ライフサイエンスコーパス: hyperpigmentation

1 e of scarring, postinflammatory erythema, or hyperpigmentation).

2 nocyte regeneration as well as skin and hair hyperpigmentation.

3 emperature, high water evaporation rate, and hyperpigmentation.

4 Nearly all patients with FES showed eyelid hyperpigmentation.

5 e, implicating keratinocytes in the aberrant hyperpigmentation.

6 rmal melanocytes, resulting in skin and hair hyperpigmentation.

7 king pigmentation phenotype characterized by hyperpigmentation.

8 nt were nausea, freckles, headache, and skin hyperpigmentation.

9 with a residual ecchymotic postinflammatory hyperpigmentation.

10 signaling and in turn leads to skin and hair hyperpigmentation.

11 e typical CALMs that appear over the general hyperpigmentation.

12 ular pressure going along with chamber angle hyperpigmentation.

13 AG lasers gave excellent results in gingival hyperpigmentation.

14 mines metformin as a potential drug to treat hyperpigmentation.

15 and represents an effective agent to reduce hyperpigmentation.

16 All patients experienced diffuse hyperpigmentation.

17 s who were included, 16 (21%) presented with hyperpigmentation.

18 h SD-OCT in eyes with larger drusen and with hyperpigmentation.

19 roducts for skin lightening and treatment of hyperpigmentation.

20 differences account completely for lesional hyperpigmentation.

21 laucoma, selected to have clinically visible hyperpigmentation.

22 us year 10 included: drusen, 99% versus 99%; hyperpigmentation, 11% versus 11%; and hypopigmentation,

23 ring (36 [100%]), induration (30 [83%]), and hyperpigmentation (29 [81%]).

24 ally significant alopecia (30%), periorbital hyperpigmentation (30%), deep rhytides on the face (20%)

25 ng eyes with undiagnosed AMD, 32 (10.0%) had hyperpigmentation, 43 (13.4%) had hypopigmentation, 249

26 yperpigmentation (7126 [14.8%]), periorbital hyperpigmentation (7076 [14.7%]), vitiligo (3394 [7.1%])

27 igmentation (8289 [17.2%)], postinflammatory hyperpigmentation (7126 [14.8%]), periorbital hyperpigme

28 er: solar lentigo (13,192 [27.5%]), axillary hyperpigmentation (8289 [17.2%)], postinflammatory hyper

29 < .001), breast pain (55% vs 74%; P = .001), hyperpigmentation (9% vs 20%; P = .002), and fatigue (9%

30 anti-inflammatory, anti-haemolytic, and anti-hyperpigmentation activities.

31 low-up, and 2 withdrew owing to inflammatory hyperpigmentation after the laser treatment.

32 ultivariable analysis, the presence of focal hyperpigmentation, almost reaching statistical significa

33 abca4b(-/-) mutants, the RPE cells exhibited hyperpigmentation, altered retinomotor behaviour and lip

34 n to decrease melanin synthesis for treating hyperpigmentation and a TYR-catalyzed in-situ activated

35 y adrenal insufficiency usually develop skin hyperpigmentation and crave salt.

36 its several characteristics of DC, including hyperpigmentation and fatal bone marrow failure at 4-5 m

37 Hyperpigmentation and grade >=2 breast shrinkage were le

38 ts novel evidence for a relationship between hyperpigmentation and increased superoxide-generating ca

39 sities, large painful varicose veins, edema, hyperpigmentation and lipodermatosclerosis of skin, and

40 aracterized by cutaneous symptoms, including hyperpigmentation and nail dystrophy.

41 0E) mutation) led to the development of skin hyperpigmentation and nevi, as well as melanoma formatio

42 STK19(D89N) knockin leads to skin hyperpigmentation and promotes NRAS(Q61R)-driven melanom

43 Transient discrete residual hyperpigmentation and scaling were present.

44 val intraepithelial melanin overproduction ("hyperpigmentation") and intraepithelial melanocytic prol

45 toderma, hypodontia, enamel hypoplasia, oral hyperpigmentation, and dysphagia.

46 ctive ORs for the presence of a large druse, hyperpigmentation, and fellow eye affected were 2.60, 1.

47 area, presence of one or five large drusen, hyperpigmentation, and fellow eye status was calculated.

48 ndrome characterized by bone marrow failure, hyperpigmentation, and nail dystrophy.

49 ging other than rhytids, such as lentigines, hyperpigmentation, and telangiectasias, should be consid

50 th telomere attrition, short life span, skin hyperpigmentation, aplastic anemia, and cerebellar hypop

51 fe-au-lait" macules (CALMs) and overall skin hyperpigmentation are early hallmarks of neurofibromatos

52 ncentrations, right upper quadrant pain, and hyperpigmentation are often substantially alleviated by

53 scarring and dyspigmentation (ie, erythema, hyperpigmentation) are common sequelae with significant

54 The data support hyperpigmentation as a protective antioxidant mechanism

55 s might be useful for the correction of skin hyperpigmentation as a side-effect of chemotherapy.

56 Five subjects developed areas of persistent hyperpigmentation at r-hSCF injection sites; by light mi

57 accumulations of mast cells in the skin and hyperpigmentation at sites of chronic cutaneous inflamma

58 For postinflammatory hyperpigmentation, azelaic acid holds promise.

59 epithelium (RPE) depigmentation (34.9%), RPE hyperpigmentation (branching reticular pigmentation) (22

60 wounds, beta2ARag reduced both scar area and hyperpigmentation by almost 50% and significantly improv

61 ethod, subretinal tissues such as those with hyperpigmentation can be visualized with increased contr

62 Although pathways underlying hyperpigmentation cascade are recognized, negative feedb

63 icating that it is an effective solution for hyperpigmentation, causing no cellular damage.

64 s frequent retinal greying and more frequent hyperpigmentations compared with eyes that have better B

65 thyrotropin level (15 participants) and skin hyperpigmentation/discoloration (8 participants).

66 Hyperpigmentation disorders are generally difficult to t

67 nin biosynthesis, is closely associated with hyperpigmentation disorders, cancer, and neurodegenerati

68 ctive skin-lightening products to treat skin hyperpigmentation disorders, including postinflammatory

69 reviously unrecognized clinical phenotype in hyperpigmentation disorders.

70 suggest that metformin may be used to treat hyperpigmentation disorders.

71 meceutical" skin lightening and treatment of hyperpigmentation disorders.

72 Secondary hyperpigmentation during interferon alfa treatment occur

73 Cases of cutaneous and mucous hyperpigmentations during interferon alfa treatment have

74 and other lesions associated with cutaneous hyperpigmentation, extracardiac myxomas, and nonmyxomato

75 a rare case of trigeminal nerve-distributed hyperpigmentation following corneal tattooing in a patie

76 ost common cutaneous reactions are alopecia, hyperpigmentation, hand--foot syndrome, radiation recall

77 were defined using a scoring system based on hyperpigmentation, hardening, and tethering of skin on t

78 In intermediate AMD, macular hyperpigmentation has high spatial correlation to SDOCT

79 hosis, eyelid erythema, eyelid edema, eyelid hyperpigmentation, high upper eyelid crease, upper eyeli

80 Hyperpigmentation, hyperkeratoses, and Bowen's disease a

81 de H syndrome, characterized by scleroderma, hyperpigmentation, hypertrichosis, hepatomegaly, cardiac

82 Among them, 29 eyes had early AMD (drusen, hyperpigmentation, hypopigmentation), 5 had extrafoveal

83 ause pruritic excoriated macules/papules and hyperpigmentation in areas where clothing seams contact

84 rosinase inhibitors for suppressing unwanted hyperpigmentation in human skin and enzymic browning in

85 t hemocyanin may act as a causative agent of hyperpigmentation in N. norvegicus.

86 ased on the presence of intermediate drusen, hyperpigmentation in one or both eyes, and Age-Related E

87 % of vitiligo lesions, respectively, without hyperpigmentation in surrounding areas or other adverse

88 luding peculiar caudal fin malformations and hyperpigmentation in the tail, were measured in several

89 Drusen size, distribution, drusen area, and hyperpigmentation in two central macular regions on base

90 n of >= 1 disc area, any hypopigmentation or hyperpigmentation in zones 2 or 3, or a combination ther

91 ptosis in the intestinal crypt and epidermal hyperpigmentation indicate the presence of elevated geno

92 Cutaneous hyperpigmentation is a common disorder due to excess mel

93 Macular hyperpigmentation is associated with progression from in

94 AG) and diode, for the treatment of gingival hyperpigmentation is compared.

95 Hyperpigmentation is observed in the interfollicular epi

96 s colocalization with large, soft drusen and hyperpigmentation is several times greater than chance,

97 postoperative skin hyperpigmentation localized to a trigeminal nerve distri

98 cular pseudodrusen (RPD), refractile drusen, hyperpigmentation, location of atrophy (foveal vs. extra

99 The phenomenon of hyperpigmentation (melanosis) in shellfish has long been

100 tation disorders, including postinflammatory hyperpigmentation, melasma and solar lentigines.

101 lanogenic effect in an ultraviolet B-induced hyperpigmentation mouse model.

102 ate deposits, including macular crystals and hyperpigmentations (n = 9, 38%), and subretinal fibrosis

103 F ) function contribute to scarring, whereas hyperpigmentation negatively affects scar quality.

104 nmyelopathy accompanied by short stature and hyperpigmentation, now better known as Fanconi anemia (F

105 In the distal limb, there were agenesis and hyperpigmentation of claws, interdigital webbing, reduce

106 syndromes that include benign neurofibromas, hyperpigmentation of melanocytes and hamartomas of the i

107 ane, acquired longitudinal melononychia, and hyperpigmentation of the face were each observed in 7 pa

108 Most patients with hyperpigmentation of the oral mucosa also had melanonych

109 Hyperpigmentation of the oral mucous membrane, acquired

110 Hyperpigmentation of the pinnae and tail could be detect

111 Hyperpigmentation of the retinal pigment epithelium was

112 membrane, and atrophy, hypopigmentation, and hyperpigmentation of the retinal pigment epithelium.

113 However, patients with hyperpigmentation of the skin did not have mucosal or na

114 All patients with hyperpigmentation of the skin had skin type III or IV an

115 of the corneal tattoo in 2023, he developed hyperpigmentation of the skin localized to the ophthalmi

116 in the central nervous system, and patterned hyperpigmentation of the skin.

117 r up to 1 month followed by temporary slight hyperpigmentation of the treated areas.

118 Individuals with postinflammatory hyperpigmentation or lentigines displayed decreased skin

119 pigmentation (OR, 9.0; 95% CI, 4.1-19.8); or hyperpigmentation (OR, 12.0; 95% CI, 6.1-23.5), referenc

120 events (including erythema, rash, pruritus, hyperpigmentation, pain, hypopigmentation, and oedema) o

121 isual acuity, bull's eye maculopathy, foveal hyperpigmentation, peripapillary atrophy, dyschromatopsi

122 Vaccine-induced hyperpigmentation persisted for at least 180 days after

123 imaging was used to assess AMD severity and hyperpigmentation (PGM) presence.

124 Finally, the hyperpigmentation phenotype can be rescued using specifi

125 monstrate that NF1 melanocytes reproduce the hyperpigmentation phenotype in vitro, and further charac

126 3 transgene is important to the onset of the hyperpigmentation phenotype.

127 t as a treatment option for postinflammatory hyperpigmentation (PIH) but can pose a clinical dilemma

128 t as a treatment option for postinflammatory hyperpigmentation (PIH) but can pose a clinical dilemma

129 V-sensitivity syndrome characterized by skin hyperpigmentation, premature aging, and increased skin c

130 orescence analysis demonstrated pathological hyperpigmentation, proliferation and hyperplasia of acti

131 onditions (alopecia, allergic skin diseases, hyperpigmentation, psoriasis, skin cancer, pachyonychia

132 ations have been reported to cause cutaneous hyperpigmentation resembling that of alkaptonuria.

133 ivity, converting Fe(3+) to Fe(2+), but that hyperpigmentation results in excessive reduction of iron

134 ng therapy only trials, these differences in hyperpigmentation (RR 0.79, 0.60 to 1.03; P=0.08) and br

135 Regions of hyperpigmentation, selected using stereo color fundus ph

136 Minocycline-induced hyperpigmentation should be considered in the differenti

137 cognized lack of attached gingiva, pretibial hyperpigmentation, skin and vascular fragility, easy bru

138 No adverse events such as hypo/hyperpigmentation, skin infection, or recurrence were re

139 succinate dehydrogenase subunit A alongside hyperpigmentation suggested coregulation of activity and

140 Transient hyperpigmentation, superficial exfoliation, and crusting

141 ult Krt9(-/-)mice develop calluses marked by hyperpigmentation that are exclusively localized to the

142 The number of participants diagnosed with hyperpigmentation was 673; with hyperkeratosis, 243; and

143 s occurred in eight of 22 patients (36%) and hyperpigmentation was noted in 12 of 22 patients (55%),

144 Marked hyperpigmentation was observed only in 25% (n = 5) of pa

145 o observed in central European patients, but hyperpigmentation was primarily mild to moderate.

146 Macular CFP hyperpigmentation was significantly associated with SDOC

147 s, 28 of 39 (71.8%) retinal CFP regions with hyperpigmentation were correlated with focal hyperreflec

148 uiring treatment for mild-to-severe gingival hyperpigmentation were enrolled.

149 Measurements on versus off hyperpigmentation were made in nine persons with suspect

150 resence of large drusen, and the presence of hyperpigmentation were not consistent risk factors for a

151 of the macular lutein pigment, macular hypo/hyperpigmentation were observed in the LE.

152 ites from 35 patients with bilateral melanin hyperpigmentation were treated with surgical stripping (

153 the reproductive abnormalities but not skin hyperpigmentation, whereas deletion of cell cycle arrest

154 e or nonfibrotic with discrete flat areas of hyperpigmentation with varying amounts of central depigm

155 d potential for addressing post-inflammatory hyperpigmentation, with piscidic and eucomic acids predi

156 herapeutics could efficiently alleviate skin hyperpigmentation within 48 h as well as resensitize the

157 h fractionated CO2 for her scarring, but her hyperpigmentation worsened with each treatment.