble
140 evaluated the effect of timolol, an aqueous humor flow suppressant, on outflow facility in healthy e
142 phenomenon may be related to reduced aqueous humor flow, but the precise mechanism remains to be dete
143 lar meshwork (TM) cells might detect aqueous humor fluid shear stress via interaction of the extracel
144 eye, particularly in the drainage of aqueous humor fluid, which are believed to bring about changes i
146 DEX was detected in the retina and vitreous humor for 6 months, with peak concentrations during the
150 ork (TM) tissue controls drainage of aqueous humor from the anterior chamber of the eye primarily by
152 e in the eye that functions to drain aqueous humor from the intraocular chamber into systemic circula
153 tify the effect of dynamic motion of aqueous humor from the posterior to the anterior chamber, and (3
157 in the primary drainage pathway for aqueous humor in the eye is responsible for ocular hypertension,
158 The principal outflow pathway for aqueous humor in the human eye is through the trabecular meshwor
163 heir apical surface, in contact with aqueous humor is hexagonal, whereas their basal surface is irreg
165 owth factor-beta2 (TGF-beta2) in the aqueous humor is the main cause of fibrosis of TM in POAG patien
166 ncentrations in intraocular tissues (aqueous humor, lens, and iris) versus eyes not receiving Y-27632
167 ts with AMD had significantly higher aqueous humor levels of cadmium (median: 0.70 micromol/L, IQR: 0
168 ificant differences were observed in aqueous humor levels of manganese and selenium between patients
169 MMC to the endothelium and into the aqueous humor may lead surgeons to reassess appropriate dosing a
170 When cultured in media containing aqueous humor, MYOC-associated exosomes increased 514% over cont
171 underwent aqueous humor (n = 5) or vitreous humor (n = 2) analysis and cerebrospinal fluid analysis
172 ssified uveitis, 7 of whom underwent aqueous humor (n = 5) or vitreous humor (n = 2) analysis and cer
173 respiratory samples, biopsies, and vitreous humor) obtained longitudinally or from different anatomi
175 Here, we provide evidence in both vitreous humor of diabetic patients and in retina of a murine mod
176 of the innate immune system, in the aqueous humor of patients undergoing repeat DMEK for graft failu
177 g 16 clinical samples collected from aqueous humor of patients undergoing therapeutic anterior chambe
178 e the cytokine concentrations in the aqueous humor of patients with acute nonarteritic anterior ische
181 free metalloproteinases (MMP) in the aqueous humor of patients with primary open angle glaucoma (POAG
182 ase family that are increased in the aqueous humor of POAG arising from a variety of conditions, it i
186 boxyfluorescein elimination from the aqueous humor of the perfused eye was reduced 80% when novobioci
188 that direct the movement of fluid (vitreous humor or cerebrospinal fluid) into and under the retina.
189 been proposed to underlie increased aqueous humor outflow (AHO) resistance, which leads to elevated
190 acterized by increased resistance to aqueous humor outflow and a stiffer human trabecular meshwork (H
192 e eye, plays a key role in promoting aqueous humor outflow and maintenance of normal intraocular pres
193 that offer the potential to improve aqueous humor outflow and protect RGCs simultaneously, and prese
194 th a reduction in available area for aqueous humor outflow and the confinement of outflow to the vici
196 cked both PEA-induced enhancement of aqueous humor outflow facility and PEA-induced phosphorylation o
197 the administration of AEA increases aqueous humor outflow facility and that this effect of AEA invol
201 gnificantly reduced IOP and improved aqueous humor outflow facility, which was sustained for at least
205 icacious in both, increasing ex vivo aqueous humor outflow in porcine eyes and inhibiting myosin ligh
207 nt regulator of TEK signaling in the aqueous humor outflow pathway and identify a new therapeutic tar
208 or alterations in morphology of the aqueous humor outflow pathway were observed after treatment with
209 able targets within the conventional aqueous humor outflow pathway, which is thought to be regulated/
210 nization is required to maintain the aqueous humor outflow resistance and intraocular pressure homeos
211 cular meshwork (TM) provides most of aqueous humor outflow resistance in the eye, an in vitro bioengi
212 ersican's potential contributions to aqueous humor outflow resistance, its segmental distribution in
214 PCG, defects in the anterior chamber aqueous humor outflow structures of the eye result in elevated i
215 e performed 3D SD-OCT imaging of the aqueous humor outflow structures with 2 devices: The Cirrus HD-O
216 caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the t
217 surgeries reduce IOP by facilitating aqueous humor outflow through a vent fashioned from the wall of
218 sults demonstrate that PEA increases aqueous humor outflow through the TM pathway and these effects a
219 ssure due to increased resistance of aqueous humor outflow through the trabecular meshwork (TM).
220 r pressure (IOP) due to insufficient aqueous humor outflow through the trabecular meshwork and Schlem
221 able inner core designed to modulate aqueous humor outflow to provide immediate IOP reduction, preven
224 he aqueous outflow pathway increases aqueous humor outflow, possibly through altered cell adhesive in
231 e changes and changes in the rate of aqueous humor outflow; agents that decrease trabecular meshwork
232 cells may also provide resistance to aqueous humor outflow; therefore, this study tests the involveme
234 To study the value and safety of aqueous humor polymerase chain reaction (PCR) analysis for Herpe
236 ial link in studying the neurodevelopment of humor processing across the lifespan, our findings contr
237 bilateral TOPJ activation may be specific to humor processing and not part of a general constellation
238 onventional outflow facility (C(t)), aqueous humor production (F(a)), and anterior chamber volume (V(
239 mouse eye results in a reduction in aqueous humor production and complete loss of the vitreous chamb
240 stent with a major role of alpha2 in aqueous humor production and suggests that, potentially, alpha2-
242 he effect of medications that reduce aqueous humor production on outflow facility in living human eye
246 luorescence or ELISA in homogenized vitreous humor, reflecting the greater spatial resolution of in s
247 s study and pazopanib levels in the vitreous humor, retina, and choroid-RPE at the end of the study w
251 t protein 1 (MCP-1) was reported in vitreous humor samples of patients with RD and diabetic retinopat
252 ines, and correlate levels with IOP, aqueous humor samples were analyzed from 23 eyes with open angle
256 echanisms: CA inhibition to decrease aqueous humor secretion (reduce inflow) and NO release to increa
257 lar anterior segment responsible for aqueous humor secretion and absorption have been well characteri
258 d to identify and study the sites of aqueous humor secretion and absorption in adult zebrafish eyes.
259 is controlled by the balance between aqueous humor secretion from the ciliary body (CB) and its drain
261 l culture from blood, saliva, urine, aqueous humor, semen, and breast milk from infected or convalesc
262 or novobiocin (0.1 mM) added to the aqueous humor side of the tissue, or MK571 (5-(3-(2-(7-chloroqui
263 ion detected parasite DNA in 8/60 OT aqueous humor specimens but failed to identify Type II strain al
268 , IL-1beta released by PMNs into the aqueous humor stimulates FGF-2 synthesis in corneal endothelium
270 alcium ionophore, and a component of aqueous humor, suggesting that TM cells respond to environmental
271 olimbic activation in children's response to humor, suggesting these regions may form a humor-essenti
272 was diminished in cells treated with aqueous humor that was first passed through a 3-kDa or a 30-kDa,
273 ntraocular environment (aqueous and vitreous humors), the capsular tissue, and the intraocular lens (
274 ian eye is responsible for secreting aqueous humor to maintain intraocular pressure, which is elevate
275 e Ussing chambers was greater in the aqueous humor-to-blood direction than in the blood-to-aqueous hu
278 oscleral outflow (F(u)), and rate of aqueous humor turnover, were calculated from measured data.
279 o significant difference in baseline aqueous humor VEGF concentration was noted, while at the 2-month
281 a recognition and quantification of vitreous humor (VH) cystine as well as provide the portability fo
282 90DeltatarO were cultured in bovine vitreous humor (VH) in vitro or inoculated into the vitreous cham
284 mized versus vitrectomized eyes for vitreous humor was 791 ng/mL (day 22) versus 731 ng/mL (day 22),
286 g, and IL-1beta concentration in the aqueous humor was elevated in a time-dependent manner after free
287 nd caspase-3 ELISA; ascorbate in the aqueous humor was evaluated by nuclear magnetic resonance spectr
288 eaction (PCR) testing of aqueous or vitreous humor was positive for herpes simplex virus (HSV) or var
290 n the iridocorneal angle tissues and aqueous humor was studied by immunohistochemistry and Western bl
292 0) and 47,200 ng . d/g, and for the vitreous humor were 213 ng/mL (day 60) and 11,300 ng . d/mL, resp
295 average, VEGF concentrations in the aqueous humor were suppressed below the lower limit of quantific
299 jection of fluorescein targeted the vitreous humor with no significant selectivity for posterior vers
300 m between production and drainage of aqueous humor, with compromised drainage generally viewed as the