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1 estrogenic side chain of endoxifen or a free hydroxyl.
2 the regioselectivity observed is greater for hydroxyl.
3 tively weak nucleophilicity of the primer 3'-hydroxyl.
4 ociated with removal of the C2-methyl and C3-hydroxyl.
5 s hydrogen bond acceptor sites to the serine hydroxyl.
6 ucosamine (O-GlcNAc) to serine and threonine hydroxyls.
7 ch Ag atom bonded with two or three terminal hydroxyls.
8 allic complexes with compounds with adjacent hydroxyls.
9 uracy), but differ in the number of terminal hydroxyls.
10 tion of RNA by selective acylation of the 2'-hydroxyl (2'-OH) group has emerged as a powerful alterna
11 egion of the CHIKV genome using selective 2'-hydroxyl acylation analysed by primer extension (SHAPE)
14 Using biophysical analyses and Selective 2' Hydroxyl Acylation analyzed by Primer Extension (SHAPE)
15 ere experimentally supported by selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE).
16 mutational profiling (DMS-MaP), selective 2'-hydroxyl acylation analyzed by primer extension and muta
17 ation of high-resolution SHAPE (selective 2'-hydroxyl acylation analyzed by primer extension) structu
18 ium site by interacting with the O3' and O4' hydroxyls alongside additional specific interactions of
19 ilicity and abundant exchangeable protons of hydroxyl, amine, and amide anchored on the surface, we r
20 to the ortho- or para-positions of phenolic hydroxyl/amino groups and the C2-position of the indole
21 -phenyl-N-tert-butyl nitrone (PBN) bearing a hydroxyl, an acetate, or an acetamide substituent on the
22 verse alkyl, alkenyl, aryl, alkynyl, fluoro, hydroxyl and amino groups at the beta position of the pa
26 tes sandwiched by two pyrene linkers and the hydroxyls and water molecules on the Zr(6) nodes, which
27 ite) and 4' (4`-hydroxymidazolam metabolite) hydroxyl, and the 1' and 4' glucuronide metabolites were
28 d sequence at the 3' end is not required, 2' hydroxyls are, paralleling requirements for Prp43p bioch
29 egio-isomers synthesized, those carrying the hydroxyl at the 7- and 9-positions presented growth inhi
30 often utilized to provide hydrophilicity and hydroxyl-based hydrogen bonds in self-assembling glycope
31 h both the backbone amide and the side-chain hydroxyl (bidentate interaction) to promote binding by s
32 3alpha5alpha-P or pregnanolone reduced to a hydroxyl, binding affinity is reduced by 1,000-fold, whe
35 l origins, five groups (i.e., amine, phenol, hydroxyl, carboxyl, and carbonyl) are found to be the do
40 he mechanism of the asymmetric BINOL-derived hydroxyl carboxylic acid catalyzed allylboration of benz
41 As, employing 2-enoyl-CoA hydratase (ECH), 3-hydroxyl-CoA dehydrogenase (HAD), and 3-ketothiolase (KT
42 eguide sensor was able to identify different hydroxyl compounds, such as water, methanol, and ethanol
43 most chemical modifications at predicted 2'-hydroxyl contact positions, whereas editing activity in
44 o group distributions of database compounds, hydroxyl-containing metabolites were severely underdetec
45 ntinental-marine mixed air had more abundant hydroxyl dicarboxylic acids (OHDCA), with anthropogenic
46 report a unique method for preparing diaryl hydroxyl dicarboxylic acids in a diastereospecific manne
47 this prediction and demonstrate that this 5'-hydroxyl dinucleotide hydrolase (HDH) activity for DXO i
48 ion of either the Mo-O5 (carboxyl) or Mo-O7 (hydroxyl) distance that switches the Mo-homocitrate liga
50 ilability of multiple functional groups like hydroxyl, ester, or lactone in the resultant products ex
52 led to the discovery of fatty acid esters of hydroxyl fatty acids (FAHFAs), which are naturally occur
53 he alkyoxy group on silicon with a substrate hydroxyl followed by activation of a nearby carbonyl by
55 pecies protonation states remain unaffected, hydroxyl-for-bisulfide ligand substitution is avoided, a
57 eport on ultracold collision dynamics of the hydroxyl free-radical OH with Sr atoms leading to quench
60 maticity decrease rejection, that methyl and hydroxyl functional groups increase rejection, and that
61 the orthogonality between the azide and the hydroxyl functional groups, the former was next selectiv
62 nes or azides onto the terephthalic phenolic hydroxyl functionalities, which are situated at opposite
64 ordinated formate ligands (HCO(2)(-)) by 1,2-hydroxyl-functionalized l-glycerate (l-gly, l-HOCH(2)(HO
67 mportant to inhibit alpha-amylase, while the hydroxyl group (OH) at C3 of the C-ring was related to i
71 lmitic acids, consisting of isomers with the hydroxyl group at different positions, were identified i
73 ) derived by systematically exchanging every hydroxyl group by a fluorine atom, we developed a strate
74 the MD simulation indicate that a ribose 2'-hydroxyl group destabilizes the pai-pai stacking of the
76 ered azaenediyne, while the substrate with a hydroxyl group gave only traces of the desired 10-member
78 by the tight-bonding of active centers with hydroxyl group intermediate, while the Mg atom coordinat
79 , we firstly investigated how the additional hydroxyl group of NE could affect the properties of the
80 e (k(1), rho = 0.65), and the pK(a)'s of the hydroxyl group of the carbinolamide (rho = 0.23) are rep
81 ned that PDI inhibition relied on the A ring hydroxyl group of the chalcone scaffold and cLogP increa
82 etween the oxygen of the directing group and hydroxyl group of the ligating acetic acid is crucial fo
83 e also establish that methylation of the C-3 hydroxyl group of the terminal alpha-l-Rha is achieved b
84 a methyltransferase that methylates the C-2 hydroxyl group of the terminal alpha-l-rhamnose (Rha) un
87 ated by a second tetrahedral Al atom and its hydroxyl group protons in zeolite HZSM-5 is clearly reso
91 ng from the integrase active site the DNA 3'-hydroxyl group that is required for strand transfer acti
94 differs from dopamine only for an additional hydroxyl group was not investigated at all in biosensing
95 l hydrophilic environments near the reactive hydroxyl group which stabilize both the proton and chlor
96 talyzes regiospecific methylation at the C-7 hydroxyl group, (ii) TnmH exhibits broad substrate promi
97 During proton transfer to a basic support hydroxyl group, electron density is distributed through
98 ' effectiveness depends on the presence of a hydroxyl group, the chain length (four carbons), and the
106 of (+)strand DNA with either a phosphate or hydroxyl group; and (iv) the 5' end of the DP-rcDNA (-)s
108 udy, we examined whether the distribution of hydroxyl groups among flavones could influence their pot
110 Carrageenan, which has a large number of hydroxyl groups and is fully negatively charged, is a ne
111 strategy enables direct introduction of key hydroxyl groups and rapid construction of key bonds and
113 is a promising technique for the analysis of hydroxyl groups because of its unique characterization c
114 hat at least two framework Al(IV) sites with hydroxyl groups can exist in acidic zeolite catalysts in
117 oscopy offers unique advantages in measuring hydroxyl groups in a single spectrum with high signal re
119 its for chemically mapping the importance of hydroxyl groups in carbohydrate-receptor interactions.
120 ive functionalization of seemingly identical hydroxyl groups in carbohydrates remains a long-standing
121 Our data demonstrate the existence of free hydroxyl groups in cutin and provide insight into how th
122 support the notion that the aminomethyl and hydroxyl groups in the capping group of Suprastat establ
127 plication templates, while lagging strand 3'-hydroxyl groups may prime endonuclease-independent L1 re
128 hat catalyze the addition of GalNAc onto the hydroxyl groups of serines or threonines in protein subs
129 roteins within multicellular eukaryotes have hydroxyl groups of specific serine and threonine residue
132 oscopy analysis confirms the presence of the hydroxyl groups on the INFGN surface, which acts as the
134 in a single aspect of the orientation of the hydroxyl groups or harbor subtle chemical modifications.
136 emonstrate the importance of the location of hydroxyl groups relative to the hydrophobic face of the
137 hydrogen-bond networks, the contribution of hydroxyl groups to affinity can reach several orders of
139 d stereoselective alkylation of carbohydrate hydroxyl groups via Rh(II)-catalyzed insertion of metal
140 insertion step, which prefers insertion into hydroxyl groups with an adjacent axial substituent.
141 to that in Y-SiO(2) but which lacks adjacent hydroxyl groups, and are 7 times more active than the ac
142 kenes, esters, ketones, acetals, unprotected hydroxyl groups, and phosphines) have been demonstrated
143 er aliphatics, free acid end-groups and free hydroxyl groups, differentiating between those derived f
144 vatives, depending on the positioning of the hydroxyl groups, induce various conformations of the est
145 -hydroxy-2-propyl)benzene, which has distant hydroxyl groups, is able to catalyze nucleophilic fluori
146 PEG2000 was bound to adenosine on the 3',4' hydroxyl groups, stimulated cAMP increases and these inc
147 ocols and does not require the protection of hydroxyl groups, thus allowing the facile synthesis of a
148 e during interactions with water and surface hydroxyl groups, which can be used as fingerprints for t
154 be analyzed in four-channel CIL LC-MS where hydroxyls (H), amines and phenols (A), carboxyls (C), an
155 (-)/ONOOH), as well as peroxynitrite-derived hydroxyl (HO(*)) and carbonate anion (CO(3) (*-)) radica
157 oroacetamide, to substitute the exchangeable hydroxyl-hydrogens with trifluoroacetate derivatives tha
158 of SO(2) by the two main isomers of isoprene hydroxyl hydroperoxide (ISOPOOH), the primary low-NO(x)
159 ut affecting TIPS protection of the phenolic hydroxyl in beta-tyrosine and N-Boc protection in lysine
160 hemistries as molecular hydrogen (H(2) ) and hydroxyl ions (OH(-) ) are produced and reduced carbon c
165 gues with diazirine moieties replacing the 3-hydroxyl (KK148 and KK150) bind to all three sites, but
166 4)](5-) complexes are favored, stabilized by hydroxyl ligands and charge balancing calcium ions in th
167 of simple functionalities such as carbonyl, hydroxyl, methyl, or methoxyl groups is known to cause d
168 (2) labeling showed that the oxygens of both hydroxyl moieties originate from molecular oxygen rather
169 o tyrosine differs only by the presence of a hydroxyl moiety in the latter, but this results in an up
171 on promoted an increase in the inhibition of hydroxyl, nitric oxide and alpha-amylase, as well as a d
172 al base abstracting a proton from the D-ring hydroxyl of 17-HOPC-CoA and Tyr-344 as the general acid
173 fined complex, where the axially oriented C2-hydroxyl of a mannose residue points toward the Ser41 of
176 ylation proceeded exclusively on the primary hydroxyl of tyrosol, thus forming rhamnosylated derivati
177 uences of amino-acid attachment at 2'- or 3'-hydroxyls of the terminal ribose in oligoribonucleotides
179 ified by the catalytic roles of the adsorbed hydroxyl (OH(ad))-water-alkali metal cation (AM(+)) addu
181 ensive picture connecting the chemistries of hydroxyl (OH) and hydroperoxy radicals, oxidized nitroge
183 environment, namely, CH(3)Cl degradation by hydroxyl ((.)OH) and chlorine ((.)Cl) radicals in the tr
184 eiki extract identified oleuropein aglycone, hydroxyl oleuropein aglycone, and oleuropein as key comp
185 atives act as antiestrogens with a free para-hydroxyl on the phenyl ring that contains an antiestroge
186 t Ag atom is mainly anchored by the terminal hydroxyls on (100) surface, forming a staple-like local
188 The presence of ligands belonging to alpha-hydroxyl or carbonyl carboxylates, such as tartrate, mal
190 (18)O(2) and (16)O(2) demonstrated that both hydroxyl oxygens originate from a single molecule of O(2
191 is a pentagonal assembly of 25 Zr-oxy/peroxo/hydroxyl polyhedra and is the largest Zr/Hf cluster topo
194 psulation of DHA in the pH dependant polymer hydroxyl-propyl-methyl-cellulose-acetate-succinate (HPMC
196 ed analyte ions highlights the importance of hydroxyl proton mobilization in this low proton mobility
198 and displayed the highest similarity to the hydroxyl pyruvate reductase isoform 2 in Arabidopsis tha
203 rocess (AOP) frequently employed to generate hydroxyl radical ((*)OH) to treat reverse osmosis permea
204 orus chemistry, and its association with the hydroxyl radical ((.) OH) to yield metaphosphorous acid
205 the well understood mechanism through which hydroxyl radical (.OH) produced by nitrate and nitrite p
208 for an autoxidation mechanism, initiated by hydroxyl radical (OH) addition to C=C bonds and propagat
212 ) is produced by the formal dehydration of a hydroxyl radical adduct of dG as well as by deprotonatio
213 s activated water molecules to form covalent hydroxyl radical adducts at nearby residues, which were
215 ities involved in these reactions are likely hydroxyl radical and singlet oxygen based on the use of
217 tial distribution of radicals, we found that hydroxyl radical concentration was strongly dependent on
221 orbic acid depletion (denoted as OP(AA)) and hydroxyl radical formation (denoted as OP(*OH)) from bot
226 trary to frequent reports in the literature, hydroxyl radical is not a key species participating in e
228 Using time-resolved X-ray-mediated in situ hydroxyl radical labeling, we probed real-time solvent a
229 ficantly increases the signal quality of the hydroxyl radical modification products and the dose-resp
230 ties of platinum nanoparticles combined with hydroxyl radical probes produced at the particle surface
232 in doxorubicin uptake, temperature increase, hydroxyl radical production and nuclear membrane modific
235 hemical oxidation of proteins (IV-FPOP) is a hydroxyl radical protein footprinting method used to stu
236 bed sunlight was affected by the presence of hydroxyl radical scavengers, indicating the likely invol
237 ing ability (DRSA), reducing power (RP), and hydroxyl radical scavenging ability (HRSA) assays to tes
238 h in-vitro assays namely, DPPH(*), ABTS(*+), hydroxyl radical scavenging ability, reducing activity,
239 s requires high flux density to overcome the hydroxyl radical scavenging reactions produced by the bu
240 d reactive conformation and guides a derived hydroxyl radical toward formation of a copper-oxyl inter
243 iologically relevant radicals, including the hydroxyl radical, peroxyl radicals, the trioxidocarbonat
245 comparable 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radical-scavenging activities in most cases.
248 ighest reducing power (absorbance 0.366) and hydroxyl-radical-scavenging activity (91%) at 15 mg/mL;
249 ter ((3)DOM*), singlet oxygen ((1)O(2)), and hydroxyl radicals ((*)OH), for surface waters collected
250 reaction for production of highly efficient hydroxyl radicals (*OH) and consequently suppressing the
251 (GAC) (O(3)/GAC) to promote the formation of hydroxyl radicals (.OH) was evaluated at 1.0 mg O(3)/mg
252 ne (epsilon(C) = -3.6 to -4.6 per mille) and hydroxyl radicals (epsilon(C) = 0.0 to -1.2 per mille).
253 de dismutase), hydrogen peroxide (catalase), hydroxyl radicals (mannitol) and singlet oxygen (sodium
254 ir-water interface from two potent oxidizers hydroxyl radicals (OH) and singlet delta oxygen (SDO).
257 es of BCA and LA due to reactions with O(3), hydroxyl radicals (OH), and due to photolysis were calcu
258 photolysis of nitrous acid (HONO) generates hydroxyl radicals (OH), and since OH is fast reacting, i
260 species - superoxide, hydrogen peroxide and hydroxyl radicals - have long been suspected of constrai
262 Our mechanistic investigations reveal that hydroxyl radicals are unreactive toward HFPO-DA, while e
263 ic pollutants with oxidants such as ozone or hydroxyl radicals by compound-specific stable isotope an
264 alytic system with the most effective use of hydroxyl radicals in oxidation treatment scenarios.
266 duced hydrogen peroxide photolysis generates hydroxyl radicals that react with solvent-accessible sid
268 mical oxidation of proteins (FPOP), utilizes hydroxyl radicals to oxidatively modify solvent accessib
269 her concentrations of oxides of nitrogen and hydroxyl radicals, is more efficient in terms of O(3) an
271 en, superoxide anion, hydrogen peroxide, and hydroxyl radicals, to afford superb antitumor efficacy o
272 f photochemically generated oxidants such as hydroxyl radicals, ultimately leading to an enhanced atm
273 ly absorbed X-rays and efficiently generated hydroxyl radicals, which enhanced the radiotherapy effec
283 esults demonstrate that a histidine-enhanced hydroxyl reactivity can contribute to protease inhibitio
285 inhibition at pH 5, indicating that A2ML1's hydroxyl reactivity is not an adaption to its acidic epi
287 ment components C3 and C4B have an increased hydroxyl reactivity that is conveyed by a conserved hist
289 ormed by a serine or threonine residue whose hydroxyl side chain H-bonds to an over-coordinated carbo
291 to demonstrate that the presence of surface hydroxyl species by co-electrolysis of CO(2) with low co
292 urated sphingomyelins (C34:1, C36:1, C42:3), hydroxyl-sphingomyelins (C34:1, C38:3), and a hexosylcer
293 glycine, but only WT A2ML1 reacted with the hydroxyl substrate glycerol, demonstrating that His-1084
294 ymerizations are well controlled and produce hydroxyl telechelic PPC with predictable molar masses an
295 lammatory and antioxidant drug conjugated to hydroxyl terminated generation-4 PAMAM dendrimer (D-Sino
296 propylene is then converted into alpha,omega-hydroxyl-terminated polypropylene and used as a macroini
299 osition using an innocent ligand (acetate or hydroxyl) to prepare dual-action and triple-action prodr