ライフサイエンスコーパス: hydrophobic core

1 alpha-helical segments packed around a small hydrophobic core.

2 eir cargo covalently encapsulated within the hydrophobic core.

3 ively charged head groups at each end of the hydrophobic core.

4 d residues of the protein are trapped in the hydrophobic core.

5 gregation and in organization of the protein hydrophobic core.

6 trimer subunits further associate to form a hydrophobic core.

7 mic cost of exposing charged residues to the hydrophobic core.

8 ative state stabilizing interaction with the hydrophobic core.

9 of ion pairs ( approximately 60,000) in each hydrophobic core.

10 unzips due to the loss of contacts with the hydrophobic core.

11 lobular domain and increased exposure of its hydrophobic core.

12 elical fold that completely buries SA in its hydrophobic core.

13 eract with the protein before disrupting the hydrophobic core.

14 ype of flanking residues at both ends of the hydrophobic core.

15 d T39 by a hydrogen-bond linkage through the hydrophobic core.

16 create desolvated pockets inside the nascent hydrophobic core.

17 for internalization, is fully buried in the hydrophobic core.

18 ed on both faces and the lack of a canonical hydrophobic core.

19 ng of five helices held together by a strong hydrophobic core.

20 fluorophenylalanine (F(5)Phe) residue in the hydrophobic core.

21 k water phase, lipid interface and the lipid hydrophobic core.

22 s organized in a highly ordered bilayer-like hydrophobic core.

23 ability to increase the order of the bilayer hydrophobic core.

24 which one Asp side chain faces the membrane hydrophobic core.

25 rged with nonpolar residues, stabilizing the hydrophobic core.

26 1 even without its proper insertion into the hydrophobic core.

27 away from the solvent to form a central dry hydrophobic core.

28 by hydrophobic interactions into a spherical hydrophobic core.

29 t an evolutionarily invariant residue in its hydrophobic core.

30 nt of the first helix and instability of the hydrophobic core.

31 and compaction of others, most notably, the hydrophobic core.

32 s governed by the formation of a well-packed hydrophobic core.

33 ying the polar Ser side chain in the bilayer hydrophobic core.

34 es and a pair of histidines, and by an inner hydrophobic core.

35 s required for destruction of the receptor's hydrophobic core.

36 signal transfer mechanism in the membrane's hydrophobic core.

37 ptide containing an elongated N-region and a hydrophobic core.

38 n, involving the formation of a well-defined hydrophobic core.

39 self-assembly does not entail formation of a hydrophobic core.

40 is likely mediated by the flexibility in the hydrophobic core.

41 otein size and the flexibility of the native hydrophobic core.

42 drophobic residues into strikingly different hydrophobic cores.

43 ubility, and tailored binding sites in their hydrophobic cores.

44 Greek key beta-sheet folds with well packed hydrophobic cores.

45 onomers to the solvent, while maintaining a "hydrophobic" core.

46 med two "cationic donuts" that protected the hydrophobic core against aggregation in water.

47 allosteric signals through soft matter-like hydrophobic core amino acids.

48 This results in a new hydrophobic core, an intraprotein hydrogen bond and a qu

49 beta (Abeta) protein possessing a structured hydrophobic core and a disordered N-terminal domain (res

50 regions: a positively charged N-terminus, a hydrophobic core and a more polar C-terminal region that

51 DOM aggregates are dynamic, consisting of a hydrophobic core and amphiphilic exterior.

52 o the main fibril axis, where they produce a hydrophobic core and are surrounded by the structurally

53 e partially unfolded structure, exposing the hydrophobic core and backbone hydrogen bond donors and a

54 In the chimeric proteins, both the hydrophobic core and charged surface independently impar

55 B), which are held together by an extensive hydrophobic core and disulphide bonds.

56 In addition, the hydrophobic core and endogenous atheroma-targeting abili

57 lymer nanoparticles with lightly-crosslinked hydrophobic core and hydrophilic surface groups are synt

58 ucing Val in place of Cys(93) stabilized the hydrophobic core and increased the RD3 affinity for the

59 s-ms time-scale dynamics of the intra-strand hydrophobic core and interfaces of the fibrils composed

60 drophobic core mutants as it is close to the hydrophobic core and known to cause instability.

61 results in increased flexibility within the hydrophobic core and loop regions that orient the DNA bi

62 r Leu, respectively, disrupts packing in the hydrophobic core and lowers RD3's apparent affinity for

63 We explored the contribution of the hydrophobic core and of the extended C terminus by exami

64 te taken by pumped protons to traverse CcO's hydrophobic core and on whether bacterial and mitochondr

65 mNramp1 and a fusion chimera of the PmNramp3 hydrophobic core and PmNramp1 N- and C-termini.

66 elin octanoyl chain is essential to form the hydrophobic core and promote access of ghrelin to the re

67 amma-zein family are arranged in the central hydrophobic core and the cross-linked protein body perip

68 Both the strength of the hydrophobic core and the existence of salt bridges at th

69 ferent alkyl linker lengths separating their hydrophobic core and the hydrophilic carboxylate headgro

70 lay between the conformational states of the hydrophobic core and the N terminus.

71 We randomized the hydrophobic core and used phage display to select varian

72 g from the interaction between the channels' hydrophobic cores and that of the lipid bilayer.

73 particles with a narrow size distribution, a hydrophobic core, and an ionic shell.

74 s driven by the lipid-facing residues in its hydrophobic core, and its NC-IN topology is determined b

75 rtain glycan mutants, mutations in the gp120 hydrophobic core, and mutations in residues involved in

76 ted by interactions arising from the central hydrophobic core, and precipitated by those arising from

77 at is, the extracellular domain, the central hydrophobic core, and the transmembrane domain.

78 is buried in the beta4-strand in the central hydrophobic core, and the Tyr structurally links to the

79 bility and cooperativity can occur without a hydrophobic core, and without alpha-helices or beta-shee

80 E and G5 domains lack a compact hydrophobic core, and yet G5 domain and multidomain cons

81 cycles lack regular secondary structures and hydrophobic cores, and can contain local structures not

82 Rearrangement of the hydrophobic core appears to be a common mechanism by whi

83 Many mutations in the hydrophobic core are also associated with drug resistanc

84 g residence urea molecules placed around the hydrophobic core are crucial to stabilize partially open

85 results reveal that dynamics in the extended hydrophobic core are important for binding site selectio

86 volved in intermolecular interactions in the hydrophobic core are only partially folded in I(2).

87 R measures, the aliphatic side chains in the hydrophobic core are slightly more dynamic in the free p

88 Hydrophobic cores are often viewed as tightly packed and

89 light the calcium-binding loop (R1597W), the hydrophobic core around the vicinal disulfide (M1528V),

90 NIPAm) (pNIPAm), held above its LCST, formed hydrophobic cores around which shells composed of NIPAm,

91 ining proteins, including a long loop region hydrophobic core associated with calcium-dependent glyca

92 The loop possesses a hydrophobic core at the center of the region with an unu

93 Thus, with increasing temperature, first the hydrophobic core awakens, followed by the hydrophilic su

94 ins much to be learnt about how and when the hydrophobic core becomes desolvated and tightly packed d

95 the cyclohexane ring buried within the gp120 hydrophobic core but able to assume multiple orientation

96 es sequesters elongating products within its hydrophobic core, but this dynamic mechanism remains poo

97 Moreover, the shielding of the hydrophobic core by the charged exterior shell decreases

98 Here we report that this hydrophobic core can be re-engineered to contain a fluor

99 Thus, altered flexibility within the hydrophobic core can modulate HIV-1 protease activity, s

100 tion of Abeta25-35 peptides into the bilayer hydrophobic core causing more pronounced disruption in i

101 The peptoid nanotubes form without a central hydrophobic core, chirality, a hydrogen bond network, an

102 0'), I84 (I84'), and V82 (V82') which create hydrophobic core clusters to further stabilize the close

103 The Rnt1p dsRBD has an extended hydrophobic core comprising helix alpha1, the alpha1-bet

104 ic reveals that the left arm forms a concise hydrophobic core comprising tryptophans Trp(21) and Trp(

105 barstar forms a partially solvent-accessible hydrophobic core consisting of several residues that hav

106 r the synthesis of hybrid micelles with PPhe hydrophobic core, cross-linked ionic PGlu intermediate s

107 ein, including the side-chain packing in the hydrophobic core, denatures in a single cooperative proc

108 nd that polar interactions buried within the hydrophobic core determine the specificity of heterodime

109 GAA hairpin reveals that dynamics within the hydrophobic core differentiate between specific and nons

110 lices, and the side-chain packing within the hydrophobic core differs fundamentally from the knobs-in

111 shells of the cationic nanoparticles and the hydrophobic core domain of the anionic central cylindric

112 Development of a tightly packed hydrophobic core drives the folding of water-soluble glo

113 Methionine in a hydrophobic core equips a protein with the capacity to d

114 In view of the high hydrophobic core exposure, hydration, and curvature pres

115 ds to form the native three-strand sheet and hydrophobic core features.

116 -benzoxadiazole (NBD) donors that occupy the hydrophobic core, followed by exposure to hydrophilic Rh

117 he voltage sensor domain translates across a hydrophobic core forming a barrier for the gating charge

118 Overall, mutations in the hydrophobic core have a significant effect on the dynami

119 that destabilize the packing of the domain's hydrophobic core have little effect on folding within th

120 ity of the amphipathic helices TH1-3 and the hydrophobic core helix TH8 at pH 6.5.

121 uM) and K162 (EC(50) = 0.080 muM), stabilize hydrophobic core I of Abeta(42) peptide (residues 17-21)

122 e importance, this phenomenon indicates that hydrophobic core I of the Abeta(42) peptide plays a majo

123 a unique spatial arrangement that caught the hydrophobic core in a cage, thereby protecting it fully

124 f which are compromised to maintain a stable hydrophobic core in the DEP domain.

125 hydrophobic cluster and another delocalized hydrophobic core in the folding kinetics, are discussed.

126 The mutation M16I loosens the hydrophobic core in the G domain and affects domain I to

127 P14 residue retains an interaction with the hydrophobic core in the intermediate state but is releas

128 viously, it is attenuated in Pol lambda by a hydrophobic core including Leu431, Ile492, and the Tyr50

129 at the slower structural fluctuations in the hydrophobic core, indicating a more tightly structured c

130 aggered by only 4 amino acids and displaying hydrophobic core interactions similar to those of the pa

131 ation promotes drug release by switching the hydrophobic core into completely hydrophilic chains.

132 ular hydrophilic patterning of its otherwise hydrophobic core is a prerequisite for the TolA-induced

133 determinants of DNA binding, whereas the RHH hydrophobic core is assembled from amino acids in both t

134 ate with the fourth arginine in S4 above the hydrophobic core is destabilized by approximately 17 kJ/

135 -coil are stabilized by Leu-110, whereas the hydrophobic core is destabilized in the SCR by Ala resid

136 namics suggest that the rearrangement of the hydrophobic core is essential for enzyme activity.

137 have shown that a glycine-rich motif in its hydrophobic core is essential for selective, aSec-mediat

138 mall, de novo-designed proteins in which the hydrophobic core is packed with various combinations of

139 hermal unfolding experiments indicate that a hydrophobic core is present in the tetramer.

140 Loose packing of hydrophobic cores is not infrequent in proteins, as the

141 on of E9, which has sparse contacts with the hydrophobic core, is linked to an allosteric activator r

142 s of two leucine residues that belong to the hydrophobic core (L17 and L34) as well as M35 residues b

143 UVF was highly dynamic because of its fully hydrophobic core, leading to a smaller loss of entropy u

144 e investigate methyl group dynamics of a key hydrophobic core leucine residue in chicken villin headp

145 ively stabilize each other by completing the hydrophobic core lining the central part of HP35.

146 hin all substructures of the WW domain fold (hydrophobic core, loop 1, loop 2, beta-sheet).

147 on the surface of the protein as well as the hydrophobic core maintaining the structural integrity ar

148 A BDTA hydrophobic core micelle coupled with a positive electri

149 The T183A mutation is related to the hydrophobic core mutants as it is close to the hydrophob

150 structure that can be perturbed by discrete hydrophobic core mutations.

151 Our findings imply that the hydrophobic core of a micelle is surrounded by a highly

152 for sensing oxidative stress centred on the hydrophobic core of a sensor protein.

153 eously mutate all methionines present in the hydrophobic core of a spidroin NTD from a nursery web sp

154 Of note, crenezumab also sequesters the hydrophobic core of Abeta and breaks an essential salt-b

155 (494-515) region and aligns with the central hydrophobic core of Abeta.

156 own (1)O2 scavenger, was incorporated in the hydrophobic core of amphiphilic copolymer micelles, and

157 from the native residue tryptophan-48 in the hydrophobic core of azurin.

158 ained by a cysteine bridge buried within the hydrophobic core of beta4.

159 m infrared results reveal an ordering of the hydrophobic core of bilayers when leakage is noted, i.e.

160 Carotenoids can accommodate into the hydrophobic core of cyclodextrins and therefore, they ar

161 N-terminus of the peptide backbone near the hydrophobic core of cylindrical nanofibers leads to stro

162 binding; and 4), VBS inserts itself into the hydrophobic core of D1.

163 active chromanol moiety residing deep in the hydrophobic core of di-14:0PC bilayers, a location that

164 rmally present in wild type that weakens the hydrophobic core of Domain II.

165 channels are separated by ~6 angstrom in the hydrophobic core of F(o), resulting in a strong local fi

166 Mutations in the hydrophobic core of frataxin affected stability whereas

167 itors are 12-amino-acids-long and target the hydrophobic core of gp41.

168 ix DNA-binding domain (GTL1N) destabilizes a hydrophobic core of GTL1N and allosterically inhibits 3(

169 issense mutations disrupt the folding of the hydrophobic core of hCDC73-NTD, while others such as the

170 show here that the P2204L mutation impairs a hydrophobic core of Ig20, generating a conformationally

171 s not affect methyl group motions within the hydrophobic core of individual cross-beta subunits but h

172 ne-conjugated acyl-group of ACP occupies the hydrophobic core of ISD11, explaining the basis of ACP s

173 rved, charged Asp-137 residue located in the hydrophobic core of its coiled-coil structure, which is

174 ile procedure is used for reconstituting the hydrophobic core of LDLs with a binary fatty acid mixtur

175 The localization of dendrimers in the hydrophobic core of lipid bilayers restricts the motion

176 ts the side chain of a lysine residue in the hydrophobic core of lobe 2 by a salt bridge.

177 e flexible peptide flip domain and the rigid hydrophobic core of lobe 2.

178 lipids allowing direct interaction with the hydrophobic core of membranes.

179 (NCBD), we have compared the dynamics of the hydrophobic core of NCBD in the ligand-free state and in

180 Their hydrophobic core of neutral lipids stores metabolic ener

181 Unlike the hydrophobic core of pathogenic amyloids, the hydrophilic

182 Positions in the hydrophobic core of peptide-membrane complex show the gr

183 ted-chitosan-zinc-insulin complexes into the hydrophobic core of PLA-PEG-PLA thermogel-copolymer mice

184 arily occurs by solvent penetration into the hydrophobic core of proteins in a sequence-independent m

185 ged side chains can be buried readily in the hydrophobic core of stable proteins without the need for

186 An artificial charge pair buried in the hydrophobic core of staphylococcal nuclease was engineer

187 in Su(H) by interacting with residues in the hydrophobic core of Su(H), illustrating the structural p

188 n the NP surface interact favorably with the hydrophobic core of the bilayer structure and guide the

189 largely encoded polar insertions within the hydrophobic core of the coiled-coil interface.

190 mide, with the interior water present in the hydrophobic core of the confined micellar medium in aque

191 could penetrate the amide layer to reach the hydrophobic core of the cross-linked micelles.

192 t after the rapid dimerization reaction, the hydrophobic core of the dimer interface has few fully na

193 tate and N(2); however, only residues in the hydrophobic core of the dimer interface perturbed the I(

194 gn of the N-terminus were used to expand the hydrophobic core of the domain, and in the third case, t

195 of this enzyme and likely interacts with the hydrophobic core of the endoplasmic reticulum membrane.

196 hrough JMJD6 interactions with the conserved hydrophobic core of the ET domain, and reinforced by ele

197 s reveals dynamical perturbations within the hydrophobic core of the folded domain, which are attribu

198 changes that allosterically propagate to the hydrophobic core of the Galphai GTPase domain.

199 The two [4Fe-4S] clusters are located in the hydrophobic core of the helical bundle as characterized

200 Mutation of residues at the hydrophobic core of the interface disrupts complex forma

201 single alanine mutation at Tyr507 within the hydrophobic core of the isolated colicin E3 rRNase domai

202 Our results support the idea that the hydrophobic core of the isolated monomer of Pfk-2 is sol

203 rane surface and penetrates further into the hydrophobic core of the lipid bilayer.

204 (1) allow the sodium ion to pass through the hydrophobic core of the membrane and (2) provide cation

205 of an organic solvent layer to represent the hydrophobic core of the membrane and short-tailed phosph

206 Delta5 isoform was more integrated into the hydrophobic core of the membrane than the FL isoform.

207 the 7-transmembrane (TM) bundle towards the hydrophobic core of the membrane, one between TM1/TM7 an

208 another phospholipid by penetrating into the hydrophobic core of the membrane.

209 disaccharide-pentapeptide as it crosses the hydrophobic core of the membrane.

210 te the transport of water molecules into the hydrophobic core of the membrane.

211 gradual drifting of the TM-helix out of the hydrophobic core of the membrane.

212 s were encapsulated noncovalently inside the hydrophobic core of the micelle, which was composed of l

213 ents showed that phenols were located in the hydrophobic core of the micelle.

214 that the aryl benzoates were located in the hydrophobic core of the micelle.

215 via even redistribution of stress along the hydrophobic core of the molecule.

216 alpha-Syn100 variant in which we removed the hydrophobic core of the non-amyloid component (NAC) doma

217 ed (NIR) emissive probes embedded within the hydrophobic core of the polymersome membrane.

218 previously been shown to bind in the central hydrophobic core of the pore region of the channel, and

219 ) did equalize rates without eliminating the hydrophobic core of the protein (i.e., without unfolding

220 The VP40 SDP Q245P affects the structure and hydrophobic core of the protein and consequently protein

221 minal leucine residues that form part of the hydrophobic core of the protein.

222 sence of distinct residues buried within the hydrophobic core of the RelB dimerization domain appears

223 The hydrophobic core of the signal sequence forms a helix th

224 Thus, the hydrophobic core of the signal sequence is primarily res

225 eals that a majority of mutations affect the hydrophobic core of the structure, indicating that most

226 d structures, is sequestered (buried) in the hydrophobic core of the T/F100 trimer.

227 75 p.M393T creates a polar side-chain in the hydrophobic core of the transmembrane, which could desta

228 bability of observing water molecules in the hydrophobic core of these lipid membranes and their prot

229 asing the probability of contact between the hydrophobic cores of adjacent membranes.

230 complex, but have mobility comparable to the hydrophobic cores of average folded proteins.

231 goal of investigating dynamical features of hydrophobic cores of proteins over a wide range of tempe

232 ERGDS sequences on the exterior surfaces and hydrophobic cores of self-assemblies, the nanoparticles

233 solvent excluded voids that are found in the hydrophobic cores of the respective native states.

234 Since reactions take place within the inner hydrophobic cores of these tailor-made nanoreactors, and

235 ty protein Im7 to examine the specificity of hydrophobic core packing during folding.

236 on of the UBL results from rearrangements to hydrophobic core packing that modify its structure.

237 These observations show that the hydrophobic core per se does not fully account for the a

238 hored to the helical scaffold by a secondary hydrophobic core, pinning down the long loops of leptin

239 f a stabilizing Leu residue in a coiled-coil hydrophobic core position d that causes this dramatic ef

240 ix-breaking mutations in the signal sequence hydrophobic core prevent synthesis of the aberrant prote

241 ne-386 at the center of ER46's transmembrane hydrophobic core prevents membrane spanning, obscures th

242 aring hydrogen bonds (H bonds) buried in the hydrophobic core protected from water attacks.

243 site and turns the side chain of M513 into a hydrophobic core, providing a basis to understand how Ca

244 t permeation occurs by diffusion through the hydrophobic core rather than through hydrophilic pores.

245 th a short alpha-helix formed at the central hydrophobic core region (L17-D23).

246 ) indicates that the domain contains limited hydrophobic core regions.

247 nding residues are sequestered back into its hydrophobic core, releasing sigma(R) to activate transcr

248 The hydrophobic core residues are a mix of an 11-mer repeat

249 Although the interfacial hydrophobic core residues Leu(12) and Tyr(84) play impor

250 e chain shifts the structure and dynamics of hydrophobic core residues of the protein so that these r

251 ervation analysis confirms the importance of hydrophobic core residues that stabilize the beta-trefoi

252 Substituting the hydrophobic core residues, Leu-331, Val-338, and Ile-345

253 In contrast, the N-terminal hydrophobic core showed extremely slow solvent exchange,

254 /F77A-AT(1) receptor, designed to weaken the hydrophobic core, showed significant agonist-induced sig

255 ese structures reveal a solvent-sequestered, hydrophobic core stabilized by a unique arrangement of l

256 catalytic activity through interactions with hydrophobic core structures (beta1, beta3, alpha5, and a

257 ty shows high flexibility inside the bilayer hydrophobic core, suggesting its potential role as a ten

258 by a specific group of residues which form a hydrophobic core surrounding the oxyferryl heme center.

259 een two molecular moieties, for the micellar hydrophobic core, tends to expose a reacting fragment di

260 ing force for assembly is the formation of a hydrophobic core that excludes water, whereas the hydrop

261 concerted structural changes in the extended hydrophobic core that govern binding of helix alpha1 to

262 an independent domain but forms part of the hydrophobic core that joins the two beta-propellers.

263 del in which the regulatory sequences form a hydrophobic core that reciprocally inhibits DNA binding

264 nosorbent assay (ELISA) results identified a hydrophobic core that stabilizes the V2 region for optim

265 and arranged in a manner that generates two hydrophobic cores that are capped at the end of the chai

266 ray structures for three small proteins with hydrophobic cores that are packed with either fluorocarb

267 vel and perhaps more protein-like folds with hydrophobic cores that in turn allow them to access nove

268 nds are often found to depend on well-packed hydrophobic cores that influence the distance between th

269 ved along the peptide backbone away from the hydrophobic core, the interactions with dodecanoic acid

270 s that Ala-40 contributes to an intrasubunit hydrophobic core, the principal effect of the A40V mutat

271 espite the large thickness mismatch in their hydrophobic cores, the hybrid membranes do not exhibit m

272 a" positions or all the "d" positions of the hydrophobic core, thereby creating an alternating packin

273 By localizing the sensor components in a hydrophobic core, these nanosensors are able to monitor

274 This protein is assumed to bind the membrane hydrophobic core through a transmembrane domain (TMD) as

275 beta(9-40) fibril suggest formation of tight hydrophobic core through M35 interactions across the fib

276 of DeltaN6 reveals a major repacking of the hydrophobic core to accommodate the nonnative peptidyl-p

277 mperatures demonstrate the distortion of the hydrophobic core to be a crucial step.

278 We show that RsrA utilizes its hydrophobic core to bind the sigma factor sigma(R) preve

279 incoming peptide and can penetrate into the hydrophobic core to disrupt the Asp23-Lys28 salt bridges

280 example, we instruct the computer "to form a hydrophobic core," "to form good secondary structures,"

281 sistent with the MSI-78 solvent-inaccessible hydrophobic core upon binding bicelles.

282 nors with Trp to probe the disruption of the hydrophobic core upon protein unfolding.

283 binding site has been incorporated into the hydrophobic core using natural amino acids, restricting

284 ssociated missense mutants of PrP are in the hydrophobic core: V180I, F198S, V203I and V210I.

285 o investigate the contributions of the fully hydrophobic core versus the fully polar surface to UVF's

286 l, polar groups were introduced into the Im7 hydrophobic core via Val-->Thr or Phe-->Tyr substitution

287 alue, less dense hydrophilic corona and more hydrophobic core volume are efficient in solubilising an

288 This hydrophobic core was well conserved throughout the m02 f

289 To further investigate the effect of this hydrophobic core, we disrupted it in Galphai1 by inserti

290 Although ATIII has N-glycans and a hydrophobic core, we found that its quality control depe

291 rtion of cysteine residues or changes in the hydrophobic core were associated with greater difference

292 any MHR residues that are not in the protein hydrophobic core were nevertheless found to be critical

293 cyanophenylalanine residues inserted in the hydrophobic core were used as a vibrational probe.

294 d NA activities map predominantly to the 4HB hydrophobic core, whereas mutations that affect only F-p

295 leaving the Asp side chain shielded from the hydrophobic core, which is also consistent with availabl

296 eed, in Az48W the radical is embedded in the hydrophobic core while, in ReAz108W it is solvent-expose

297 d reference dyes are encapsulated inside the hydrophobic core, while a pH-sensitive probe is covalent

298 lyzed hydration of an alkyne proceeds in the hydrophobic core, while the Rh-catalyzed asymmetric tran

299 he protein displays a well organized compact hydrophobic core with structural changes confined to the

300 tal results revealed that, through forming a hydrophobic core with the conserved SAT motif of the N-t