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1 en bonding) and sp(3)C-sp(2)C (CH-pai and/or hydrophobic).
2 icles are coated with thiolated dextran, and hydrophobic acetal groups are installed through direct c
4 ration of self-healing in alternating/random hydrophobic acrylic-based copolymers in the presence of
5 the N6-methyl group is accommodated within a hydrophobic active-site subpocket explaining why N6-meth
7 me has been shown to bind on the surfaces of hydrophobic aggregates, such as detergent micelles, lipo
9 d gate in the ion-conducting pore, formed by hydrophobic amino acid side chains, located ~60 angstrom
11 T of Bacillus halodurans is a transporter of hydrophobic amino acids and a homologue of the eukaryoti
12 he isostere of lopinavir in combination with hydrophobic amino acids on the opposite P2/P2' position.
15 up to six monosaccharide units attached to a hydrophobic amino-pentyl linker, a construct not expecte
18 folded polypeptide chains, even those with a hydrophobic and charged sequence composition typical of
20 s a metal and a superfine ionomer layer with hydrophobic and hydrophilic functionalities that extend
21 igand structure interacted directly with the hydrophobic and hydrophilic halves of the CA II active s
22 ristine graphene flakes possess well-defined hydrophobic and hydrophilic regions: the basal plane and
24 ol hydrogen-bonding networks confined within hydrophobic and hydrophilic zeolite catalysts modify rea
25 the encounter complex, transient nonspecific hydrophobic and long-range electrostatic contacts form b
26 wer and more convergent repertoire with more hydrophobic and strongly interacting amino acid residues
27 The two faces of the beta-sheet core are hydrophobic and surrounded by the membrane-mimicking env
29 ne is stabilizing, our results indicate that hydrophobic and/or electrostatic effects in the cavity a
30 dies suggest that activators use nonspecific hydrophobic and/or electrostatic interactions to bind to
31 enrichment strategies (i.e., hydrophilic and hydrophobic) and a liquid handling platform allowing for
33 Surprisingly, these interactions are largely hydrophobic, and they do not include the previously iden
34 ferent wetting properties of hydrophilic and hydrophobic areas in the channels, we improve the extrac
37 he licorice root and possesses a triterpenic hydrophobic backbone and a hydrophilic headgroup built f
38 hibition by posttranslational sumoylation, a hydrophobic barrier within the pore, and a low open prob
41 nspecific ionic interactions involving basic-hydrophobic (BH) sites but the mechanism of myosin 1s di
43 illararenes (PAs; e.g. rigid, capacious, and hydrophobic cavities, as well as exposed functional grou
44 strategy highlights the crucial role of BLG hydrophobic cavity and opens up new possibilities for th
46 -based molecule and a beta-cyclodextrin (CD) hydrophobic cavity for asymmetric catalytic applications
47 turally simple BODIPY derivatives within the hydrophobic cavity of a water-soluble, flexible Pd(II)(6
48 hat one to two water molecules can enter the hydrophobic cavity of alpha(3)Y and hydrogen bond to Y(3
49 usion of a d-glucosamine derivative into the hydrophobic cavity of beta-CD increased its surface area
51 tinol, which has a high affinity for the BLG hydrophobic cavity, significantly stabilizes BLG both in
53 lle, pointing the farnesyl moieties into the hydrophobic center and positioning the head groups at th
54 del indicates that m102.4 targets the common hydrophobic central cavity and a hydrophilic rim on the
55 6-tetrachloroisophtalonitrile, TPN) into the hydrophobic channel and observed that the most energetic
58 how that the evaluation of electrostatic and hydrophobic characters of the mabs is useful in predicti
61 e interactions of resin with protein surface hydrophobic clusters distributed across CDRs of light ch
62 de the secreted proteins BslA, which forms a hydrophobic coat over the biofilm, and TasA, which forms
64 ament displays a paucity of salt bridges and hydrophobic complementarity between the TnT tail (TnT1)
66 toside, which preserved both hydrophilic and hydrophobic components of the SDBC and allows the retent
69 a subtle inhibitory effect on the binding of hydrophobic compounds to alpha-amylase, thereby increasi
71 l similar but with a higher degree of native hydrophobic contact formation in the transition state of
75 te taken by pumped protons to traverse CcO's hydrophobic core and on whether bacterial and mitochondr
76 ation promotes drug release by switching the hydrophobic core into completely hydrophilic chains.
78 ted-chitosan-zinc-insulin complexes into the hydrophobic core of PLA-PEG-PLA thermogel-copolymer mice
79 mide, with the interior water present in the hydrophobic core of the confined micellar medium in aque
81 hored to the helical scaffold by a secondary hydrophobic core, pinning down the long loops of leptin
83 NIPAm) (pNIPAm), held above its LCST, formed hydrophobic cores around which shells composed of NIPAm,
84 rhodamine 110 and 6G dyes paired with bulky hydrophobic counterions, which prevent dye self-quenchin
85 atal water loss by transpiration through the hydrophobic cuticle is ubiquitous in land plants, but th
87 We sought to explore if PET imaging using hydrophobic cyclic peptides that partition into the cell
88 method (VA-DES-DLME) was developed based on hydrophobic deep eutectic solvent for extraction of foli
90 demonstrated long-term stability because the hydrophobic DMIMPF(6) layer blocked moisture permeation.
91 arge binding site (1000 angstrom) with fewer hydrophobic domains that makes a challenge to identify t
92 d water and it displays both hydrophilic and hydrophobic domains, a net negative charge, and high por
93 ethods of making carrier-free nanodrugs from hydrophobic drug molecules, evaluating their performance
94 ionally high encapsulation efficiencies of a hydrophobic drug simvastatin (SV) and a photosensitizer
96 ide range of bioactive molecules, from small hydrophobic drugs to large biomolecules such as proteins
100 for proteins with different properties and a hydrophobic dye and describe for the first time how thes
106 problem of accommodating charges in a highly hydrophobic environment while maintaining selective subs
107 o stabilize serine and threonine residues in hydrophobic environments while concomitantly providing t
108 cted by interactions between the classic I44 hydrophobic face of the distal Ub and the conserved MGF
109 d and contorted backbones, which incorporate hydrophobic fluorinated and hydrophilic sulfonic acid fu
112 structure of the SepF-FtsZ complex reveals a hydrophobic FtsZ-binding pocket, which defines the SepF
114 t channel structure, reveal a double-barrier hydrophobic gate formed by two S6 amino acids in the cen
117 s showed that Phactr1 binding remodels PP1's hydrophobic groove, creating a new composite surface adj
119 ors (6a, 6b, 6d, and 6e) with flexible bulky hydrophobic groups instead of the rigid polyheterocyclic
120 itates adhesion of Salmonella Typhimurium to hydrophobic host cell surfaces, and contributes to effic
121 33 C terminus revealed that it fits into the hydrophobic hot spot region of the accessible surface of
122 eptors is complex, with strong dependence on hydrophobic hot spots and networks of water-mediated hyd
124 tical for achieving interactivity, relies on hydrophobic, hydrophilic, supramolecular, and ionic inte
125 sociated islet amyloid polypeptide (IAPP), a hydrophobic-hydrophilic interface-dependent process with
127 n and cellular uptake, tryptophan to enhance hydrophobic interaction with cell membranes, histidine t
128 tures such as membrane binding of the MA via hydrophobic interactions and exhibit several differences
129 ic model, which revealed that both polar and hydrophobic interactions are crucial for binding affinit
131 a, thioflavin-T-positive aggregates, whereas hydrophobic interactions dominate self-assembly in [R273
132 vent combinations to disrupt the H-bonds and hydrophobic interactions holding together the beta-sheet
133 ilizes the N-NTD dimers through simultaneous hydrophobic interactions with both partners, resulting i
134 he aromatic groups of SV and PpIX and strong hydrophobic interactions with the alkyl chains of the ca
136 port that 4E10 establishes electrostatic and hydrophobic interactions with the viral membrane surface
137 T domain known to be important for ionic and hydrophobic interactions with ubiquitin may have equival
138 additional stabilization compared to purely hydrophobic interactions, we infer that the six M101-F99
139 acid through a network of electrostatic and hydrophobic interactions, which provides insights into t
142 expectedly, mutating the PEP surface and the hydrophobic interface of A3G does not abolish virion pac
144 d hormone receptors, we show that an ancient hydrophobic interface, conserved for hundreds of million
145 homodimer through N-terminal segments and a hydrophobic interface, with putative active sites within
146 acid-base chemistry, ion distributions near hydrophobic interfaces, and electric fields near the sur
149 tentially involved in the degradation of the hydrophobic layer and pyrolysed organic matter, such as
150 are covered by the cuticle, an extracellular hydrophobic layer that provides protection against abiot
153 n most cases, the interactions between short hydrophobic ligands dominate and dictate assembly outcom
155 extents are hot spots for interactions with hydrophobic ligands, lipids and ions, as well as discret
156 m) on the nonpolar cellulose surfaces and on hydrophobic lignin, and equivalent water-rich nanocluste
157 oMan-containing dendrimers, which have their hydrophobic linker connected via a thiourea group to the
160 s membrane anchoring moiety, consisting of a hydrophobic loop located at the tip of two amphipathic d
161 ider a balance of curvature free energy with hydrophobic matching and demonstrate how our data suppor
162 The interaction of various factors such as hydrophobic material, smooth optic surface, and sharp po
164 and the interfaces between water and air or hydrophobic media represent asymmetric environments with
166 specific sequence features and principles of hydrophobic membrane motifs that mediate their accumulat
167 oplets" with hydrophilic surface and elastic hydrophobic membrane, we developed an oil-free passive m
170 g this region revealed that relatively small hydrophobic moieties are preferred, with 10 being the mo
172 design of self-immolative and crosslinkable hydrophobic moieties offer stable and high encapsulation
174 th a p-acetamido azobenzene substituting the hydrophobic moiety present in many beta(2)-AR antagonist
175 o creating an almost impenetrable barrier to hydrophobic molecules that can otherwise pass through ph
180 e of poorly soluble molecules and water into hydrophobic nanopores of a host material where the lower
181 ntinuous and spontaneous liquid outflow from hydrophobic nanopores with high and stable efficiency ca
184 strate ultra-long release profile due to the hydrophobic nature of the linker, and as per characteris
186 nti-cancer drugs are restricted due to their hydrophobic nature, requiring use of harmful organic sol
188 , binding proteins are believed to transport hydrophobic odorant molecules across the aqueous lymph p
189 ples such as plasma-treated gold substrates, hydrophobic or hydrophilic self-assembled monolayers, an
190 sequence variants representing all possible hydrophobic or polar single- and double-point mutations.
192 generally can predict the bioaccumulation of hydrophobic organic contaminants by benthic and sessile
194 ides the first proof-of-concept that stable, hydrophobic oxidovanadium complexes retain excellent cel
195 oligomers is driven by hydrogen bonding and hydrophobic packing of the residues from the central and
196 nly a few residues in the fibrils, including hydrophobic pai-pai interactions with aromatic rings of
197 ient areas (75%), likely due to preferential hydrophobic partitioning, electrostatic interactions, an
198 the pan-group cyclic CSPs exhibit a chimeric hydrophobic patch conformation that resembles the hydrop
202 nvestigate the substrate-docking region, the hydrophobic patch, on the fission yeast mitotic cyclin C
203 phobic patch conformation that resembles the hydrophobic patches required for both ComD1 and ComD2 bi
204 Secretions were analysed to estimate total hydrophobic peptide concentrations, presence of known AM
205 ng ligands, an ionic molecular tweezer and a hydrophobic peptide that despite their different interac
208 made in understating how S4 moves through a hydrophobic plug upon voltage changes, the possible heli
209 included 2-pyridyl ethers directed into the hydrophobic pocket and small carbocyclic rings accessing
210 rom unique interactions of the ligand with a hydrophobic pocket at the interface of the second extrac
211 D, which revealed a conserved horseshoe-like hydrophobic pocket formed by an unusually long loop.
212 bic ridge from one Ig1 domain inserts into a hydrophobic pocket from the opposing Ig1 domain producin
213 appears to be due to the emergence of a new hydrophobic pocket generated by the insertion of the six
215 et at the caspase-1 L2 and L2' loops bound a hydrophobic pocket within the GSDMD C-terminal domain di
216 ology modeling as a deep, sterically limited hydrophobic pocket, with the outward pointing piperidine
218 ane architecture, an "intrinsic ligand," and hydrophobic pockets off a pore cavity that is surprising
219 ed protein structures have a lower number of hydrophobic pockets, leading to a lower capacity to entr
221 ion from electrospinning solutions made of a hydrophobic polymer dissolved in a water-miscible or pol
222 m selected polymers, specifically a somewhat hydrophobic polymer that was extremely effective at inhi
227 the highest GLP-1 response was found with a hydrophobic positively charged peptide, pointing to the
228 hange and dilution, transformation of larger hydrophobic precursors in sediments can be a source to P
229 ors (TMF, 3.7-9.3 for L-PFOS), suggests that hydrophobic precursors in sediments undergo transformati
231 wo-chain intermediate state is stabilized by hydrophobic rather than ionic interactions, as in AtLEGg
232 n of ordered water molecules confined within hydrophobic reaction pockets alters the energetics of ad
233 contributes more to the exposure (i) to more hydrophobic, recalcitrant congeners, and (ii) of adults
234 e, which is the key component in sensing the hydrophobic regions exposed to solution after protein un
236 u-binding groove in the ACD also binds short hydrophobic regions within HspB1 itself, and HspB1 mutat
237 ith a glutamine residue at position +1 and a hydrophobic residue at position -1, thus elucidating the
238 NCE In this study, we identified an aromatic hydrophobic residue in foot-and-mouth disease virus (FMD
242 on between WhiB1 and sigmaA4 is dominated by hydrophobic residues in the [4Fe-4S] cluster binding poc
243 ctric charge of the filaments, the number of hydrophobic residues in the constituent keratin polypept
244 tal structure near the A-cluster, defined by hydrophobic residues including F229, forms a cage surrou
245 from the inner leaflet and is coordinated by hydrophobic residues of the M and E transmembrane helice
246 required for Rap1A activation and identified hydrophobic residues on the surface of the RA2 domain th
247 ls an ~160- angstrom long channel lined with hydrophobic residues suitable for solubilizing multiple
248 esidue 375 mutations that mimic the bulky or hydrophobic residues typically found in simian immunodef
249 h the binding interfaces feature clusters of hydrophobic residues, overall, the protein-protein assoc
250 mbly of LC domains that are nearly devoid of hydrophobic residues, such as the 214-residue LC domain
256 mponents, we identified that deletion of the hydrophobic rodlet layer or dihydroxynaphthalene-melanin
257 eal a second CypA-binding site formed by the hydrophobic sequence (47) GVVHGVATVA(56) , termed PreNAC
258 ng to HDAC1 with tetrahydropyran acting as a hydrophobic shield from water at the enzyme surface.
263 s the perfect alternation of cationic versus hydrophobic side chains, representing a significant impr
265 inates can be tuned from superhydrophilic to hydrophobic simply by exchanging the cations; hydrophili
266 dox environments regulate cargo binding to a hydrophobic site within the cysteine-rich region of Erv4
267 on of a Hf-DBP nMOF for the co-delivery of a hydrophobic small-molecule toll-like receptor 7 agonist,
268 Additionally, reactant adsorption within hydrophobic Sn-Beta is driven by the breakup of intrapor
269 ordered H-bonding solvent network present in hydrophobic Sn-Beta stabilizes the transfer hydrogenatio
270 s rate enhancement stems from the ability of hydrophobic Sn-Beta to inhibit the formation of extended
273 mably n-pai*), sp(2)C-sp(2)C (pai-pai and/or hydrophobic), sp(2)O-sp(2)N (hydrogen bonding) and sp(3)
276 ricaprylin) owing to the tricyclic diterpene hydrophobic structure in their molecules that enables th
277 uried in multimeric interfaces to accumulate hydrophobic substitutions to levels that are not tolerat
278 ize exclusion mechanism, thus protecting the hydrophobic substrate from being wetted by the low-surfa
282 the N53I substitution exposes an additional hydrophobic surface and that the intramolecular dynamics
283 layer and pyrolysed organic matter, such as hydrophobic surface binding proteins, laccases (AA1_1),
286 physiological temperatures indicate that the hydrophobic surfactant proteins disrupt the ordered stru
288 his approach could be generalized to another hydrophobic tag (HyT) degrader by demonstrating the impr
291 H3-53 antibody that used a long CDRH3 with a hydrophobic tip to bridge between adjacent down RBDs, th
292 change the local nature of the surface from hydrophobic to hydrophilic(19), resulting in the pinning
293 iogenesis faces the challenge of chaperoning hydrophobic transmembrane helices for faithful membrane
294 of H3K27me3 by BAHCC1 is achieved through a hydrophobic trimethyl-L-lysine-binding 'cage' formed by
295 grates to the catalytic heme site via a long hydrophobic tunnel and displaces LeuE11 away from the fe
296 sists of seven stacked rings, with a central hydrophobic tunnel sufficiently long to span the peripla
297 ygen transport follows a single well-defined hydrophobic tunnel, formed from both enzyme and substrat
298 ytosolic domain contains a large, moderately hydrophobic vestibule that can bind a substrate's transm
300 r on anode and filling the pores of MOF with hydrophobic Zn(TFSI)(2) -tris(2,2,2-trifluoroethyl)phosp