ライフサイエンスコーパス: hydroxymethyluracil

1 lycol, uracil glycol, 5-hydroxyuracil, and 5-hydroxymethyluracil.

2 f the otherwise very rare DNA modification 5-hydroxymethyluracil (5-hmU), and many others.

3 e modifications, 5-formyluracil (5-fU) and 5-hydroxymethyluracil (5-hmU), found naturally in DNA.

4 5-Hydroxymethyluracil (5hmU) is a thymine base modificatio

5 uding uracil (U), 5-fluorouracil (5FU) and 5-hydroxymethyluracil (5hmU) on DNA-protein interactions a

6 es the mismatched base, uracil, thymine or 5-hydroxymethyluracil (5hmU), as well as removes 5-formylc

7 anine (G:X), where X is uracil, thymine or 5-hydroxymethyluracil (5hmU).

8 mismatches, where X is uracil, thymine or 5-hydroxymethyluracil (5hmU).

9 glycosylase activity (HMUDG) that released 5-hydroxymethyluracil (5hmUra) from the DNA of Bacillus su

10 We found that 5-hydroxymethyluracil accumulated in Smug1 (-/-) tissues a

11 Beta-D-Glucosyl-hydroxymethyluracil, also called base J, is an unusually

12 olecular dynamics simulations suggest that 5-hydroxymethyluracil alters the flexibility and hydrophil

13 s and maintenance of base J (beta-d-glucosyl-hydroxymethyluracil), an epigenetic modification of thym

14 f SMUG1 deficiency, we measured uracil and 5-hydroxymethyluracil, another SMUG1 substrate, in Smug1 (

15 oth - 5fC and a thymine base modification, 5-hydroxymethyluracil, are comparable in these systems.

16 hymine modification, 5-(beta-glucopyranosyl) hydroxymethyluracil (base J), plays a key role during tr

17 vely, followed by TDG-mediated thymine and 5-hydroxymethyluracil excision repair.

18 d with 4 nt loops or with substitutions of 5-hydroxymethyluracil for thymine.

19 The efficiency of formation of 5-hydroxymethyluracil from thymine is observed to be simil

20 ne in DNA can generate a base pair between 5-hydroxymethyluracil (HmU) and adenine, whereas the oxida

21 d by tandem mismatches and by substituting 5-hydroxymethyluracil (hmU) for thymine (T).

22 inds with nM affinity to DNA that contains 5-hydroxymethyluracil (hmU) in place of thymine and to T-c

23 nity for 37 bp preferred sites in DNA with 5-hydroxymethyluracil (hmU) in place of thymine.

24 the thymine methyl group in DNA generates 5-hydroxymethyluracil (HmU) whereas the misincorporation o

25 nic mispairs of uracil (U), thymine (T) or 5-hydroxymethyluracil (hmU) with guanine (G) are substrate

26 ing to DNA in which thymine is replaced by 5-hydroxymethyluracil (hmU), as it is in the phage genome.

27 also excises the oxidation-damage product 5-hydroxymethyluracil (HmU), but like UNG is inactive agai

28 ximately 3 nM) to preferred sites within the hydroxymethyluracil (hmU)-containing phage genome, ident

29 and other lesions including uracil (U) and 5-hydroxymethyluracil (hmU).

30 enzymes that hydroxylate thymine, forming 5-hydroxymethyluracil (hmU).

31 thylcytosine (5hmC) as well as thymine and 5-hydroxymethyluracil (i.e., the deamination products of 5

32 Oxidation of a DNA thymine to 5-hydroxymethyluracil is one of several recently discovere

33 Base J, beta-d-glucosyl-hydroxymethyluracil, is an epigenetic modification of th

34 ich contained about 26-fold higher genomic 5-hydroxymethyluracil levels than the wild type.

35 5-Hydroxymethyluracil may be formed in deamination reactio

36 removes uracil and modified uracils (e.g., 5-hydroxymethyluracil) mispaired with guanine.

37 ucosylated thymine DNA base (beta-d-glucosyl-hydroxymethyluracil or base J) is present within sequenc

38 of the modified thymine base beta-D-glucosyl-hydroxymethyluracil, or J, within telomeric DNA of Trypa

39 Base J (beta-D-glucosyl-hydroxymethyluracil) replaces 1% of T in the Leishmania

40 are first deaminated by AID to thymine and 5-hydroxymethyluracil, respectively, followed by TDG-media

41 Base J (beta-D-glucosyl-hydroxymethyluracil) was discovered in the nuclear DNA o