ライフサイエンスコーパス: hydroxytryptophan

1 d by biogenic amine precursors (L-DOPA and 5-hydroxytryptophan).

2 precursor levodopa and serotonin precursor 5-hydroxytryptophan.

3 produce 5-HT from its immediate precursor, 5-hydroxytryptophan.

4 up and metabolize the serotonin precursor 5-hydroxytryptophan.

5 h further improvement with the addition of 5-hydroxytryptophan.

6 n-dependent hydroxylation of tryptophan to 5-hydroxytryptophan.

7 it IV), almost certainly due to formation of hydroxytryptophan.

8 f molecular oxygen into tryptophan to form 5-hydroxytryptophan.

9 ths after T1D diagnosis (n = 16), by (11)C-5-hydroxytryptophan ((11)C-5-HTP) positron emission tomogr

10 on emission tomography (PET) marker [(11)C]5-hydroxytryptophan ([(11)C]5-HTP) for this purpose.

11 n fVAS was similar in placebo- (37.6%) and 5-hydroxytryptophan (35.6%)-treated patients (P = .830).

12 adjunct treatment with the 5-HT precursor 5-hydroxytryptophan (5-HTP) elevates 5-HTExt beyond the SS

13 5-hydroxytryptophan (5-HTP) has shown therapeutic promise

14 ) determination ex vivo of accumulation of 5-hydroxytryptophan (5-HTP) in tissue from the dorsal and

15 Accumulation of 5-hydroxytryptophan (5-HTP) in vivo, in the presence of th

16 ed, treatment with the serotonin precursor 5-hydroxytryptophan (5-HTP) increased the intensity of ser

17 ons of serotonin with the direct precursor 5-hydroxytryptophan (5-HTP) would modulate the ability of

18 bution of the immediate precursor of 5-HT, 5-hydroxytryptophan (5-HTP), in two model opisthobranch mo

19 ed during lactation and after injection of 5-hydroxytryptophan (5-HTP).

20 ented with saline (CON, 8 mL/day n = 4) or 5-hydroxytryptophan (5-HTP, 90 mg/day, n = 4) for 10 conse

21 Following oxidation of 5-hydroxytryptophan (5-HTPP) at a pyrolytic graphite elect

22 pair to insert the noncanonical amino acid 5-hydroxytryptophan (5-OHTrp) at position 72 in recombinan

23 Central serotonin (5-hydroxytryptophan, 5-HT) modulates somatosensory transdu

24 mically promoted coupling reaction between 5-hydroxytryptophan (5HTP) and simple aromatic amines-elec

25 azo-coupling reaction (CRACR) directed to 5-hydroxytryptophan (5HTP) is compatible with strain-promo

26 e by itself, was then combined either with 5-hydroxytryptophan (5HTP), a serotonin precursor, or with

27 The concentrations of 5HT and 5-hydroxytryptophan (5HTP, an index of 5HT synthesis) were

28 urther show that 7-azatryptophan (7AW) and 5-hydroxytryptophan (5HW) can also serve as a FRET accepto

29 yptophan analogues, 7-azatryptophan (7AW), 5-hydroxytryptophan (5HW), and 4-, 5-, and 6-fluorotryptop

30 The set of tryptophan analogues includes 5-hydroxytryptophan, 7-azatryptophan, 4-fluorotryptophan,

31 The tryptophan analogues, 5-hydroxytryptophan, 7-azatryptophan, 4-fluorotryptophan,

32 After intravenous injection of (11)C-hydroxytryptophan, a 60-min dynamic PET scan was acquire

33 (11)C-hydroxytryptophan accumulated rapidly in both endocrine

34 ll line (CM) were applied for in vitro (11)C-hydroxytryptophan accumulation/efflux experiments and bl

35 Tyrosine and the serotonin-precursor 5-hydroxytryptophan also activate AHR signaling in combina

36 ) antagonist, N-acetyl-5-hydroxytryptophyl-5-hydroxytryptophan amide, and by 1.0 microM tropisetron,

37 5-Hydroxytryptophan and 7-azatryptophan have red-shifted a

38 73; P = .660) were both comparable between 5-hydroxytryptophan and placebo treatment as well as chang

39 Despite a significant increase in serum 5-hydroxytryptophan and serotonin levels, oral 5-hydroxytr

40 s of 5-HT, its precursors L-tryptophan and 5-hydroxytryptophan and the metabolite 5-hydroxyindole ace

41 et-a-308 (phenylalanine), met-a-584 (X-12100 hydroxytryptophan), and met-a-337 (5-hydroxyproline), wh

42 xyindoles serotonin (5-hydroxytryptamine), 5-hydroxytryptophan, and 5-hydroxyindole acetic acid are r

43 In conclusion, phenylalanine, X-12,100 hydroxytryptophan, and 5-hydroxyproline have a causal re

44 ed for the synthesis of physostigmine from 5-hydroxytryptophan, as shown by in vitro total reconstitu

45 ctively monitors the fluorescence yield of 5-hydroxytryptophan by exciting the reaction mix at 300 nm

46 hesis and similarly serves as a cofactor for hydroxytryptophan decarboxylase, the enzyme that is part

47 , such as l-(11)C-methionine and l-1-(11)C-5-hydroxytryptophan, demonstrated promising results, inclu

48 tracer for beta-cell mass, based on an (11)C-hydroxytryptophan derivative with increased resistance t

49 droxytryptophan and serotonin levels, oral 5-hydroxytryptophan did not modulate IBD-related fatigue b

50 The unfolding data show that 5-hydroxytryptophan does not perturb the stability of wild

51 -Raman spectroscopy proves the presence of 5-hydroxytryptophan, epidermal TPH activity is completely

52 treatment, a significant increase in serum 5-hydroxytryptophan (estimated mean difference, 52.66 ng/m

53 Chemical-quench analyses show that 5-hydroxytryptophan forms with a rate constant of 1.3 s(-1

54 ically encoded the noncanonical amino acid 5-hydroxytryptophan in both E. coli and eukaryotes, enabli

55 sm and the retention of the PET tracer (11)C-hydroxytryptophan in endocrine and exocrine pancreas in

56 oxyphenylalanine, N'-formylkynurenine, and 5-hydroxytryptophan in the nmol/mol-mmol/mol amino acid ra

57 ET images showed clear accumulation of (11)C-hydroxytryptophan in the pancreas in both animal groups,

58 demonstrate that both the formation of the 6-hydroxytryptophan intermediate (+16 Da) and subsequent o

59 spectral characteristics of tryptophan and 5-hydroxytryptophan is presented.

60 (11)C-hydroxytryptophan is trapped in beta-cells but not in ex

61 an initial increase in the 5-HT precursor 5-hydroxytryptophan it too decreased with increasing ammon

62 f the purified fusion enzyme is 80 nmol of 5-hydroxytryptophan/min/mg.

63 the occurrence of four indolic compounds (5-hydroxytryptophan, N-acetylserotonin, 3-indoleacetic aci

64 rescence lifetimes of "free" Trp derivatives hydroxytryptophan (OH-Trp), N-formylkynurenine (NFK), ky

65 urenine (Kyn), N-formylkynurenine (NFK), and hydroxytryptophan (OH-Trp).

66 ted in a crossover manner with 100 mg oral 5-hydroxytryptophan or placebo twice daily for 2 consecuti

67 Cbln2 KO mice with the serotonin precursor 5-hydroxytryptophan or the serotonin reuptake-inhibitor fl

68 eagents onto a site-specifically installed 5-hydroxytryptophan residue (5HTP) on full-length proteins

69 of the N-(1,1-dimethyl-2,3-epoxypropyl)-beta-hydroxytryptophan residue of cyclomarin A was further il

70 The 5-hydroxytryptophan residue was shown to allow rapid, chem

71 anine and tryptophan, forming tyrosine and 5-hydroxytryptophan, respectively.

72 xindolylalanine, hydroxypyrroloindole, and 5-hydroxytryptophan result in characteristic chemical shif

73 Supplementing milk replacer with 5-hydroxytryptophan (serotonin precursor) or fluoxetine (r

74 s and fatigue, we determined the effect of 5-hydroxytryptophan supplementation on fatigue in patients

75 recursor of dopamine), and tryptophan into 5-hydroxytryptophan (the precursor of serotonin), respecti

76 During 5-hydroxytryptophan treatment, a significant increase in s

77 agments were isolated and characterized as 6-hydroxytryptophan using matrix-assisted laser desorption

78 A general approach to anti-beta-hydroxytryptophans via the corresponding alpha-amino-bet

79 lated tryptophan (W(1)) and C(2)-hexosylated hydroxytryptophan (W(2)), the latter of which is redox a

80 ndole acetic acid, but not L-tryptophan or 5-hydroxytryptophan, were reduced in the medulla by 45 and

81 iguously distinguish oxindolylalanine from 5-hydroxytryptophan, which are undistinguishable by MS due

82 rbance spectrum of W(2) is consistent with 7-hydroxytryptophan, which represents an intriguing new th