ライフサイエンスコーパス: hydrogenolysis

1 tituent, which could be removed by catalytic hydrogenolysis.

2 sters, by further esterification followed by hydrogenolysis.

3 orary blocking groups removable by catalytic hydrogenolysis.

4 ion of the aryl iodide followed by catalytic hydrogenolysis.

5 onverted to the alkaloid australine (3) upon hydrogenolysis.

6 subsequently be removed in a single step by hydrogenolysis.

7 ion reaction and subsequent Ni/NHC-catalyzed hydrogenolysis.

8 s demonstrated not to be the initial step of hydrogenolysis.

9 ctions with more complex mechanisms, such as hydrogenolysis.

10 Pt NP size on activity and selectivity in PE hydrogenolysis.

11 tructures for the Fe sites catalyze C-O bond hydrogenolysis.

12 H) are alternatives for efficient polyolefin hydrogenolysis.

13 highly efficient active sites for polyolefin hydrogenolysis.

14 the most promising catalysts for polyolefin hydrogenolysis.

15 coupling is undeveloped because of competing hydrogenolysis.

16 osphorylated hexasaccharide by hydrogenation/hydrogenolysis.

17 ng inhibition by H2, also observed in alkane hydrogenolysis.

18 es that suffer alpha-ketol mediated transfer hydrogenolysis.

19 d by one-step catalytic (Pd/C) hydrogenation/hydrogenolysis.

20 roup and organometallic addition followed by hydrogenolysis.

21 at near theoretical yields during subsequent hydrogenolysis (47 mole % of Klason lignin for beech and

22 ge, 1 exhibits one of the highest polyolefin hydrogenolysis activities (9,800 (CH(2) units) . mol(Ta)

23 lated diagenesis via catalytic hydrogenation/hydrogenolysis affording their sterane hydrocarbon count

24 ubstituted isoxazoles by SN Ar reactions and hydrogenolysis allows access to useful products.

25 For hydrogenolysis, AlS/TaNp(x) is effective for a wide vari

26 depolymerization can be accomplished through hydrogenolysis, although the development of catalysts ba

27 ination by reductive elimination rather than hydrogenolysis and (ii) sequestration of metals as sulfi

28 a stronger electron-donating group promotes hydrogenolysis and a stronger electron-withdrawing group

29 razole, which can be cleaved using oxidative hydrogenolysis and acidic conditions.

30 +) sites supported on SAO that are active in hydrogenolysis and alkane metathesis reactions.

31 lly modulating the H(2) pressure during MTHF hydrogenolysis and applying phase-sensitive detection (P

32 the protective groups in (-)-29 followed by hydrogenolysis and decarboxylation afforded the cross-li

33 yield and provided a substrate suitable for hydrogenolysis and deprotection.

34 source of the reducing equivalents for both hydrogenolysis and hydrogenation is exclusively H(2)/D(2

35 transition states, and kinetic barriers for hydrogenolysis and hydrogenation pathways is the key to

36 ermodynamics and kinetics of electrochemical hydrogenolysis and hydrogenation pathways, which also pr

37 This means that although both hydrogenolysis and hydrogenation require adding H atoms

38 geneous Pd catalyst to achieve the selective hydrogenolysis and hydrogenation.

39 Hydrogenolysis and hydrolysis of aryl ethers in the liqu

40 of the 4-O-5 linkage is cleaved via parallel hydrogenolysis and hydrolysis.

41 tely functionalized benzylamine, followed by hydrogenolysis and lactam formation.

42 use of the ligand lability, 2 also undergoes hydrogenolysis and rapid exchange with labeled NH(3).

43 s, namely selective oxidation, hydrogenation/hydrogenolysis and reforming of biomass derived molecule

44 planar variants promote beta-H elimination, hydrogenolysis, and catalytic hydrogenation of unactivat

45 aldehyde, olefination, tandem hydrogenation/hydrogenolysis, and cyclization upon reaction with 4-bro

46 shed some light on the mechanism of epoxide hydrogenolysis, and further, deuterium labeling studies

47 platform for electrocatalytic hydrogenation, hydrogenolysis, and isotopic labeling, offering a compet

48 es (ca. 5 s) were observed in Pd/C-catalyzed hydrogenolysis, and several intermediates were seen in N

49 ype protocol, facilitated by a tandem Suzuki-hydrogenolysis approach.

50 cates that ring hydrogenation and side-chain hydrogenolysis are much faster than ring-opening hydroge

51 s at 475 degrees C, followed by vapour-phase hydrogenolysis at 275 degrees C (0.4 MPa H(2), 2.4 s), y

52 at the picolinyl ether is readily removed by hydrogenolysis at atmospheric pressure and room temperat

53 C-O hydrogenolysis becomes the preferred deoxygenation route

54 The rate difference of the hydrogenolysis between two diastereomeric epoxide interm

55 f the surface hydrogen coverage in improving hydrogenolysis catalyst performance.

56 map out a plausible mechanism of aryl ether hydrogenolysis catalyzed by nickel.

57 debenzylated aminoindolizidines by selective hydrogenolysis catalyzed by Pt/C or Pd/C, respectively,

58 ies with final deprotection by hydrogenation/hydrogenolysis caused by the presence of galacturonic ac

59 ich, low-coordinate variants demonstrate any hydrogenolysis chemistry.

60 way for both CH(3)OH dehydrogenation and DMT hydrogenolysis, compared to Cu supported on a redox-neut

61 up, followed by continuous-flow microfluidic hydrogenolysis completed the total synthesis of the stru

62 up that is conveniently removed via benzylic hydrogenolysis concomitantly with the catalytic hydrogen

63 The group is stable to mild acid, base, hydrogenolysis conditions, and lithium/halogen exchange

64 onverted into ortho-alkylated alcohols under hydrogenolysis conditions.

65 corresponding DTPA analogues under very mild hydrogenolysis conditions.

66 3.6) to low molecular weight paraffins under hydrogenolysis conditions.

67 situ H(2) source for the catalytic transfer hydrogenolysis (CTH) of DMT to p-xylene (PX, ~63 % at 24

68 vity outcome (inversion vs retention) of the hydrogenolysis depends on the tertiary benzylic alcohol

69 pplications in olefin polymerization, alkane hydrogenolysis, depolymerization of branched polymers, r

70 rasting catalytic reactivities in polyolefin hydrogenolysis, despite similar diameters.

71 Ethane hydrogenolysis displayed significant structure sensitivi

72 Diaryl ethers undergo electrocatalytic hydrogenolysis (ECH) over skeletal Ni cathodes in a mild

73 ce of oxidative cleavage/reductive amination/hydrogenolysis enables the preparation of N-substituted

74 numerous catalytic processes (hydrogenation, hydrogenolysis, etc.).

75 ) to a cyanohydrin (3) which is subjected to hydrogenolysis followed by lactamization and reduction t

76 agent; (2) deprotection of the "top" unit by hydrogenolysis, followed by exhaustive aryl triflate for

77 An efficient, scalable, hydrogenolysis-free synthesis of C2-O-sLe(X)-Thr-COOH wa

78 n provided isoxazoline derivative which upon hydrogenolysis furnished the B-hydroxy ketone expedientl

79 Hydrogenolysis has the highest standard free energy of a

80 of these reactants (i.e., hydrogenation and hydrogenolysis) have undergone extensive mechanistic inv

81 While Ru-catalyzed hydrogenolysis holds significant promise in converting w

82 r four major catalytic upcycling strategies: hydrogenolysis, (hydro)cracking, tandem processes involv

83 epoxidation of the Delta(6)-double bond, and hydrogenolysis/hydrogenation of the 5,6-epoxy enone syst

84 is the key to understanding and controlling hydrogenolysis/hydrogenation selectivity of carbonyl com

85 of reactant molecules that can affect their hydrogenolysis/hydrogenation selectivity on a Zn electro

86 e hydrogenation of the C=N bond, followed by hydrogenolysis-hydrolysis.

87 nanoribbons could remarkably prohibited the hydrogenolysis in chemoselective hydrogenation of C=C bo

88 erent selectivity of acyl formation and acyl hydrogenolysis in hydroformylation reactions.

89 r the studied metals, but the selectivity to hydrogenolysis increases in the order Pd<Rh<Ir<Ru~Pt in

90 Hydrogenolysis initiated by H addition in water is more

91 The role of the N-C support in catalytic hydrogenolysis is analogous to the behavior of chemicall

92 On supported noble metals, hydrogenolysis is initiated by a hydrogen addition to th

93 e on H(2) pressure, thus, the selectivity to hydrogenolysis is maximized by increasing temperature an

94 The catalytic C-O hydrogenolysis is shown to have significant scope, and t

95 The mechanism of hydrogenolysis is supported by experimental and computat

96 the carboxylation of a model alkyl bromide, hydrogenolysis is the primary side reaction.

97 Upon hydrogenolysis, it is generally assumed that the p-hydro

98 n is selective for the iodomethyl group over hydrogenolysis-labile protecting groups, such as benzylo

99 However, little is known about the hydrogenolysis mechanism of primary and secondary benzyl

100 Two divergent hydrogenolysis mechanisms are found; direct 1,2-dihydrog

101 xothermic reactions including hydrogenation, hydrogenolysis, metathesis, cyclization, oxidation, and

102 of these diastereoisomeric lactones through hydrogenolysis, N-Boc protection, reduction, methanolysi

103 Instead, hydrogenation and hydrogenolysis occur in parallel, and they are competing

104 viously, it was shown that on a Cu electrode hydrogenolysis occurs mainly through proton-coupled elec

105 Triphasic hydrogenolysis of (13)C-labeled benzyl phenyl ether (BPE

106 1 is alternatively synthesized upon hydrogenolysis of (BDI)Nb(N(t)Bu)Me2 in the presence of

107 distinguishable reaction pathways during the hydrogenolysis of 2-methyltetrahydrofuran (MTHF) on Ni,

108 The Hammett plot of the hydrogenolysis of 4-methoxyacetophenone displayed two op

109 e empirical rate law was determined from the hydrogenolysis of 4-methoxyacetophenone: rate = kobsd[Ru

110 e was fabricated, demonstrating an efficient hydrogenolysis of 5-hydroxymethyl furfural into 5-methyl

111 Hydrogenolysis of [Cp(PMe(3))Rh(Me)(CH(2)Cl(2))](+)BAr'(

112 A challenge in electrochemically achieving hydrogenolysis of a carbonyl group with high selectivity

113 Hydrogenolysis of a p-nitrobenzyl ester is effected usin

114 y not being fully determined until the final hydrogenolysis of a platinum acyl intermediate.

115 Here, we report hydrogenolysis of a terminal uranium(V)-nitride under mi

116 gous Mukaiyama reaction and a stereospecific hydrogenolysis of a tertiary benzylic center using Pd/C

117 ct, noncatalytic quantitative observation of hydrogenolysis of acyl dicarbonyls.

118 lead to a mixture of products from competing hydrogenolysis of aliphatic C-O bonds and hydrogenation

119 Currently, the hydrogenolysis of aromatic C-O bonds requires heterogene

120 bit high selectivity towards alkylarenes for hydrogenolysis of aryl ethers as model bio-oxygenates wi

121 synthesized and employed as catalyst for the hydrogenolysis of aryl ethers as models for lignin.

122 Mechanistic studies of the hydrogenolysis of aryl ethers by nickel were undertaken

123 Heterogeneous catalytic hydrogenolysis of aryl ethers is important both in hydro

124 erogeneous nickel catalyst for the selective hydrogenolysis of aryl ethers to arenes and alcohols gen

125 eactions of other late metal hydroxides, the hydrogenolysis of AuOH to form the corresponding Au(III)

126 eld by coupling of two monomers, followed by hydrogenolysis of benzyl ether protecting groups.

127 esis, microwave-assisted palladium-catalyzed hydrogenolysis of benzyl ethers was used to reduce react

128 yromellitate (27b) was obtained by catalytic hydrogenolysis of benzyl tri-l-menthyl pyromellitate (31

129 loping a method for the tandem hydrogenative hydrogenolysis of bio-based furfuryl aldehydes to methyl

130 Here, we report the efficient hydrogenolysis of biomass-derived 5-hydroxymethylfurfura

131 Selective CH(2)-OH hydrogenolysis of biomass-derived aromatic alcohols to p

132 y 40% greater than that of ethanol, involves hydrogenolysis of both the aldehyde (C=O) and the alcoho

133 Hydrogenolysis of C(5)-functionalized isoxazolines, bear

134 was also effective for the methanolysis and hydrogenolysis of C-C bonds (compared to C-O bonds for P

135 2) to produce the hydrogen necessary for the hydrogenolysis of C-S bonds and the removal of sulfur.

136 d to exhibit high catalytic activity for the hydrogenolysis of carbonyl compounds to yield the corres

137 which gives highly efficient conversions for hydrogenolysis of Cbz-protected amines and benzyl protec

138 Selective hydrogenolysis of cyclic and linear ether C-O bonds is a

139 report detailed mechanistic analysis of the hydrogenolysis of diaryl ethers catalyzed by the combina

140 Catalyst 1 is highly effective for the hydrogenolysis of diverse linear and branched hydrocarbo

141 utstanding catalytic performance in apparent hydrogenolysis of etheric, alcoholic, and esteric C-O bo

142 oduct (2-methyl furan) in catalytic transfer hydrogenolysis of furfural at low temperatures.

143 ts and provide a general description for the hydrogenolysis of hydrocarbons.

144 II)H remains highly selective and active for hydrogenolysis of iPP admixed with polyvinyl chloride, a

145 Sulfated zirconium oxide (SZO) catalyzes the hydrogenolysis of isotactic polypropylene (iPP, M(w)=13.

146 Hydrogenolysis of lignin generates a portfolio of produc

147 Hydrogenolysis of lignin model compounds highlights the

148 iO(2); X is the mean NP diameter), catalyzes hydrogenolysis of melt-phase polyethylene (PE) into a na

149 Hydrogenolysis of model gamma-p-hydroxybenzoylated beta-

150 Hydrogenolysis of n-butane catalyzed by these hydrides w

151 ne derivatives underwent palladium-catalyzed hydrogenolysis of one C-F bond at atmospheric pressure,

152 Catalytic hydrogenolysis of polyolefins into valuable liquid, oil,

153 non-thermal plasma-assisted method for rapid hydrogenolysis of polystyrene (PS) at ambient temperatur

154 Efficient hydrogenolysis of post-consumer PS materials using this

155 Hydrogenolysis of tertiary benzylic alcohols on palladiu

156 [C(5)H(3)(SiMe(3))-3](2)) was synthesized by hydrogenolysis of the allyl complex Cp(An)Y(eta(3)-C(3)H

157 The hydrogenolysis of the aromatic C-O bond in aryl ethers c

158 Selective hydrogenolysis of the aromatic carbon-oxygen (C-O) bonds

159 Dihydroxylation of the alkene followed by hydrogenolysis of the benzyl protecting groups results i

160 mation involves dehydrogenation of C(a) -OH, hydrogenolysis of the C(B) -O bond and reductive aminati

161 tion with dihydrogen, resulting in selective hydrogenolysis of the C-C sigma-bond.

162 We report the chemo- and regioselective hydrogenolysis of the C-O bonds in di-ortho-substituted

163 he absence of mediator, the major pathway is hydrogenolysis of the C-X bond, a 2 e(-) process occurri

164 Hydrogenolysis of the cyclometalated rhodium dichloride

165 d to the methyl-substituted enye 20, through hydrogenolysis of the derived bromide 19.

166 h both hydrogen addition to the C=C bond and hydrogenolysis of the ester.

167 he Ir-H bond of (Phebox)Ir(OAc)(H), and (ii) hydrogenolysis of the Ir-alkyl bond of (Phebox)Ir(OAc)(n

168 e for key sigma-complex intermediates in the hydrogenolysis of the iridium-methyl bond of (PONOP)Ir(H

169 The catalytic hydrogenolysis of the isoxazoline N-O bond was optimal u

170 rbon cleavage, while under basic conditions, hydrogenolysis of the metal-carbon bond was predominant.

171 Hydrogenolysis of the resultant polymers affords the pol

172 on with subsequent Bronsted acid cocatalyzed hydrogenolysis of the resulting oxa- or azarhodacyclohep

173 Transfer hydrogenolysis of the resulting ruthenium(II) diolate me

174 The catalytic hydrogenolysis of the titanium-amide bond in (eta(5)-C5M

175 lkoxylation/beta-C-O scission and subsequent hydrogenolysis of the vinyl benzoate intermediate.

176 The hydrogenolysis of titanium-nitrogen bonds in a series of

177 the C-O of fatty acid esters, leading to the hydrogenolysis of triglycerides.

178 ed efforts in developing a rhodium-catalyzed hydrogenolysis of unstrained C(aryl)-C(alkyl) bonds in 2

179 ecarbonylation (C-C cleavage) instead of C-O hydrogenolysis on Ir, Pt, and Ru, leading to strong inhi

180 pha-O-4 and beta-O-4 linkages are cleaved by hydrogenolysis on Ni, while the C-O bond of the 4-O-5 li

181 The hydrogenolysis or hydrodeoxygenation of a carbonyl group

182 as esterification, Suzuki-Miyaura coupling, hydrogenolysis, or Petasis borono-Mannich.

183 ectrode that was previously shown to promote hydrogenolysis over hydrogenation.

184 r easily reduced functionality by controlled hydrogenolysis over Lindlar catalyst.

185 f the acetyl protected aglycons, followed by hydrogenolysis over Pearlman's catalyst.

186 mechanistic investigation of gaseous propane hydrogenolysis over the single-site heterogeneous polyol

187 c reactions: hydrogenation, dehydrogenation, hydrogenolysis, oxidative dehydrogenation, alkane and cy

188 MXene catalysis, offering a straightforward hydrogenolysis pathway for challenging substrates.

189 As an alternative to this hydrogenolysis pathway, here we show that transmetalatio

190 ) that cleave C-O bonds by hydrogenation and hydrogenolysis pathways.

191 eactions favored on terrace sites, while C-C hydrogenolysis prefers sites with lower coordination, be

192 Hydrogenation/hydrogenolysis procedures would achieve these ends but h

193 In water, hydrolysis and hydrogenolysis proceed by partial hydrogenation of the a

194 ng studies indicate the hydrogen atom in the hydrogenolysis product comes solely from the aprotic ele

195 that are key to understanding the different hydrogenolysis product distributions from naturally acyl

196 elevant electrocarboxylation conditions, the hydrogenolysis product is formed via deprotonation of th

197 ther analysis reveals that hydrogenation and hydrogenolysis products are generated by parallel ECH pa

198 Chemical derivatization of the hydrogenolysis products showed that the reaction proceed

199 A following hydrogenolysis provides the azepanes in just two steps.

200 A following hydrogenolysis provides, with full diastereocontrol, the

201 The hydrogenolysis rate of benzylic alcohol on Pd/C increase

202 Methyl substituents at C-C bonds influence hydrogenolysis rates and selectivities of acyclic and cy

203 C-O hydrogenolysis rates are independent of H2 pressure and

204 n-alkyl R-groups exerted opposite effects on hydrogenolysis rates in homogeneous versus heterogeneous

205 Branched alkyl R-groups decreased hydrogenolysis rates relative to their straight-chain ho

206 pillover, showcasing a threefold increase in hydrogenolysis rates.

207 euterium isotope effect was observed for the hydrogenolysis reaction catalyzed by 1/p-X-C6H4OH with a

208 d atomic charge distributions and calculated hydrogenolysis reaction energies.

209 ence, of catalytic performance in the alkane hydrogenolysis reaction of Ir clusters in the subnanomet

210 y the structural changes were evaluated by a hydrogenolysis reaction of strained species resulting in

211 t mechanistic pathways are presented for the hydrogenolysis reaction on the basis of these kinetic an

212 cross metathesis followed by a hydrogenation/hydrogenolysis reaction stereoselectively formed the pip

213 (100) surface is specifically active for the hydrogenolysis reaction, breaking the C-O bond, whereas

214 Some C-C bond hydrogenolysis reactions also have been examined includi

215 d from 0.7 to 7 nm; these trends reflect C-O hydrogenolysis reactions favored on terrace sites, while

216 In contrast to hydrogenolysis reactions of other late metal hydroxides,

217 Hydrogenolysis reactions of palladium(II) hydroxide and

218 ontinued utility of such approaches even for hydrogenolysis reactions, with complexity seemingly beyo

219 nt in remote, Pd-catalyzed hydrogenation and hydrogenolysis reactions.

220 ates, which then undergo manganese-catalyzed hydrogenolysis, regenerating the promoter.

221 s indicate each safener can undergo stepwise hydrogenolysis (replacement of chlorine by hydrogen) in

222 Hydrogenolysis selectivity correlates with the Gibbs fre

223 This single-site system exhibits unique hydrogenolysis selectivity that favours cleaving branche

224 zyl phosphite phosphorylation and subsequent hydrogenolysis sequence (3b --> 3c --> 3d).

225 ic hydrogenation sites for the C=O group and hydrogenolysis sites for the C-OH group through a scarce

226 n and poplar biomass through methods such as hydrogenolysis, solvolysis, and reductive catalytic frac

227 The first hydrogenolysis step generates compounds similar (in one

228 n that they incorporate an alkylation in the hydrogenolysis step to close the second ring of the azab

229 A final hydrogenolysis step to remove the protective groups prod

230 Here we report a vapour-phase hydrogenolysis strategy catalysed by Ru single atoms on

231 novel heterogeneous catalytic hydrogenation-hydrogenolysis strategy has been developed for the alpha

232 hermore, by designing a tandem fractionation-hydrogenolysis strategy, the dissolved lignin is depolym

233 Specifically, reported hydrogenolysis studies with Ni and other catalysts have

234 sostructural uranium(VI)-nitride is inert to hydrogenolysis, suggesting the 5f(1) electron of the ura

235 rrangement and a regioselective cyclopropane hydrogenolysis, the total synthesis of 9-epi-pentalenic

236 , which reduces quantitatively via catalytic hydrogenolysis to afford 1-DMJ (4) in 55% overall yield

237 d identify Bronsted acid cocatalyst assisted hydrogenolysis to be the most difficult step.

238 The ratio of C-O hydrogenolysis to decarbonylation rates increased almost

239 ed N-benzyl tetrazoles can be deprotected by hydrogenolysis to form the corresponding NH tetrazoles i

240 mono- and dicarbonyl intermediates and their hydrogenolysis to give aldehydes.

241 N) in benzene at reflux for 36 h resulted in hydrogenolysis to give ethyl hexanoate (60%), whereas no

242 eprotected by catalytic (Pd/C) hydrogenation/hydrogenolysis to give the desired, amino-functionalized

243 For polyethylene, quantitative hydrogenolysis to light hydrocarbons proceeds within 48

244 Co(3)O(4)), decoupling depolymerization from hydrogenolysis to overcome the toluene yield-selectivity

245 -phosphorylation, followed by desilation and hydrogenolysis to the free mono- and diphosphates, and,

246 tomated plug-flow catalytic reactor, propane hydrogenolysis turnover frequencies approach 3,000 h(-1)

247 hos)Co(CO)(2) C(O)CH(2) CH(2) Ph, which upon hydrogenolysis under 4 atm H(2) produced the correspondi

248 ectively break bonds in polymer and initiate hydrogenolysis under mild condition.

249 hesis of glycans as they can be subjected to hydrogenolysis under neutral conditions.

250 ansition states-bimolecular metal-alkyl bond hydrogenolysis vs. unimolecular beta-alkyl elimination.

251 In the final synthetic step, hydrogenolysis was applied to remove the thiol handle fr

252 The use of bicarbonate in the hydrogenolysis was key in providing protection of the py

253 Hydrogenolysis was performed under mild conditions over

254 hts can be controlled via hydrogen addition (hydrogenolysis), which is unusual for late-transition-me

255 residual oxygen species, boosting selective hydrogenolysis while suppressing furan and CH=O hydrogen

256 -4 and beta-O-4 linkages can undergo further hydrogenolysis, while phenol (produced by hydrolysis of

257 on, O-Me oxime formation, and RaNi-catalyzed hydrogenolysis with concomitant cyclization under basic

258 Coupling exothermic hydrogenolysis with endothermic aromatization renders th

259 zylamide and lactams which are refractory to hydrogenolysis with hydrogen and a catalyst.

260 -ylsulfonyl)hexanoate underwent quantitative hydrogenolysis within 1 h under these conditions.

261 otection by ester saponification followed by hydrogenolysis yielded the free procyanidins, which were