ライフサイエンスコーパス: hydroxybutyrate

1 reased acylcarnitines (ACs) and reduced beta-hydroxybutyrate.

2 tent) of glucose, free fatty acids, and beta-hydroxybutyrate.

3 a transporter of the major ketone body beta-hydroxybutyrate.

4 the high metabolic burden-biopolymer poly-3-hydroxybutyrate.

5 ormations found in model compounds of poly-4-hydroxybutyrate.

6 dogenous ligand for the receptor may be beta-hydroxybutyrate.

7 thyl (R)-3-hydroxydecanoate and methyl (R)-3-hydroxybutyrate.

8 d urea at physiological pH, but not for beta-hydroxybutyrate.

9 inability of the hbd mutant to grow on beta-hydroxybutyrate.

10 atalyze the oxidation of the ketone body d-3-hydroxybutyrate.

11 and glucose, or glucose plus insulin or beta-hydroxybutyrate.

12 with no increase in free fatty acids or beta-hydroxybutyrate.

13 , with different properties and without beta-hydroxybutyrate.

14 hentic (2R,3R)- and (2R,3S)-2,3-dideuterio-2-hydroxybutyrate.

15 (epoxypropane) to form acetoacetate and beta-hydroxybutyrate.

16 of the endogenous storage compound poly-beta-hydroxybutyrate.

17 yl-CoA), butyryl CoA, acetoacetate, and beta-hydroxybutyrate.

18 observed on exogenous administration of beta-hydroxybutyrate.

19 eps from commercially available methyl (R)-3-hydroxybutyrate.

20 it is also induced by both enantiomers of 3-hydroxybutyrate.

21 together with increases in the ketone body 3-hydroxybutyrate.

22 after direct ventricular application of beta-hydroxybutyrate.

23 ith increased myocardial utilization of beta-hydroxybutyrate.

24 th medium also increased the yield of poly-3-hydroxybutyrate.

25 onsumed a KE drink [(R)-3-hydroxybutyl (R)-3-hydroxybutyrate; 0.45 mL/kg body weight] or taste-matche

26 2-Hydroxybutyrate (2HB) is a byproduct of endogenous cyste

27 ing carbon through the 3-hydroxypropionate/4-hydroxybutyrate (3-HP/4-HB) CO(2) -fixation cycle.

28 Myocardial utilization of 3-hydroxybutyrate (3-OHB) is increased in patients with he

29 tyl neuraminic acid, 3-hydroxyisobutyrate, 3-hydroxybutyrate/3-aminoisobutyrate, tyrosine, valine and

30 ation step, showed that it was composed of 3-hydroxybutyrate (3HB) (60%) and 3-hydroxyvalerate (3HV)

31 83 x 10(-2) +/- 1.25 x 10(-2) s(-1)) or beta-hydroxybutyrate (4.11 x 10(-2) +/- 0.62 x 10(-2) s(-1)).

32 variant CPS lacking one methyl group on the hydroxybutyrate, 4-(3-hydroxybutanamido)-4,6-dideoxy-d-g

33 her levels of dicarboxylic fatty acids and 2-hydroxybutyrate (a known marker of glucose malabsorption

34 t that, when ingested, is converted to gamma-hydroxybutyrate, a drug of abuse with depressant effects

35 orrelations with aggression, with only one-3-hydroxybutyrate, a ketone body produced during fasting-s

36 y, isotonic solution (IS) enriched with beta-hydroxybutyrate, a nonlactate-generating substrate, was

37 between C(4) ketogenesis (production of beta-hydroxybutyrate + acetoacetate), C(5) ketogenesis (produ

38 odies are comprised of three compounds (beta-hydroxybutyrate, acetoacetate, and acetone) that circula

39 tly increased the output of 13C-labeled beta-hydroxybutyrate, acetoacetate, and CO2, indicating stimu

40 tine increased synthesis of 13C-labeled beta-hydroxybutyrate, acetoacetate, and N-acetylglutamate.

41 olic (lactate/pyruvate) and mitochondrial (3-hydroxybutyrate/acetoacetate) NADH redox states were ele

42 acetoacetate yields a markedly reduced beta-hydroxybutyrate:acetoacetate ratio of 1:3, compared with

43 We identified eight metabolites (3-D-hydroxybutyrate, acetone, acetoacetate, citrate, lactate

44 ially beneficial decreases in ferritin, beta-hydroxybutyrate, acetone, and ketone bodies, with an inc

45 activation of the 3-hydroxyl of HBCoA (or a hydroxybutyrate acyl enzyme) for nucleophilic attack on

46 content and 2-fold increases in plasma beta-hydroxybutyrate, acylcarnitines, and hepatic mRNA expres

47 The serum metabolite alpha-hydroxybutyrate (AHB) is increasingly recognized as a re

48 a from nondiabetic subjects identified alpha-hydroxybutyrate (alpha-HB) and linoleoyl-glycerophosphoc

49 abolic substrates pyruvate, acetoacetate, or hydroxybutyrate also prevented mitochondrial failure and

50 lar rescue through increased amounts of beta-hydroxybutyrate, an endogenous HDACi.

51 infusions of: [D(7)]glucose, [(13)C(4)]beta-hydroxybutyrate and [3-(13)C]lactate before and after a

52 l syndrome suggesting toxic effects of gamma-hydroxybutyrate and a history of ingesting 1,4-butanedio

53 onal pleotropic signaling properties of beta-hydroxybutyrate and AcAc are discussed including epigene

54 Hydroxybutyrate and acetoacetate (AC), alone or in combi

55 Both 3-beta-hydroxybutyrate and acetoacetate+acetone individually as

56 These metabolites were identified as beta-hydroxybutyrate and acetoacetate.

57 ting enzyme for myocardial oxidation of beta-hydroxybutyrate and acetoacetate.

58 In particular, increased concentrations of 3-hydroxybutyrate and alanine and reduced concentrations o

59 ma-butyrolactone, another precursor of gamma-hydroxybutyrate and an industrial solvent, began to be m

60 cetate, adenosine, xanthine, acetoacetate, 3-hydroxybutyrate and betaine in alcohol-fed mice and decr

61 tion of four-carbon beta-hydroxyacids like d-hydroxybutyrate and d-threonine.

62 ease the efficacy of the endogenous ligand 3-hydroxybutyrate and enhance its potency almost 10-fold.

63 similar to those of its counterparts, gamma-hydroxybutyrate and gamma-butyrolactone.

64 Complexes of poly-(R)-3-hydroxybutyrate and inorganic polyphosphate (PHB/polyP),

65 After reports of toxic effects of gamma-hydroxybutyrate and its resultant regulation by the fede

66 ing mechanisms by testing the effect of beta-hydroxybutyrate and octanoate on rat hippocampal synapti

67 ions were used to assess the ability of beta-hydroxybutyrate and octanoate to support neuronal activi

68 ratory quotient, together with elevated beta-hydroxybutyrate and reduced plasma fatty acid levels, su

69 Two metabolic intermediates, gamma-hydroxybutyrate and succinic semialdehyde, inactivated t

70 cerebral dysfunction of subjects ingesting 4-hydroxybutyrate and to the mental retardation of patient

71 Serum beta-hydroxybutyrate and total ketone levels significantly in

72 ranes, and consisting of a complex of poly(3-hydroxybutyrate) and calcium polyphosphate.

73 h both hyperketonemia (acetoacetate and beta-hydroxybutyrate) and hyperglycemia.

74 Ketone bodies, 3-hydroxybutyrate, and acetoacetate, were nonstatistically

75 nature of the ketone bodies (acetoacetate, 3-hydroxybutyrate, and acetone).

76 elevations in gamma-aminobutyric acid, gamma-hydroxybutyrate, and homocarnosine, and low glutamine.

77 plasma and liver triglycerides, plasma beta-hydroxybutyrate, and insulin.

78 McCarey-Kaufman medium, with or without beta-hydroxybutyrate, and other known media (Optisol and Liko

79 d reduced body weight, increased plasma beta-hydroxybutyrate, and reduced plasma insulin compared wit

80 ivatives, hydroxysteroids, alcohols and beta-hydroxybutyrate, and the capacity to bind amyloid-beta p

81 Amino acids, beta-hydroxybutyrate, and tricarboxylic acid cycle intermedia

82 amino acids, nonesterified fatty acids, beta-hydroxybutyrate, and urinary nitrogen but no change in b

83 Further, the ketone body beta-hydroxybutyrate, another metabolite that impacts redox s

84 he O-2 of the sugar ring and at the C-3 of 3-hydroxybutyrate are not essential for induction of cross

85 However, acetoacetate and 3-hydroxybutyrate are produced not as acids but as their c

86 s supplemented with (R)-3-hydroxybutyl (R)-3-hydroxybutyrate as 30% of calories.

87 When placed in medium with d-beta-hydroxybutyrate as the principal energy substrate, COS c

88 ction of the fluorinated diketide 2-fluoro-3-hydroxybutyrate at approximately 50 % yield.

89 beta-Hydroxybutyrate augmented insulin secretion in human isl

90 mass spectrometry (LC-MS/MS), we show that B-hydroxybutyrate (B-OHB) accumulated in the ischaemic hea

91 and acetoacetate (B: -0.50, P < 0.001) and B-hydroxybutyrate (B: -0.46, P < 0.001), as well as intake

92 and acetoacetate (B: 0.47, P < 0.001) and B-hydroxybutyrate (B: 0.52, P < 0.001).

93 dy composition, plasma concentration of beta-hydroxybutyrate (beta-HB) and appetite-related hormones

94 the ketone body acetoacetate (AcAc) to beta-hydroxybutyrate (beta-HB) by the mitochondrial enzyme be

95 PE cells, like hepatocytes, can produce beta-hydroxybutyrate (beta-HB) from fatty acids.

96 We found increased levels of beta-hydroxybutyrate (beta-HB) in the apical medium following

97 the vitamin niacin and the ketone body beta-hydroxybutyrate (beta-HB).

98 However, VMH beta-hydroxybutyrate (beta-OHB) and VMH-to-serum beta-OHB rat

99 Beta-hydroxybutyrate (beta-OHB) is a signalling molecule and

100 ients had similar ISR but higher plasma beta-hydroxybutyrate (beta-OHB) levels during L/H infusion an

101 substrates, we examined the effects of beta-hydroxybutyrate (betaHB) on synaptic transmission and mo

102 Beta-hydroxybutyrate (betaHB), a ketone body produced during

103 An increased concentration of beta-hydroxybutyrate (betaHBA) is a key biomarker for diagnos

104 We report that the ketone body d-beta-hydroxybutyrate (betaOHB) is an endogenous and specific

105 production of ketone bodies, including beta-hydroxybutyrate (betaOHB), distinguishes self-renewing L

106 We have investigated whether beta-hydroxybutyrate (betaOHB), the main ketone body (KB) pro

107 The ketone bodies beta-hydroxybutyrate (BHB) and acetoacetate (AcAc) support ma

108 d media triglyceride (TG), and glucose and B-hydroxybutyrate (BHB) export were quantified, as well as

109 ellular triglyceride (TG), and glucose and B-hydroxybutyrate (BHB) export were quantified.

110 umarate and the HCAR2 endogenous ligand beta-hydroxybutyrate (BHB) in wild-type (WT) and HCAR2-null m

111 G) stimulates muscle protein synthesis and B-hydroxybutyrate (BHB) inhibits muscle breakdown.

112 Beta-hydroxybutyrate (BHB) is a ketone body and has recently

113 The ketone body beta-hydroxybutyrate (BHB) is synthesized in the liver from f

114 concentrations of lactate, pyruvate, or beta-hydroxybutyrate (BHB) on the sympathoadrenal response to

115 sting conditions, this mutation reduced beta-hydroxybutyrate (BHB) plasma levels as well as BHB relea

116 to acetate and propionate, we show that beta-hydroxybutyrate (BHB), a metabolite produced during keto

117 of the ketone bodies acetoacetate (AA), beta-hydroxybutyrate (BHB), and acetone (ACE).

118 It has been reported that beta-hydroxybutyrate (BHB), one of the main ketone bodies pro

119 lytical device (pop-up-EPAD) to measure beta-hydroxybutyrate (BHB)-a biomarker for diabetic ketoacido

120 vated levels of acetoacetate (AcAc) and beta-hydroxybutyrate (BHB).

121 th ketone bodies (acetoacetate [AA] and beta-hydroxybutyrate [BHB]) in the presence or absence of hig

122 ylalanine, tyrosine, valine, glycerol, beta -hydroxybutyrate (BHBA), and acetate were predicted less

123 s of hepatic PEPCK mRNA, blood glucose, beta-hydroxybutyrate, blood urea nitrogen, and gluconeogenesi

124 nd that physiological concentrations of beta-hydroxybutyrate (BOH) induced proteolysis in cells maint

125 , as validated by parallel venous blood beta-hydroxybutyrate (BOHB) measurements.

126 egative relationship between carnitine and B-hydroxybutyrate (BOHB); higher branched-chain amino acid

127 d glucose and exogenous ketone ester (d-beta-hydroxybutyrate) bolus.

128 Conversely, the ketone body 3-hydroxybutyrate, branched chain amino acids, and their b

129 efficient method for the synthesis of poly(3-hydroxybutyrate) by the carbonylative polymerization of

130 Components of the 3-hydroxypropionate/4-hydroxybutyrate carbon fixation cycle, as well as sulfur

131 hysiological measurements indicate that beta-hydroxybutyrate causes an increase in neurotransmitter r

132 class with commercial applicability, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) can be prod

133 e also tested for the coproduction of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) coupled wit

134 propriate substrate, the copolymer poly(beta-hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV).

135 ing whole-body fat oxidation and plasma beta-hydroxybutyrate concentration increased, whereas markers

136 ation enzyme activity and portal plasma beta-hydroxybutyrate concentration without significantly affe

137 to beta-hydroxybutyrate; higher fasting beta-hydroxybutyrate concentration; slower beta-hydroxybutyra

138 levels increased, and free fatty acids and 3-hydroxybutyrate concentrations and the rate of lipolysis

139 The LC diet induced ketosis with mean 3-hydroxybutyrate concentrations of 1.52 mmol/L in plasma

140 try), and ketogenesis (from circulating beta-hydroxybutyrate concentrations).

141 ion, phosphorylation of ACC, and plasma beta-hydroxybutyrate concentrations.

142 Measures of beta-hydroxybutyrate confirmed that all participants were in

143 er in the presence of the ketone body R-beta-hydroxybutyrate, consistent with earlier findings that k

144 oline, N-acetylcarbohydrates, lactate, and B-hydroxybutyrate could be considered as putative markers

145 ellular carbon via the 3-hydroxypropionate/4-hydroxybutyrate cycle (3HP/4HB).

146 pathway suggests that the hydroxypropionate/hydroxybutyrate cycle emerged independently in Crenarcha

147 version of the autotrophic hydroxypropionate/hydroxybutyrate cycle of Crenarchaeota that is far more

148 crenarchaeota) use the 3-hydroxypropionate/4-hydroxybutyrate cycle to assimilate CO2 into cell materi

149 hway in the form of the 3-hyroxypropionate/4-hydroxybutyrate cycle were identified.

150 oxylate bypass and the 3-hydroxypropionate/4-hydroxybutyrate cycle were observed.

151 the fatty acid-derived ketone body (D)-beta-hydroxybutyrate ((D)-beta-OHB) specifically activates PU

152 that the infusion of the ketone body d-beta-hydroxybutyrate (DbetaHB) in mice confers partial protec

153 f cellular energy with a ketone body, D-beta-hydroxybutyrate, decreased rotenone toxicity in MN9D cel

154 e (beta-HB) by the mitochondrial enzyme beta-hydroxybutyrate dehydrogenase (BDH) depends upon NADH av

155 (R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring

156 (R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring

157 g pathway were enriched, i.e. SLC22A17 and 3-hydroxybutyrate dehydrogenase (BDH2).

158 B detection has been realized using the beta-hydroxybutyrate dehydrogenase (HBD) enzymatic reaction a

159 In addition, a gene encoding beta-hydroxybutyrate dehydrogenase (hbd) was identified.

160 Conversely, expression of beta-hydroxybutyrate dehydrogenase 1, a key enzyme in the ket

161 me differs from all the presently known beta-hydroxybutyrate dehydrogenases which are well establishe

162 For the 3-hydroxyisobutyrate- and 3-hydroxybutyrate derived enolates, the catalyst-controlle

163 he identification and verification of a beta-hydroxybutyrate-derived protein modification, lysine bet

164 ts, while the degradation of glucose or beta-hydroxybutyrate did not.

165 el sulphonium compound 4-dimethylsulphonio-2-hydroxybutyrate (DMSHB), which is oxidatively decarboxyl

166 enous infusion of the ketone body BOHB (beta-hydroxybutyrate) during the MI induction.

167 dence suggests that ketosis, in particular B-hydroxybutyrate, exerts a beneficial effect on aging and

168 The time courses of acetoacetate and beta-hydroxybutyrate formaton indicate that acetoacetate is t

169 amphiphilic, solvating polyester, poly-(R)-3-hydroxybutyrate, frequently associated with polyP.

170 thylenedioxymethamfetamine, ephedrine, gamma-hydroxybutyrate; gamma-butyrolactone, 1,4-butanediol, fl

171 Overdose of gamma-hydroxybutyrate (GHB) frequently causes respiratory depr

172 gamma-Hydroxybutyrate (GHB) naturally occurs in the brain, but

173 ith normal human islets, we found that gamma-hydroxybutyrate (GHB), a potent inhibitory neurotransmit

174 estigate, in normal young men, whether gamma-hydroxybutyrate (GHB), a reliable stimulant of slow-wave

175 t sample was thermally desorbed sodium gamma-hydroxybutyrate (GHB), and the second sample was a liqui

176 ey are derived from the drugs of abuse gamma-hydroxybutyrate (GHB), gamma-hydroxypentanoate(GHP), in

177 reased central nervous system GABA and gamma-hydroxybutyrate (GHB).

178 the biosynthesis of the neuromodulator gamma-hydroxybutyrate (GHB).

179 including arabinose, malate, succinate, beta-hydroxybutyrate, glycerol, formate, and galactose.

180 ed from lactate, 3-hydroxyisobutyrate, and 3-hydroxybutyrate have been investigated.

181 eases in circulating levels of ketone body 3-hydroxybutyrate have beneficial acute hemodynamic effect

182 ed on the electrochemical monitoring of beta-hydroxybutyrate (HB) as the dominant biomarker of ketone

183 omposed of two monomers in which the growing hydroxybutyrate (HB) chain alternates between C149 on ea

184 (HB-CoA) have been used to detect oligomeric hydroxybutyrate (HB) units covalently bound to the synth

185 KPD had slower acetyl CoA conversion to beta-hydroxybutyrate; higher fasting beta-hydroxybutyrate con

186 ty, which is in contrast to the natural poly(hydroxybutyrate) homopolymer.

187 ession were both significant predictors of 3-hydroxybutyrate in multi-rater models.

188 In vivo oxidation of (13)C-labeled beta-hydroxybutyrate in neonatal Oxct1(-/-) mice, measured us

189 tin regulation and diverse functions of beta-hydroxybutyrate in the context of important human pathop

190 Blood beta-hydroxybutyrate in the KLC dieters was 3.6 times that in

191 Analysis revealed a significant increase of hydroxybutyrates in AD, including 3-hydroxybutanoic acid

192 sure 1,4-butanediol or its metabolite, gamma-hydroxybutyrate, in urine, serum, or blood.

193 application of pyruvate, iodoacetate or beta-hydroxybutyrate induced electromechanical and [Ca2+]i tr

194 propylene oxide carboxylation and that beta-hydroxybutyrate is a secondary product formed by the red

195 Since beta-hydroxybutyrate is both a major fuel and a signaling mol

196 We have discovered that the action of beta-hydroxybutyrate is specifically upon HDAC2 and HDAC3, wh

197 As in R. etli, a 4-carbon fatty acid, beta-hydroxybutyrate, is esterified to (omega - 1) of the LCF

198 Changes in beta-hydroxybutyrate, isoleucine, lactate, and pyridoxate wer

199 tegy with a KE comprised of hexanoyl-hexyl-3-hydroxybutyrate KE (KE-1) diet, and 77 rats were treated

200 n, elevated fatty acid oxidation, and 3-beta-hydroxybutyrate ketone levels, and reduced appetite-stim

201 production of the fat breakdown product beta-hydroxybutyrate, leading to increased production of pros

202 n kinase B) and the ability to suppress beta-hydroxybutyrate levels are not impaired in TGN.

203 metabolomics, we identify circulating alpha-hydroxybutyrate levels as a robust marker of an elevated

204 so produced higher free fatty acids and beta-hydroxybutyrate levels compared with placebo.

205 The KE-1 diet in mice elevated beta-hydroxybutyrate levels during nocturnal feeding, whereas

206 ly, TCDD reduced hepatic acetyl-CoA and beta-hydroxybutyrate levels eliciting starvation-like conditi

207 In humans, elevations in circulating alpha-hydroxybutyrate levels have previously been associated w

208 Loss of MPC1 in BAT increased 3-hydroxybutyrate levels in blood and BAT in response to t

209 tically induced in response to elevated beta-hydroxybutyrate levels in cultured cells and in livers f

210 Blood d-beta-hydroxybutyrate levels in the KE group were 3-5 times th

211 enhanced; in patients with T2D, fasting beta-hydroxybutyrate levels rose from 246 +/- 288 to 561 +/-

212 ing the 4-hour resting period, circulating 3-hydroxybutyrate levels were 10-fold higher after KE trea

213 Plasma 3-beta-hydroxybutyrate levels were increased 3-5 days after inf

214 acid oxidation, as inferred from serum beta-hydroxybutyrate levels, was increased in response to fas

215 y changes in plasma free fatty acid and beta-hydroxybutyrate levels.

216 l antibody normalized blood glucose and beta-hydroxybutyrate levels.

217 ve gained depsipeptide (D-Ala-D-Lac, D-Ala-D-hydroxybutyrate) ligase activity with dipeptide/depsipep

218 he acetyl moiety of citrate, C-1 + 2 of beta-hydroxybutyrate, malonyl-CoA, and acetylcarnitine.

219 etic modifications through elevation of beta-hydroxybutyrate may provide a feasible strategy to treat

220 owing an epigenetic switch triggered by beta-hydroxybutyrate-mediated inhibition of HDAC3.

221 cellular depolymerases), as well as PhaZ2 (a hydroxybutyrate oligomer hydrolase).

222 urinol, followed by Melatonin, Clemastine, B-Hydroxybutyrate, Omegaven, and Iodide.

223 ogical concentrations of ketone bodies (beta-hydroxybutyrate or acetoacetate) reduced the spontaneous

224 decreased in the presence of insulin or beta-hydroxybutyrate or both (from 1.14 +/- 0.3 to 0.58 +/- 0

225 ucturally related molecules acetate and beta-hydroxybutyrate or cofactors NAD(+) and NADH.

226 y inhibited in hepatocytes incubated in beta-hydroxybutyrate or fatty acids, and the observed inhibit

227 thylamphetamine (MDMA), 221 (10%) used gamma-hydroxybutyrate or gamma-butyrolactone, 175 (8%) used me

228 cose, free fatty acids (FFAs), lactate, beta-hydroxybutyrate, or insulin levels relative to controls,

229 e mitochondrial complex II activator, D-beta-hydroxybutyrate, or the anti-apoptotic bile acid taurour

230 8 +/- 0.16 [insulin], to 0.75 +/- 0.17 [beta-hydroxybutyrate] or to 0.53 +/- 0.17 [both], P < 0.05).

231 2 micromol.kg(-1).min(-1)), net hepatic beta-hydroxybutyrate output (0.1 +/- 0.0 and 0.4 +/- 0.1 micr

232 a-hydroxybutyrate concentration; slower beta-hydroxybutyrate oxidation; faster leucine oxidative deca

233 ate step two by coupling oxidation of poly(3-hydroxybutyrate) (P3HB) to NO2(-) reduction.

234 f the new absorbable polymer scaffold poly-4-hydroxybutyrate (P4HB) in complex abdominal wall reconst

235 were closed with polyglactin 910 and poly-4 hydroxybutyrate (P4HB) sutures in opposite halves of the

236 beta-Hydroxybutyrate permeability was not increased above bac

237 Poly-3-hydroxybutyrate (PHB) and bacterial cellulose (BC) are b

238 onproteinaceous polymers, namely, poly-(R)-3-hydroxybutyrate (PHB) and inorganic polyphosphate (polyP

239 opha produces both the homopolymer poly-beta-hydroxybutyrate (PHB) and, when provided with the approp

240 ultative methylotroph, accumulates poly-beta-hydroxybutyrate (PHB) as a carbon and energy reserve mat

241 meliloti stores carbon and energy in poly-3-hydroxybutyrate (PHB) as a contingency against carbon sc

242 gions containing genes involved in poly-beta-hydroxybutyrate (PHB) biosynthesis and degradation and a

243 store excess carbon as intracellular poly-3-hydroxybutyrate (PHB) granules that assist survival unde

244 The use of poly-beta-hydroxybutyrate (PHB) is an alternative polymer that can

245 To evaluate if the compound poly-beta-hydroxybutyrate (PHB) might be a suitable immunoprophyla

246 idly under mild conditions to produce poly(3-hydroxybutyrate) (PHB) and poly(3-hydroxyvalerate) (PHV)

247 Numerous bacteria accumulate poly(3-hydroxybutyrate) (PHB) as an intracellular reservoir of

248 d natural gas (bioCNG), conversion to poly(3-hydroxybutyrate) (PHB) bioplastic, and conversion to sin

249 Poly(3-hydroxybutyrate) (PHB) is well-known as a high molecular

250 e to dissolve these compounds in molten poly(hydroxybutyrate) (PHB), having a hydroxyvalerate co-mono

251 rades the carbon storage molecule poly((R)-3-hydroxybutyrate) (PHB).

252 the above, the potential of using the poly(3-hydroxybutyrate), PHB, depolymerase from Psuedomonas lem

253 s copurify with two homopolymers, poly[(R)-3-hydroxybutyrate] (PHB) and inorganic polyphosphate (poly

254 Intracellular poly[D-(-)-3-hydroxybutyrate] (PHB) depolymerases degrade PHB granule

255 h an emphasis on the synthesis of poly[(R)-3-hydroxybutyrate] (PHB), a renewable biodegradable PHA po

256 herichia coli complexed with a D-Ala-D-alpha-hydroxybutyrate phosphonate and the structure of the Y21

257 otinate fermentation and downregulation of 3-hydroxybutyrate production and flagellation.

258 Disruption of beta-hydroxybutyrate production increases hepatic NAD(+)/NADH

259 erol was directly correlated with blood beta-hydroxybutyrate (r = 0.297, P = 0.025).

260 The K(m)s for NAD+ and (R)-3-hydroxybutyrate (R-HOB) of expressed BDH are similar to

261 ncentration of generated (R)-ethyl-4-cyano-3-hydroxybutyrate ((R)-CHCN).

262 The dietary R-3-hydroxybutyrate- R-1,3-butanediol monoester increases re

263 of calories as corn starch, palm oil, or R-3-hydroxybutyrate-R-1,3-butanediol monoester (3HB-BD ester

264 asured the effects of a diet in which D-beta-hydroxybutyrate-(R)-1,3 butanediol monoester [ketone est

265 regimen using a commercially available beta-hydroxybutyrate-(R)-1,3-butanediol monoester (DeltaG; KE

266 s received 2 weeks of KE treatment (25 g D-B-hydroxybutyrate-(R)-1,3-butanediol x 4 daily) and isocal

267 Three pathways, 2-hydroxybutyrate-related metabolites, gamma-glutamyl dipe

268 rsely associated with 5 metabolites in the 2-hydroxybutyrate-related subpathway and positively associ

269 wer than wild-type hepatocytes, whereas beta-hydroxybutyrate release was increased 2-fold, supporting

270 hydrogenase, high plasma concentrations of 4-hydroxybutyrate result in high concentrations of 4-hydro

271 ere seeded onto poly (glycolic acid)/poly (4-hydroxybutyrate) scaffolds for 5 days.

272 d with activation of the renoprotective beta-hydroxybutyrate signaling pathway.

273 Inhibition of beta-hydroxybutyrate signalling or prostaglandin production s

274 In hippocampal slices beta-hydroxybutyrate supported synaptic transmission under lo

275 f SCOT-KO mice diminish de novo hepatic beta-hydroxybutyrate synthesis by 90%.

276 serum concentrations of fatty acids and beta-hydroxybutyrate than control mice, regardless of whether

277 tions of non-esterified fatty acids and beta-hydroxybutyrate than mid-postpartum animals and control

278 nts in persistent AF revealed a rise in beta-hydroxybutyrate, the major substrate in ketone body meta

279 rsion of (2 S)-acetolactate or (2 S)-aceto-2-hydroxybutyrate to 2,3-dihydroxy-3-alkylbutyrate.

280 The KE increased d-beta-hydroxybutyrate to a maximum of ~3.4 mM (P < 0.001) duri

281 NTHi P5 associates with polyP and poly-(R)-3-hydroxybutyrate to create large, cation-selective pores

282 ivity, and reduced H2S levels; however, beta-hydroxybutyrate treatment had no effect.

283 included BCAAs, trimethylamine N-oxide, beta-hydroxybutyrate, trimethyl uric acid, and alanine.

284 nd higher rates of methamphetamine and gamma hydroxybutyrate use when compared to young MSM who teste

285 activity in villus tip cells and plasma beta-hydroxybutyrate values in portal vein and carotid artery

286 , as well as portal and arterial plasma beta-hydroxybutyrate values, were determined.

287 beta-hydroxybutyrate was 2- to 7-fold higher in INSR versus a

288 lus glutamine, or methyl succinate plus beta-hydroxybutyrate was also decreased in the PC knockdown c

289 g values for higher plasma glycerol and beta-hydroxybutyrate were 1.37 (1.18-1.59) and 1.18 (1.03-1.3

290 eucine, valine, alanine, and alpha- and beta-hydroxybutyrate were found to have decreased concentrati

291 Serum concentrations of beta-hydroxybutyrate were greater with MCTs plus LCTs than wi

292 of insulin, glucose, FFAs, lactate, and beta-hydroxybutyrate were normal.

293 Plasma and urinary beta-hydroxybutyrate were similar on both diets.

294 At GW 16-19, branched-chain AAs and hydroxybutyrates were positively associated with SGA ris

295 opy), and hepatic fat oxidation (plasma beta-hydroxybutyrate) were measured.RESULTSLipolysis was 2- t

296 s a high molecular weight homopolymer of R-3-hydroxybutyrate which accumulates in storage granules wi

297 The metabolite beta-hydroxybutyrate, which increases after prolonged exercis

298 etylmuramic acid product to 2,3-dideuterio-2-hydroxybutyrate, which was shown to be (2R) by enzymatic

299 lucose to alternative fuels, lactate or beta-hydroxybutyrate, while monitoring the spontaneous firing

300 n all lines was achieved by combining d-beta-hydroxybutyrate with tauroursodeoxycholic acid but not w