ライフサイエンスコーパス: humoral

1 How these cellular and humoral actors interact is unclear, but peripheral DSA m

2 nction as an effector arm of vaccine-induced humoral adaptive antibacterial immunity.

3 and reveals essential molecular programs of humoral adaptive immunity.

4 ll-mediated rejection, the importance of the humoral alloimmune response has progressively emerged.

5 otential to result in improved inhibition of humoral alloimmunity.

6 hat shall be followed to evaluate and manage humoral alloreactivity in VCA recipients.

7 CTLA-4 blockade enhanced the humoral alloresponse and, in combination with anti-CD28

8 gorously augmented influenza vaccine-induced humoral and CD8(+) T cell immune responses in mice by si

9 Glycoprotein E (gE)-specific humoral and cell-mediated immune (CMI) responses and the

10 Persistence of humoral and cell-mediated immune (CMI) responses to 2 in

11 of ChAd-SARS-CoV-2-S induces robust systemic humoral and cell-mediated immune responses and protects

12 -2 have suggested a protective role for both humoral and cell-mediated immune responses in recovery f

13 skewed T cell responses can drive protective humoral and cell-mediated immune responses(2) and might

14 to enhance immune cross-protection, improve humoral and cell-mediated immunity, and promote antigen

15 ritical for the induction and maintenance of humoral and cell-mediated immunity.

16 is immunogenic in mice and elicites a robust humoral and cell-mediated response.

17 cally, HP is characterized by an exaggerated humoral and cellular immune response affecting the small

18 or a prime-boost regimen) induced a balanced humoral and cellular immune response of type-1 and type-

19 6) and homologous Ad26,Ad26 regimens induced humoral and cellular immune responses 21 days post-dose

20 ptable safety profile and elicited sustained humoral and cellular immune responses after a single imm

21 el bivalent Ebola VLP vaccine elicits strong humoral and cellular immune responses against pathogenic

22 vely, the results from this study reveal the humoral and cellular immune responses and the protective

23 icacy may benefit from the induction of both humoral and cellular immune responses of maximal breadth

24 as evidenced by robust induction of adaptive humoral and cellular immune responses postvaccination an

25 The presence of humoral and cellular immune responses to ASP in HIV-1 pa

26 ndividuals exposed to sand fly bites develop humoral and cellular immune responses to sand fly saliva

27 discuss what is currently known about human humoral and cellular immune responses to severe acute re

28 ChAd155-RSV generated increases in specific humoral and cellular immune responses without raising si

29 ds in the upper and lower respiratory tract, humoral and cellular immune responses, and pathologic ev

30 Vaccinated animals developed humoral and cellular immune responses, including neutral

31 s develop robust SARS-CoV-2 antigen-specific humoral and cellular immune responses, including potent

32 results, together with the induction of both humoral and cellular immune responses, support large-sca

33 aining an EBOV insert induce strong, durable humoral and cellular immune responses.

34 group developed strong mucosal and systemic humoral and cellular immunity but did not exhibit delaye

35 However, the importance of humoral and cellular immunity for protection against inf

36 une cells to initiate and maintain effective humoral and cellular immunity.

37 of this report were to assess the safety and humoral and cellular immunogenicity of a single-dose and

38 Now we describe safety and exploratory humoral and cellular immunogenicity of the vaccine, from

39 myeloma (MM) is currently being redefined by humoral and cellular immunotherapies.

40 TEMRA CD8(+) T cells play a pivotal role in humoral and cellular rejection and reveal the potential

41 ne adjuvants enhance the vaccine Ag-specific humoral and cellular responses and induce homing to the

42 Here we further investigated the humoral and cellular responses to Tp0126 during experime

43 AC-HIV vector could increase both protective humoral and cellular responses.

44 diococcus pentosaceus suppressed Ag-specific humoral and cellular responses.

45 NP formulations and the iLNPs induced strong humoral and cellular-mediated immune responses in mice t

46 ially able to elicit strong antigen-specific humoral and cellular-mediated immune responses to virtua

47 Strong anamnestic humoral and CMI responses were elicited by 1 additional

48 Ten years post-initial vaccination, humoral and CMI responses were ~6-fold and ~3.5-fold abo

49 hrough the fecal-oral route, we investigated humoral and mucosal (salivary immunoglobulin A [IgA]) im

50 s by testing the hypothesis that preexisting humoral and mucosal immunity may influence viral recover

51 RZV induced strong humoral and polyfunctional CMI responses that persisted

52 ing to lower rates of CMV disease and robust humoral and T-cell responses.

53 Collectively, defining the humoral antibody functions induced by distinct adjuvants

54 production in heart tissue, and TnI-directed humoral autoimmune responses, was also present in 2 case

55 Inducing humoral, cellular and mucosal immunity is likely to impr

56 otypes are potentially protective within the humoral compartment.

57 A responses occur in an increasingly complex humoral defence network that also encompasses IgM, IgG a

58 ld), meningitis (up to 5.3-fold), as well as humoral deficiency (up to 17.6-fold) and autoimmune cyto

59 lantation, or rituximab, except for IRRs for humoral deficiency, which were consistently higher after

60 sease but may be responsible for a secondary humoral deficiency.

61 Fc effector activity, pointing to deficient humoral development rather than disease-enhancing humora

62 dothelium, in vitro experiments implicated a humoral factor in the anti-inflammatory effects generate

63 Klotho), carrying glycosidase activity, is a humoral factor that regulates renal health.

64 Parabiosis experiments testing whether humoral factors from one animal affect the other have be

65 fic brain circuits, the role of cellular and humoral factors of the immune system, the gut microbiota

66 il and basophil granulocytes, mast cells and humoral factors such as IgE are key drivers of allergic

67 esthesia depends on inhibition of release of humoral factors.

68 assessment of allergen-specific cellular and humoral IgG1(+) immunity may help to identify individual

69 lammatory cytokines, chemokines and specific humoral IgM and IgG responses.

70 This argues for a novel humoral immune escape mechanism that may also have impor

71 These results delineate the key humoral immune events that follow primary and recurrent

72 n vaccines that can selectively leverage the humoral immune functions, beyond binding and neutralizat

73 -6(+) T(FH) cell generation and dysregulated humoral immune induction early in COVID-19 disease, prov

74 Female humoral immune measures were unaffected, indicating that

75 The reduction in humoral immune memory after measles infection generates

76 te clearance and the formation of protective humoral immune memory responses.

77 properties, and mediate distinct aspects of humoral immune memory.

78 Humoral immune protection against influenza virus infect

79 orally administered to mice and generated a humoral immune response against both peptide antigen, an

80 TCD colonization is associated with a humoral immune response against toxins A and B, with evi

81 To understand the humoral immune response elicited upon natural infections

82 ays, despite the development of an effective humoral immune response following symptomatic primary in

83 it is glycosylated, does not induce a strong humoral immune response in mice, and does not activate A

84 We determined and compared the humoral immune response in patients with severe (hospita

85 ted that PvCSP-VK210 was the major target of humoral immune response in studied population, presentin

86 et the relationship between severity and the humoral immune response is poorly understood.

87 We compared humoral immune response kinetics in a panel study of sub

88 on and the extensive and variable breadth of humoral immune response observed in the volunteers at ba

89 The humoral immune response plays an important role in the c

90 The humoral immune response provides specific, long-lived pr

91 ve TcdB, very little is known about the host humoral immune response to C. difficile and TcdB during

92 known about the nature and durability of the humoral immune response to infection with severe acute r

93 Molecular determinants of human humoral immune response to N9 neuraminidase (NA) protein

94 The primary humoral immune response to natural infection is neutrali

95 We also detected and quantitated the humoral immune response to NiV by virus-specific immunog

96 ing that immunodominance plays a role in the humoral immune response to NoV infections.

97 Our results indicate that the humoral immune response to SHIV infection develops with

98 ere, we show that TBL1XR1 mutations skew the humoral immune response toward generating abnormal immat

99 We monitored the humoral immune response under natural pollen exposure to

100 26 potential convalescent plasma donors, the humoral immune response was evaluated using a severe acu

101 nt is focused on the principal target of the humoral immune response, the spike (S) glycoprotein, whi

102 on the principal target of the neutralizing humoral immune response, the spike (S) glycoprotein.

103 ted antibacterial effector functions and the humoral immune response.

104 ffects on virus replication and the adaptive humoral immune response.

105 d virus as the vaccine is complicated by the humoral immune response.

106 virus on viral replication and the adaptive humoral immune response.IMPORTANCE Using computer algori

107 lerability profile and induced rapid, robust humoral immune responses after 1 intramuscular dose of v

108 ide high-resolution molecular information on humoral immune responses after HuNoV vaccination and dem

109 Although studies analyzing humoral immune responses against SARS-CoV-2 were availab

110 anscription factor T-bet are associated with humoral immune responses and autoimmunity.

111 losteric inhibition in preclinical models of humoral immune responses and B-cell lymphomas.

112 ved the gastrointestinal conditions, induced humoral immune responses and drived protection against p

113 Humoral immune responses at mucosal surfaces have histor

114 Humoral immune responses attack different parasite stage

115 elp to support germinal center reactions and humoral immune responses by antigen-specific wild-type B

116 these vaccination regimens and cellular and humoral immune responses compared between the RV144 seri

117 In this study, humoral immune responses in CHIKV-infected patients and

118 r findings provide a better understanding of humoral immune responses in human cancer and suggest tha

119 e evaluated the generation of virus-specific humoral immune responses in infant (n = 6) and adult (n

120 nnate immune responses and downregulation of humoral immune responses in lymphoid tissues were confir

121 immune disease and PD, impaired cellular and humoral immune responses in PD, imaging evidence of infl

122 for protective immunity, namely, V2-specific humoral immune responses inversely correlating with HIV

123 r inhibitory activities against cellular and humoral immune responses of S. exigua.

124 es more potent antigen-specific cellular and humoral immune responses than those elicited by traditio

125 This approach enables humoral immune responses that may be difficult to elicit

126 They orchestrate humoral immune responses that modulate activities of oth

127 to mount cross-reactive and cross-protective humoral immune responses to antigens from the most preva

128 In this Review, we compare the adaptive humoral immune responses to human immunodeficiency virus

129 Humoral immune responses to influenza virus vaccines in

130 We analyzed humoral immune responses to nonhuman leukocyte antigen (

131 imeric V1V2 scaffold alters the hierarchy of humoral immune responses to V2 region epitopes, providin

132 ation before patients have mounted their own humoral immune responses(2,3).

133 macaques with bivalent VLPs generated strong humoral immune responses, including high titers of bindi

134 Th2 helper cells that mediate cell-based and humoral immune responses, respectively.

135 c in eliciting glycan-dependent cellular and humoral immune responses.

136 ulting in severe graft fibrosis and aberrant humoral immune responses.

137 er, hypoxia elicited changes in cellular and humoral immune responses.

138 ce as a potential strategy for strengthening humoral immune responses.

139 distinct complement of adaptive cellular and humoral immune responses.

140 tion, nutrient dynamics, gene expression, or humoral immune responses.

141 roteins, and initiation of wound healing and humoral immune responses.

142 on safety, reactogenicity, and cellular and humoral immune responses.

143 high efficacy and potency to help Env trimer humoral immune responses.

144 lopment of assays capable of detecting early humoral immune responses.Recent advances in understandin

145 The role of the humoral immune system in vaccine-induced protection is w

146 ems likely that selective pressures from the humoral immune system were responsible for driving the h

147 The generation of protective humoral immunity after vaccination relies on the product

148 way serves as a key node in the induction of humoral immunity against AAV serotypes.

149 the development of long-lived and effective humoral immunity against Plasmodium takes many years and

150 However, our knowledge of pre-existing humoral immunity against various AAV serotypes in cats i

151 Notably, only humoral immunity and activated B cell frequency in the a

152 ibutions of donor and recipient to antiviral humoral immunity and evaluate longitudinal changes.

153 l activation, germinal center reactions, and humoral immunity and how impaired responses to, or produ

154 a TFR cell effector molecule that regulates humoral immunity and limits systemic autoimmunity.

155 of allergic sensitization, the generation of humoral immunity and memory remains to be elucidated.

156 We performed a comprehensive evaluation of humoral immunity and secondary lymphoid tissues in an es

157 offer some protection, due to cross-reactive humoral immunity and T cell immunity between common coro

158 tion and selection to both provide effective humoral immunity and to protect against genomic instabil

159 cell responses in vivo However, the role of humoral immunity and viral modulation of anti-CMV antibo

160 Pre-existing humoral immunity can impact immune responses to heterolo

161 Humoral immunity depends on efficient activation of B ce

162 ow and blood, perhaps as a means to optimize humoral immunity during diurnal periods of activity.

163 clones remained as important contributors to humoral immunity following their initial establishment d

164 ng rise to novel viruses that can escape the humoral immunity generated by current influenza virus va

165 Driving robust humoral immunity has been a challenge given preexisting,

166 a tool to distinguish the differences in HIV humoral immunity in infants versus adults.

167 rized the molecular features of the elicited humoral immunity in mice.

168 e clearance of B. burgdorferi is mediated by humoral immunity in NZW rabbits, the previously reported

169 ell defects, and induced robust cellular and humoral immunity in the periphery.

170 Cs and elicitation of prolonged Env-specific humoral immunity in the rectal mucosa.

171 r specific contribution to the regulation of humoral immunity in the spleen.

172 T cell help in humoral immunity includes interactions of B cells with a

173 Humoral immunity is an essential component of the protec

174 Humoral immunity is complemented by a cellular immune re

175 The establishment of protective humoral immunity is dependent on the ability of mature B

176 sistently infect humans, but how HCMV avoids humoral immunity is not clear.

177 or B-T-cell interactions because the loss of humoral immunity leads to a smaller but less stable plaq

178 Such cross-reactive humoral immunity may provide vital first-line defense ag

179 ew exceptions, the development of protective humoral immunity of more than a year is the norm.

180 lts highlight the importance of neutralizing humoral immunity on disease progression and the need to

181 The influence of humoral immunity on the prevention of primary cytomegalo

182 ntibody production, development of long-term humoral immunity requires T-dependent B cell responses.

183 mechanism used by Plasmodium vivax to escape humoral immunity targeting PvDBP, the key ligand involve

184 wever, we also identified characteristics of humoral immunity that differed across species.

185 The BCR recognizes foreign Ags to initiate humoral immunity that needs isotype-switched Abs generat

186 Generating durable humoral immunity through vaccination depends upon effect

187 al importance of functional antigen-specific humoral immunity to guide patient care and vaccine devel

188 e studies provide guidance for comparison of humoral immunity to LASV of distinct lineages following

189 , for example, the placenta, enhancing fetal humoral immunity to levels similar to their mothers'.

190 Humoral immunity to pathogens and other environmental ch

191 of a diverse antibody repertoire, providing humoral immunity to pathogens, requires the participatio

192 le of the pathogen are shedding light on how humoral immunity to Salmonella operates.

193 thorough understanding of the mechanisms of humoral immunity to SARS-CoV-2(4).

194 lly infected animals, immunizations enhanced humoral immunity to sequences located in the putative Tp

195 anslatable approach to significantly improve humoral immunity to subunit vaccines using a clinical ad

196 ICOSL and ICOS in a mouse model of increased humoral immunity using B6(mir146a-/-) mice and a model o

197 r whether it will occur more frequently when humoral immunity wanes following primary infection.

198 ptide-specific Phl p 1- and Bet v 1-specific humoral immunity was demonstrated in subjects undergoing

199 able infants were eligible for assessment of humoral immunity, and eight studies with 4254 infants we

200 resulted in both MOMP-specific cellular and humoral immunity, and while there was a slight enhanceme

201 ppreciated that in addition to their role in humoral immunity, B cells also exert regulatory mechanis

202 dentifies a multi-signal relay of organismal humoral immunity, establishing adult Drosophila as model

203 helper T cell (T(FH)), a critical player in humoral immunity, is associated with disease severity an

204 ion to impairing CD8(+) T cell responses and humoral immunity, STING N153S also promoted the replicat

205 Therefore, to fully define protective humoral immunity, we dissected the early evolution of th

206 revealed significant boosting (by 4-fold) of humoral immunity, which occurred only in subjects (10 of

207 al development rather than disease-enhancing humoral immunity.

208 CBCs) are critical for generating long-lived humoral immunity.

209 ell response declines, resulting in impaired humoral immunity.

210 ot included a detailed analysis of meningeal humoral immunity.

211 B cells (MBCs) are essential for long-lived humoral immunity.

212 innate lymphoid cells (ILC2s) in regulating humoral immunity.

213 secrete antibodies and form a cornerstone of humoral immunity.

214 d the generation of increased sensitivity to humoral immunity.

215 e from in vitro studies that HCMVs can evade humoral immunity.

216 elp and are crucial for generating long-term humoral immunity.

217 t the parasite's ability to evade anti-PvDBP humoral immunity.

218 essary for affinity maturation and effective humoral immunity.

219 infection and the need for early functional humoral immunity.

220 comparable mucosal and systemic cellular and humoral immunity.

221 , B lymphocytes are an indispensable part of humoral immunity.

222 melanization, and antibacterial activity for humoral immunity.

223 t-population turnover and individual loss of humoral immunity.

224 ts and strategies to improve anti-Plasmodium humoral immunity.

225 nd will provide insight into the kinetics of humoral immunity.

226 sis of cellular immunity and quantitation of humoral immunity.

227 SARS-CoV-2 proteins, we detected preexisting humoral immunity.

228 orbent assays (gpELISAs) were used to assess humoral immunity; anti-varicella virus T-cell responses

229 obulinemia (XLA) is the prototype of primary humoral immunodeficiencies.

230 l-tolerated and elicited potent cellular and humoral immunogenicity in the United Kingdom and Senegal

231 baseline, with little changes in the overall humoral immunoreactivity pattern measured after immuniza

232 as necessary and sufficient for the improved humoral inhibition observed with selective CD28 blockade

233 traxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selec

234 red the role of B cells in both cellular and humoral-mediated CNS conditions.

235 NK cell activation in blood is mediated by humoral mediators released by other immune cells and doe

236 ability of V160 to induce robust and durable humoral memory responses to HCMV, justifying further cli

237 Thus preexisting humoral or cellular memory alloresponses are typically a

238 CE elevates humoral parameters, such as growth factors, and stimulat

239 hus, our results suggest that PTX3 acts as a humoral pattern recognition molecule in gout facilitatin

240 renal allografts as a result of cellular and humoral rejection on days 140, 89, and 84.

241 m the engineered pigs are resistant to human humoral rejection, cell-mediated damage and pathogenesis

242 To examine the protective humoral response against HBV, we cloned and characterize

243 omprehensive understanding of the protective humoral response against Plasmodium falciparum (Pf) circ

244 lciparum (Pf) - has been associated with the humoral response against the repeats.

245 arameters, bringing additional evidence that humoral response against this protein region is not esse

246 ntimicrobial humoral response, regulation of humoral response and various metabolic processes.

247 their presence reflects a redirecting of the humoral response away from targeting more protective epi

248 ity, we dissected the early evolution of the humoral response in 193 hospitalized individuals ranging

249 ieved to play a crucial role in cellular and humoral response in AD, but accumulating evidence has sh

250 can offer a more accurate assessment of the humoral response in patients and its impact on survival.

251 ough which tumor-associated antigens trigger humoral response is not well delineated.

252 Humoral response to HCMV, but not Epstein-Barr or herpes

253 d low-avidity antibody assays to measure the humoral response to HIV-1.

254 The humoral response to invading mucosal pathogens comprises

255 study aimed to characterize the longitudinal humoral response to KSHV in a cohort of HIV-infected Zam

256 Also, to our knowledge, the development of humoral response to SARS-CoV-2 has not been previously r

257 ptoms in patients unable to mount a specific humoral response to SARS-CoV-2.

258 each antibody isotype/source to the mucosal humoral response, parallel investigation of the specific

259 inine-associated genes include antimicrobial humoral response, regulation of humoral response and var

260 verse Pf proteins, showing a wide breadth of humoral response.

261 e immune systems critical for establishing a humoral response.

262 lls play a very important role in mounting a humoral response.

263 experienced antibody-mediated rejection with humoral-response rebound, suggesting desensitization mus

264 ated with protection, supporting the role of humoral responses against DENV NS1 as correlates of prot

265 crucial for inducing effective cytotoxic and humoral responses against pathogens.

266 All animals exhibited antigen-specific humoral responses already after the poxvirus boost, whic

267 oxviruses, both by potentiating cellular and humoral responses and by directly killing infected cells

268 g capable to trigger systemic and intestinal humoral responses and thus it constitutes a promising or

269 e both been shown to be essential for proper humoral responses as well as autoimmune Ab development i

270 Humoral responses at baseline and after each vaccination

271 Humoral responses at baseline and following vaccination

272 Anti-BAFF treatment interferes with humoral responses at multiple levels in this model of al

273 a prefusion-closed conformation, can elicit humoral responses capable of neutralizing HIV-1 strains

274 ralization displayed infectious profiles and humoral responses comparable to mice given high doses of

275 HD-MAP delivery resulted in enhanced humoral responses compared with IM injection with higher

276 arily advantageous through better evasion of humoral responses directed against HCMV virions.

277 However, the ontogeny of humoral responses during acute HIV infection is poorly d

278 Here, we profiled SARS-CoV-2-specific humoral responses in a cohort of 22 hospitalized individ

279 Humoral responses in coronavirus disease 2019 (COVID-19)

280 cells and triggered systemic and intestinal humoral responses in immunized mice.

281 tence, will aid intervention to modulate CNS humoral responses in the context of infection and associ

282 ivo immunogenicity and generate cellular and humoral responses that are proportionate to protein expr

283 B cell(GRKO) mice mounted normal humoral responses to immunizations with T-dependent and

284 To date, characterization of humoral responses to Plasmodium falciparum transmission-

285 Understanding humoral responses to severe acute respiratory syndrome c

286 The increase in humoral responses was associated with the expression of

287 fic IgG levels were observed, spike-specific humoral responses were enriched among convalescent indiv

288 Humoral responses within the central nervous system (CNS

289 e surrogate viral assays to screen antiviral humoral responses, define correlates of immune protectio

290 Although coexpression of CD40L did increase humoral responses, it blunted type 1 CD4(+) T cell respo

291 /c mice induced strong specific cellular and humoral responses.

292 derstanding of how infection history impacts humoral responses.

293 promote autoimmunity and further amplifying humoral responses.

294 also bolstered the HIV-specific cellular and humoral responses.

295 ted with adjuvanted gp120 protein to enhance humoral responses.

296 ) cells are essential for inducing efficient humoral responses.

297 fficient elimination of plasmablast-mediated humoral responses; however, long-lived bone marrow (BM)

298 Analysis of the humoral system shows that blood cell counts and inflamma

299 While loss of humoral tolerance has been associated with microbial inf

300 These data highlight distinct humoral trajectories associated with resolution of SARS-