ライフサイエンスコーパス: hydroxylase

1 rphic cell populations (kisspeptin, tyrosine hydroxylase).

2 lso stained for neurturin, RET, and tyrosine hydroxylase.

3 in allowed optimizing the performance of the hydroxylase.

4 6A1 (CYP46A1) is the major brain cholesterol hydroxylase.

5 the assignment of purified JMJD6 as a lysyl hydroxylase.

6 this enzyme to become a specific 4-arginine hydroxylase.

7 expression of the castor (Ricinus communis) hydroxylase.

8 the 1-hydroxylase and catabolized by the 24-hydroxylase.

9 eactivity for dopamine but not dopamine beta-hydroxylase.

10 pressing the castor (Ricinus communis) FAH12 hydroxylase.

11 requires prolyl hydroxylation by PHD1 prolyl hydroxylase.

12 and the catalytic repertoire of nonheme iron hydroxylases.

13 BAHD acyltransferase and two cytochrome P450 hydroxylases.

14 ion into streptavidin to assemble artificial hydroxylases.

15 lls that are highly enriched with tryptophan hydroxylase 1 (Tph1), the rate limiting enzyme regulatin

16 LAM)) via induction of the enzyme tryptophan hydroxylase 1 (Tph1).

17 on of MafB in beta-cells elevated tryptophan hydroxylase 1 mRNA production during pregnancy, which dr

18 Gene-specific hypermethylation of 25-hydroxylase, 1-alpha-hydroxylase, and VDR, and hypomethy

19 Overexpression of tryptophan hydroxylase-1 (TPH-1), an enzyme involved in 5-MTP synth

20 ing from deficiency in the enzyme tryptophan hydroxylase-1, restored the thrombocytopenic phenotype.

21 Specifically, the enzymes lysyl hydroxylase 2 (LH2) or lysyl oxidase (LOX) and LOX-like

22 The human hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) readily crystallises as a homotrime

23 lpha), proliferation and upregulation prolyl hydroxylase 2 (PHD2), the enzyme which prevents activati

24 Among the SNPs analysed, a tryptophan hydroxylase 2 (TPH2) gene polymorphism-G703T-significant

25 Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in 5-HT

26 ucleus (DRN) and colocalized with tryptophan hydroxylase 2 (TPH2), a marker of serotonin (5-HT) neuro

27 The maize (Zea mays) enzyme beta-carotene hydroxylase 2 (ZmBCH2) controls key steps in the convers

28 tors with an upstream sequence of tryptophan hydroxylase 2 gene efficiently transduced serotonergic n

29 Expression of tyrosine hydroxylase 2 in the brain was elevated in cdnf mutants

30 HIF (hypoxia-inducible factor)/PHD-2 (prolyl hydroxylase 2)-constituted oxygen machinery, we hypothes

31 hydrobiopterin-dependent aromatic amino acid hydroxylase, 2-oxoglutarate-dependent hydroxylase, Riesk

32 iosynthetic enzyme for serotonin, tryptophan-hydroxylase-2 (TPH2), in the ventral subnucleus of the d

33 Here, we demonstrate that tyrosine-hydroxylase-2-expressing (th2+) DA neurons in the zebraf

34 canonical HIF signaling pathway, HIF-prolyl hydroxylase 3 (PHD3) suppresses HIF-2alpha protein by po

35 Ven1 encodes beta-carotene hydroxylase 3, an enzyme that modulates carotenoid compo

36 -component monooxygenase 3-hydroxybenzoate 6-hydroxylase (3HB6H) depresses the pK(a) of the bound sub

37 show that Syt2a is colocalized with tyrosine hydroxylase, a biosynthetic enzyme in the dopamine pathw

38 We examined the distribution of tyrosine hydroxylase, a conserved precursor for the synthesis of

39 ngly, these cells immunolabeled for tyrosine hydroxylase, a key component in dopamine synthesis.

40 . benthamiana We characterized two flavanone hydroxylases, a flavonol synthase, a flavonoid 3'-hydrox

41 K(a) values and to monitor protein events in hydroxylase active sites.

42 We also found that the lysyl-hydroxylase activity of Jumonji Domain Containing 6 (Jmj

43 Unexpectedly, we did not detect prolyl-hydroxylase activity on any reported non-HIF protein or

44 NA substrates, but it did exhibit the prolyl hydroxylase activity that has also been ascribed to it.

45 ios were compared between groups to estimate hydroxylase activity.

46 YAP1 accumulation and expression of prolyl 4-hydroxylase alpha-2 (P4HA2) which increases collagen dep

47 A1 is a cytochrome P450 enzyme with 17-alpha-hydroxylase and C17,20-lyase activities.

48 s-epoxycarotenoid dioxygenase, beta-carotene hydroxylase and carotene epsilon-monooxygenase), enzymes

49 -dihydroxyvitamin D (1,25(OH)(2)D), by the 1-hydroxylase and catabolized by the 24-hydroxylase.

50 her, our data identify the collagen prolyl 3-hydroxylase and collagen prolyl 4-hydroxylase families a

51 ation, and function of the collagen prolyl 3-hydroxylase and collagen prolyl 4-hydroxylase families i

52 ydroxylation, catalyzed by collagen prolyl 3-hydroxylase and collagen prolyl 4-hydroxylase, and is es

53 proteins chalcone synthases and flavonone 3-hydroxylase and different glutathione S-transferases rel

54 brain areas and in the analysis of tyrosine hydroxylase and dopamine D2 receptor levels.

55 proteins and evidence of decreased tyrosine hydroxylase and dopamine transporter expression in the o

56 number and volume and expression of tyrosine hydroxylase and dopamine transporter.

57 vector delivery of the two enzymes, tyrosine hydroxylase and guanosine-5'-tri-phosphate-cyclohydrolas

58 of the l-DOPA synthesizing enzymes, tyrosine hydroxylase and guanosine-tri-phosphate-cyclohydrolase-1

59 nregulation of the dopamine markers tyrosine hydroxylase and Nurr1.

60 endent enzymes, l-Ile 4-hydroxylase, l-Leu 5-hydroxylase and polyoxin dihydroxylase, are previously r

61 Melanized neurons displayed intense tyrosine hydroxylase and RET proto-oncogene expression in nigral

62 main, which is proposed to position the beta-hydroxylase and the NRPS-bound amino acid prior to hydro

63 The selectivities of many HIs for HIF hydroxylases and possible off-target effects in cellulo

64 able to other two-component flavin-dependent hydroxylases and promises to expand our understanding of

65 nduction of catabolism (CsCYP707A, an ABA 8'-hydroxylase) and buildup of dehydrophaseic acid (DPA).

66 d CYP27A1 (25-hydroxylase), CYP27B1 (1-alpha-hydroxylase), and vitamin D receptor (VDR) were downregu

67 inergic neuronal markers, dopamine, tyrosine hydroxylase, and dopamine transporter are deficient in t

68 n prolyl 3-hydroxylase and collagen prolyl 4-hydroxylase, and is essential for normal cell function.

69 enzyme AsCYP72A475 as a triterpene C-21beta hydroxylase, and showed that expression of this enzyme t

70 levels of the dopamine transporter, tyrosine hydroxylase, and the dopamine receptor D1, effects consi

71 hypermethylation of 25-hydroxylase, 1-alpha-hydroxylase, and VDR, and hypomethylation of CYP24A1 was

72 in its alpha-subunit, carried out by prolyl-hydroxylases, and subsequent ubiquitination via the E3 l

73 on utilizing a targeted-toxin (dopamine beta-hydroxylase antibody conjugated to saporin, DBH-Sap), an

74 /alpha-ketoglutarate-dependent aspartyl beta-hydroxylases are identified in siderophore biosynthetic

75 HIF hydroxylases are the family of oxygen-sensing enzymes pr

76 irmed by coimmunolabeling with dopamine beta-hydroxylase, as well as by retrograde bone-brain tracing

77 ependent oxygenase aspartate/asparagine-beta-hydroxylase (AspH) catalyses the hydroxylation of Asp/As

78 Human aspartate/asparagine-beta-hydroxylase (AspH) is a 2-oxoglutarate (2OG)-dependent o

79 ion with brain iron accumulation (fatty acid hydroxylase-associated neurodegeneration, FAHN), heredit

80 al HIs, categorizing them into pan-HIF-alpha hydroxylase (broad spectrum), PHD-selective, and FIH-sel

81 ind no evidence ALKBH7 functions as a prolyl-hydroxylase, but we do find Alkbh7(-/-) mice have elevat

82 haliana supports a role for this coumarate 3-hydroxylase (C3H) in the early steps of lignin biosynthe

83 cripts with high similarity to p-coumarate 3-hydroxylase (C3H), hydroxycinnamoyl-CoA:shikimate/quinat

84 Cinnamate 4-hydroxylase (C4H; CYP73A) is a cytochrome P450 monooxyge

85 ubtilisin inhibitor (IAAS) and Flavonoid 3_5 hydroxylase (C75A1) in Nicotiana benthamiana followed by

86 iosynthetic enzyme PqqB is an iron-dependent hydroxylase catalyzing oxygen-insertion reactions that a

87 Cholesterol 24-hydroxylase (CH24H) is a brain-specific enzyme that conv

88 l to 25-hydroxycholesterol by cholesterol 25-hydroxylase (CH25H) has been shown to have broad antivir

89 Cholesterol 25-hydroxylase (CH25H) is an interferon-stimulated gene tha

90 eron-stimulated genes (ISGs), cholesterol 25-hydroxylase (CH25H), is induced by SARS-CoV-2 infection

91 d expression of IFN-inducible cholesterol 25-hydroxylase (CH25H).

92 PtmO6 represent the first dedicated C7 beta-hydroxylases characterized to date and, together with Pt

93 in mice lacking CMP-N-acetylneuraminic acid hydroxylase (CMAH) enzyme, which synthesizes N-glycolyl

94 nophosphate-N-acetylneuraminic acid (Neu5Ac) hydroxylase (CMAH), which occurred in hominin ancestors

95 y a molecular interface between COQ9 and the hydroxylase COQ7, motivating a model whereby COQ9 presen

96 hydroxylase (CYP2R1) with 3-epi-25(OH)D3; 24-hydroxylase (CYP24A1) with 25(OH)D3, 3-epi-25(OH)D3, and

97 The all-trans-retinoic acid (atRA) hydroxylase Cyp26a1 is essential for embryonic developme

98 ol 7alpha-hydroxylase (Cyp7a1) and sterol 27-hydroxylase (Cyp27a1) double knockout (DKO) mice by cros

99 step in the classical pathway, and sterol 27-hydroxylase (CYP27A1) initiates the hydroxylation of cho

100 lished, that would describe presence of VDR, hydroxylases CYP27B1 and CYP24A1, and RORalpha and RORga

101 ihydroxyvitamin D3 [1,25(OH)2D3]; and 1alpha-hydroxylase [(CYP27B1) with 3-epi-25(OH)D3 and 1,25(OH)2

102 e VD metabolism genes CYP2R1 and CYP27A1 (25-hydroxylase), CYP27B1 (1-alpha-hydroxylase), and vitamin

103 -25(OH)D3]; cubilin (CUBN) with 25(OH)D3; 25-hydroxylase (CYP2R1) with 3-epi-25(OH)D3; 24-hydroxylase

104 that overexpression of human cholesterol 24S-hydroxylase (CYP46A1) increases the levels of both 24(S)

105 ase (NCED) and inactivation of ABA by ABA 8'-hydroxylase (CYP707A) are key regulatory metabolic steps

106 Liver cholesterol 7alpha-hydroxylase (Cyp7a1) activity and sterol 12alpha-hydroxy

107 in vivo model, we created cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 27-hydroxylase (Cyp27a1)

108 e displayed high hepatic cholesterol 7 alpha-hydroxylase (CYP7A1) expression, reduced serum cholester

109 We show that TFEB induces cholesterol 7alpha-hydroxylase (CYP7A1) in human hepatocytes and mouse live

110 Cholesterol 7alpha-hydroxylase (CYP7A1) performs the initial and rate-limit

111 most prominent impact on Cholesterol 7 alpha-hydroxylase (CYP7A1).

112 atic G6P accumulation induces sterol 12alpha-hydroxylase (Cyp8b1) expression, which is mediated by th

113 Dopamine beta-hydroxylase (DBH) activity was associated with rs1611115

114 found to be downregulation of dopamine beta-hydroxylase (DBH) gene expression, encoding the enzyme t

115 NTS neurons immunoreactive to dopamine beta-hydroxylase (DBH).

116 dopamine transporter (DAT) or dopamine beta-hydroxylase (DBH; marker of noradrenergic/adrenergic cel

117 The respective prolyl-hydroxylases (DdPhyA and TgPhyA) catalyze prolyl-hydroxy

118 hat Cmah (cytidine monophosphate-sialic acid hydroxylase)-deficient mdx mice (Cmah-/-;mdx) have an ac

119 elftibactin arises from the stand-alone beta-hydroxylase DelD.

120 (d) Immunostains for tyrosine hydroxylase demonstrate that there is selective colocali

121 xyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH).

122 between the inhibition of HIF-alpha prolyl-4-hydroxylase domain (PHD) enzymes and HIF-alpha asparagin

123 The oxygen-sensing prolyl hydroxylase domain (PHD) enzymes are key to maintaining

124 cer elements in the promoters of the proline hydroxylase domain (PHD) proteins to increase expression

125 Prolyl hydroxylase domain (PHD)-2 protein, a major PHD in ECs,

126 The prolyl hydroxylase domain (PHD)-hypoxia inducible factor (HIF)

127 The HIF prolyl hydroxylase domain enzymes (PHDs) are Fe(II)- and 2-oxog

128 and its regulatory hydroxylases, the prolyl hydroxylase domain enzymes (PHDs).

129 activity of iron-dependent intestinal prolyl hydroxylase domain enzymes.

130 lase (TH) homologous to the 5-methylcytosine hydroxylase domain in TET proteins and a J-DNA-binding d

131 obactin arise from hydroxylation by the beta-hydroxylase domain integrated into NRPS AltH, while l-er

132 We show that loss of the prolyl hydroxylase domain isoform 1 oxygen sensor in mice (PHD1

133 Oxygen sensing is mediated by prolyl hydroxylase domain proteins (PHDs), which use O(2) as a

134 that knockout of EGLN1, which encodes prolyl hydroxylase domain-containing protein 2 (PHD2), reduced

135 Prolyl-4-hydroxylase domain-containing proteins 1-3 (PHD1 to PHD3

136 4-Hydroxyphenylacetate 3-hydroxylase (EcHpaB) from Escherichia coli is capable of

137 erted to the active form (calcitriol) by the hydroxylase enzyme CYP27B1 In multiple sclerosis lesions

138 rted to octopamine by the host tyramine beta-hydroxylase enzyme.

139 Cells rely on prolyl hydroxylase enzymes to sense low levels of oxygen, but t

140 we show the involvement of striatal tyrosine hydroxylase-expressing interneurons in mediating this in

141 identifies a specific population of tyrosine hydroxylase-expressing neurons that is critical to autor

142 go alternative activation to induce tyrosine hydroxylase expression and catecholamine production medi

143 -synuclein content, restores nigral tyrosine hydroxylase expression and striatal neurotransmitter lev

144 y weight than that in seeds following simple hydroxylase expression, the highest yet measured in a no

145 3'-hydroxylase (F3'H), and a flavonoid 3'5'-hydroxylase (F3'5'H).

146 lants carried a mutation in the FLAVONOID-3' HYDROXYLASE (F3'H) gene, nco in CHALCONE ISOMERASE (CHI)

147 xylases, a flavonol synthase, a flavonoid 3'-hydroxylase (F3'H), and a flavonoid 3'5'-hydroxylase (F3

148 Ferulate 5-hydroxylase (F5H) of the monolignol pathway catalyzes th

149 ed S-lignin was downregulation of ferulate 5-hydroxylases (F5Hs).

150 he endoplasmic reticulum enzyme fatty acid 2-hydroxylase (FA2H) plays a major role in the formation o

151 omain (PHD) enzymes and HIF-alpha asparagine hydroxylase factor inhibiting HIF (FIH).

152 -hydroxylases (PHD1/2/3) and the asparaginyl-hydroxylase factor-inhibiting HIF are oxygen-sensing enz

153 During studies with the hydroxylase, factor inhibiting hypoxia-inducible factor

154 n prolyl 3-hydroxylase and collagen prolyl 4-hydroxylase families as potentially important regulators

155 n prolyl 3-hydroxylase and collagen prolyl 4-hydroxylase families in melanoma.

156 We show that the collagen prolyl 3-hydroxylase family exemplified by Leprel1 and Leprel2 is

157 a subset of melanomas, the collagen prolyl 4-hydroxylase family members P4HA1, P4HA2, and P4HA3 are o

158 fibroblast markers type I collagen, prolyl-4-hydroxylase, fibroblast specific protein-1, and fibrobla

159 phore biosynthetic enzyme A (SidA) ornithine hydroxylase from Aspergillus fumigatus is a fungal disea

160 enultimate enzyme in the pathway, hispidin 3-hydroxylase, from the luminescent fungus Mycena chloroph

161 integration of the drive into the kynurenine hydroxylase gene by rescuing its function.

162 fluorescent protein driven from the tyrosine hydroxylase gene, and then used RNA sequencing to confir

163 However, two-component hydroxylases (group D), which use reduced flavin as a co

164 Hyoscyamine 6beta-hydroxylase (H6H) is an alphaKG-dependent nonheme iron o

165 aded under normoxic conditions by HIF-prolyl hydroxylase (HIF-PHD).

166 X-ray analysis of artificial hydroxylases highlights critical details of the second c

167 Human phenylalanine hydroxylase (hPAH) hydroxylates L-phenylalanine (L-Phe)

168 onent monooxygenase 4-hydroxyphenylacetate 3-hydroxylase (HPAH), revealing depression of the pK(a) of

169 Dysfunction of human phenylalanine hydroxylase (hPAH, EC 1.14.16.1) is the primary cause of

170 Dopamine- and tyrosine hydroxylase-immunopositive cells (TH cells) modulate vis

171 icant increases in the diameters of tyrosine hydroxylase immunoreactive soma in cave Astyanax in the

172 inence, as well as the reduction in tyrosine hydroxylase immunostaining and postsynaptic density-95-p

173 Although expressing a castor OLEATE 12-HYDROXYLASE in Arabidopsis thaliana leads to the synthes

174 , expression of the D2 receptor and tyrosine hydroxylase in brain tissue, while markers of neurodegen

175 gnificantly increased the levels of tyrosine hydroxylase in the brain of the Nile Grass rat (NGR), a

176 identify C3H as the only non-membrane bound hydroxylase in the lignin pathway and revise the current

177 tent with the presence of both types of beta-hydroxylases in the biosynthetic gene cluster.

178 - over PHD-selective HIs likely reflects HIF hydroxylase independent off-target effects.

179 These data demonstrate that hydroxylase inhibition attenuates the recruitment of neu

180 In studies into the effect of pharmacologic hydroxylase inhibition on TLR-induced inflammation in mo

181 Finally, hydroxylase inhibition reduced cytokine-induced chemokin

182 X), proteasome inhibitor (MG132), or proline hydroxylase inhibitor (DHB) were applied to explore the

183 ermine whether antenatal or postnatal prolyl-hydroxylase inhibitor (PHi) therapy increases lung HIF e

184 itor (pevonedistat [MLN-4924]), and a prolyl hydroxylase inhibitor (roxadustat [FG-4592]).

185 vious studies have demonstrated that the pan-hydroxylase inhibitor dimethyloxalylglycine (DMOG) is ef

186 section=ALPPS) or the addition of the prolyl-hydroxylase inhibitor dimethyloxalylglycine (DMOG) to PV

187 effects of treatment with the pharmacologic hydroxylase inhibitor DMOG, which mimics hypoxia, on dis

188 Pharmacologic HIF hydroxylase inhibitors (HIs) are effective for the treat

189 Prolyl hydroxylase inhibitors (PHI) promote stabilization of hy

190 or topical application of the pharmacologic hydroxylase inhibitors dymethyloxalylglycine (DMOG) or J

191 on with multiple selective collagen prolyl 4-hydroxylase inhibitors reduces proliferation and inhibit

192 reens of the hypoxia-inducible factor prolyl-hydroxylase inhibitors revealed that vadadustat inhibits

193 Accordingly, HIF prolyl hydroxylase inhibitors stabilize HIF and stimulate expre

194 ovel therapies such as ascorbic acid, prolyl hydroxylase inhibitors, activin traps, hepcidin, and bon

195 ute to the anti-inflammatory activity of HIF-hydroxylase inhibitors.

196 at selective inhibition of collagen prolyl 4-hydroxylase is an attractive strategy to reduce the inva

197 chrome P450 46A1 (CYP46A1) or cholesterol-24-hydroxylase is responsible for cholesterol metabolism an

198 These data suggest a mechanism by which the hydroxylase is tuned for converting hispidin into the fu

199 One of the candidate genes, Abscisic acid 8'-hydroxylase, is verified to play a negative role in plan

200 ic pathways in wild-type and cholesterol 24S-hydroxylase knockout mouse brain.

201 nd 2-oxoglutarate dependent enzymes, l-Ile 4-hydroxylase, l-Leu 5-hydroxylase and polyoxin dihydroxyl

202 ynuclein neuropathological load and tyrosine hydroxylase levels in the nucleus accumbens, dorsal puta

203 dioxygenase 2 (PLOD2) encodes the only lysyl hydroxylase (LH) isoform that specifically hydroxylates

204 n); and chromaffin (chromogranin A, tyrosine hydroxylase) markers similar to those of the populations

205 Thus, pharmacologic inhibition of HIF hydroxylases may be an effective new therapeutic approac

206 Similar to other class A flavoprotein hydroxylases, McH3H did not form a stable hydroperoxyfla

207 to the phylogenetic tree of siderophore beta-hydroxylases, methods to predict beta-OHAsp stereochemis

208 lipoxygenase and 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial.

209 oxylase (Cyp7a1) activity and sterol 12alpha-hydroxylase mRNA levels were induced, while ileum FXR ta

210 Geraniol-10 hydroxylase (NnCYP76B6) an important enzyme in CPT biosy

211 or substrate-binding (W116C) site of 11beta-hydroxylase, or alterations in its stability (L299P and

212 lation (CPH), which is catalyzed by prolyl 4-hydroxylase (P4H), is the most prevalent posttranslation

213 c reticulum-localized transmembrane prolyl 4-hydroxylase (P4H-TM)-is found in animals.

214 Prolyl 4-hydroxylases (P4Hs) catalyze post-translational hydroxyl

215 KU), caused by variants in the phenylalanine hydroxylase (PAH) gene, is the most common autosomal-rec

216 Phenylalanine hydroxylase (PAH) is a key enzyme in the catabolism of p

217 oth Snca-/-, and SNCA-A30P mice but tyrosine hydroxylase+ periglomerular OB neurons were only decreas

218 enic potential of MDSPCs derived from prolyl hydroxylase (Phd) 3-knockout (Phd3(-/-)) mice, which dis

219 in HIF-1alpha protein by activating proline hydroxylase (PHD) and the ubiquitin proteasome system (U

220 The discovery of the HIF prolyl-hydroxylase (PHD) enzymes as oxygen sensors raises a key

221 cts of cellular hypoxia are sensed by prolyl hydroxylase (PHD) enzymes which regulate HIFs.

222 evention of HIF-1alpha degradation by prolyl hydroxylase (PHD) under normoxic conditions is emerging

223 ioxygenase family, including the HIF proline hydroxylase (PHD, alias EGLN), and an E3 ubiquitin ligas

224 f five hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) inhibitors on PC12 cells and primary

225 The prolyl-hydroxylases (PHD1/2/3) and the asparaginyl-hydroxylase

226 t on expression of the oxygen-sensing prolyl hydroxylase PHD2.

227 novel binding partner of the main HIF-prolyl hydroxylase, PHD2, but not of PHD1 or PHD3.

228 nse to chronic hypoxia is mediated by prolyl hydroxylases (PHDs) that regulate the levels of hypoxia-

229 occurring R68S substitution of phenylalanine hydroxylase (PheH) causes phenylketonuria (PKU).

230 is hydroxylated by an O2-dependent prolyl-4-hydroxylase (PhyA), and the resulting hydroxyproline can

231 es of histone deacetylases (HDACs), and Tet2 hydroxylase play a critical role in keeping cancer cells

232 s of neuromelanin-containing versus tyrosine hydroxylase positive nigral cells.

233 ells give rise to new dopaminergic [tyrosine hydroxylase-positive (TH(+))] neurons.

234 uces serotonin immunoreactivity and tyrosine hydroxylase-positive cell populations in specific larval

235 d brain serotonin immunoreactivity, tyrosine hydroxylase-positive cell populations, and rescued venla

236 In the putamen, dense staining of tyrosine hydroxylase-positive fibres was observed in areas that c

237 he putative oxygen sensor Pseudomonas prolyl hydroxylase (PPHD) in the control of virulence and antib

238 aided by a peptide chaperone (PqqD), a dual hydroxylase (PqqB), and an eight-electron, eight-proton

239 of the noradrenergic-specific dopamine beta-hydroxylase promoter (DBH-hSNCA).

240 ion of DANs (~35%) in the SNpc, the tyrosine hydroxylase protein level in the striatum (~60%), the DA

241 and 2OG, supported its assignment as a lysyl hydroxylase rather than an N-methyl arginyl-demethylase.

242 ssion of Ricinus communis (castor) OLEATE 12-HYDROXYLASE (RcFAH12) in Arabidopsis has resulted in onl

243 ctor HIF-alpha and its oxygen-sensing prolyl hydroxylase repressor, EGLN Despite this loss, phenotypi

244 ptors (VDR), the activating and inactivating hydroxylases, respectively, CYP27B1 and CYP24A1, and the

245 chrome P450 (CYP) 2R1, the main vitamin D 25-hydroxylase responsible for the first bioactivation step

246 o acid hydroxylase, 2-oxoglutarate-dependent hydroxylase, Rieske dioxygenase, and thiol dioxygenase.

247 Anti-dopamine beta-hydroxylase-saporin toxin (DbetaH-SAP) was used to selec

248 ize that pharmacologic inhibition of the HIF-hydroxylases selectively targets monocytes for cell deat

249 We found differences in tyrosine hydroxylase staining in regions that are associated with

250 fy adenylosuccinate lyase (ADSL) as an EglN2 hydroxylase substrate in triple negative breast cancer (

251 ation reaction hinders the identification of hydroxylase substrates.

252 ein conditional genetic ablation of prolyl 4-hydroxylase subunit beta (P4HB), the gene that encodes P

253 duct (pan-neuronal marker; PGP9.5), tyrosine hydroxylase (sympathetic neuron marker; TH), calcitonin

254 genes of this pathway, namely taxane 13alpha-hydroxylase (T13alphaH) and 10-deacetylbaccatin III-10-b

255 tion of the 2OG-dependent oxygenase, taurine hydroxylase (TauD), revealed a strong link between the r

256 further show that the level of tyramine-beta-hydroxylase (TBH), the enzyme that converts tyramine int

257 ngle hydroxylation step catalyzed by jasmone hydroxylase (TcJMH).

258 and Ten-eleven translocation methylcytosine hydroxylases (Tet2) in nephron progenitor cells (Six2 (C

259 microdialysis, quantified levels of tyrosine hydroxylase (TH) and dopamine transporter (DAT) mRNA usi

260 Tyrosine hydroxylase (TH) catalyzes the hydroxylation of L-tyrosi

261 imately 20% and 38% of oxytocin and tyrosine hydroxylase (TH) cells, respectively, were responsive to

262 Dpp stems from modulation of brain tyrosine hydroxylase (TH) expression and dopamine biosynthesis.

263 cute PD animal models by recovering tyrosine hydroxylase (TH) from the TH-negative dormant dopaminerg

264 at this enhancer targets the nearby tyrosine hydroxylase (TH) gene responsible for dopamine synthesis

265 wo known functional domains: an N-terminal T hydroxylase (TH) homologous to the 5-methylcytosine hydr

266 combined in situ hybridization with tyrosine hydroxylase (TH) immunochemistry for better characteriza

267 xpress the catecholaminergic marker tyrosine hydroxylase (TH) in developing murine and human submandi

268 osphoprotein of 32 kDa (DARPP32) or tyrosine hydroxylase (TH) in tissue sections of adult mouse stria

269 unofluorescence experiments against tyrosine hydroxylase (TH) or dopamine transporter (DAT).

270 ng with immunocytochemistry against tyrosine hydroxylase (TH) or glutamate decarboxylase (GAD) to sys

271 ted transcriptional activity at the tyrosine hydroxylase (TH) promoter, which is mediated by the inte

272 loss of SDHC in cells that express tyrosine hydroxylase (TH), a compartment where PPGL is known to o

273 late VTA glutamate neurons in which tyrosine hydroxylase (TH), and thus DA biosynthesis, was conditio

274 evaluated whether the expression of tyrosine hydroxylase (TH), the rate limiting enzyme in dopamine c

275 ed with an antiserum raised against tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholam

276 ecided to study the distribution of tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthe

277 Intriguingly, fibers expressing tyrosine hydroxylase (TH), the rate-limiting enzyme of dopamine s

278 drenergic phenotype, which includes tyrosine hydroxylase (TH), vesicular monoamine transporter 2, and

279 c reward system, it was absent from tyrosine hydroxylase (TH)-expressing cells, but tac3a cells were

280 Although tyrosine hydroxylase (TH)-immunoreactive neurons in NPPa are hypo

281 sis of PD and demonstrated >300,000 tyrosine hydroxylase (TH)-positive grafted cells per side with no

282 nd dopaminergic function, including tyrosine hydroxylase (TH).

283 of the dopamine-synthesizing enzyme tyrosine hydroxylase (TH).

284 neurons marked by the expression of tyrosine hydroxylase (TH).

285 ne function [striatal expression of tyrosine hydroxylase (Th)], glucocorticoid receptor (GR) and plas

286 cus, by means of antibodies against tyrosine hydroxylase (TH; the first enzyme in the synthesis of ca

287 iods alters the number of dopamine (tyrosine hydroxylase, TH+) and somatostatin (SST+) neurons in the

288 onian phenotypes, including loss of tyrosine hydroxylase (Th1)-positive dopaminergic (DA) neurons, re

289 n ubiquitin ligases, is modified by a prolyl hydroxylase that mediates O(2) regulation of the social

290 Because the prolyl hydroxylases that regulate HIF stability are oxygen- and

291 rotonation of substrate, in single-component hydroxylases that use flavin as a cofactor (group A).

292 suppressing expression of cholesterol 7alpha-hydroxylase, the rate-limiting enzyme for the classical

293 hypoxia-inducible factor) and its regulatory hydroxylases, the prolyl hydroxylase domain enzymes (PHD

294 heme-dependent dehaloperoxidase and tyrosine hydroxylase, thiolate-ligated heme-dependent cytochrome

295 Tryptophan hydroxylase (TPH1) and monoamine oxidase (MAO-A) are the

296 attributed to an up-regulation of fatty acid hydroxylase transcription.

297 ng from wild-type rats, knockout of tyrosine hydroxylase was achieved with adeno-associated viral (AA

298 Colocalization of NOS and tyrosine hydroxylase was observed in numerous cells of the ventra

299 The expression of CYP24A1 (24-hydroxylase) was significantly increased, which cataboli

300 Thus, in both types of hydroxylases, we confirmed that binding favors the pheno