ライフサイエンスコーパス: hydrophobic pocket

1 itated by hydrogen-bonding interactions in a hydrophobic pocket.

2 protein and the methyl group inserted into a hydrophobic pocket.

3 her with Trp(803) and Phe(804), form a large hydrophobic pocket.

4 ciation of the RS20 domain from calmodulin's hydrophobic pocket.

5 g increased complementarity with the primary hydrophobic pocket.

6 e dihydroisoquinoline to bind in an adjacent hydrophobic pocket.

7 in but with distinct interactions within the hydrophobic pocket.

8 inal chemical investigation of the conserved hydrophobic pocket.

9 conformation, allowing access to an extended hydrophobic pocket.

10 ospholipid-cycling into and out of the Sfh1* hydrophobic pocket.

11 teraction site was identified in a conserved hydrophobic pocket.

12 of the penetration protein and embedded in a hydrophobic pocket.

13 ormation of the ferric protein with a closed hydrophobic pocket.

14 1, spanned from the active site pocket to a hydrophobic pocket.

15 l vicinal disulfide bond that is buried in a hydrophobic pocket.

16 were changed to match those of CatM in this hydrophobic pocket.

17 cacy of anticancer drugs directed toward its hydrophobic pocket.

18 isting of a shallow groove linked to a small hydrophobic pocket.

19 d, ordered beta1-alpha1 loop and an adjacent hydrophobic pocket.

20 groups of our analogs bind in an active site hydrophobic pocket.

21 smembrane receptor that contains a conserved hydrophobic pocket.

22 teraction between the N-terminal helix and a hydrophobic pocket.

23 istinct nonpolar side chains that fill three hydrophobic pockets.

24 nd-gated ion channels, and ligand binding to hydrophobic pockets.

25 through a complex network of interconnected hydrophobic pockets.

26 Spa15 where labels are seen to be buried in hydrophobic pockets.

27 th scales that accompany exposure of protein hydrophobic pockets.

28 d and the cyclohexylmethyl moiety occupy two hydrophobic pockets.

29 Importantly, we have identified a hydrophobic pocket accessory to the S1 site that can be

30 human cells, and I2 acts as a "flap" on the hydrophobic pocket accommodating template G.

31 troduction of a single substitution into the hydrophobic pocket affected entry through both nectin-4

32 A conserved hydrophobic pocket allows the hugely diverse PfEMP1 prot

33 erated tyrosine then collapses into a nearby hydrophobic pocket, anchoring a modified conformational

34 We hypothesize that compound 7 binds to this hydrophobic pocket and as a consequence inhibits EBOV in

35 LPS binds to the MD-2 hydrophobic pocket and bridges the dimerization of two T

36 d a novel binding mode with occupancy of the hydrophobic pocket and channel of ATX but no interaction

37 The alphaTSR domain possesses a hydrophobic pocket and core, missing in TSR domains.

38 The D ring of the chromophore sits within a hydrophobic pocket and is tilted by approximately 80 deg

39 nd that the myristoyl group inserts into the hydrophobic pocket and leads to a tighter packing of the

40 included 2-pyridyl ethers directed into the hydrophobic pocket and small carbocyclic rings accessing

41 d on the surface of MDM2 and will "open" the hydrophobic pocket and stabilize the MDM2-p53 complex, w

42 te determinant NUMB with both the N-terminal hydrophobic pocket and the acidic domain of MDM2 also in

43 , involving interactions with the N-terminal hydrophobic pocket and the acidic domain of MDM2.

44 x to the CP where it enters and exits the CP hydrophobic pocket and then folds back to contact the vi

45 nalyses suggest that these mutations distort hydrophobic pockets and affect residues in the NA active

46 evel scale rationalizes the hydration of two hydrophobic pockets and the presence of a void in a thir

47 rings bind into distinct relatively narrow, hydrophobic pockets, and both are required for biochemic

48 ocated in the alpha5-beta3 loop, buried in a hydrophobic pocket approximately 16 A from the SAM-bindi

49 ed to sequence differences in a known distal hydrophobic pocket are also described.

50 gs with modifications that interact with the hydrophobic pocket are potential specific inhibitors of

51 P binding pocket not only contributes to the hydrophobic pocket, as previously thought, but also recr

52 ive-helix bundle; Tyr-377 of F3 docks into a hydrophobic pocket at one end of the bundle, whereas a b

53 e in its prefusion conformation, suggested a hydrophobic pocket at or near the GP1 and GP2 interface

54 the long hypothesized binding of CO(2) in a hydrophobic pocket at the active site and demonstrate th

55 bl tyrosine kinase, myristate binds within a hydrophobic pocket at the base of the kinase domain and

56 on-induced dimerization that features a deep hydrophobic pocket at the center of the receiver domain

57 The existence of a hydrophobic pocket at the elbow region of the Fc appears

58 ral model, showed that Tyr(981) may lie in a hydrophobic pocket at the end of the S6 transmembrane se

59 rom unique interactions of the ligand with a hydrophobic pocket at the interface of the second extrac

60 HEG1 binds in a hydrophobic pocket at the KRIT1 F1 and F3 interface, and

61 The domain structure includes: (i) a hydrophobic pocket at the N terminus of MDM2 that is inv

62 could spontaneously release from its initial hydrophobic pocket before MA protein interacts with the

63 The active site is located in a hydrophobic pocket between an N-terminal dinucleotide bi

64 is located in the extracellular domain in a hydrophobic pocket between the beta7-beta10 strands.

65 I relative to TM-III by sliding into a tight hydrophobic pocket between TM-III and TM-V and that the

66 ubstitution of the residues constituting the hydrophobic pocket between TM-III and TM-V in the ghreli

67 channel-drug complex revealed six equivalent hydrophobic pockets between the peripheral and pore-form

68 and that are vital for the enzymatic or the hydrophobic pocket binding activity of CypA.

69 binds in a channel-specific orientation to a hydrophobic pocket bounded by the S5/pore helix/S6 of on

70 nding kinetics of a ligand to a prototypical hydrophobic pocket by explicit-water molecular dynamics

71 residue is located immediately adjacent to a hydrophobic pocket, called the switch 3 loop.

72 e we show that the binding affinity of MDM2s hydrophobic pocket can be regulated through the RING fin

73 ent of the C-terminal cap region, creating a hydrophobic pocket centered around residue Trp197.

74 ide chain of alanine binds in a well defined hydrophobic pocket characterized by conserved residues I

75 structure allows the definition of conserved hydrophobic pockets comparable with those of ClpS or Bam

76 the ATG3 binding surface on ATG12 contains a hydrophobic pocket corresponding to the binding pocket o

77 eptides and small molecules that bind in the hydrophobic pocket could be selectively detected, provid

78 acids in the G domain demonstrated that the hydrophobic pocket created by these amino acids is neces

79 dies suggest that the 4'-ethynyl fits into a hydrophobic pocket defined by RT residues Ala-114, Tyr-1

80 r dictated tetramer assembly: the N-terminal hydrophobic pocket (defined by L227(K1), Y230(K1), F231(

81 erged adjacent to a computationally designed hydrophobic pocket during directed evolution.

82 A single mutation of murine MD-2 at the hydrophobic pocket entrance, E122K, substantially reduce

83 igopyridines potentially targeting the Mcl-1 hydrophobic pocket, evaluated their capacity to inhibit

84 ling structure shows that ZAA binds the MD-2 hydrophobic pocket exclusively via specific molecular re

85 The binding mode of BPTES on the hydrophobic pocket explains its specificity to KGA.

86 s(naphthalene)-8,8'-disulfonate (bis-ANS) to hydrophobic pockets exposed in the sheared protein.

87 gages the receptor by binding to an extended hydrophobic pocket facilitated by the large outward move

88 Tyr residue that provides the bottom of the hydrophobic pocket for ATP yielded a PI4KIIIbeta enzyme

89 erring substrate oxidation, and a C-terminal hydrophobic pocket for substrate binding.

90 This is critical both for creating a hydrophobic pocket for the catalytic base and for mainta

91 nding pockets at the BSSalpha active site: a hydrophobic pocket for toluene binding and a polar pocke

92 Moreover, the unusual hydrophobic pocket for Y(0) explains the distinctive abi

93 rm, three hydrophobic helical grooves, and a hydrophobic pocket for Y(0)).

94 (TBHQ), shows that the inhibitor binds in a hydrophobic pocket formed at an interface between HA mon

95 be rotated away from the metal center, to a hydrophobic pocket formed by Ala212, Val293 and Phe295.

96 D, which revealed a conserved horseshoe-like hydrophobic pocket formed by an unusually long loop.

97 modeling indicates that PD-118057 binds to a hydrophobic pocket formed by L646 of one hERG1 subunit a

98 site to interact with a telomerase-specific hydrophobic pocket formed by motifs 1 and 2 in the finge

99 XLF Leu-115 ("Leu-lock") inserts into a hydrophobic pocket formed by XRCC4 Met-59, Met-61, Lys-6

100 gatively charged glutamate residues within a hydrophobic pocket formed from six of the alpha-helices,

101 This hydrophobic pocket, formed by the alphaF-alphaG loop and

102 rm IgE-Fc structures and that it retains the hydrophobic pocket found in the hinge region of the clos

103 bic ridge from one Ig1 domain inserts into a hydrophobic pocket from the opposing Ig1 domain producin

104 appears to be due to the emergence of a new hydrophobic pocket generated by the insertion of the six

105 that mutation of a highly conserved FAK-like hydrophobic pocket (HP1) abrogates CCM3-CCM2 interaction

106 receptor, including the highly sought after hydrophobic pocket important for the binding of the C3 a

107 adopts a short alpha-helix to snuggle into a hydrophobic pocket in Bcl-xL via its noncanonical Trp120

108 ined that the binding site for Taxol is in a hydrophobic pocket in beta-tubulin, little was known abo

109 1 is Ca2+-dependent and involves a conserved hydrophobic pocket in CMI1 and calmodulin binding-like d

110 These changes create a hydrophobic pocket in COX-2, with Arg-513 located at the

111 residue, to engage an arginine finger and a hydrophobic pocket in H2A.Z-H2B, enhancing the binding p

112 Furthermore, the hydrophobic pocket in HCAII that stabilizes the apolar m

113 f some of the residues in the GAF domain and hydrophobic pocket in interaction with isoleucine and GT

114 eling studies demonstrate the existence of a hydrophobic pocket in pol eta that participates in the i

115 dium lack side chains that typically block a hydrophobic pocket in protein kinases.

116 kinase phosphorylation, which defines a new hydrophobic pocket in S1P(1).

117 A hydrophobic pocket in the active site chamber is positio

118 yl or even cyclododecyl groups, fit into the hydrophobic pocket in the active site of CA IX but not C

119 The unique hydrophobic pocket in the allosteric regulatory domain o

120 henylalanine side-chain inserts into a major hydrophobic pocket in the apple 2 domain and the isoleuc

121 lecules reveals that the compounds bind in a hydrophobic pocket in the CDC25 domain of SOS adjacent t

122 f ADAMTS13 that appears to interact with the hydrophobic pocket in the central A2 domain of von Wille

123 s are mediated by the binding of cdE2 into a hydrophobic pocket in the CP.

124 is issue of Blood, de Groot et al identify a hydrophobic pocket in the Cys-rich domain of ADAMTS13 th

125 e burial of Ubc12's N-acetyl-methionine in a hydrophobic pocket in the E3, Dcn1, promotes cullin nedd

126 Mutations to alanine identified a hydrophobic pocket in the extracellular cavity of NET, c

127 re indicates that SMARCA3 peptide binds to a hydrophobic pocket in the heterotetramer.

128 idated by the docking simulation: one at the hydrophobic pocket in the ICAM-1 binding domain (the alp

129 d a high-affinity propofol binding site in a hydrophobic pocket in the middle of a triangular cleft l

130 are noncompetitive inhibitors that bind in a hydrophobic pocket in the p66 subunit of reverse transcr

131 e complementarity of the 5-substituent for a hydrophobic pocket in the protein.

132 tors are designed to effectively fill in the hydrophobic pocket in the S1'-S2' subsites and retain al

133 EX5 structures reported here reveal a unique hydrophobic pocket in the subdomain interface that might

134 RVs) and enteroviruses (EVs) by binding to a hydrophobic pocket in viral capsid protein 1 (VP1).

135 psid-binding antiviral compounds because the hydrophobic pocket in VP1 is filled with multiple bulky

136 ing has suggested that they also bind to the hydrophobic pocket in VP1.

137 n a catalytic pocket, (ii) the creation of a hydrophobic pocket in water, (iii) self-replication prop

138 tains six antiapoptotic members, each with a hydrophobic pocket in which Bcl-2 homology region 3 (BH3

139 rounding residues, and (2) the presence of a hydrophobic pocket in which the chloride resides.

140 The receptor features a hydrophobic pocket in which the substrate is bound and p

141 their phenolic moieties occupying equivalent hydrophobic pockets in each protomer and their CoA moiet

142 gh affinity for the target by utilizing four hydrophobic pockets in its binding groove.

143 turing of transient substrates and revealing hydrophobic pockets in proteins.

144 binding mode of this molecule in two similar hydrophobic pockets in the Aurora A kinase.

145 binaphthyl-5,5'-disulfonic acid (bis-ANS) to hydrophobic pockets in the blood protein von Willebrand

146 a ligand side chain that binds in a shallow hydrophobic pocket, in the presence and absence of a nei

147 through a local conformational change and a hydrophobic pocket interaction, whereas the S443 destabi

148 omplementary surface on Rae1 displays a deep hydrophobic pocket, into which Met51 fastens like a bolt

149 orresponding regions in ADAMTS1 identified a hydrophobic pocket involving residues Gly471-Val474 as b

150 We hypothesize that a hydrophobic pocket is formed by residues I366 and W410 i

151 pite the small size of the protein domain, a hydrophobic pocket is formed by the side chains of nonpo

152 An allosteric model for regulation of the hydrophobic pocket is supported by differences in protei

153 on at this, or any other positions in BRAF's hydrophobic pocket, is predominant.

154 tes the enrichment of the substrate into the hydrophobic pocket, leading to superior catalytic perfor

155 ed protein structures have a lower number of hydrophobic pockets, leading to a lower capacity to entr

156 ing to a 156 +/- 18 microM Kd interaction: a hydrophobic pocket lined by 4 critical residues (L173, N

157 show that CBD interacts with TRPV2 through a hydrophobic pocket located between S5 and S6 helices of

158 RPR binds to a hydrophobic pocket located between two adjacent hERG1 su

159 binding site for RPR, previously mapped to a hydrophobic pocket located between two adjacent subunits

160 A resolution revealed a flavivirus-conserved hydrophobic pocket located next to the AdoMet-binding si

161 The docking of the farnesyl group to the hydrophobic pockets located at both CaM lobes further en

162 ative long-chain fatty acids (LCFAs), within hydrophobic pockets, maintaining favorable electrostatic

163 three structural elements contributing to a hydrophobic pocket, namely, the hydrophobic loop, the DN

164 ent-copalyl diphosphate substrate binds to a hydrophobic pocket near a cluster of Asp and Arg residue

165 etwork of interactions in a fairly conserved hydrophobic pocket near the active site.

166 that serves as the gatekeeper to the buried hydrophobic pocket occupied by 2,4-difluorophenyl of PH-

167 Using antibodies (Abs) that bind near the hydrophobic pocket of AMA1 and AMA1 mutated in the pocke

168 results identify the binding of RON2 to the hydrophobic pocket of AMA1 as the step that commits Plas

169 esults identify the molecular surface of the hydrophobic pocket of ATX as a target-binding site for i

170 compete with one another for binding at the hydrophobic pocket of BTD using overlapping but specific

171 broadening effects occur for residues in the hydrophobic pocket of Ca2+-S100A4.

172 (76) of Orai1-CMBD, which interacts with the hydrophobic pocket of CaM-C.

173 Ten residues lining the hydrophobic pocket of COMPcc were mutated into alanine;

174 We then mutated residues that reside in the hydrophobic pocket of CypA where proline-containing pept

175 the inhibitors bind to an allosteric, mostly hydrophobic pocket of dengue NS3 and hold the protease i

176 h this mechanism, where 4EGI-1 attaches to a hydrophobic pocket of eIF4E between beta-sheet2 (L60-T68

177 to flip out of the bilayer directly into the hydrophobic pocket of GM2AP.

178 information on small molecules bound in the hydrophobic pocket of gp41, using a paramagnetic probe p

179 of Glu37, a glutamate residue embedded in a hydrophobic pocket of HdeA, is important in controlling

180 , these results indicate that the C-terminal hydrophobic pocket of MA, which encompasses both residue

181 protrusion of that fatty acyl chain from the hydrophobic pocket of MD-2, independent of association w

182 -3 binds as an asymmetrical dimer within the hydrophobic pocket of MD-2, inducing an active receptor

183 in interaction occurs between the N-terminal hydrophobic pocket of MDM2 and the transactivation motif

184 g transient structures that bind to the same hydrophobic pocket of MDM2 as TAD1.

185 The N-terminal hydrophobic pocket of Mdm2 binds to p53 and thereby inhi

186 ubstrate or "lid" adjacent to the N-terminal hydrophobic pocket of MDM2 has a phosphorylation site, a

187 results demonstrate the crucial roles of the hydrophobic pocket of Munc18 in mast cell degranulation,

188 (D3R, L8A) that perturb interaction with the hydrophobic pocket of Munc18-1 rescues impaired secretio

189 e 5 has identified the E132A mutation in the hydrophobic pocket of Munc18-2, prompting us to examine

190 tants (F115E, E132A, and F115E/E132A) in the hydrophobic pocket of Munc18.

191 We also identified Leu-89, a residue in the hydrophobic pocket of NCS1, as being critical for facili

192 an be modulated by altering or occluding the hydrophobic pocket of NCS1.

193 E6A Pisoform 1 (Ki22M) reported to bind the hydrophobic pocket of other Hect ligases, presumably blo

194 SSB-Ct binds the hydrophobic pocket of RecO in a conformation similar to

195 The PLD2-GEF catalytic site is formed by a hydrophobic pocket of residues Phe-107, Phe-129, Leu-166

196 d in the packing of Phe(50) in PrxI within a hydrophobic pocket of Srx.

197 ecule, termed deep water, Dw, and bound in a hydrophobic pocket of the active site forms a short, str

198 at the leucine side chain protrudes into the hydrophobic pocket of the active site that accommodates

199 oplasmic domain of alphaIIb is buried in the hydrophobic pocket of the C-lobe of Ca(2+)-CIB1.

200 models places the P-CR connector loop into a hydrophobic pocket of the catalytic core, with the coile

201 petitive binding of the co-salt anion to the hydrophobic pocket of the host and counterion binding to

202 (NTA) is held in the helix alpha1 and loop 5 hydrophobic pocket of the human eIF3b RNA recognition mo

203 The lipid chain of the cysLT binds in a hydrophobic pocket of the N-terminal domain, whereas bin

204 nes of TrxR perfectly fit into the conserved hydrophobic pocket of the NrdH-redoxin.

205 ue from one clamp subunit is anchored into a hydrophobic pocket of the opposing subunit.

206 We identified a hydrophobic pocket of the P-protein C-terminal domain as

207 the peptide (F263) anchors into a transient hydrophobic pocket of the receptor to facilitate the for

208 ial to inhibit HIV-1 fusion by targeting the hydrophobic pocket of transmembrane glycoprotein gp41.

209 A-binding loop, is critical for engaging the hydrophobic pocket of TRN-1 at position W730.

210 hat overexpressed spartin binds to the Ile44 hydrophobic pocket of ubiquitin, suggesting spartin migh

211 tyl)-cognitin presumably interacted with the hydrophobic pockets of Abeta, which confers stabilizing

212 anism of binding between the hydrophilic and hydrophobic pockets of CA IX versus CA II.

213 is required for binding to CaM and that the hydrophobic pockets of CaM can accommodate the prenylate

214 vity is the recognition of TcO(4) (-) by the hydrophobic pockets of the structure.

215 D)-helix with its anchors buried in the main hydrophobic pockets of the two CaM lobes establishes tha

216 Sterols are transferred between hydrophobic pockets of vacuolar NPC2 and membrane-protei

217 ane architecture, an "intrinsic ligand," and hydrophobic pockets off a pore cavity that is surprising

218 er and the (2)beta(2)85 Phe-(2)beta(2)88 Leu hydrophobic pocket on a different tetramer is observed b

219 Upon binding Ca(II), native CaM opens a hydrophobic pocket on each of its domains.

220 easing when Pro-139 (IC-2 loop) anchors in a hydrophobic pocket on Galphai1 (Val-34, Leu-194, Phe-196

221 teracting region (RIR) motifs that bind in a hydrophobic pocket on the C-terminal domain of Rev1.

222 ative allosteric substrate-binding site in a hydrophobic pocket on the enzyme surface.

223 an unexpected binding mode identifying a new hydrophobic pocket on the enzyme.

224 eracting protein (PIP) motifs that bind in a hydrophobic pocket on the front side of PCNA as well as

225 -27) directing the binding of Phe(22) into a hydrophobic pocket on the GLP-1R.

226 Da) and could occupy more space in the deep hydrophobic pocket on the gp41 NHR trimer.

227 the PIP motif of polymerase eta binds in the hydrophobic pocket on the Rev1 C-terminal domain.

228 a mutagenesis approach, we have identified a hydrophobic pocket on the Spt5 NGN domain as binding sit

229 orms a striking hook that binds to a shallow hydrophobic pocket on the surface of each She2p subunit

230 that a loop from TBC1d5 binds to a conserved hydrophobic pocket on VPS29 opposite the VPS29-VPS35 int

231 ementarity of the molecules that include two hydrophobic pockets on IL-13 that accommodate Phe32 [com

232 ents are the two leucine residues binding in hydrophobic pockets on sigma2.

233 region, which is anchored to one of the two hydrophobic pockets on the GABARAP molecule.

234 Finally, we found two hydrophobic pockets on the HUS1 outer surface that were

235 hor of MT-WQ-IDL also binds with the shallow hydrophobic pocket outside the groove of the NHR trimer,

236 he Mcl-1 hot-spots which are related to four hydrophobic pockets P1-P4 and one major electrostatic in

237 of KRAS4b that binds tightly in the central hydrophobic pocket present in PDEdelta.

238 conserved interaction between Phe(727) and a hydrophobic pocket present on the adjacent subunit is cr

239 e 3-phenoxyphenyl side chain is located in a hydrophobic pocket previously reported to bind farnesyl

240 A tight hydrophobic pocket provides p-hydroquinones access to th

241 tructural event - a closure of the A/B helix hydrophobic pocket results from the integrated effect of

242 to levels of full efficacy in vivo through a hydrophobic pocket separate from the orthosteric site of

243 ers identified previously, which occupy both hydrophobic pockets simultaneously.

244 roduct to 5hmC, probably because the reduced hydrophobic pocket size restricts the binding of 5hmC as

245 ester the Trp residue of the ULM ligand in a hydrophobic pocket, Snu17p and Bud13p utilize a large in

246 site with concomitant formation of a highly hydrophobic pocket spatially suited to accommodate SL010

247 e four leucine residues in Ca(V)beta3 form a hydrophobic pocket surrounding key residues in the alpha

248 ophagy receptors interact with two conserved hydrophobic pockets (termed the W-site and L-site) of mA

249 site of human and Drosophila Notum, a large hydrophobic pocket that accommodates palmitoleate.

250 y-Pro analog revealed that ARM1 binds in the hydrophobic pocket that accommodates the omega-end of LT

251 city to the substrate PexRD54 by shaping the hydrophobic pocket that accommodates this protein's ATG8

252 recognition centre connected to an interior hydrophobic pocket that adaptively expands to ensheath d

253 rrel structure with a characteristic central hydrophobic pocket that binds a variety of volatile comp

254 e crystal structure of SIRT6 reveals a large hydrophobic pocket that can accommodate long-chain fatty

255 peptide reveals that SIRT2 possesses a large hydrophobic pocket that can accommodate the myristoyl gr

256 of the passenger, at the entrance of a large hydrophobic pocket that contains a bound detergent molec

257 2.4 A from the isopeptide bond in the partly hydrophobic pocket that contains the cross-link.

258 receiver domain, promoting the opening of a hydrophobic pocket that is essential for homodimer forma

259 The MIF molecule contains a hydrophobic pocket that is important for many of its pro

260 he chlorine substituent is accommodated by a hydrophobic pocket that is larger than the homologous si

261 rtially buries protoporphyrin within a large hydrophobic pocket that is located at the end of its bet

262 odes of these hits and revealed an auxiliary hydrophobic pocket that is positioned adjacent to the ph

263 in the binding site to create a constrained hydrophobic pocket that is selective for branched alipha

264 ter of 10'-demethoxystreptonigrin binds in a hydrophobic pocket that mainly consists of cap domain re

265 ase protein family and contains a novel core hydrophobic pocket that may be responsible for binding a

266 The Arc N-terminal lobe evolved a unique hydrophobic pocket that mediates intermolecular binding

267 re, with the acyl chain deeply buried into a hydrophobic pocket that runs perpendicular to a long gro

268 s is due, in part, to a phenylalanine in the hydrophobic pocket that selects for the alternative ster

269 ATP-binding site of Grp94 possesses a unique hydrophobic pocket that was used to design isoform-selec

270 n formed a stable dimer, which contained two hydrophobic pockets that provide a molecular interface f

271 tures, including a central basic patch and a hydrophobic pocket, that are important for dsRNA binding

272 In crystal structures, AurkinA binds to a hydrophobic pocket (the 'Y pocket') that normally accomm

273 uilibrium between the destabilization of the hydrophobic pocket, the overall folding energy, the acti

274 Within this hydrophobic pocket, there is a significant reduction in

275 suggested that compounds 1 and 2 target the hydrophobic pocket, thereby blocking access to the activ

276 action site on MAPKs, the common docking and hydrophobic pocket, they use distinct kinase interaction

277 95.5-8 is able to use a reactive lysine in a hydrophobic pocket to accelerate promiscuous Knoevenagel

278 to the formation of a previously undisclosed hydrophobic pocket to accommodate the alpha-phenyl ring

279 t help to accommodate the bulky damages in a hydrophobic pocket to facilitate TLS.

280 s is necessary to complete a solvent-exposed hydrophobic pocket to form the catalytically competent a

281 at these type II inhibitors utilize the same hydrophobic pocket to gain strong inhibitory potency (13

282 agates conformational energy from within the hydrophobic pocket to the helical unit that gates pocket

283 hain of PS, PE, and PC lipids is buried in a hydrophobic pocket whereas the 1'-acyl chain is exposed.

284 ety of 2 which is favorably located within a hydrophobic pocket, whereas in NTPDase1 it is exposed to

285 ed end of the fatty acid chain buried in the hydrophobic pocket, whereas the carboxylate end of the l

286 The function of the Munc18-1 protein hydrophobic pocket, which interacts with the syntaxin-1

287 small central volume surrounded by four deep hydrophobic pockets, which may explain hERG's unusual se

288 the tetramer, the "inner" beta-sheet forms a hydrophobic pocket while the helix and loop are solvent-

289 iphatic tail of the fatty acid is bound in a hydrophobic pocket with two potential entrances.

290 ology modeling as a deep, sterically limited hydrophobic pocket, with the outward pointing piperidine

291 Small molecule inhibitors binding into a hydrophobic pocket within capsid viral protein 1 were pr

292 The hydrophobic pocket within the coiled coil domain of HIV-

293 otinic, and 5-HT3A receptors suggests that a hydrophobic pocket within the Cys-loop and the M4 segmen

294 et at the caspase-1 L2 and L2' loops bound a hydrophobic pocket within the GSDMD C-terminal domain di

295 udies reveal chloride ion (Cl(-)) binds to a hydrophobic pocket within the kinase domain of WNKs to i

296 system, we selected mimetics of a conserved hydrophobic pocket within the N-heptad repeat region of

297 y to be nonspecific and does not involve the hydrophobic pocket within the PER2 PAS domains that in o

298 r) of [FeFe]-hydrogenases is embedded into a hydrophobic pocket within the protein.

299 rotein includes a GAF domain that contains a hydrophobic pocket within which isoleucine and valine bi

300 Phe105 and Met109 insert into hydrophobic pockets within the catalytic domain of the s