ライフサイエンスコーパス: hurdle

1 ogenetics holds the promise to overcome this hurdle.

2 ns, suggesting that resistance will remain a hurdle.

3 ychological evaluation remains a significant hurdle.

4 tment systems remains as one major technical hurdle.

5 r two-dimensional structure presents a major hurdle.

6 into higher affinity binders remains a major hurdle.

7 ics, poor systemic stability remains a major hurdle.

8 ne expression in vivo presents a significant hurdle.

9 unction (V2F) problem, remains a significant hurdle.

10 (MVA) can help to overcome this significant hurdle.

11 , and propose strategies to resolve existing hurdles.

12 pment and primary operational and regulatory hurdles.

13 scientific advances may help overcome these hurdles.

14 that are being considered to overcome these hurdles.

15 sidues has been unclear because of technical hurdles.

16 untable technical, financial, and logistical hurdles.

17 g stem cell-based transplantation faces many hurdles.

18 ong-term functional integration remain major hurdles.

19 evolved different strategies to evade these hurdles.

20 articipants present significant experimental hurdles.

21 anotechnology as a means of addressing these hurdles.

22 However, this approach may present various hurdles.

23 t least two inherent and thus far unresolved hurdles: 1) provision of an unlimited source of function

24 Overcoming this hurdle, a new study discovers a high incidence of non-ca

25 Despite these hurdles, a subset of HIV-infected individuals eventually

26 se-to-brain drug delivery could overcome the hurdle and improves the therapeutic efficiency of CNS ac

27 et al. describe methods for overcoming this hurdle and provide a new quantitative picture of the mit

28 This study has overcome this technical hurdle and provides new insights into this fundamental s

29 ation, but there are technical and practical hurdles and difficulties in interpretation.

30 ls is rapidly advancing but faces regulatory hurdles and environmental concerns.

31 countries are still plagued by technological hurdles and limited market potential.

32 United States, likely because of logistical hurdles and oncology study design.

33 been some significant moves to easing these hurdles and, potentially, to bringing new drugs to the c

34 es and health-care workers are another major hurdle, and every effort should be made to get a valid p

35 ver, these emerging therapies face difficult hurdles, and truly creative approaches to vascular acces

36 Translational hurdles are not adequately addressed yet, especially dev

37 Two different architectures, channels and hurdles, are generated, and thin films of thermite are d

38 o functionally relevant groups is a critical hurdle as an increasing number of sequences are deposite

39 we offer a perspective on the implementation hurdles as well as the knowledge gaps that must be fille

40 ment with the MSC secretome could circumvent hurdles associated with cellular therapy, including onco

41 th clinical features at scale has remained a hurdle because of a lack of frameworks for analyzing het

42 Adressing the types is still a major hurdle because type-specific markers are lacking, and th

43 tion or sequence replacement remains a major hurdle before application of CRISPR-Cas9 technology is f

44 strategies have additional and considerable hurdles before it can be shown that they are safe and ef

45 There are, however, at least three major hurdles before lithium metal anodes can become a viable

46 e we demonstrate a strategy to overcome this hurdle by avoiding the gaseous or liquid phase, and dire

47 Here we overcome this fundamental hurdle by constructing a mutable and deformable array of

48 Here, we overcome this hurdle by developing a chromosomal-barcoding technique t

49 We overcome this hurdle by employing high throughput in utero RNAi-mediat

50 Here we bypassed this hurdle by generating a 2D agent-based model of a prolife

51 Here, we overcome this hurdle by showing that ChIP-nexus captures the endogenou

52 all living systems; however, major technical hurdles challenge analyses of this class of proteins.

53 In this study we hypothesized that this hurdle could be due to the presence of inhibitory factor

54 s less uniform as in 2015, zero-inflated and hurdle count models were superior to standard mixed mode

55 ylotroph alleviated a so far uncharacterized hurdle, DNA-protein crosslinking (DPC), by insertion seq

56 ysis of potent binders remains a significant hurdle due to limited sensitivity and accompanied deplet

57 overcome the increasing number of technical hurdles due to the complexity of manipulating large data

58 gh carbonate formation can be addressed as a hurdle during CO2 splitting, the problem can be avoided

59 to eukaryotic genome complexity, a critical hurdle en route to the evolution of complex cells.

60 The hurdles encountered in the recent research and future pr

61 However, hurdles exist in activating thermogenic adipose tissue i

62 expected, XR-NTX had a substantial induction hurdle: fewer participants successfully initiated XR-NTX

63 This is a major hurdle for accurately recapitulating disease phenotypes

64 mmetry parameters has remained a significant hurdle for any structural technique and could thus far n

65 This presents a significant hurdle for data sharing, reanalysis, or meta-analysis of

66 genetic manipulation remains a translational hurdle for diabetes therapy.

67 The primary hurdle for diagnosis of some diseases is the long incuba

68 in variable phenotypes, and remains a major hurdle for disease diagnosis and therapy.

69 It maintains brain homeostasis and is a hurdle for drug delivery to the CNS to treat neurodegene

70 he blood-brain barrier (BBB) strongly impede hurdle for drug transport to brain.

71 iology of these pests presents a significant hurdle for either protein- or nucleotide-based managemen

72 ormally diagnosed or treated, posing a major hurdle for elimination efforts.

73 n of off-target cysteines represents a major hurdle for expansion of covalent drug programs.

74 A major hurdle for functional recovery after both spinal cord in

75 A significant technical hurdle for HCP analysis is the overwhelmingly large back

76 early ART, which may represent an additional hurdle for HIV cure efforts.IMPORTANCE Chronic viral inf

77 hough low tumor mutational burden is a major hurdle for immune checkpoint inhibitors, an immature or

78 teady-state kinase bias imposes an energetic hurdle for inappropriate ligands to elicit signal transd

79 as highly immunosuppressive, posing a major hurdle for inducing immune-mediated destruction of cance

80 late in free flight has been a long-standing hurdle for insect flight studies.

81 r, its low oral bioavailability is the major hurdle for moving this drug to clinical trial.

82 t pre-existing resistance may not be a major hurdle for novel-target antimalarial candidates, and foc

83 Lipid oxidation is the main hurdle for omega-3 fatty acid enrichment in food and bev

84 fluorophore functionality, which is a major hurdle for systematic characterization.

85 of a cancerous cell in patients is the major hurdle for the above circumstances.

86 od-brain barrier (BBB) remains a significant hurdle for the development of biopharmaceuticals with th

87 However, the major hurdle for the extensive application of antibody therapi

88 However, a major hurdle for their applications is the immature state of t

89 lops during disease progression is a serious hurdle for therapy(1-3).

90 Resistance to chemotherapy is a major hurdle for treating patients with cancer.

91 antigenic evolution of IAVs remains a major hurdle for vaccine selection and effective vaccination.

92 As such, PML-NBs serve as an important hurdle for viruses to overcome to successfully establish

93 To overcome these hurdles for budding yeast, we recently optimized an arti

94 hat are enabling the field to overcome these hurdles for clinical impact.

95 ng of subject-level data and hence lower the hurdles for collaboration between institutions considera

96 sly for hundreds of samples create technical hurdles for data analysis.

97 Overcoming the hurdles for fully validating a quantitative method will

98 ts, and we describe the remaining issues and hurdles for genomic footprinting.

99 the need for specialized staff remain major hurdles for laboratories with limited resources for impl

100 We also discuss current technical hurdles for recreating the cell-type complexity and spat

101 concentration in plasma created significant hurdles for scientists working to reveal its identity.

102 tries, we should remain vigilant and explore hurdles for the full public health impact of TCV, includ

103 laucoma, as well as anticipated barriers and hurdles for the future adoption of teleophthalmology.

104 low stability, and short life times, posing hurdles for their mass deployment to capture a complete

105 Two major hurdles for therapeutic use of Hsp90 inhibitors are syst

106 ntibodies have not been identified, creating hurdles for vaccine development.

107 ing of multiple genes, which remains a major hurdle given various associated epistatic and pleotropic

108 A major hurdle has been dissecting macrophage-specific functions

109 A key hurdle has been the inability to generate a homogeneous

110 But, a computational hurdle has stymied attempts to measure large-scale infor

111 This technical hurdle has stymied progress toward understanding persist

112 However, one of the hurdles has been understanding and quantifying the effec

113 Efforts to overcome these hurdles have been blunted by a lack of mechanistic under

114 ntified zones in the striatum, yet technical hurdles have hampered the study of the functions of thes

115 mutation in neurons; however, methodological hurdles have prevented testing this hypothesis directly.

116 , reflecting convergent solutions to genetic hurdles imposed by complex multicellularity among indepe

117 ey amide-iminol tautomerization is the major hurdle in an otherwise energetically favorable cycloaddi

118 e to BRAF inhibitors (BRAFi) remains a major hurdle in attaining durable therapeutic responses.

119 whole blood ex vivo represents a logistical hurdle in clinical and research settings.

120 erminal centers, has emerged as an important hurdle in designing effective vaccines.

121 mically administered drugs have been a major hurdle in designing therapies with desired efficacy and

122 A major technical hurdle in determining any neuroprotective effect by DBS

123 A central hurdle in developing small interfering RNAs (siRNAs) as

124 To overcome this hurdle in DNA quantification, we present droplet digital

125 elopment of drug resistance has been a major hurdle in gemcitabine therapy leading to unsatisfactory

126 kinase inhibitors (RTKi) represents a major hurdle in improving the management of clear cell renal c

127 However, the major hurdle in initiating therapeutic responses is the ineffi

128 "sampling fraction" and demonstrate a major hurdle in performing DA analysis of microbiome data is t

129 ing current therapies, thus creating a major hurdle in radiotherapy/chemotherapy.

130 A major hurdle in studying glycans through functional glycomics

131 The curse of dimensionality has long been a hurdle in the analysis of complex data in areas such as

132 Toxicity assessment is thus a major hurdle in the compound discovery pipeline, currently inv

133 A major hurdle in the development of the strategy has been to el

134 The use of non-standard toxicity models is a hurdle in the early development of antimicrobial peptide

135 ne dysfunction due to microgravity remains a hurdle in the next step of human space exploration.

136 is a major cause of mortality and remains a hurdle in the search for a cure for cancer.

137 A significant hurdle in the Treg field has been the identification, or

138 ion remain to be elucidated and pose a major hurdle in treating or preventing chronic HCV-induced adv

139 ering with optogenetics to overcome critical hurdles in cancer immunotherapy.

140 fungal infections, which creates significant hurdles in conducting clinical trials in a timely and ec

141 ons was required to overcome major technical hurdles in MSI-NACE-MS prior to a rigorous method valida

142 poor biological understanding of aging, and hurdles in performing clinical trials for aging.

143 One of the fundamental hurdles in plasmonics is the trade-off between electroma

144 However, technological hurdles in producing defined protein sialylation due to

145 The hurdles in realizing successful cancer immunotherapy ste

146 lycystin complex is lacking due to technical hurdles in reliably measuring its activity.

147 nd their control has become one of the major hurdles in successfully adapting these biological machin

148 Among many hurdles in synthesizing proteoglycan glycopeptides, one

149 al of the tethering approach to overcome the hurdles in systematic PPI stabilizer discovery.

150 Overall this strategy helps to address major hurdles in the design of antivirulence vaccines, enablin

151 ing variable regions of the HIV proteome are hurdles in the development of an effective AIDS vaccine.

152 This new concept has also created hurdles in the development of safe and efficacious drug

153 in the UK in November 2019, identifying key hurdles in the field, as well as priorities for overcomi

154 ct the next major technological advances and hurdles in the field.

155 utstanding questions and remaining technical hurdles in this field.

156 One of the hurdles in using CO as a therapeutic agent is the develo

157 There are numerous hurdles in vaccine development, of which knowing the app

158 These hurdles include a lack of awareness of the benefits, a l

159 These hurdles include template preparation, fungal morphology,

160 Major hurdles include the increasing need for powerful new too

161 al application of ADC remains elusive; major hurdles include the instability of antibody-chemotherapy

162 nslation is limited by several drug delivery hurdles including renal clearance, phagocytosis, enzymat

163 ng required surmounting multiple challenging hurdles, including defeating a sizable ligand with subna

164 current approaches face major translational hurdles, including limited cell sources and the need for

165 Instead, we show that replication hurdles, including secondary structures in template, slo

166 Regulatory hurdles involved in validating quantitative assays and t

167 This hurdle is largely due to the differentiation of long-ter

168 A significant hurdle is the availability of antivirals to treat the in

169 A significant hurdle is the extraction of the functional protein from

170 A severe hurdle is the hypervariability of its major antigen, the

171 A major hurdle is the lack of an efficient and safe in vivo deli

172 A major hurdle is the lack of methods for selective detection of

173 One hurdle is the use of covert (silent) in-scanner recall t

174 Despite these hurdles, macrocyclic natural products, including FK506,

175 nal levels where these infants can encounter hurdles may assist caregivers in identifying a potential

176 COZINE relies on the multivariate Hurdle model to infer a sparse set of conditional depend

177 solution to this key issue by introducing a hurdle model, which is a mixture between a binomial pept

178 strated by various theoretical and technical hurdles, mostly stemming from the dramatic heterogeneity

179 Two main hurdles must be overcome.

180 However, many hurdles need to be overcome in tissue-engineering approa

181 HiC-DC uses hurdle negative binomial regression account for systemat

182 To overcome these hurdles, novel therapies need to be investigated.

183 umination microscopy, fairSIM takes away the hurdle of generating yet another implementation of the r

184 ncy of sky-blue PeLEDs by overcoming a major hurdle of low photoluminescence quantum efficiency in wi

185 By overcoming the technical hurdle of nonspecific Cre-loxP-mediated recombination, t

186 The insurmountable hurdle of targeting oncogene KRAS, the most prevalent ge

187 To overcome the hurdles of a decision process that must reconcile diverg

188 Here, we surmount the conventional hurdles of activity measurement with a multiplexing appr

189 It aims to alleviate the hurdles of conventional tissue engineering methods by pr

190 By removing bioinformatic hurdles of data access and management, HMP16SData enable

191 cterial infections circumventing some of the hurdles of protein IgG delivery.

192 960s, unknown toxicity, cost and the ethical hurdles of research in humans have hindered the translat

193 astases seen in patients and to overcome the hurdles of systemic delivery of OV, we developed melanom

194 potential benefits, research, and potential hurdles of this approach through discussion; and reached

195 disease-causing mutations and circumvent the hurdles of traditional gene- and cell-based therapies.

196 Major hurdles overcome by the ancestor of these lineages were

197 icult pathogens because of the immunological hurdles posed, including B cell immunodominance and germ

198 ncy of cardiac gene delivery remains a major hurdle preventing success but also that improvements nee

199 te setting-including current limitations and hurdles regarding this approach-are illustrated.

200 ssed by permutational multivariate ANOVA and hurdle regression models using the negative binomial dis

201 This is partly a consequence of specific hurdles related to the large size of these organisms and

202 f an indivisible resource is an evolutionary hurdle relatively few species have overcome.

203 This is a proof of principle, and major hurdles remain before optimization and scale-up could be

204 However, many hurdles remain in making them a robust and reliable tool

205 However, some hurdles remain prior to commercialization of these mater

206 However, major hurdles remain to be addressed to acquire an ultraclean,

207 n genomics and bioinformatics, technological hurdles remain to examine host-microbe transcriptomics.

208 nized the field of cancer immunotherapy, but hurdles remain, especially for solid tumors.

209 d regeneration, perhaps the most significant hurdle remains the establishment of non-destructive mean

210 explosives still possesses a huge analytical hurdle, rendering explosives detection an issue of burni

211 ptibility, and navigating the administrative hurdles required to integrate an assay into a clinical l

212 on of electrochemical sensors to tackle this hurdle requires sensors that can undergo analysis withou

213 jumps of DNA polymerase through this triplex hurdle, result in repeat contractions in the nascent lag

214 (RSV) can be partly attributed to regulatory hurdles resulting from vaccine enhanced respiratory dise

215 e therapy for this disease presents inherent hurdles since MECP2 is expressed throughout the brain an

216 As a way to avoid this hurdle, sticholysin (St) II, a pore-forming protein from

217 tive protein modification and consider which hurdles still need to be overcome for more widespread us

218 ammed fibroblast replacement, although major hurdles still remain.

219 ear-infrared (NIR) region has been the major hurdle that has hindered further development and clinica

220 sic properdin biology, emphasizing the major hurdles that have complicated the interpretation of resu

221 hallenges that face women in science and the hurdles that impair their development into leadership po

222 However, there are substantial technologic hurdles that must be addressed before clinical efficacy

223 Classes of nucleic acids, hurdles that must be overcome for effective intracellula

224 influence on solid electrolytes and are key hurdles that must be overcome for their successful appli

225 These findings reveal hurdles that must be overcome to successfully analyze fu

226 for regenerative medicine, while pointing to hurdles that must be overcome to translate this technolo

227 In addition, we discuss potential hurdles that need to be addressed prior to mass scale cl

228 ill faces important financial and regulatory hurdles that should be addressed to optimise clinical ad

229 Research hurdles that were overcome included considering that fac

230 tain characteristics of microbiome data have hurdled the accuracy and effectiveness of differential a

231 t have enabled this progress, the regulatory hurdles the field has yet to overcome, and cutting edge

232 Because of aforementioned hurdles, the automation of lesion boundary detection in

233 inated tumor cells can overcome the numerous hurdles they encounter during the transition from the si

234 Such learned dependence is likely a hurdle to autonomy to be overcome for many robot locomot

235 ain barrier (BBB) poses the most significant hurdle to brain tumor treatment.

236 The hurdle to bridging MD with LBM is the computational expe

237 current study, we analyze the causes of one hurdle to clinical development, off-target reactivity, o

238 A major hurdle to clinical translation of brain-machine interfac

239 H) fosters drug resistance and is a critical hurdle to clinical treatment.

240 The discrepancies between assays are a hurdle to clinical trials that aim to measure the effica

241 of Citral in acidic conditions is viewed as hurdle to commercialize it in food/beverage industries.

242 A major hurdle to data analysis is spike sorting, and this probl

243 erapeutic molecules, presenting a formidable hurdle to drug development in brain diseases.

244 hat underlie neural activity is the greatest hurdle to faster advances.

245 of root exudate composition, which is a key hurdle to functional exploitation of root exudates for c

246 One hurdle to implementation of DESI-MS intraoperatively is

247 nd addition of arginine did not constitute a hurdle to lactic and probiotic bacteria survival, with p

248 s found in eukaryotic cells has been a major hurdle to our understanding of their specific roles.

249 inner mitochondrial layer represents a major hurdle to overcome for most drugs.

250 ations of their backbone amides is the major hurdle to overcome for the construction of discrete fold

251 nding sites from distant proteins is a major hurdle to rational drug design.

252 Delivery of siRNA is a key hurdle to realizing the therapeutic promise of RNAi.

253 They add yet another hurdle to the challenges faced by low-status individuals

254 Such memory requirements are a significant hurdle to the computation of minimal absent words in lar

255 FP site of vulnerability.IMPORTANCE A major hurdle to the development of an effective HIV-1 vaccine

256 Antiviral immune responses present a major hurdle to the efficacious use of oncolytic adenoviruses

257 uous and reliable cold chain remains a major hurdle to the global distribution of safe and effective

258 However, a critical hurdle to the latter is how to safely and densely store

259 in cell function has presented a significant hurdle to the successful clinical translation of many ce

260 A hurdle to the use of materials for cell delivery is the

261 regression but their rareness poses a major hurdle to their clinical application.

262 One hurdle to treating tuberculosis could be that it is so d

263 A major hurdle to understanding the mechanisms underlying gene r

264 The main hurdle to using lipoplexes in gene therapy lies in their

265 However, bacterial recombination poses hurdles to a sequential Markov approximation, as it lead

266 er for advancing research and clinical care, hurdles to be overcome, and the need for multidisciplina

267 Although there are still hurdles to be overcome, the prospect that such approache

268 essive function of T(reg) cells remain major hurdles to broader effectiveness of tumour immunotherapy

269 ost or infrastructure security pose critical hurdles to deployment.

270 development of NTD vaccines and some of the hurdles to ensuring their availability to the world's po

271 have detailed strategies that overcome prior hurdles to generate functional beta-like cells from huma

272 aracteristics of tumors present considerable hurdles to immune cell function and cancer immunotherapy

273 se model of PDA, overcoming one of the major hurdles to immunotherapy for PDA.

274 w area of medicine in which the conventional hurdles to implementing chemicals to effect human health

275 The major hurdles to overcome to achieve this goal are expensive m

276 therapeutics field is discussed, as well as hurdles to overcome to develop potent and selective RNA-

277 c assay development that have been difficult hurdles to overcome.

278 innovative approaches to overcoming existing hurdles to practical biosensor designs and explore poten

279 lped clarify these relationships, overcoming hurdles to provide a range of potential models for ESCRT

280 reactions, and huge volume effect are major hurdles to the commercial application of Li-metal anodes

281 The hurdles to the development of commercial MFC technology

282 ld, and in vitro instability are substantial hurdles to the successful determination of GPCR structur

283 eforestation, as there are normally no legal hurdles to their clearance, therefore making them excell

284 nanoparticle at any feeding ratios are major hurdles to their widespread applications.

285 Significant hurdles to vaccine development include host range specif

286 However, important hurdles to widespread application still exist; for examp

287 establish CTL escape variants presents major hurdles toward this goal.

288 e of drug resistance continues to be a major hurdle towards improving patient outcomes for the treatm

289 tion of engineered dental pulp poses a major hurdle towards successful implementation of pulp regener

290 perimental procedures represents a potential hurdle towards their routine use in laboratories.

291 ctrolyte has been considered one of the main hurdles towards practical application.

292 Our protocol overcomes hurdles typically encountered by structural biology tech

293 cal practice will depend on overcoming major hurdles, ultimately including evidence that the detectio

294 To address this hurdle, we developed a vaccine based-approach comprised

295 To overcome this hurdle, we utilized non-canonical amino acids and bio-or

296 To overcome these hurdles, we have developed a switchable CAR-T cell platf

297 To overcome these hurdles, we improved TPE efficiency by controlling tempo

298 Approaching both hurdles, we present the design and synthesis of a small-

299 a condition which is essential and is a key hurdle when operating at short wavelength due to the str

300 One of the biggest hurdles yet to be overcome for the continued improvement