ライフサイエンスコーパス: hypermethylated

1 G islands are intragenic and gene bodies are hypermethylated.

2 redistribution of Pol V to sites that become hypermethylated.

3 ands surrounding the PGC7-binding motifs are hypermethylated.

4 lated, and 216 (out of 936 downregulated) as hypermethylated.

5 dinucleotides in the Cosmc core promoter are hypermethylated.

6 re hypomethylated, while EMX2 and HOXB1 were hypermethylated.

7 centromeres can be either hypomethylated or hypermethylated.

8 quence carried by the transgene was markedly hypermethylated.

9 CpG site within the calbindin1 promoter was hypermethylated.

10 CpG islands of the down-regulated genes are hypermethylated.

11 d and 98 (out of 430 genes downregulated) as hypermethylated.

12 being hypomethylated and male hybrids being hypermethylated.

13 sites at the upstream region of miR-184 were hypermethylated.

14 nscript, mature kinetoplastid mRNA acquire a hypermethylated 5'-cap structure, but its function has b

15 Loci that are hypermethylated across cancer types are enriched for sit

16 the atherosclerotic portion of the aorta was hypermethylated across many genomic loci in comparison w

17 ptome analysis as well as significantly hypo/hypermethylated after acute RE, chronic RE, detraining a

18 buted DMRs are largely intergenic and become hypermethylated after the blastocyst stage.

19 The hypermethylated allele accounts for 50% of disease allel

20 tion level, with 684 CpG sites significantly hypermethylated and 1,640 hypomethylated in tumor, compa

21 ons (DMRs) identified in ACF, 537 (66%) were hypermethylated and 274 (34%) were hypomethylated.

22 e discovered that 440 DMRs of 648 genes were hypermethylated and 274 DMRs of 336 genes were hypomethy

23 ndividuals aged 2 to 92 yr identified 18,735 hypermethylated and 45,407 hypomethylated CpG sites asso

24 pleters relative to comparison subjects (273 hypermethylated and 93 hypomethylated).

25 es, identifying only LGALS4 as significantly hypermethylated and down-regulated in smokers.

26 ative damage under high light conditions, is hypermethylated and downregulated in CMD1 mutant cells c

27 , we identify ISL1 as a direct DNMT1 target, hypermethylated and downregulated in mammary tumours and

28 yte survival, such as BCL2L2 and NDRG1, were hypermethylated and expressed at lower levels in multipl

29 w that, although the E-cadherin gene becomes hypermethylated and heterochromatic, kinase inhibitors c

30 cells, with HOXD8, HOXC9, HOXB1 and HOXC-AS3 hypermethylated and HOXC10 and HOXC-AS2 hypomethylated.

31 many differentially-methylated regions, both hypermethylated and hypomethylated, across the entire ge

32 of miR-342 within an intron of the EVL gene, hypermethylated and involved in tumorigenesis, suggested

33 protein coupled receptor 39 (GPR39) gene was hypermethylated and its expression downregulated in heav

34 More specifically, miR-199B is extensively hypermethylated and its mature transcript miR-199b-5p wa

35 t to placental trophoblast, however, ELF5 is hypermethylated and largely repressed in human ES cells

36 ogenic variants in early-stage TNBC and that hypermethylated and mutated cases have similarly improve

37 Gene loci that are hypermethylated and repressed in embryonic (ESCs) but hy

38 In normal GECs, P1 was hypermethylated and repressed, whereas in immune lineage

39 omain-containing protein 6) as an aberrantly hypermethylated and significantly downregulated gene in

40 ometrial stroma) is one of the most commonly hypermethylated and silenced genes in endometrial cancer

41 is a putative tumor suppressor gene that is hypermethylated and silenced in T or NK LGL leukemia.

42 its corresponding endogenous RD29A gene are hypermethylated and silenced in the Arabidopsis DNA deme

43 COL2A is hypermethylated and silenced, while COL2D is repressed i

44 issues that have recovered from infection is hypermethylated and that host recovery requires AGO4, a

45 contrast, in dml3 the promoters of SAGs were hypermethylated and their transcript levels were remarka

46 genes, including tumor suppressor genes, are hypermethylated and transcriptionally repressed, a pheno

47 n B cell lymphoma (B-NHL), in which TET1 was hypermethylated and transcriptionally silenced.

48 e WNT pathway antagonist FRZB was aberrantly hypermethylated and underexpressed in MDS stroma.

49 YA4 is frequently and concomitantly deleted, hypermethylated and underexpressed in multiple independe

50 he methyltransferase, DNMT3A, was aberrantly hypermethylated and underexpressed, but not mutated in m

51 athways, including 1-carbon metabolism, were hypermethylated and underexpressed.

52 ing, because the pericentromeric regions are hypermethylated and were expected to be the regions most

53 l key players of the ferroptosis pathway are hypermethylated and/or mutated in human ACCs.

54 ic expression of the noncoding RNA MHM (male hypermethylated) and acetylation of histone 4 lysine 16

55 , isolated from murine dorsal root ganglion (hypermethylated) and striated cells (hypomethylated), wa

56 The CpG islands surrounding miR-433 were hypermethylated, and the DNA methylation agent 5'-aza-2'

57 RNA (snoRNA), and telomerase RNA, is further hypermethylated at the exocyclic N2 of the guanosine to

58 igenetic gene regulation, which binds to the hypermethylated BAI1 gene promoter.

59 colocalization of hypomethylated R-DMRs with hypermethylated C-DMRs and bivalent chromatin marks, and

60 Many DNA-hypermethylated cancer genes are occupied by the Polycom

61 Hypermethylated cancer populations are hard to treat due

62 ut of 37) and 2 (out of 4) downregulated and hypermethylated 'cancer' genes following acute and chron

63 level, while the expression is suppressed in hypermethylated carcinoma cell lines (R=-0.73).

64 Significant enrichment of hypermethylated cDMRs in CGI shores (P < 10(-60)), non-C

65 in chromosomal regions encompassing compact, hypermethylated centromeric and pericentromeric DNA.

66 uences of epivariations, and identifies many hypermethylated CGG repeat expansions.

67 Hypermethylated CGI events in the model were predicted b

68 i-2/NuRD is important for the maintenance of hypermethylated chromatin in B cells.

69 s lacking the CCR5-Delta32 mutation but with hypermethylated cis-regions have CCR5 levels similar to

70 , CD49d expression was recovered in CD49d(-) hypermethylated CLL cells upon in vitro treatment with t

71 hylation-related genes that could rescue the hypermethylated Cnr mutant.

72 Hypermethylated common probes affect predominantly gene

73 Lastly, genomic DNA from most CRPC was hypermethylated compared with benign prostate tissue.

74 duplicate gene pairs, one partner is always hypermethylated compared with the other.

75 Aged muscle tissue was hypermethylated compared with young tissue, enriched for

76 interrogated, we observed disproportionately hypermethylated costimulatory genes and hypomethylation

77 beta1 could promote expression of COX-2 in a hypermethylated COX-2 vector, and observed TGF-beta1-ind

78 ed epigenetic modification recapitulated the hypermethylated CpG island methylator phenotype (CIMP) o

79 d metabolic pathway expression patterns, the hypermethylated CpG island methylator phenotype-associat

80 Several of these hypermethylated CpG islands are associated with genes in

81 Most genes with hypermethylated CpG islands at promoters are suppressed

82 Genes with hypermethylated CpG islands in malignant meningiomas (su

83 elopmental expression patterns of genes with hypermethylated CpG islands in primary human lung carcin

84 erentially methylated regions (DMRs) such as hypermethylated CpG islands, which may account for epige

85 The hypermethylated CpG loci included promoter, 5'-UTRs, ups

86 s prior to chemo/radiotherapy identified one hypermethylated CpG site (CpG6882469) in the VAV1 gene b

87 % showed marked enrichment and selection for hypermethylated CpG sites within the proximal region of

88 We identified 1541 hypermethylated CpGs, representing 1745 genes (2.0-fold

89 FP locus stably integrated and silenced by a hypermethylated cytomegalovirus (CMV) promoter.

90 YB5 contains a hypermethylated cytomegalovirus promoter driving green f

91 Hypermethylated DMCs were enriched at transcription star

92 example of a newly discovered agglomerate of hypermethylated DMRs associated with gene silencing in b

93 Hypermethylated DMRs were more likely to overlap with Cp

94 strated that 37%-63% of cases had detectable hypermethylated DNA (>/= 5% methylation) for these five

95 y, the sequence characteristics of hypo- and hypermethylated domains in cerebellum were distinct.

96 y, increased forces were required to convert hypermethylated dsDNA into an extended S-form configurat

97 igidity and intrinsic stiffness decreased in hypermethylated dsDNA, pointing at structural compaction

98 The transition from primed hypermethylated embryonic stem cells (ESCs) to naive hyp

99 Upregulation of hypermethylated endogenous retrovirus (ERV) genes accomp

100 Hypermethylated enhancer regions overlapped with binding

101 A signature based on the number of hypermethylated events distinguished patients with high-

102 ated maternal sequences are digested leaving hypermethylated fetal sequences detectable.

103 e determined that the IRF8 gene promoter was hypermethylated frequently in human STS.

104 lanilide hydroxamic acid in induction of the hypermethylated genes and anti-MCL cytotoxicity.

105 We discover pancancer hypo- and hypermethylated genes and identify novel methylation-dri

106 e-wide analysis, we demonstrate that ~75% of hypermethylated genes are marked by PcG in the context o

107 hypermethylated in reprogramming cells, and hypermethylated genes associated with pluripotency fail

108 ng; however, expression of only 245 of these hypermethylated genes becomes downregulated in A2780/cp7

109 tatistical criteria, we further identified 4 hypermethylated genes CDKN2B, MLF-1, PCDH8, and HOXD8 an

110 Hypermethylated genes exhibited enrichment of repressive

111 the biological function of the collective of hypermethylated genes has not been conducted so far.

112 loit this vast dataset to identify hypo- and hypermethylated genes in cancer.

113 tor, decitabine, restored expression of some hypermethylated genes in EBV-infected and EBV-negative t

114 One of the hypermethylated genes in GBM, ULK2, an upstream autophag

115 ociated microbiota induced higher numbers of hypermethylated genes in murine colonic mucosa (vs.

116 Elevated DNMT3A is also demonstrated at hypermethylated genes in Wilms' tumour cells, including

117 y expressed genes, in which 20.7% distinctly hypermethylated genes showed down-regulated expression i

118 and mRNA expression data, we identified 164 hypermethylated genes showing concurrent down-regulation

119 SCLC cell lines had a greater number of hypermethylated genes than primary tumors.

120 ls exist that can formally identify hypo and hypermethylated genes that are predictive of transcripti

121 A subset of 7 differentially hypermethylated genes was assayed by quantitative revers

122 Hypomethylated and hypermethylated genes were associated with increased and

123 a pharmacologic unmasking approach to detect hypermethylated genes whose inactivation contributes to

124 identified many lymphoma-specific candidate hypermethylated genes, including Stk39.

125 gulated RAS/MAPK signaling with silencing of hypermethylated genes, which normally inhibit these path

126 ls of hydroxymethylation and distinct set of hypermethylated genes.

127 embryonic stem cells were enriched among the hypermethylated genes.

128 eplication, transcription, and reparation of hypermethylated genetic regions.

129 erase chain reaction and revealed 6 genes: 4 hypermethylated ( HEY2, MSR1, MYOM3, and COX17), 2 hypom

130 PCDHGC3 was hypermethylated in 17/28 carcinomas (60.7%) according to

131 TFAP2E was hypermethylated in 38 of 74 patients (51%) in the initia

132 the GADD45A promoter region was shown to be hypermethylated in 82% of wild-type TP53 sarcomas that d

133 At least one of these genes was hypermethylated in 87% of the cases, suggesting that mea

134 IRF6 promoter was hypermethylated in 9 (45%) of 20 VLS specimens, 1 (20%)

135 etic stem cells expanded with cytokines were hypermethylated in a DNMT3A-dependent manner, suggesting

136 ncodes the ubiquitin ligase subunit FBXL7 is hypermethylated in advanced prostate and pancreatic canc

137 HOXC9, HOXB1, HOXB3, HOXC-AS2 and HOXC10 all hypermethylated in aged tissue.

138 embryonic stem cells were preferentially DNA hypermethylated in APL cells.

139 We also found that 12% of the loci were hypermethylated in apparently normal urothelium from bla

140 2/3 NHD13 mice and 2/3 RUNX1 mice) were also hypermethylated in at least two of 19 human MDS samples.

141 In addition, FOXA1 is hypermethylated in basal bladder cancer cell lines, and

142 30B, a promising hub gene, was significantly hypermethylated in blood and downregulated in brain tiss

143 iption, we showed that the GAD1 promoter was hypermethylated in both colon and liver cancer cells, le

144 some promoters were either hypomethylated or hypermethylated in both females and males.

145 n, containing multiple CpG dinucleotides, is hypermethylated in both naive Tet1KO mice and after exti

146 sites in various genomic contexts that were hypermethylated in both non-CIMP and CIMP colon cancers

147 The SOX7 promoter is hypermethylated in breast cancer cell lines compared wit

148 is region has previously been reported to be hypermethylated in breast cancer.

149 Here, we identify Hypermethylated in cancer 1 (Hic1) as a marker of MPs in

150 This chromosomal region contains HYPERMETHYLATED IN CANCER 1 (HIC1), a transcriptional re

151 activation of another tumor suppressor gene, Hypermethylated in Cancer 1 (HIC1), often occurs in huma

152 The tumor suppressor gene hypermethylated in cancer 1 (HIC1), which encodes a tran

153 The tumor suppressor gene hypermethylated in cancer 1 (HIC1), which encodes a tran

154 HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene

155 HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene

156 The transcriptional repressor HIC1 (Hypermethylated in Cancer 1) is a tumor suppressor gene

157 influence the propensity of a gene to become hypermethylated in cancer and that DNMT3B plays an impor

158 articularly, CpG rich regions are frequently hypermethylated in cancer tissues, but not methylated in

159 omoter that contains binding sites for HIC1 (hypermethylated in cancer) protein.

160 of PRC2 targets that were more likely to be hypermethylated in cancer.

161 ation of PcG target genes that are typically hypermethylated in cancer.

162 with key developmental genes, is frequently hypermethylated in cancers and in vitro cell culture, po

163 nes encoding for hsa-miR-9 are significantly hypermethylated in ccRCC tumors compared with adjacent n

164 This region contained a CpG island that was hypermethylated in CD133-ve glioma stem cells (GSC) and

165 e, CpG dinucleotides adjacent to the DHS are hypermethylated in CD8(+) T cells.

166 s, we identified loci at 4092 genes becoming hypermethylated in chemoresistant A2780/cp70 compared wi

167 An additional 2026 sites were found to be hypermethylated in CIMP tumors only; and importantly, 80

168 lation of sites that are already prone to be hypermethylated in colon cancer.

169 gulation) was hypomethylated in placenta and hypermethylated in cord blood.

170 , ALX4, SEPT9, and WIF1 promoters were found hypermethylated in CRC but not in normal tissues or effl

171 genes that have previously been shown to be hypermethylated in cutaneous T-cell lymphomas (CTCLs), u

172 copy number gains such as STC2 and CCND1 and hypermethylated in deletions such as CLCNKB, VHL, and CD

173 GC B cells, but many of them are aberrantly hypermethylated in DLBCL, suggesting disruption of norma

174 re both significantly altered, 16 genes were hypermethylated in DNA associated with decreased mRNA ex

175 n 16 genes (including HTR2B cg27531267) were hypermethylated in EA cases (5.6 x 10(-9) </= P </= 9.5

176 and pyrosequencing showed that survivin was hypermethylated in endometrial tumors and correlated wit

177 In addition, the CpG sites that are hypermethylated in ependymomas are proximal to CpG islan

178 A total of 13/41 genes were consistently hypermethylated in further independent cisplatin-resista

179 sses, whereas low-CpG genes, predicted to be hypermethylated in germlines, are enriched with function

180 CpG sites that were hypermethylated in group H were more frequently located

181 d a CpG-rich region in the first intron were hypermethylated in HCC cells.

182 ith a genome-wide approach, additional genes hypermethylated in HCC that could be used for more accur

183 The 5'-promoter of DCLK1-gene is reportedly hypermethylated in hCRCs, resulting in loss of expressio

184 lation analysis in humans shows that IDO1 is hypermethylated in human sperm but partially methylated

185 s, and only 3%, 2%, and 4% of CpG sites were hypermethylated in IDH(mut) AML, melanoma, and cholangio

186 65,092 analyzed CpG sites, 70,591 (19%) were hypermethylated in IDH(mut) gliomas compared to wild-typ

187 We found that GPC5 was significantly hypermethylated in lung cancer tissues and lung cancer c

188 he first intron of the human BCL6 locus were hypermethylated in lymphoma cells that expressed high am

189 te pyrosequencing shows that CYP24A1 gene is hypermethylated in malignant lesions compared with match

190 After showing the ID4 promoter is hypermethylated in MCF7 cells but hypomethylated in MCF/

191 romoter region of LXN was almost universally hypermethylated in melanoma cell lines and tumors, and t

192 ver, numerous promoters and gene bodies were hypermethylated in mutant iPGCs, which is consistent wit

193 d1, Arg1, Cdk18, and Fes, were significantly hypermethylated in Mvarphis isolated from hyperlipidemia

194 We previously described genes that were hypermethylated in neuroblastoma; in this paper we repor

195 showed an average of 512/3445 (14.9%) genes hypermethylated in NHD13 MDS, and 331 (9.6%) genes hyper

196 at 25% were adjacent to sites that were also hypermethylated in non-CIMP tumors.

197 strate bipolar DNA methylation pattern, i.e. hypermethylated in one cell subset but hypomethylated in

198 ses the distal enhancer element of P1-rr, is hypermethylated in P1-pr compared to P1-rr.

199 IL12RB2, TYK2, IFNGR1, JAK1, and JAK2) were hypermethylated in patients with TB.

200 KLF8, MOB3B, SLC18A2, and GSTP1) known to be hypermethylated in PC.

201 ent and function, and lipid metabolism) were hypermethylated in placenta and cord blood from SGA newb

202 ller and distinct from PMDs, with some being hypermethylated in placenta compared with other tissues.

203 ied the promoter region of the DOC2B gene as hypermethylated in pre-malignant, malignant cervical tis

204 ing the transcriptional start site of LTF is hypermethylated in prostate cancer cell lines.

205 After HR, the repaired DNA is hypermethylated in recombinant clones showing low GFP ex

206 The genome of Aid-null cells remains hypermethylated in reprogramming cells, and hypermethyla

207 fite sequencing confirmed that 14 genes were hypermethylated in resistant cell lines but not in the s

208 roblasts identified multiple genes that were hypermethylated in response to PGE(2).

209 ethylated in NHD13 MDS, and 331 (9.6%) genes hypermethylated in RUNX1 MDS.

210 rmined that the PTPRT promoter is frequently hypermethylated in several cancers, including HNSCC (60.

211 GI, is hypomethylated in male germ cells but hypermethylated in somatic tissues, regardless of genomi

212 CpGs (tet2-DMCs) in NCGIs, 86% of which were hypermethylated in TET2-MT cases, suggesting a strikingl

213 To determine whether the same CpG island is hypermethylated in the cerebella of cases in whom aberra

214 e maternal allele of many A. lyrata PEGs was hypermethylated in the CHG context.

215 DNA was not hypermethylated in the Cyp3a locus at any age.

216 ted B cells produce iPSCs that are uniformly hypermethylated in the imprinted Dlk1-Dio3 gene cluster

217 of the 9 CpG loci in SST were significantly hypermethylated in the older individuals.

218 t identify all individual CpG sites that are hypermethylated in the presence of a mutation.

219 Spermatazoal DNA was hypermethylated in the saccharin-exposed fathers, especi

220 Of these, 537 CpG sites were hypermethylated in the tumor DNA, whereas 1,689 sites sh

221 equencing revealed that the Tnf promoter was hypermethylated in tumor-induced MDSCs in vivo.

222 However, when DNA-hypermethylated in tumors, we find that these genes are

223 s more than 20) consecutive CpG islands were hypermethylated in tumors.

224 region was confirmed as being substantially hypermethylated in two other cortical regions (superior

225 ethylated CpG sites (76% hypomethylated, 24% hypermethylated) in patients with advanced vs mild NAFLD

226 hat also binds the transcriptional repressor Hypermethylated-In-Cancer-1 (HIC1).

227 nuclear chromatin architecture for genes in hypermethylated inactive versus nonmethylated active sta

228 er CpG islands of ABCC3 and SLCO2A1 were not hypermethylated, indicating that these genes were not ep

229 Two other clusters of hypermethylated islands were at sequences of recent gene

230 However, the hypermethylated loci in ER-negative tumors were clustere

231 evels of nuclear methylation, we detected 23 hypermethylated loci in gene-poor, repeat-rich regions.

232 rone receptor-positive tumors displayed more hypermethylated loci than estrogen receptor (ER)-negativ

233 as in Monos, 155 hypomethylated loci and 247 hypermethylated loci were found (fold change >/=1.3; P <

234 ildren, while regions in RAD50 and IL13 were hypermethylated (lowest P-value (STAT6) = 0.001).

235 other tumors and normal tissues possessed a hypermethylated LTR preventing proviral expression.

236 lications to delay the progression of RASSF1-hypermethylated lung tumors.

237 consisting of novel and known breast cancer hypermethylated markers identified by mining our previou

238 as characterized by numerous novel, aberrant hypermethylated marks that were located mainly outside o

239 ation also has been observed across the male hypermethylated (MHM) region, which has been suggested t

240 analysis found a significant correlation of hypermethylated miR-129-2 with microsatellite instabilit

241 thylated ( CTGF and MMP2); and 2 microRNA: 1 hypermethylated (miR-24-1), 1 hypomethylated (miR-155) w

242 L-6, HMGA2, and Sox2 protein expressions and hypermethylated miR142-3p promoter also demonstrate poor

243 In cell lines with a hypermethylated MITF-pathway, overexpression of MITF did

244 ite sequencing of KLF4 promoter identified a hypermethylated myocyte enhancer factor-2 binding site.

245 ptive behavior are separable as males with a hypermethylated OA neuronal genome exhibited a decrease

246 In this study, we describe the TERT hypermethylated oncological region (THOR), a 433-bp geno

247 hose from patients with Lynch syndrome, MLH1-hypermethylated, or microsatellite-stable tumors.

248 sited on hypomethylated maternal alleles and hypermethylated paternal alleles, respectively.

249 Furthermore, hypermethylated PAX1 associated with poor prognosis in c

250 ours harbour increased H3K27me3 signal and a hypermethylated phenotype, mainly occupying the polycomb

251 Additionally, the hypermethylated Pomc gene was detected in sperm of fetal

252 ed segment and amplifies the HR-L expressor (hypermethylated) population.

253 Aged cells also demonstrated a hypermethylated profile in pathways; axon-guidance, adhe

254 ZNF238 to be most significantly enriched in hypermethylated promoter regions.

255 Three downregulated genes with hypermethylated promoters and restored expression in res

256 2i in all three epitypes, despite exhibiting hypermethylated promoters in constitutively methylated E

257 alent chromatin marks, and colocalization of hypermethylated R-DMRs with hypomethylated C-DMRs and th

258 We further confirmed that hypermethylated RAB25 is inversely correlated with its m

259 Eleven samples (12%) had no detectable hypermethylated RASSF1A and 10 of these (91%) had gestat

260 Use of this assay for the detection of hypermethylated RASSF1A as a universal fetal marker has

261 The hypermethylated RASSF1A promoter has been reported as a

262 Hypermethylated RASSF1A was amplified for 79 samples (88

263 ions, including a previously identified male hypermethylated region 1 (MHM1; CGNC: 80601).

264 ion ratios on the chicken Z Chromosome (male hypermethylated region 2 [MHM2]; CGNC: 80602).

265 We identified 2,465 differentially hypermethylated regions and 4,692 hypomethylated regions

266 in both models with a shared core set of DNA hypermethylated regions and suppression of stem cell-rel

267 Hypermethylated regions in enhancers may alter regulatio

268 Furthermore, hypermethylated regions in MM were methylated in stem ce

269 DNA pyrosequencing identified hypermethylated regions of the alpha-SMA gene in PARP-1-

270 Hypomethylated and hypermethylated regions were associated with increased a

271 ly expressed memory markers; rather, several hypermethylated regions were identified in known transcr

272 actor binding sites and human differentially hypermethylated regions.

273 mi-1, and/or Nanog and their CpG islands are hypermethylated relative to nontumorigenic cells.

274 mDnmt2 silencing and the identification of a hypermethylated, repetitive intron within a predicted fo

275 Among hypermethylated sequences identified, several fragments

276 As in differentiated cells, hypermethylated sequences were enriched in chromatin rep

277 demonstrated that four TFBS were enriched in hypermethylated sequences.

278 The hypermethylated set was enriched for genes known to be i

279 By analysing sequence motifs surrounding hypermethylated sites across the four cancer types, and

280 ter-associated CpG islands (CGIs) in cancer, hypermethylated sites in MM, as opposed to normal plasma

281 s and primary lung tumor tissues harboring a hypermethylated SOX30.

282 Importantly, this hypermethylated state correlates with the failure of the

283 tified a small number of CpG sites showing a hypermethylated state with age, in both muscle tissue an

284 Further analysis identifies a hypermethylated subtype which shows a functional converg

285 We identify predominately hypermethylated T2D-related differentially methylated re

286 Approximately half of the hypermethylated targets are developmental regulators, an

287 c acid receptor activation pathway among the hypermethylated targets.

288 at normal temperature, root hairs were more hypermethylated than were stripped roots.

289 ers, with ratios of significantly (P < .001) hypermethylated to hypomethylated CpGs of 1.7 and 2.9, r

290 , the sites outside CpG islands were heavily hypermethylated to the same degree in both genders.

291 C1) occupy the promoters of several of these hypermethylated TSGs and physically and functionally int

292 evealed that genes whose promoter region was hypermethylated upon myoblast differentiation were highl

293 erentiation and signaling are preferentially hypermethylated, whereas those of housekeeping genes rem

294 er region of the peptide ligand gene EPF2 is hypermethylated, which greatly reduces EPF2 expression a

295 een bivalent genes that do and do not become hypermethylated, which is also mirrored in cancer.

296 r cells frequently have regions of their DNA hypermethylated, which results in transcriptional silenc

297 g analysis shows that the paternal allele is hypermethylated while the maternal allele shows low leve

298 were enriched at genomic regions that become hypermethylated with increasing cell culture passage.

299 uated, only one c9FTD sample was found to be hypermethylated within the C9orf72 promoter region.

300 It is hypermethylated within transposable elements (TEs), acco