ライフサイエンスコーパス: hydroxyecdysone

1 orms are induced as a primary response to 20-hydroxyecdysone.

2 omosomes initiated by the molting hormone 20-hydroxyecdysone.

3 o become pupally committed in response to 20-hydroxyecdysone.

4 ion of cholesterol to the molting hormone 20-hydroxyecdysone.

5 that includes the insect steroid hormone 20-hydroxyecdysone.

6 mutant larvae the insect steroid hormone 20-hydroxyecdysone.

7 R, IR, and mass spectra not only for pure 20-hydroxyecdysone (100-400 microg on column) but also the

8 ficantly up-regulated after stimulated by 20-hydroxyecdysone (20-E) in vivo.

9 ections and find that the steroid hormone 20-hydroxyecdysone (20-HE) can regulate the quality of the

10 influential roles of the steroid hormone 20-hydroxyecdysone (20-HE) during development, we tested th

11 by the prepupal peak of the ecdysteroid, 20-hydroxyecdysone (20-HE).

12 ating titer of the insect molting hormone 20-hydroxyecdysone (20-HE).

13 Kc167) that differentiates in response to 20-hydroxyecdysone (20-HE).

14 droxyecdysone-3-O-beta-D-glycopyranoside, 20-hydroxyecdysone, 20-hydroxyecdysone-3-O-beta-D-xylose an

15 d wing disk growth in vitro requires both 20-hydroxyecdysone (20E) and either brain extract or bombyx

16 ryos have very low titers of ecdysone and 20-hydroxyecdysone (20E) and fail to express IMP-E1 and L1,

17 utonomous response to the steroid hormone 20-hydroxyecdysone (20E) and involves mitochondrial demise

18 show that the Drosophila steroid hormone 20-hydroxyecdysone (20E) and its nuclear receptor directly

19 nduction of BR-C mRNA in the epidermis by 20-hydroxyecdysone (20E) and its suppression by JH were sho

20 sstalk between two major insect hormones, 20-hydroxyecdysone (20E) and juvenile hormone (JH) to elici

21 aximal levels within 12h by low levels of 20-hydroxyecdysone (20E) and repressed by physiologically r

22 ture, AaFTZ-F1 expression is inhibited by 20-hydroxyecdysone (20E) and superactivated by its withdraw

23 and developmental hormones, the steroidal 20-hydroxyecdysone (20E) and the sesquiterpenoid juvenile h

24 squito Anopheles gambiae, the ecdysteroid 20-hydroxyecdysone (20E) appears to have evolved to both co

25 or genes activated by the steroid hormone 20-hydroxyecdysone (20E) are dually controlled by the ecdys

26 n occurs as levels of the steroid hormone 20-hydroxyecdysone (20E) are rising during the pupal stage.

27 of the tobacco hornworm Manduca sexta by 20-hydroxyecdysone (20E) during larval and pupal molts, wit

28 Remarkably, 20-hydroxyecdysone (20E) has opposite effects on USP isofor

29 Blood feeding triggers a 20-hydroxyecdysone (20E) hormonal cascade, which activates

30 Here, we investigate the role of 20-hydroxyecdysone (20E) in CW assessment and pupation timi

31 competence factor for the steroid hormone 20-hydroxyecdysone (20E) in Drosophila melanogaster metamor

32 day 2 fifth larval epidermis in vitro by 20-hydroxyecdysone (20E) in the absence of JH with dose-res

33 ormone receptor family that is induced by 20-hydroxyecdysone (20E) in the epidermis of the tobacco ho

34 a key requirement for the steroid hormone 20-hydroxyecdysone (20E) in the maintenance of numerous pat

35 hen day 2 fourth epidermis was exposed to 20-hydroxyecdysone (20E) in vitro, MHR4 mRNA appeared betwe

36 d the Manduca GV1 cell line is induced by 20-hydroxyecdysone (20E) in vitro.

37 The steroid hormone 20-hydroxyecdysone (20E) initiates metamorphosis in insects

38 that the male-transferred steroid hormone 20-hydroxyecdysone (20E) is a key regulator of monandry and

39 insect metamorphosis, the steroid hormone 20-hydroxyecdysone (20E) is responsible for coordinating th

40 The steroid 20-hydroxyecdysone (20E) is the primary regulatory hormone

41 nowledge, because exposure to the steroid 20-hydroxyecdysone (20E) leads to a robust regulated secret

42 n successive phases of rising and falling 20-hydroxyecdysone (20E) levels, leading to a cascade of nu

43 Tonic exposure to moderate levels of 20-hydroxyecdysone (20E) or its precursor, ecdysone, are re

44 tivates transcription in complex with the 20-hydroxyecdysone (20E) receptor (EcR).

45 vealed that pulses of the steroid hormone 20-hydroxyecdysone (20E) regulate ganglionic fusion, but li

46 In Drosophila, the primary steroid twenty-hydroxyecdysone (20E) regulates ovarian germline stem ce

47 that the ecdysone receptor (EcR)-mediated 20-hydroxyecdysone (20E) signaling regulates miRNA expressi

48 blished that fat-body remodeling requires 20-hydroxyecdysone (20E) signaling.

49 sexta in a pattern-specific manner as the 20-hydroxyecdysone (20E) titer rises for the larval molt.

50 t includes the principal molting hormone, 20-hydroxyecdysone (20E), and ecdysone (E), which is the pr

51 The mechanism of 20-hydroxyecdysone (20E), but not of JH action, is well und

52 activated in larval organs cultured with 20-hydroxyecdysone (20E), consistent with EcR/USP acting as

53 Upon blood feeding, a steroid hormone, 20-hydroxyecdysone (20E), initiates a reproductive program

54 pally orchestrated by the steroid hormone 20-hydroxyecdysone (20E), remains largely unknown.

55 converts ecdysone (E) to the more active 20-hydroxyecdysone (20E), specifically in mature follicle c

56 Here, we show that 20-hydroxyecdysone (20E), the active metabolite of ecdysone

57 nly thought to be a hormone precursor and 20-hydroxyecdysone (20E), the physiologically active steroi

58 The ecdysteroid hormone 20-hydroxyecdysone (20E), transferred from male to female d

59 n direct response to the prepupal rise in 20-hydroxyecdysone (20E), whereas APR(4)s survive through t

60 d by the male-synthetized steroid hormone 20-hydroxyecdysone (20E), which is packaged together with o

61 ssion of DHR3 and betaFTZ-F1 is part of a 20-hydroxyecdysone (20E)-triggered transcriptional cascade

62 es vitellogenesis through the function of 20-hydroxyecdysone (20E).

63 ly candidate for sexual selection is male 20-hydroxyecdysone (20E).

64 evelopment and metamorphosis regulated by 20-hydroxyecdysone (20E).

65 ests its regulation by a steroid hormone, 20-hydroxyecdysone (20E).

66 tamorphosis through its active metabolite 20-hydroxyecdysone (20E).

67 osis is controlled by the steroid hormone 20-hydroxyecdysone (20E).

68 under the control of the steroid hormone 20-hydroxyecdysone (20E).

69 , and the JH I induction is suppressed by 20-hydroxyecdysone (20E).

70 nesis is regulated by the steroid hormone 20 hydroxyecdysone (20E).

71 cell autonomously by the steroid hormone 20-hydroxyecdysone (20E).

72 a blood-meal-initiated, elevated titer of 20-hydroxyecdysone (20E).

73 , juvenile hormone (JH) and ecdysteroids (20-hydroxyecdysone, 20E, is the most active form) govern fe

74 sis and is essential for molting hormone (20-hydroxyecdysone; 20E) biosynthesis.

75 that the most prevalent phytoecdysteroid, 20-hydroxyecdysone (20HE), was secreted (leached) from inta

76 d and used to identify four ecdysteroids: 20-hydroxyecdysone-3-O-beta-D-glycopyranoside, 20-hydroxyec

77 ta-D-glycopyranoside, 20-hydroxyecdysone, 20-hydroxyecdysone-3-O-beta-D-xylose and a hydroxyecdystero

78 After ingestion of blood, 20-hydroxyecdysone activates yolk protein precursor (YPP) g

79 We conclude that 20-hydroxyecdysone acts through the Broad-Complex to contro

80 imal concentration of the steroid hormone 20-hydroxyecdysone and with hemolymph taken from growing la

81 posure to the hormone and lower levels of 20-hydroxyecdysone, and by being sensitive to either 20-hyd

82 We examine the role of juvenile hormone, 20-hydroxyecdysone, and insulin/insulin-like growth factor-

83 en used for the analysis of a standard of 20-hydroxyecdysone- and ecdysteroid-containing plant extrac

84 residues were identified as critical for 20-hydroxyecdysone binding.

85 y induced in larval epidermis in vitro by 20-hydroxyecdysone, but EcR-B1 mRNA accumulated more rapidl

86 Specifically, we show that the 20-hydroxyecdysone (commonly referred to as "ecdysone") sec

87 The holoreceptor of 20-hydroxyecdysone consists of two nuclear receptors (NRs)

88 The steroid hormone 20-hydroxyecdysone coordinates the stages of Drosophila dev

89 ion in Drosophila Schneider S2 cells in a 20-hydroxyecdysone-dependent manner, via its interaction wi

90 The steroid hormone 20-hydroxyecdysone (ecdysone) activates a relatively small

91 development is regulated by two hormones, 20-hydroxyecdysone (ecdysone) and juvenile hormone.

92 Following an increase in the steroid 20-hydroxyecdysone (ecdysone) at the end of larval developm

93 Drosophila, pulses of the steroid hormone 20-hydroxyecdysone (ecdysone) control the timing of the tra

94 amorphosis, pulses of the steroid hormone 20-hydroxyecdysone (ecdysone) direct the destruction of obs

95 The steroid hormone 20-hydroxyecdysone (ecdysone) is the key regulator of poste

96 ich is coordinated by the steroid hormone 20-hydroxyecdysone (ecdysone) through the ecdysone receptor

97 Drosophila melanogaster, fluctuations in 20-hydroxyecdysone (ecdysone) titer coordinate gene express

98 hological response to the steroid hormone 20-hydroxyecdysone (ecdysone).

99 The insect steroid hormone 20-hydroxyecdysone enhanced BrdU incorporation into the nuc

100 in the production of the steroid hormone 20-hydroxyecdysone from the prothoracic gland, the primary

101 studies have suggested that production of 20-hydroxyecdysone in Drosophila and other arthropods invol

102 elevated response to the steroid hormone 20-hydroxyecdysone in mosquitoes in a state of arrest.

103 of premoult concentrations (10(-6) M) of 20-hydroxyecdysone in the epidermal and muscle tissue of th

104 ntral nervous system, the steroid hormone 20-hydroxyecdysone induces a wide spectrum of cellular resp

105 The steroid hormone 20-hydroxyecdysone is a key regulatory factor, controlling

106 The steroid insect molting hormone 20-hydroxyecdysone is believed to control critical aspects

107 most abundant phytoecdysteroids including 20-hydroxyecdysone is yet to be clarified.

108 atory mechanism upon a hormonal stimulus (20-hydroxyecdysone) is to influence pause-release rather th

109 exogenous and endogenous compounds, like 20-hydroxyecdysone (natural ligand of the ecdysone receptor

110 Precocious application of 20-hydroxyecdysone on the first day of pupal life accelerat

111 reasing the levels of the steroid hormone 20-hydroxyecdysone or by decapitation.

112 cdysone, and by being sensitive to either 20-hydroxyecdysone or its precursor, ecdysone.

113 g the mutants the steroid molting hormone 20-hydroxyecdysone, or the precursors of ecdysone biosynthe

114 ments stimulating direct development (the 20-hydroxyecdysone pathway: Ecr, Shd, Broad; the Wnt pathwa

115 lly identified in these extracts included 20-hydroxyecdysone, polypodine B, and integristerone A.

116 The steroid hormone 20-hydroxyecdysone (referred to here as ecdysone) directs D

117 The Broad-Complex, a 20-hydroxyecdysone-regulated gene, is essential for the dev

118 oad-Complex (BR-C) is a key member of the 20-hydroxyecdysone regulatory hierarchy that coordinates ch

119 d in vitro by the insect molting hormone, 20-hydroxyecdysone, suggesting that this, or some related s

120 Although 20-hydroxyecdysone titers were elevated under heat shock co

121 depends on ecdysone signaling, as feeding 20-hydroxyecdysone to PTTH mutants reverses the effect.

122 Bombyxin evidently acts together with 20-hydroxyecdysone to stimulate cell division and growth of

123 Importantly, AaGATAr can override the 20-hydroxyecdysone transactivation of YPP genes, and its tr

124 tured fat body became less abundant after 20-hydroxyecdysone treatment.

125 Later, high levels of 20-hydroxyecdysone trigger a wave of apoptosis within the a

126 e have shown that the fly steroid hormone 20-hydroxyecdysone triggers both the elongation itself and

127 d and orchestrated by the steroid hormone 20-hydroxyecdysone, which initiates a cascade of coordinate

128 The insect steroid hormone 20-hydroxyecdysone works through a ligand-activated nuclear