ライフサイエンスコーパス: hydrolyzable

1 the imido linkage usually regarded to be non-hydrolyzable.

2 (5)P, indicating that the replacement of the hydrolyzable 5-phosphate group does not compromise the b

3 Abscisic acid glucosyl ester (ABA-GE) is a hydrolyzable ABA conjugate that accumulates in the vacuo

4 plex with a pair of substrates TMP and a non-hydrolyzable adenosine triphosphate analog, and in compl

5 The hydrolyzable agonist ADP (10 microM) produced 32% inhibi

6 oiety at the 1-position of PtdCho with a non-hydrolyzable alkyl moiety prevented degradation to GPC.

7 ithiocarbamate, carbamate, and pH responsive hydrolyzable amide analogues.

8 In this study we develop a class of non-hydrolyzable amine-selective di-ortho-phthalaldehyde (DO

9 environmental stresses, we investigated the hydrolyzable amino acid distribution and concentration i

10 The high proportions of total hydrolyzable amino acids and presence of chemical specie

11 We extracted hydrolyzable amino acids from leaf litter and fine (< 2

12 cells, where it is processed releasing a non-hydrolyzable aminoacyl adenylate that inhibits an essent

13 the MccF clade can specifically detoxify non-hydrolyzable aminoacyl adenylates differing in their ami

14 on in real time, we found that AMP and a non-hydrolyzable AMP analog (deoxyadenosine 5'-monophosphona

15 -RFC was capable of unloading PCNA using non-hydrolyzable AMP-PNP.

16 ADP, AMP and the non-hydrolyzable analog adenosine 5'-(beta, gamma-iminodipho

17 te when presented with either ATP or the non-hydrolyzable analog AMP-PNP, and these cycles of elongat

18 stranded DNA, in the presence of the ATP non-hydrolyzable analog AMP-PNP, have been performed, using

19 icrom) and is displaced by ATP or by its non-hydrolyzable analog AMPPNP (concentrations for half-maxi

20 the absence of ATP or presence of the poorly hydrolyzable analog ATP-gamma-S unexpectedly revealed th

21 When p21(cip1) is added, followed by the non-hydrolyzable analog ATPgammaS to block helicase function

22 inds to HSP90 also in the absence of the non-hydrolyzable analog ATPgammaS.

23 g ATP (K1/2, 1.3 +/- 0.7 mm) but not the non-hydrolyzable analog ATPgammaS.

24 the mechanisms by which substituting the non-hydrolyzable analog GDPCP for GTP or adding thiostrepton

25 g IF3, and/or (c) replacing GTP with the non-hydrolyzable analog GDPCP.

26 Both GTP and its non-hydrolyzable analog guanosine 5'-O-(thiotriphosphate) st

27 the eEF2-dependent dissociation, while a non-hydrolyzable analog of ATP was inactive in ribosome spli

28 n phosphorylation since 5 mM AMPPNP, the non-hydrolyzable analog of ATP, reversibly inhibited channel

29 only when the internal solution contained a hydrolyzable analog of ATP.

30 In this study, a novel non-hydrolyzable analog of cADPR, N1-cIDPR (N1-cyclic inosin

31 he production of NO were induced by a slowly hydrolyzable analog of cGMP, 8-bromo-cGMP, but not by no

32 In x-ray structures of hpol eta with a non-hydrolyzable analog of dATP or dGTP opposite an abasic s

33 polymer formed with GTP or GMPCPP (a slowly hydrolyzable analog of GTP) is moderate (micromolar rang

34 (alpha,beta-methylene)triphosphate, a slowly hydrolyzable analog of GTP, became larger and polydisper

35 ced by EF-G in the presence of GTP and a non-hydrolyzable analog of GTP, GDP*BeF3(-) are similar.

36 d without alpha-l-Glu-l-Glu dipeptide, a non-hydrolyzable analog of poly-gamma-d-glutamic acid, in th

37 omplex with the canonical tRNA2(Thr) and non-hydrolyzable analog of threonyl adenylate.

38 presence and absence of ATP, and of the non-hydrolyzable analog, adenosine 5'-O-(3-thiotriphosphate)

39 ATPgammaS, a slowly hydrolyzable analog, switches SUR1 conformations, albeit

40 Replacement of ATP with the poorly hydrolyzable analogs 5'-adenylyl methylenediphosphate, 5

41 nhydrolyzable analog GMP-PNP, and the slowly hydrolyzable analogs guanosine 5'-O-(2-thiodiphosphate)

42 anic phosphate rather than ATP, and that non-hydrolyzable analogs of ATP cannot support the enzymatic

43 f ATP was not specifically required, and non-hydrolyzable analogs of ATP that blocked 90% of the ATPa

44 icient DNA binding is only observed with non-hydrolyzable analogs of ATP, suggesting that ATP hydroly

45 hough substantial activity remained when non-hydrolyzable analogs were used instead.

46 In contrast, the addition of the non-hydrolyzable analogue ATPgammaS, did not reverse nuclear

47 creased by the addition of GTP or its slowly hydrolyzable analogue guanosine 5'-3-O-(thio)triphosphat

48 f the bound peptide in the presence of a non-hydrolyzable analogue of GTP, indicative of the alternat

49 oduction of IP(3), and adenophostin A, a non-hydrolyzable analogue of IP(3).

50 hate (O(3)P-NH-PO(2)-NH-PO(3); PNPNP), a non-hydrolyzable analogue of PPPi, is the most potent known

51 Here, we show that non-hydrolyzable analogues of PPi, bisphosphonates, are pote

52 Guanosine triphosphate (GTP) and its non-hydrolyzable analogues optimally enhance the phosphoryla

53 r elevation of cholesterol because (i) a non-hydrolyzable and a degradable SL analog elevated cellula

54 further enhanced upon the addition of a non-hydrolyzable ATP analog (adenylyl-imidophosphate), where

55 sed by vanadate (Vi), acetate, ATP, or a non-hydrolyzable ATP analog (AMP-PNP), with differential eff

56 Escherichia coli PhoQ complexed with the non-hydrolyzable ATP analog adenosine 5'-(beta,gamma-imino)t

57 both in the presence and absence of the non-hydrolyzable ATP analog ADP(BeF3).

58 the NtrC1 ATPase domain, bound with the non-hydrolyzable ATP analog ADP-beryllium fluoride, we studi

59 sults demonstrate that the presence of a non-hydrolyzable ATP analog allows Mtr4p to discriminate bet

60 tors or intracellular perfusion with the non-hydrolyzable ATP analog AMP-PNP dramatically reduce the

61 x structure of activated NTPDase3 with a non-hydrolyzable ATP analog and the cofactor Mg(2+) to a res

62 es bound to either a SMG1 inhibitor or a non-hydrolyzable ATP analog at overall resolutions ranging f

63 45 can also be interrupted by adding the non-hydrolyzable ATP analog ATP-gamma-S.

64 ls of closed clamps in the presence of a non-hydrolyzable ATP analog compared with the wild type enzy

65 ontrast, the presence of either ADP or a non-hydrolyzable ATP analog induces conversion to a monomeri

66 The protection from inhibition by a non-hydrolyzable ATP analog or acetylphosphate, in conjuncti

67 SynAPSK in complex with either APS and a non-hydrolyzable ATP analog or APS and sulfate revealed the

68 the wild-type enzyme is titrated with a non-hydrolyzable ATP analog or the enzyme is mutated such th

69 omplex of NS3 bound to labeled RNA and a non-hydrolyzable ATP analog provide a direct view of how lar

70 A non-hydrolyzable ATP analog was a competitive inhibitor.

71 ell as differences compared to AMPPNP (a non-hydrolyzable ATP analog) bound to PhoQcat and radicicol

72 ,gamma-methylene)triphosphate (AMP-PCP) (non-hydrolyzable ATP analog) bound were also solved at 1.9-A

73 he presence of ATP as well as AMP-PCP (a non-hydrolyzable ATP analog).

74 ly (i.t.) with or without adenosine or a non-hydrolyzable ATP analog, adenosine 5'-(gamma-thio)-triph

75 Using either ATP or the non-hydrolyzable ATP analog, adenosine 5'-O-(3-thiophosphate

76 y at high pH only in the presence of the non-hydrolyzable ATP analog, ADP(BeF3).

77 nucleosome while in the presence of the non-hydrolyzable ATP analog, ADP-beryllium fluoride, we obse

78 studies of this complex reveal that the non-hydrolyzable ATP analog, ATPgammaS, induces a high-affin

79 step in its functional cycle by use of a non-hydrolyzable ATP analog, ATPgammaS, to mimic the ATP-bou

80 ATP-gamma-S, a poorly hydrolyzable ATP analog, did not support endocytosis but

81 However, in the presence of a non-hydrolyzable ATP analog, DNA binding was only slightly c

82 ta,gamma-imido]triphosphate (AMP-PNP), a non-hydrolyzable ATP analog, has no effect on MGAD activity.

83 hen SecA associated with ATPgammaS, a poorly hydrolyzable ATP analog, or ADP plus AlF(4), which mimic

84 observed either with ATP-gamma-s, the slowly hydrolyzable ATP analog, or with ATP in the presence of

85 subunit poorly, whereas with AMP-PNP, a non-hydrolyzable ATP analog, the affinity was 11 nM.

86 e-5-maleimide-actin with bound AMPPNP, a non-hydrolyzable ATP analog, was determined to 1.85-A resolu

87 were suppressed by binding of a specific non-hydrolyzable ATP analog.

88 t in apo form as well as that bound to a non-hydrolyzable ATP analog.

89 Non-hydrolyzable ATP analogs (but not ATP or ADP) release P1

90 ither nonhydrolyzable (AMP-PNP, AMP-PCP) nor hydrolyzable ATP analogs (GTP, CTP, UTP, and ITP) activa

91 Non-hydrolyzable ATP analogs did not substitute for ATP in t

92 Nonhydrolyzable or poorly hydrolyzable ATP analogs inhibited MgATP-supported bindi

93 Finally, experiments with non-hydrolyzable ATP analogs suggest that SpoIIIE can operat

94 The finding that slowly hydrolyzable ATP analogs trigger slower nucleotide relea

95 challenged with neutral-backbone DNA and non-hydrolyzable ATP analogs.

96 DNA in a reaction promoted by ATP or the non-hydrolyzable ATP analogue AMP-PNP.

97 osine 5'-(gamma-thio)-triphosphate (a slowly hydrolyzable ATP analogue) differently from Hsp104.

98 ) In contrast, the hexokinase-treated poorly hydrolyzable ATP analogue, adenosine 5'-O-(thiotriphosph

99 The non-hydrolyzable ATP analogue, gamma-S-ATP, gave a similar p

100 Cl- channels were similarly affected by non-hydrolyzable ATP analogues and mutations in the CFTR R d

101 ration does not occur in the presence of non-hydrolyzable ATP analogues, nor when mutant rad54 protei

102 OS induction minimally require ssDNA and non-hydrolyzable ATP analogues.

103 ranscription by RNA polymerase II requires a hydrolyzable ATP cofactor for synthesis of the first pho

104 Strikingly, the presence of a non-hydrolyzable ATP derivative, ATPgammaS, not only increas

105 Inclusion of hydrolyzable ATP in binding reactions increased the appa

106 cordings and Ca(2+) imaging demonstrate that hydrolyzable ATP is essential to maintain synaptic Ca(2+

107 olar affinity to both Arp2 and Arp3 and that hydrolyzable ATP is required for actin nucleation activi

108 e-released factor(s) specifically required a hydrolyzable ATP substrate and was inhibited by procedur

109 Addition of hydrolyzable ATP to this complex results in the disrupti

110 titor substrate) began within 30 s, required hydrolyzable ATP, and plateaued after 60-70 s.

111 Consistently, non-hydrolyzable ATP, ATPgammaS, only inhibited but did not

112 y-purified and stabilized by addition of non-hydrolyzable ATP, which binds specifically to the ATPase

113 g SERCA in the presence and absence of a non-hydrolyzable ATP-analog, AMPPCP.

114 it compacts the DNA only in the presence of hydrolyzable ATP.

115 lex by displacement of E2 in the presence of hydrolyzable ATP.

116 addition of fractionated nuclear extract and hydrolyzable ATP.

117 lent metal, and adenosine nucleotides with a hydrolyzable beta,gamma-phosphate bond.

118 The presence of a hydrolyzable bond linking laccase to the cell wall was s

119 They usually contain ester and other hydrolyzable bonds, such as anhydride, acetal, ketal, or

120 , do not have peptidic features, and have no hydrolyzable bonds.

121 ly linked doxorubicin with a peptide that is hydrolyzable by prostate-specific antigen.

122 GaFK-Doxaz is hydrolyzable by the proteases plasmin and cathepsin B, b

123 design of peptide-based antibiotics that are hydrolyzable by wastewater peptidases.

124 s: (1) how the recognition properties of non-hydrolyzable C-glycoside analogues compare with those of

125 diesterase (PDE) inhibition, as well as by a hydrolyzable cAMP analog, but not by a nonhydrolyzable c

126 When hydrolyzable cations such as aluminum interact with soli

127 generation and hydrolysis; and exogenous PDE hydrolyzable cGMP analog induced iNOS and NO.

128 e synthase-derived and/or PDE type 5 (PDE-5)-hydrolyzable cGMP undetected at the sarcolemmal membrane

129 mediate over the less stable and more easily hydrolyzable cis-enamine and imine co-intermediates.

130 comprised of undecomposed plant material and hydrolyzable components associated with mineral surfaces

131 three Rho active sites are empty or bear non-hydrolyzable compounds.

132 wo insertion complexes revealed incoming non-hydrolyzable dATP or dGTP analogs not pairing with but i

133 Poorly hydrolyzable derivatives of ADP and ATP were effective c

134 ythrine prevented the PMA effects; and (3) a hydrolyzable diacylglycerol analogue, 1-oleoyl-2-acetyl-

135 ition of the lipolysis induced by the poorly hydrolyzable dibutyryl cAMP analog.

136 s oocytes that was able to transport the non-hydrolyzable dipeptide [3H]d-Phe-l-Gln, although unlike

137 ated with three-dimensional studies, the non-hydrolyzable donor analog UDP-phosphono-galactose (UDP-C

138 lysis of a single catalytic turnover using a hydrolyzable duplex oligodeoxyribonucleotide substrate c

139 circularity by incorporation of more easily hydrolyzable ester bonds, additional dynamic bonds, or d

140 er conjugation to octaarginine via a readily hydrolyzable ester linkage inhibits ENR activity, tachyz

141 tion of Ins(1,4,5,6)P4, a membrane-permeant, hydrolyzable ester was used to deliver it to the intrace

142 pCB can also be prepared in a hydrolyzable form as cationic pCB esters, which can kill

143 This required MgCl2 and a hydrolyzable form of ATP and was prevented by P1,P5-di-a

144 A hydrolyzable form of ATP is necessary to maintain the M

145 equired the presence of a DNA mismatch and a hydrolyzable form of ATP.

146 rtin with Nup153 could be disrupted by a non-hydrolyzable form of GTP or by a GTPase-deficient mutant

147 e triphosphate (ATP) or dATP whereas the non-hydrolyzable gamma-S-ATP does not support activity.

148 ARS-CoV-2 NiRAN domain with a beta-gamma-non-hydrolyzable GTP analog (GMPPNP) and RNA-nsp9 (PDB: 8GWE

149 nding domain of Sec5 and RalA bound to a non-hydrolyzable GTP analog (GppNHp) at 2.1 A resolution, pr

150 etween microtubules stabilized with a slowly hydrolyzable GTP analog and microtubules stabilized with

151 n the presence or absence of IF2 and the non-hydrolyzable GTP analog GDPCP, alongside structures of 7

152 -family GTPases in these extracts by the non-hydrolyzable GTP analog GTPgammaS stimulated barbed-end

153 actor 1 (ARF1) in the presence of the poorly hydrolyzable GTP analog guanosine 5'-O-(3-thiotriphospha

154 ures of (K180P)G alpha(i1) bound to a slowly hydrolyzable GTP analog, and the GDP.magnesium fluoroalu

155 ystals were obtained in complexes with a non-hydrolyzable GTP analog, GppNHp.

156 y, in two states: bound to GDP, and to a non-hydrolyzable GTP analog, guanosine-5'-(beta, gamma)-imid

157 Here, we have used the slowly-hydrolyzable GTP analog, guanylyl-(alpha,beta)-methylene

158 lizes ternary complex in the presence of non-hydrolyzable GTP analogs.

159 G to the ribosome in the presence of the non-hydrolyzable GTP analogue GDPNP or GTP plus fusidic acid

160 ure in vitro, but were unaffected by the non-hydrolyzable GTP analogue GMP-PNP.

161 eabilized parasites was augmented by the non-hydrolyzable GTP analogue guanosine 5'-3-O-(thio)triphos

162 y(catastrophe) was obtained using the slowly hydrolyzable GTP analogue guanylyl-(a,b)-methylene-dipho

163 in in microtubules assembled with the slowly hydrolyzable GTP analogue guanylyl-(alpha, beta)-methyle

164 ent of agonist-occupied receptors with a non-hydrolyzable GTP analogue shifted the receptor into its

165 cyclase by receptors and GTP gamma S (a non-hydrolyzable GTP analogue) is reduced by up to 95%.

166 ules (MTs) polymerized with GMPCPP, a slowly hydrolyzable GTP analogue, are stable in buffer but are

167 duced by GTP and nearly abolished by the non-hydrolyzable GTP analogue, guanosine-5'-[thio]-triphosph

168 mutant fusion proteins using a fluorescent, hydrolyzable GTP analogue.

169 evertheless inhibited by the addition of non-hydrolyzable GTP analogues.

170 s, in contrast to smaller proteins, requires hydrolyzable GTP and the small GTPase Ran.

171 In the presence of non-hydrolyzable GTP, EF4 showed chemical protections simila

172 2 alone or with RF3 alone-RF3 bound to a non-hydrolyzable GTP-analog-have been reported.

173 S2 prevented stimulation of alpha1E with non-hydrolyzable guanosine 5'-0-(3-thiotriphosphate).

174 assays were performed in the presence of non-hydrolyzable guanosine 5'-triphosphate (GTP) analogue, 5

175 Using hydrolyzable H2B-Ub analogs, we show that Ubp10 activity

176 alpha-bromoacyl taxanes were synthesized as hydrolyzable hydrophobic prodrugs of paclitaxel.

177 involve the formation of bromophosgene as a hydrolyzable intermediate.

178 bicity from either the copolymerization of a hydrolyzable lactone ring or the hydrogel polymer conten

179 l of these duplexes are constructed with non-hydrolyzable lesion analogs that mimic the natural 8-oxo

180 can be rationalized by considering CFTR as a hydrolyzable-ligand-gated channel with cytoplasmic ATP a

181 All monomers contain hydrolyzable linkages to pendant functional groups, and

182 n, optimally linked through a differentially hydrolyzable linker unit, N-4-carboxymethylphenyl-methyl

183 isomerase I inhibitor) through a proprietary hydrolyzable linker.

184 he tissues either after hydrolysis or as non-hydrolyzable lipid esters.

185 Binding of non-hydrolyzable MgATP analogs or ATP in the absence of Mg i

186 studies suggest that MgAMP-PNP acts as a non hydrolyzable MgATP analogue for myosin.

187 e amide bond of anandamide (5, AN) to a less hydrolyzable moiety, analogues 1a-1l, 2a-2c, 3a-3c, and

188 and NBD2 as a site of fast turnover, the non-hydrolyzable N(3)AMP-PNP bound preferentially to NBD1.

189 nitrogen atoms of the l-histidine through a hydrolyzable N-glycosidic bond.

190 crystallized PEIII in the presence of a less hydrolyzable NAD analog, beta-methylene-thiazole-4-carbo

191 The activity required a hydrolyzable nucleoside triphosphate and both 5'- and 3'

192 ted nucleotide hydrolysis in the presence of hydrolyzable nucleoside triphosphates ATP, CTP, UTP, and

193 ure, complexes are also presented with a non-hydrolyzable nucleotide analog (adenosine 5'-(beta,gamma

194 imen crystallized in the presence of the non-hydrolyzable nucleotide analog, adenosine 5'-O-(thiotrip

195 ese studies utilized transition state or non-hydrolyzable nucleotide analogs, it is not clear at what

196 Further, using a combination of non-hydrolyzable nucleotide analogues and mutations that blo

197 Compared to those of the other hydrolyzable nucleotide triphosphates, the ATPase activi

198 The non-hydrolyzable nucleotides adenosine 5'-(beta,gamma-imino)

199 We conclude that poorly hydrolyzable nucleotides are less effective than ATP at

200 ein for Ypt7p:GTP), GTPgammaS or GppNHp (non-hydrolyzable nucleotides), and mutant forms of Ypt7p tha

201 - and time-dependent, and detected only with hydrolyzable nucleotides.

202 les was not sensitive to hydrolyzable or non-hydrolyzable nucleotides.

203 This study suggests that hydrolyzable O-alkyl soil OM components may block high a

204 Likewise, its affinity for the non-hydrolyzable oligonucleotide 6-FAM approximately d(CAA)

205 s with the microtubules was not sensitive to hydrolyzable or non-hydrolyzable nucleotides.

206 is into PGE2, were not observed with the non-hydrolyzable PGE2-serinol amide, and were completely pre

207 negatively charged substituents para to the hydrolyzable phosphate dramatically promote hydrolytic e

208 Extended extracellular exposure to the non-hydrolyzable phosphatidic acid and LPA analog carbocycli

209 DEDNPP via P-O bond break, forming a quickly hydrolyzable phosphorylated intermediate, regenerating t

210 ogy for site-directed incorporation of a non-hydrolyzable phosphoserine mimic, we show how phosphoryl

211 Biocatalytic degradation of non-hydrolyzable plastics is a rapidly growing field of rese

212 e reports of oxidative enzymes acting on non-hydrolyzable plastics, including polyethylene or poly(vi

213 Hydrolyzable polymers are widely used materials that hav

214 Here, we report the first design of hydrolyzable polyureas bearing dynamic hindered urea bon

215 trategy, phenylsilanes were employed as acid-hydrolyzable precursors of the silanol group.

216 ct is reported as a new member of a class of hydrolyzable prodrugs of the duocarmycin and CC-1065 fam

217 roach that transforms a weak and general non-hydrolyzable pTyr mimetic (F(2)Pmp, phosphonodifluoromet

218 s been accomplished by replacing the rapidly hydrolyzable Schiff-base moiety of first-generation memb

219 even-amino acid peptide was documented to be hydrolyzable specifically by the serine protease prostat

220 on in complex with magnesium ion and the non-hydrolyzable substrate analog, alpha,beta-imido dUTP.

221 (DRV), a potent clinical inhibitor, or a non-hydrolyzable substrate analogue, Ac-Thr-Ile-Nle-r-Nle-Gl

222 ith alpha-maltose-C-phosphonate (MCP), a non-hydrolyzable substrate analogue, was solved to 1.9 A res

223 -MSA synthases with both nonhydrolyzable and hydrolyzable substrate mimics have provided additional i

224 in complex with NAD, deamido-NAD, and a non-hydrolyzable TAD analogue beta-CH(2)-TAD.

225 logs co-exist in galloylated flavan-3-ol- or hydrolyzable tannin-rich plant species.

226 We experimentally induced hydrolyzable-tannin defenses in red oak, to show that in

227 nt extractions resulted in similar levels of hydrolyzable tannins (10.3-6.0 mg/g), anthocyanins (7.8-

228 Almost 200years ago, hydrolyzable tannins (HTs) were the first group of plant

229 nnins, including condensed tannins (CTs) and hydrolyzable tannins (HTs), are widely distributed in th

230 d fatty acids and phenolic compounds (namely hydrolyzable tannins and anthocyanins) with antioxidant

231 hytochemical tests indicated the presence of hydrolyzable tannins and saponins.

232 C-DAD-MS(n) allowed the identification of 44 hydrolyzable tannins as single and mixed hexosides beari

233 ficient for the extraction of poorly soluble hydrolyzable tannins but affected the stability of antho

234 Last, cyanidin-3-O-glucoside and hydrolyzable tannins from the ultrasonic extract inhibit

235 dilactone and pointed to higher contents in hydrolyzable tannins than by summing individual polyphen

236 ts, which are rich in copigments, especially hydrolyzable tannins, are suitable natural antioxidants

237 one of the duplexes contains a central, non-hydrolyzable, tetrahydrofuran (THF) abasic site analog,

238 ther substitution of this residue with a non-hydrolyzable the phosphoserine/phosphothreonine mimetic

239 incorporated acetyl-lysine (AcK) and the non-hydrolyzable thioacetyl-lysine (ThioAcK) into full-lengt

240 ns of long chain fatty acyl-CoAs and the non-hydrolyzable thioether analog of palmitoyl-CoA markedly

241 s rapidly catabolized by V. furnissii, a non-hydrolyzable thioglycoside analogue was used: methyl bet

242 plasma was enriched in isoflavones that were hydrolyzable with a combined beta-glucuronidase and sulf